Phototherapy is a pathogenetic method in the treatment of acute sinusitis

2020 ◽  
pp. 34-39
Author(s):  
Arsen Korkmazov
Keyword(s):  
Nasal Mucosa ◽  
Local Effect ◽  
Nasal Secretion ◽  
Visible Range ◽  
Neutrophil Granulocytes ◽  
Physical Treatment ◽  
Local Immunity ◽  
Acute Rhinosinusitis ◽  
Therapeutic Measures ◽  
Effect Of Light

Currently, physical treatment methods, in particular use of photochromotherapy in the treatment of sinusitis, are of interest. Is to investigate the local effect of light in the visible range (450 nm) on the factors of local infection protection of the nasal mucosa. The study involved 50 patients with a diagnosis of acute rhinosinusitis at the age of 27.23±3.29 years. Exposure of the mucous membrane of the nasal cavity was carried out in accordance with the parameters: 450 nm wavelength (monochromatic non-polarized blue light), during 5 minutes for each nostril. Sessions of photochromotherapy were carried out according to the "Sanitary norms and rules for the design and operation of lasers" No. 5804-91. Inclusion of photochromotherapy in the complex of therapeutic measures for patients with acute rhinosinusitis helps to reduce the total number of neutrophils in nasal secretion, normalize their lysosomal activity, NBT-reducing activity, activity and intensity of phagocytosis. Restoration of local immunity factors in nasal mucosa, expressed in normalizing the functional and metabolic status of neutrophil granulocytes of the nasal secretion, can serve as one of the criteria for the effectiveness of treatment using photochromotherapy

Carbonic Anhydrase in Human Nasal Epithelium: Localization and Effect of the Inhibition by Dichlorphenamide

1996 ◽  
Vol 10 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Franco Cavaliere ◽  
Simonetta Masieri ◽  
Stefania Nori ◽  
Sergio I. Magalini ◽  
Salvatore R. Allegra
Keyword(s):  
Carbonic Anhydrase ◽  
Nasal Mucosa ◽  
Ph Value ◽  
Inferior Turbinate ◽  
Nasal Secretion ◽  
Human Nasal Mucosa ◽  
Human Nasal Epithelium ◽  
Stratified Squamous Epithelium ◽  
Nasal Secretions ◽  
K Concentration

Carbonic anhydrase has not hitherto been reported in nasal mucosa. In the first part of this study, five specimens of human nasal mucosa from the inferior turbinate were obtained from five healthy subjects and tested for this enzyme with a histochemical reaction. Carbonic anhydrase was identified in the columnar ciliated respiratory epithelium, but was absent in the adjacent stratified squamous epithelium. The effect of the inhibition of this enzyme on the pH values and Na, K, and Cl activity in nasal secretion was subsequently investigated. Fifteen patients, affected by endocranial hypertension and to whom dichlorphenamide—an inhibitor of carbonic anhydrase—was administered, were studied. The pH value, determined with a surface electrode before giving the drug and 30, 60, and 90 minutes later, significantly increased and reached a peak at 60 minutes. Na, K, and Cl concentration was assessed by indirect potentiometry in the nasal secretion and in the plasma both before giving dichlorphenamide and 60 minutes later. Although no change was observed in the plasma, in the nasal secretion Na and Cl concentration increased and K concentration decreased. As a consequence, the gradients of Na and K between plasma and secretion decreased, and that of Cl increased. We assume analogous changes in the rate of transport through the mucosa to occur. These results thus suggest that carbonic anhydrase is involved in control of the pH of nasal secretions as well as in the electrolyte transport through the epithelium.

scholarly journals EPITHELIAL CELLS EXPRESSING TLR-2 LEVEL AND NOSE MUCOSA BIOCENOSIS IN ALLERGIC RHINITIS PATIENTS

2013 ◽  
Vol 10 (6) ◽  
pp. 20-24
Author(s):  
Yu A Tyurin ◽  
A A Sharifullina ◽  
I G Mustafin ◽  
R S Fassakhov
Keyword(s):  
Allergic Rhinitis ◽  
Epithelial Cells ◽  
Healthy Volunteers ◽  
Nasal Mucosa ◽  
Allergic Diseases ◽  
Nasal Lavage ◽  
Control Group ◽  
Healthy Individuals ◽  
Local Immunity

