The impact of harmful industrial factors on the reproductive health of workers in chemical production

2020 ◽  
pp. 27-35
Author(s):  
Alena Alekseevna Vorobyova ◽  
Elena Mikhailovna Vlasova ◽  
I. V. Leshkova
Keyword(s):  
Reproductive Health ◽  
Comparison Group ◽  
Reproductive Function ◽  
Ca 125 ◽  
Endocrine Disorders ◽  
Additional Risk Factor ◽  
Observation Group ◽  
Chemical Factor ◽  
Activation Markers ◽  
The Impact

In order to solve the demographic problems of the Russian Federation, the urgent task is to develop medical and preventive technologies for managing the reproductive health risks of chemical workers, and to reduce the risk of male and female infertility. 82 workers of chemical industries were examined. The indicators of specific hormonal status, immunological, genetic, parameters of functional studies, including the reproductive system, were studied. Class of working conditions by chemical factor 3.1 («harmful» with degree of harmfulness 1). In the structure of somatic diseases in women, endocrine pathology predominated (60 % of women in the observation group and 24 % of the comparison group), in men), inflammatory diseases of the genitourinary system (41.1 % and 46.6 %, respectively). Gynecological pathology in workers exposed to harmful chemicals was found 2 times more often than in the comparison group. Workers in the observation group revealed polymorphism of genes responsible for reproductive function. When exposed to a chemical factor, immunological disorders are formed in the form of a decrease in activation markers CD95 +, CD25 + (p < 0.05); disorders of neuroendocrine regulation, hormonal dysfunction (decreased FSH in women and decreased testosterone, antisperm antibodies in men); increased content of tumor markers (CA-125 and CA-153); functional changes in the thyroid gland, structural changes in blood vessels, impaired reproductive function. Thus, exposure to production chemical factors of even low intensity contributes to the formation of hormonal and endocrine disorders, is an additional risk factor for miscarriage and the development of secondary infertility.

FEATURES OF THE INFLUENCE OF CHEMICAL SUBSTANCES ON THE REPRODUCTIVE HEALTH OF MEN WORKING IN CHEMICAL INDUSTRIES

2021 ◽  
Author(s):  
O.Yu. Gorbushina ◽  
Keyword(s):  
Erectile Dysfunction ◽  
Reproductive Health ◽  
Data Processing ◽  
Statistical Data ◽  
Comparison Group ◽  
Clinical Laboratory ◽  
Observation Group ◽  
Chemical Factor ◽  
Chemical Substances ◽  
Statistical Data Processing

Abstract. Introduction. A long exposure of chemical substances of low intensity can manifest itself in the form of impaired adaptability of the body, which may be accompanied by an increase in the frequency of erectile dysfunction in men. Purpose of the study: to study the features of the impact of chemical substances on the reproductive health of men working in the chemical industry. Мethods. 72 workers of a chemical enterprise were examined: an observation group - 49 men exposed to a chemical factor; comparison group - 23 engineering and technical employees of the enterprise administration who are not in contact with the studied harmful production factors. The following examinations were performed: hygienic, sociological, clinical, laboratory, statistical data processing. The survey was completed: hygienic, sociological, clinical, laboratory, statistical data processing. Results. According to the chemical factor, the class of working conditions at workplaces corresponded to class 3. 1 degree. Results of a handout survey: 14.2% - inflammatory diseases of the genitourinary system; 19.1% - seeking medical help for infertile marriages. (ICEF in the observation group 18.7, in the comparison group – 21. Analysis of the general incidence: 16.3% - diseases of the endocrine system. Analysis of laboratory data showed that reproductive dysfunction is formed in chemical workers as a result of dishormonosis against the background of detoxification and reproduction gene polymorphism. Conclusion. The exposure of a chemical factors contributes to the development of erectile dysfunction and disruption of spermatogenesis.

scholarly journals Pesticides as endocrine distruptors of the reproductive system (literature review and own research)

2021 ◽  
pp. 49-62
Author(s):  
Ninel Shepelska ◽  
Mykola Prodanchuk ◽  
Yana Kolianchuk
Keyword(s):  
Reproductive Health ◽  
Endocrine Disruptors ◽  
Reproductive System ◽  
Reproductive Toxicity ◽  
Endocrine System ◽  
Reproductive Function ◽  
Dose Dependence ◽  
Animal Cells ◽  
Wide Range ◽  
The Impact

