Metastatic Cutaneous Melanoma in a White African Lioness (Panthera leo)

Malignant melanomas tend to be locally destructive, aggressive tumours commonly associated with recurrence and/or metastasis. In this report, a 13-year-old captive white African lioness (Panthera leo), with a recent history of intermittent bouts of lethargy and inappetence, presented with a distended abdomen (due to ascites) and a small, round crusty lesion on the ear. An abdominal ultrasound showed the presence of masses on the liver and an exploratory laparotomy revealed multiple pale lesions on the liver and omentum. Histopathology revealed sheets of pleomorphic neoplastic cells compressing the non-neoplastic liver tissue. Similar neoplastic cells had multifocally expanded and effaced omentum adipose tissue, as well as formed a well-circumscribed mass in the ear sample, extending from close to the epidermis to the lateral and deep margins of the section. All three tissue samples had a high mitotic index (15 per 10 HPF), and critically, in the ear sample, there were rafts of neoplastic cells in the lymphatics, indicating lymphovascular invasion. Immunohistochemistry for the melanoma marker, PNL-2, showed strong positivity in all three tissue samples. Thus, the diagnosis was of malignant melanoma with metastasis to the liver and omentum. This is the first report of metastatic cutaneous melanoma in a lion.

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Identification of Mycobacterium genavense natural infection in a domestic ferret

Journal of Veterinary Diagnostic Investigation ◽

10.1177/1040638718812137 ◽

2018 ◽

Vol 31 (1) ◽

pp. 133-136 ◽

Cited By ~ 2

Author(s):

Bérengère Dequéant ◽

Quentin Pascal ◽

Héloïse Bilbault ◽

Elie Dagher ◽

Maria-Laura Boschiroli ◽

...

Keyword(s):

Natural Infection ◽

Abdominal Ultrasound ◽

Needle Aspiration ◽

Mesenteric Lymph Nodes ◽

Mustela Putorius ◽

Tissue Samples ◽

Acid Fast Bacilli ◽

Mycobacterium Genavense ◽

History Of ◽

Progressive Weight Loss

A 6-y-old neutered male ferret ( Mustela putorius furo) was presented because of a 1-mo history of progressive weight loss, chronic cough, and hair loss. On clinical examination, the animal was coughing, slightly depressed, moderately hypothermic, and had bilateral epiphora. Thoracic radiography was suggestive of severe multinodular interstitial pneumonia. Abdominal ultrasound examination revealed hepatosplenomegaly and mesenteric and pancreaticoduodenal lymphadenopathy. Fine-needle aspiration of the pancreaticoduodenal lymph node, followed by routine Romanowsky and Ziehl–Neelsen stains, revealed numerous macrophages containing myriad acid-fast bacilli, leading to identification of mycobacteriosis. Autopsy and histologic examination confirmed the presence of disseminated, poorly defined, acid-fast, bacilli-rich granulomas in the pancreaticoduodenal and mesenteric lymph nodes, intestines, and lungs. Destaining of May-Grünwald/Giemsa–stained slides with alcohol, and then restaining with Ziehl–Neelsen, revealed acid-fast rods and avoided repeat tissue sampling without affecting the Ziehl–Neelsen stain quality and cytologic features. Tissue samples were submitted for a PCR assay targeting the heat shock protein gene ( hsp65) and revealed 100% homology with Mycobacterium genavense. We emphasize the use of special stains and PCR for identification of this potential zoonotic agent.

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A Case of Phosphoglyceride Crystal Deposition Disease in the Pelvic Soft Tissues Recurring after Initial Surgery

Case Reports in Obstetrics and Gynecology ◽

10.1155/2015/751582 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Yuki Yamada ◽

Kazuhiro Nishioka ◽

Hirotaka Kajihara ◽

Taketoshi Noguchi ◽

Katsuhiko Naruse ◽

...