Background. Determination of local epithelial cells expressing TLR2 as an indicator of local immunity in allergic rhinitis (AR) patients with opportunistic species of staphylococci nasal mucosa colonization. Methods. Washed epithelium samples obtained from patients with seasonal AR (n=8) aged 19—42 years, and perennial AR (n=15) aged 19 —45 years, as well as a control group (20 patients) aged 19—45 years without allergic diseases were investigated. Epithelial cells expressing TLR2 receptors were determined by flow cytometry. Results. The level of epithelial cells expressing TLR2 receptor in patients with seasonal AR was almost in 1,9 times, in perennial AR group — in 1,7 times lower then in healthy individuals. In patients with perennial AR S. aureus was obtained in 96,0% (CI: 79,5—99,2), in association with Str. pyogenes in 29% (CI: 14,9—49,2), Neisseria spp. — in 63,0% (CI: 42,7—78,8). Seasonal allergic rhinitis was characterized by association of S. aureus and S. hemolyticus (70,0%, 44,4—85,8). Conclusion. Ratio of epithelial cells positive for TLR2 in nasal lavage from patients with AR was lower than in healthy volunteers. Indicators proportion of epithelial cells expressing TLR2 in nasal lavage in patients with seasonal AR during an exacerbation period was significantly reduced (1,7—1,9 times), in comparison with healthy volunteers. In AR patients with increased density of staphylococci strains in nasal mucosa increased local epithelial cells expressing TLR2 in nasal lavage was established.

scholarly journals Стан екстрацелюлярного потенціалу фагоцитів статевих органів у кішок

2017 ◽  
Vol 19 (73) ◽  
pp. 71-74
Author(s):  
M.M. Zhelavskyi ◽  
I.M. Shunin
Keyword(s):  
Reproductive Organs ◽  
Neutrophil Granulocytes ◽  
Immune Protection ◽  
Phagocytic Cells ◽  
Local Immunity ◽  
Antimicrobial Potential ◽  
Protection Mechanisms ◽  
Reproductive Pathology ◽  
Experimental Researches ◽  
Dependent Mechanism

This article shows the results of the experimental researches in the cellular link of local immune protection of cats' genitals. Due to the urgency of the problem the aim of our study was to investigate the functional state of the phagocytic cells and to explore and interpret their role in the formation of the antimicrobial potential of homeostasis in the system of local immunity of the cats' reproductive organs. Cytochemical research determined the antimicrobial reactive Oxygen-dependent mechanism for the protection of neutrophil granulocytes in reaction with NBT It was found out, that the antimicrobial potential of phagocyte cells actively realizes via Oxygen dependent protection mechanisms. The total number of NBT + phagocytic cells in the investigated micropreparations was 21.35 ± 0.86%. Cytochemical reactivity of primary phagocytic cells was shown on the I and II level, which reflects the full manifestation of the phagocytic defense. The activated phagocytes have also shown the active adhesion and phagocytosis of epithelial cells and of apoptosial macrophages, which is also one of the signs of the maintenance of cellular homeostasis. The interpretation of the results was done according to the outcomes of the research and the conclusions and recommendations on the application of cytochemical studies in a comprehensive assessment of the antimicrobial potential of phagocytic cells and for predicting clinical evaluation of reproductive diseases in small animals were developed. It is recommended to perform cytochemical studies during complex testing of the local immune protection of the reproductive organs of animals, which will allow to objectively assess the state of cellular immunity, diagnose subclinical manifestation of reproductive pathology and predict the risk of complications.

Protective role of the mucous membrane of the upper respiratory tract in terms of local immunity

1926 ◽  
Vol 22 (5-6) ◽  
pp. 750
Author(s):  
O. Vasil'yeva
Keyword(s):  
Respiratory Tract ◽  
Mucous Membrane ◽  
Nasal Mucosa ◽  
Protective Role ◽  
Upper Respiratory Tract ◽  
Local Immunity ◽  
Upper Respiratory

Prof. IP Voloshin (West. Rhinolaryngo-otiatry. 1925, No. 1), taking into account the well-known works of Bezredk on local immunity, finds that the protective role of the nasal mucosa and upper respiratory tract is reduced to the development of natural local immunity of these organs than the general immunity of the whole organism is acquired from all microorganisms inhabiting the mucous membrane of these pathways.