Currently, one of the main threats to human health is undoubtedly endocrine disruptors (ED), since they directly disrupt the processes of homeostasis maintenance, controlled by the endocrine system, the purpose of which is to maintain normal functions and development in a constantly changing environment. Pesticides can disrupt the physiological functioning of many endocrine axes, including the endocrine mechanisms that ensure reproductive health. It should be noted that research aimed at preventing chemically induced reproductive disorders in the human population is one of the central areas of preventive medicine, both in terms of their importance and the complexity of the tasks being solved. Analysis and generalization of the results of our own long-term studies have shown that the selective, and, therefore, the most dangerous toxicity of pesticides for the reproductive system is determined by endocrine-mediated mechanisms of etiopathogenesis. The low level of doses inducing pathological changes in reproductive function in our studies fully confirms one of the universal signs inherent in endocrine-distruptive compounds. The above examples demonstrate a wide range of possible endocrine-mediated mechanisms of reproductive toxicity of pesticides - endocrine disruptors. However, it is very important to note that low doses may be more effective in changing some endpoints compared to high (toxic) doses. Currently, several mechanisms have been identified and studied that demonstrate how hormones and ED induce non-monotonic reactions in animal cells, tissues and organs. The reproductive system, the functioning of which is ensured by a fine balancing of the action of androgens and estrogens, is one of the systems that presents a unique opportunity for modeling a non-monotonic dose dependence. All of the above indicates the extreme danger of the impact of hormonally active agents on the reproductive health of a person and his offspring. At the same time, the threat of endocrine-mediated disorders for subsequent generations can also be realized through the induction of mechanisms of development of epigenetic transgenerational effects. Taking into account the results of studies of the mechanisms of the ED destructive action, as well as their ability to induce non-monotonic dose dependence at an extremely low dose level, it should be admitted that, apparently, there is a need to revise the paradigm of methodological approaches to the regulation of pesticides with endocrine-disruptive properties. Key words: pesticides, endocrine disruptors, reproductive system

Assessment of male reproductive function and prevention of androgen deficiency

2020 ◽  
Vol 60 (11) ◽  
pp. 746-748
Author(s):  
P. A. Vuytsik
Keyword(s):  
Reproductive Health ◽  
Health Program ◽  
Harmful Effect ◽  
Reproductive Function ◽  
Social Significance ◽  
Reproductive Disorders ◽  
Male Reproductive Function ◽  
Human Pathology ◽  
Demographic Processes ◽  
The Impact

Introduction. Reproductive problems in marriage are an important component of demographic processes; therefore, attempts to resolve them have not only medical but also social significance. The state of male reproductive health plays an important role in demographic indicators, in particular, in population reproduction. This dictates the need to increase the volume of preventive measures, which requires early detection of reproductive disorders due to the impact of environmental factors, including occupational ones, that have a harmful effect on men. The aim of the study is to develop a prevention program aimed at preserving and improving the reproductive health of employees engaged in harmful working conditions. Materials and methods. To predict the quality of health of a future individual, it is necessary to consider many risk factors that can participate in the development of human pathology. Methods for studying reproductive health disorders in men include both conventional, classical methods of examining men by urologists, andrologists, and expert ones, which allow us to find out the role of harmful factors in the development of reproductive disorders of professional etiology by specialists in occupational medicine. The implementation of a reproductive health program requires monitoring the progress of the actions taken and evaluating their effectiveness. Results. Implementing a reproductive health program requires monitoring the progress of actions and evaluating their effectiveness. Conclusions. The ability to assess the risk of damage to reproductive health and the health of the offspring makes it possible to manage this risk, to prevent and reduce the levels of occupationally determined morbidity and morbidity associated with exposure to harmful factors.

scholarly journals Norming the reproductive health disturbances in the workers-women working at the sulphate cellulose production

2005 ◽  
Vol 54 (1) ◽  
pp. 64-69
Author(s):  
N. M. Meshakova ◽  
V. S. Rukavishnikov ◽  
S. I. Kulinich
Keyword(s):  
Reproductive Health ◽  
Preventive Measures ◽  
Reproductive Function ◽  
Work Conditions ◽  
Chemical Factor ◽  
Cellulose Production ◽  
Health States ◽  
Chemical Substances ◽  
The Central Nervous System ◽  
High Degree

The work conditions and reproductive health states have been studied in the women working at the sulphate cellulose production and systematically exposed to harmful chemical substances polluting the workplace air. Among them methyl sulfide compounds (MSC) in the concentrations which than a hygienical normative were found to be of a principal importance. In the structure of extragenital pathology the diseases of the respiratory system and the functional disturbances of the central nervous system were found to prevail in the women working at the shops with the chemical factor. Their biochemical states were characterized with protein metabolism disorders, process hyperactivity of lipid peroxidation and the activity reduction in glutathionic link of antioxidant protection. A significant disturbance prevalence of ovarian-menstrual functions, complications and birth courses as well as the newborns health states have been revealed in the women at the childbearing ages. A high degree of productive stipulation of these disturbances has been revealed. Concept of forming the reproductive function disturbances in the workers women has been grounded. A system of hygienic and medical-preventive measures for work conditions optimizations of the workers-women as well as their reproductive health protection has been developed.