Keyword(s):

Soft Tissues ◽

Malignant Tumors ◽

Exploratory Laparotomy ◽

Abdominal Ultrasound ◽

Crystal Deposition ◽

Crystal Deposition Disease ◽

Deposition Disease ◽

Initial Surgery ◽

Abdominal Masses ◽

History Of

Phosphoglyceride crystal deposition disease (PGDD) is a rare disease entity that is characterized by phosphoglyceride crystal deposition that stimulates the formation of masses in soft tissue scars or bones. We report a case of PGDD in the pelvic soft tissues that recurred after initial surgical treatment. A 50-year-old woman was referred to our hospital for the evaluation of pelvic masses that were observed on an abdominal ultrasound. Magnetic resonance imaging (MRI) revealed masses in the pelvic region, with the largest being 10 cm in diameter. The masses were diagnosed as ovarian malignant tumors, and an exploratory laparotomy was performed. Operative findings revealed them to be foreign body granulomas, and the patient was diagnosed with PGDD. The patient had a history of cesarean delivery at the age of 24 years. PGDD is extremely rare, but it should be considered in the differential diagnosis of abdominal masses in patients with a history of abdominal surgery.

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Chronic Nocturnal Abdominal Pain as the Presentation of Inverted Meckel Diverticulum: A Case Report

Children ◽

10.3390/children9010069 ◽

2022 ◽

Vol 9 (1) ◽

pp. 69

Author(s):

Ting-Yu Wang ◽

Yu-Tsun Su ◽

Po-Jui Ko ◽

Yea-Ling Chen ◽

Hsiang-Hung Shih ◽

...

Keyword(s):

Abdominal Pain ◽

Meckel’S Diverticulum ◽

Clinical Manifestations ◽

Exploratory Laparotomy ◽

Meckel's Diverticulum ◽

Distended Abdomen ◽

History Of ◽

The Common ◽

Hospital Visits ◽

Inverted Meckel’S Diverticulum

The common clinical manifestations of Meckel’s diverticulum include painless lower gastrointestinal bleeding and intestinal obstruction due to intussusception. Intussusception induced by inverted Meckel’s diverticulum has rarely been reported; furthermore, there is no report thus far of chronic nocturnal abdominal pain as a presenting symptom in children with Meckel’s diverticulum. A 4-year-and-10-month-old girl with no significant history of previous illness presented with the sole complaint of chronic nocturnal abdominal pain for 3 months. The patient was reported to be asymptomatic during the day. A provisional diagnosis of chronic ileoileal intussusception was already under consideration in her previous hospital visits elsewhere. Physical examination revealed a soft, non-distended abdomen without tenderness. Imaging studies revealed ileoileal intussusception. Exploratory laparotomy showed ileoileal intussusception induced by an inverted Meckel’s diverticulum with ulceration. The patient underwent successful surgery and made a full recovery. We report this case to remind physicians that Meckel’s diverticulum should be considered in differential diagnosis of children presenting with the isolated symptom of chronic nocturnal abdominal pain.

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Horn-induced traumatic caudoventral abdominal wall hernia management and repair in an adult Highland cow

Veterinary Record Case Reports ◽

10.1136/vetreccr-2020-001121 ◽

2020 ◽

Vol 8 (3) ◽

pp. e001121

Author(s):

Caroline Knox Benham ◽

Vincent Doré ◽

Pierre-Yves Mulon

Keyword(s):

Abdominal Wall ◽

Body Wall ◽

Abdominal Wall Hernia ◽

Exploratory Laparotomy ◽

Abdominal Ultrasound ◽

History Of ◽

The Right ◽

Resection And Anastomosis ◽

Haemorrhagic Diarrhoea

An adult Highland cow weighing 380 kg presented following a five-day history of inappetence, recumbency and trauma inflicted by herd-mates. Physical exam demonstrated significant swelling of the right ventral abdomen with skin excoriations. Abdominal ultrasound of the bulging area indicated significant oedema within pockets, thinning of the right body wall compared with the left side, as well as accumulation of free abdominal fluid. Severe mastitis was noted in three quarters of its udder. The patient was stabilised with intravenous fluids, electrolytes and a belly band. It developed severe, haemorrhagic diarrhoea over the following days, and an exploratory laparotomy was performed. A complete 50 cm-long abdominal wall laceration in the caudoventral right paralumbar fossa was repaired, and jejunal resection and anastomosis performed. The patient recovered with supportive care. Surgical complications included postoperative pneumonia and development of a surgical site infection. The patient maintains good quality of life.