Early signs of upper limb lesions in workers exposed to local vibration

2019 ◽  
pp. 960-965
Author(s):  
Ju. A. Ivashova ◽  
E. A. Polevaya ◽  
T. A. Ponomareva
Keyword(s):  
Working Conditions ◽  
Upper Limb ◽  
Comparison Group ◽  
Average Length ◽  
Group Analysis ◽  
Observation Group ◽  
Years Of Experience ◽  
Local Vibration ◽  
Early Signs ◽  
The Impact

Vibration pathology, including disorders of the vascular, nervous and musculoskeletal systems, occupies one of the first places in the structure of health disorders in workers of vibration-hazardous industries.The aim of the study was to identify informative diagnostic criteria for identifying early signs of upper limb lesions.The observation group consisted of 90 workers aged 46.7±2.5 years (p>0.05), with experience of 22.4±3.9 years; the comparison group–60 workers whose working conditions were not associated with the studied factor; the average age of 45.8±2.4 years, experience of 24.1±4.1 years (p>0.05). The survey included the analysis of working conditions and professional route, clinical examination, questionnaires, laboratory and functional studies, statistical processing of the results, calculation of epidemiological indicators.The analysis of working conditions showed that the level of local vibration exceeded the maximum permissible level by 2–6 dB for the employees of the observation group. The survey showed that going to the doctor is a last resort for workers, even in the case of chronic pain. According to the results of the survey and examination, it was found that the formation of pain syndrome in employees of the observation group occurs against the background of the development of vascular and neurovascular disorders. There was an increase in the estimated age of the arteries of the upper extremities (5.3±2.8 years) in 23.3% of the observation group. Analysis of dynamometry results in dynamics for three years showed a slowly progressive decline in 21.1% of workers in vibration-hazardous professions with 11.3±3.4 years of experience, and only 3.3% of workers in the comparison group with 23.6±6.3 years of experience. In General, there is a high risk of decreased muscle strength, which is prognostically significant for the preservation of professional ability to work. The calculation of epidemiological indicators confirmed the connection of vasospastic reactions with the impact of local vibration (χ2=5.85, p<0.001; F=0.177, p<0.05; RR=2.5, 95% CI=1.7–3.7; EF=65%). Under the influence of local vibration, early signs of upper limb lesions develop with 5 years of experience and are characterized by vascular changes. Clinical syndromes characteristic of vibrational pathology are formed with an average length of service of 10 years. It is necessary to improve the complex of diagnostic measures aimed at identifying early signs of damage to the upper limbs, in order to improve the labor prognosis in workers under the influence of local vibration.

Arterial hypertension and cardiovascular risk factors in employees of underground mining ore minerals

2019 ◽  
pp. 945-949 ◽  
Author(s):  
A. S. Baydina ◽  
N. V. Zaitseva ◽  
V. G. Kostarev ◽  
O. Yu. Ustinova
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Clinical Features ◽  
Work Experience ◽  
Comparison Group ◽  
Underground Mining ◽  
Observation Group ◽  
Permanent Disability ◽  
Production Factors ◽  
The Impact

Introduction. The wide spread of mining in Russia determines the high relevance of the preservation of labor resources in this industry, the prevention of occupational and production-related morbidity, reducing cases of temporary and permanent disability. Mine mining is characterized by the impact on workers of several nonspecific harmful (dangerous) factors: industrial noise, general and local vibration, the severity of labor, heating or cooling microclimate, low light. The impact of these factors predisposes to the development of pathology of the cardiovascular system.The aim of the study was to study the prevalence of hypertension among underground miners, clinical features and changes in the complex of biochemical risk factors for cardiovascular complications.Materials and methods. The observation group consisted of 98 employees of underground chrome ore mining. The comparison group (working in conditions outside the influence of the studied production factors) consisted of 75 employees of this enterprise. All employees surveyed are male. To study the impact of working conditions on the health of workers, workplaces with a characteristic set of harmful production factors (chrome, dust, noise, vibration, labor severity, labor intensity, cooling microclimate) and the same working modes (sliding three-shift schedule with a shift duration of eight hours) were selected. The study of laboratory parameters (markers of risk of cardiovascular disease) was performed by unified General clinical, biochemical and enzyme immunoassay methods.Results. In the group of underground miners, the prevalence of arterial hypertension was established (in 31.3% in the observation group and in 17.2% of the surveyed in the comparison group, p=0.042), which becomes statistically significant when the work experience is more than 10 years. The study established the clinical features of the anamnesis and objective status of employees of the mine for the extraction of chrome ore. The laboratory study in the group of miners revealed the presence of a number of paraclinic syndromes: systemic inflammation and immune activation syndrome, dyslipidemia syndrome, oxidative stress syndrome, hormonal profile disorder, renal dysfunction syndrome.Conclusions. Employees of underground mining of chrome ore are characterized by a high incidence of hypertension with experience of more than 10 years. The clinical and instrumental changes revealed in the work in the observation group give grounds for the development of directed preventive programs in this category of ore mine workers.