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Jejunal Lesion Identified at a Previous Anastomosis Site in a Dog Using Capsule Endoscopy

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6712 ◽

2020 ◽

Vol 56 (1) ◽

pp. 30-33 ◽

Cited By ~ 1

Author(s):

Millie Grimes ◽

Todd Cohen ◽

Jill S. Pomrantz

Keyword(s):

Gastrointestinal Bleeding ◽

Capsule Endoscopy ◽

Clinical Signs ◽

Unknown Origin ◽

Exploratory Laparotomy ◽

Abdominal Ultrasound ◽

History Of ◽

Focal Abnormality ◽

Small Intestinal Diverticulum ◽

Resection And Anastomosis

ABSTRACT A 3 yr old spayed female French bulldog was evaluated for a progressive regenerative anemia of unknown origin that was unresponsive to empiric immunosuppressive and gastroprotective therapy. The patient had a history of previous resection and anastomosis of a small intestinal diverticulum ∼2 yr prior to evaluation for her anemia. Capsule endoscopy revealed a focal abnormality in the distal jejunum at the site of a previous bowel resection and anastomosis. This lesion was suspected to be the cause of ongoing gastrointestinal bleeding and anemia. Exploratory laparotomy combined with endoscopy was performed to further investigate and localize the jejunal lesion. The lesion was resected, and a primary end-to-end jejunal anastomosis was performed. Histopathology of the specimen revealed jejunal suture granulomas with focal ulceration. The patient recovered well from surgery with significant improvement of the anemia and resolution of clinical signs at recheck examinations 1 and 2 wk postoperatively. Complete resolution of the anemia was noted at a 6 wk follow-up. The case report demonstrates how, in cases of unknown causes of anemia, capsule endoscopy is a noninvasive method of identifying the presence of gastrointestinal bleeding as a result of lesions that might otherwise not be detectable with abdominal ultrasound or conventional endoscopy. The report also documents a long-term complication to a resection and anastomosis surgery.

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Myxosarcoma Associated with the Kidney in a Cat: Case Report

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6863 ◽

2020 ◽

Vol 56 (2) ◽

Author(s):

Brittany Champagne Madere ◽

Andrea Dedeaux ◽

Tatiane Terumi Negrao Watanabe ◽

Nobuko Wakamatsu ◽

Lorrie Gaschen ◽

...

Keyword(s):

Case Report ◽

Renal Mass ◽

Abdominal Mass ◽

Vena Cava ◽

Exploratory Laparotomy ◽

Abdominal Ultrasound ◽

History Of ◽

Pendulous Abdomen ◽

Disease Free ◽

Abdominal Hemorrhage

ABSTRACT A 12 yr old spayed female domestic shorthair with a history of lethargy, anorexia, and a pendulous abdomen was referred after a cranial abdominal mass was palpated on physical examination. Thoracic radiographs and an abdominal ultrasound revealed a mass associated with the kidney and moderate hemoperitoneum. Exploratory laparotomy revealed abdominal hemorrhage originating from a right renal mass that was adhered to the caudal vena cava. Following a right nephrectomy, histopathology diagnosed the mass as a perirenal/renal myxosarcoma. Based upon thoracic radiographs and abdominal ultrasound, the patient remains disease free at 14 mo postoperatively.

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1715-P: Impaired Postprandial Adipose Tissue Microvascular Blood Flow in Healthy People with a Family History of Type 2 Diabetes

Diabetes ◽

10.2337/db20-1715-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1715-P

Author(s):

KATHERINE ROBERTS-THOMSON ◽

RYAN D. RUSSELL ◽

DONGHUA HU ◽

TIMOTHY M. GREENAWAY ◽

ANDREW C. BETIK ◽

...

Keyword(s):

Type 2 Diabetes ◽

Blood Flow ◽

Adipose Tissue ◽

Family History ◽

Healthy People ◽

Microvascular Blood Flow ◽

History Of

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Associations of residential and occupational history with the distribution of persistent pollutants mixtures in adipose tissue samples

Environmental Research ◽

10.1016/j.envres.2020.110687 ◽

2020 ◽

pp. 110687

Author(s):

Ruth Echeverría ◽

Petra Vrhovnik ◽

Inmaculada Salcedo-Bellido ◽

Francisco M. Pérez-Carrascosa ◽

Celia Gómez-Peña ◽

...

Keyword(s):

Adipose Tissue ◽

Occupational History ◽

Tissue Samples ◽

Persistent Pollutants

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Adherence to Primary Prevention and Skin Self-Examination Practices by Spanish Melanoma Patients

Dermatology ◽

10.1159/000512887 ◽

2021 ◽

pp. 1-7

Author(s):

Irene Torrecilla-Martínez ◽

Esperanza Manrique-Silva ◽

Victor Traves ◽

Celia Requena ◽

Eduardo Nagore

Keyword(s):

Primary Prevention ◽

Cutaneous Melanoma ◽

Public Health Problem ◽

Global Public Health ◽

Prevention Measures ◽

Online Questionnaire ◽

Cross Sectional ◽

History Of ◽

High Level ◽

Self Examination

Background: The incidence of cutaneous melanoma, an important global public health problem, has been increasing over the last several decades. Objectives: In order to decrease melanoma-related mortality, ways to communicate and implement the correct methods for conducting primary and secondary prevention measures (such as early detection via self-examination) should be investigated. Materials and Methods: An observational, cross-sectional, retrospective study consisting of 409 patients diagnosed with cutaneous melanoma was conducted. An online questionnaire was created to evaluate knowledge levels, attitudes, and adherence to primary preventive measures and to skin self-examination practices. Results: The results revealed that even when 43% of the patients perform cutaneous self-examinations, only half of them fully followed the recommendations. Patients aged <45 years, female, with a I–II phototype, with an intermediate/high level of education, and with a history of NMSC were more likely to have an adequate degree of knowledge. Moreover, patients aged <45 years and with an adequate degree of knowledge more frequently showed an adequate adherence to the primary prevention measures. Finally, patients aged 45–60 years and with an adequate degree of knowledge presented a good adherence to the self-skin examination measures. Limitations: Possible limitations of this study were memory bias through the influence of age within the study population, and bias due to a greater proportion of subjects with a high education level. Conclusion: Within the population of patients with melanoma, a high percentage of patients do not rigorously follow the recommended prevention measures. Our study highlights the need to implement awareness in this population to improve the prevention of cutaneous cancer.

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Choledochal Cyst Coexisting with Gallbladder Carcinoma - An Uncommon Case Report

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v16i4.33621 ◽

2017 ◽

Vol 16 (4) ◽

pp. 602-605

Author(s):

Jahangir Hossain Bhuiyan ◽

Mohibul Aziz ◽

Omar Faruk ◽

Mahbub Hasan

Keyword(s):

Choledochal Cyst ◽

Gallbladder Carcinoma ◽

Medical Science ◽

Rare Condition ◽

Exploratory Laparotomy ◽

Abdominal Ultrasound ◽

Low Grade ◽

College Hospital ◽

Medical College ◽

Operative Recovery

Choledochal Cyst is a relatively rare condition. Even rarer is a choledochal cyst in association with a gallbladder carcinoma. This study reports a rare case of choledochal cyst coexisting with gallbladder carcinoma in a Bangladeshi patient. A 35 year old lady presented at IBN Sina Medical College Hospital, Kallyanpur, Dhaka with the history of recurrent right upper quadrant abdominal pain from childhood, which became severe for last 4 days before admission. The pain was colicky in nature and radiated to the back. Episodes were associated with low-grade fever, anorexia as well as vomiting. The preoperative diagnosis was made by abdominal ultrasound and MRCP. Exploratory laparotomy, enbloc cholecystectomy with excision of the choledochal cyst and roux-en-Y hepaticojejunostomy was also done. Post operative recovery was uneventful. Patient was followed up for six months and no obvious complication was noticed. Early suspicion of this rare pancreato-billiary disease is important because surgical treatment is the only way to avoid the complications of the disease.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.602-605

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