Role of chromium (III) in the nutrition of pigs and cattle

2016 ◽  
Vol 3 (2) ◽  
pp. 56-62
Author(s):  
R. Iskra ◽  
V. Vlizlo ◽  
R. Fedoruk
Keyword(s):  
Growth And Development ◽  
Reproductive Function ◽  
Metabolic Effect ◽  
Considerable Part ◽  
Cultural Medium ◽  
Milk Performance ◽  
Chromium Compounds ◽  
The Impact ◽  
Different Sources

The results of our studies and the data of modern literature regarding the biological role of Cr(III) compounds in conditions of their application in the nutrition for pigs and cattle are discussed. The metabolic impact of Cr(III), coming from different sources – mineral and organic compounds, obtained by chemical synthesis or a nanotechnological method (chromium citrate), as well as in the form of biocomplexes from the cultural medium of Saccharomyces cerevisiae yeasts was analyzed. The metabolic connection between the impact of Cr(III) and the biosynthesis of some hormones – insulin, cortisol – as well as the sensitivity of some tissues and organs to the effect of chromium compounds was studied. A considerable part of the review material was dedicated to the metabolic effect of Cr(III) compounds on the reproductive function of pigs and cattle and their impact on the viability of the offspring and gametes of animals. The data about the stimulating effect of Cr(III) on the growth and development of the organism of piglets and calves, meat and milk performance of these species of animals are discussed. The relevance of dosing Cr(III) in the nutrition of pigs and cattle is highlighted.

Modern approaches to the prevention and treatment of alterations in reproductive health in women with somatoform disorders and autonomic homeostasis

2016 ◽  
pp. 98-101
Author(s):  
Vl.V. Podolsky ◽  
◽  
V.V. Podolsky ◽  
Keyword(s):  
Reproductive Health ◽  
Hormonal Regulation ◽  
Preventive Measures ◽  
Somatoform Disorders ◽  
Emotional Health ◽  
Uterine Fibroids ◽  
Reproductive Function ◽  
Epidemiological Studies ◽  
Prevention And Treatment ◽  
Artificial Abortion

The objective: the developing of a system of preventive measures and principles of pregravid preparation for women with somatoform disorders and violation of autonomic homeostasis (VAH), in which observed changes in reproductive health (CRH) in the shape of states after undergoing artificial abortion, infertility and uterine fibroids. Patients and methods. Conducted clinical and epidemiological studies in the population of women of fertile age (WFA) allowed identifying for further examination of women with CRH in the form of state after undergoing artificial abortion, infertility and uterine fibroids in women with VAH. Further women were examined, in particular the conducted clinical and instrumental methods of research; determined the state of autonomic homeostasis and psycho emotional health of the biotopes of the organism, immunity; analyzed the hormonal regulation of the menstrual cycle; performed genetic studies and determined the morphofunctional state of reproductive system. Results. The most frequent complications during pregnancy in women who had CRH in history in the form of abortions, infertility and uterine fibroids and in the background of the PAF, there was a threat of interruption of pregnancy (often in I and II trimester – 56%) and preterm delivery (21%). The study of the catamnesis of further reproductive health found that in the case of well-conducted therapeutic measures in women undergoing artificial abortion, had infertility and uterine leiomyoma in the background of VAH, restore reproductive function, and in 82% of cases occurred a pregnancy. Conclusion. The the provided study of reproductive health, and state of various organs and systems of fertile aged women with somatoform disorders and violations of the autonomic homeostasis allowed to develop preventive measures for these women and pregravid preparation with the inclusion to the therapy Magnesium and vitamins (Magne-В6®). Key words: somatoform disorders, violation of autonomic homeostasis, changes in reproductive health, prevention and treatment, women of fertile age, Magne-В6®.

Assessment of the impact of factors of the working environment on the health of workers in oil refining based on the analysis of morbidity

2020 ◽  
pp. 600-600 ◽  
Author(s):  
I. V. Ginko ◽  
T. M. Sushinskaya ◽  
A. L. Rybina
Keyword(s):  
Comparison Group ◽  
Main Group ◽  
Working Environment ◽  
Oil Refinery ◽  
Oil Refining ◽  
Production Environment ◽  
The Impact

Studies have been conducted to assess the impact of factors of the production environment on employees of the oil refinery ofJSC «Naftan». Significant differences with the comparison group on the indicators of SVT were revealed. Priority nosological forms of employees of the main group are identified.

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