The Combined Laser Therapy in Patients with Psoriasis

2015 ◽  
Vol 22 (4) ◽  
pp. 99-103
Author(s):  
Утц ◽  
S. Utts ◽  
Москвин ◽  
S. Moskvin ◽  
Шнайдер ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Pulse Repetition Frequency ◽  
Local Effect ◽  
Research Centre ◽  
Treatment Technique ◽  
External Impact ◽  
Therapeutic Measures ◽  
Inflammatory Changes ◽  
Methods Of Treatment ◽  
Made In

One of the known methods of treatment of patients with psoriasis is laser therapy, however, the task of improving the efficiency of this method is still relevant. The objective of this study was the evaluation of the effectiveness of treatment technique of patients with psoriasis, including the intravenous laser light of blood and the local effect of pulse infrared laser radiation. 42 patients with widespread forms of psoriasis in the stage of progression (12 women and 30 men) aged 35 to 60 years (the average age 47), having a disease duration of 5 to 20 years, were observed. In the complex of therapeutic measures of the main group the laser therapy was included. It is the original technique by means of laser therapeutic apparatus ʺLasmik‐VLOKʺ (Registration certificate № RZN 2014/1410 from 06.02.2014) with the laser emitting heads KL‐VLOK‐525‐20 for intravenous laser light of blood and ML‐635‐ 40 for external impact. For this technique the disposable sterile lights KIVL ‐01 on TU 9444‐005‐72085060‐ 2008 made in Research centre ʺMatrixʺ (Russia, Moscow) were used.It is shown that the combined laser therapy of patients with moderate form of psoriasis (PASI index 40‐ 50), including local effects on psoriatic lesions by pulsed radiation of the red spectrum (635 nm) of 40 watts with the change of the pulse repetition frequency to 10000 Hz and VLOK‐525, allows effectively to stop the inflammatory changes, to decrease of erythema, infiltration and desquamation. The rapid decrease in the area affected of the skin is observed.

scholarly journals Fibrinolytic components in nasal mucosa and nasal secretion

1998 ◽  
Vol 110 (5) ◽  
pp. 449-455 ◽  
Author(s):  
Toyotoshi Yasuda ◽  
Y. Sakata ◽  
Seiji Madoiwa ◽  
Jun Mimuro ◽  
Michio Matsuda ◽  
...  
Keyword(s):  
Nasal Mucosa ◽  
Nasal Secretion

Nasal allergy and leukotriene. 1. Extraction and measurement of LTC4 and LTD4 in nasal secretion induced by antigen challenge, and the effect of LTC4 and LTD4 on nasal mucosa.

1987 ◽  
Vol 90 (8) ◽  
pp. 1196-1207 ◽  
Author(s):  
NOBUHISA TERADA ◽  
AKIYOSHI KONNO ◽  
HIDEKI ANDO ◽  
YOSHITAKA OKAMOTO ◽  
KATSUMI MONOO ◽  
...  
Keyword(s):  
Nasal Mucosa ◽  
Nasal Secretion ◽  
Antigen Challenge ◽  
Nasal Allergy

Capsaicin's Effect on Rat Nasal Mucosa Substance P Release: Experimental Basis for Vasomotor Rhinitis Treatment

1997 ◽  
Vol 11 (4) ◽  
pp. 313-316 ◽  
Author(s):  
Frederick A. Kuhn ◽  
Sergio Gonzalez ◽  
Magdalena Rodriguez ◽  
Carlos Cuilty Siller ◽  
Venetia Zachariou ◽  
...  
Keyword(s):  
Substance P ◽  
Nasal Mucosa ◽  
Stimulus Change ◽  
Nerve Fibers ◽  
Nasal Secretion ◽  
Plasma Extravasation ◽  
Vasomotor Rhinitis ◽  
C Fibers ◽  
P Release ◽  
Substance P Release

Substance P (SP) is one of several neuropeptides found in nasal mucosa. It exists primarily in sensory afferent neurons, which are best demonstrated by immunohistochemical staining. These substance P-like immunoreactive (SPLI) nerve fibers are unmyelinated C fibers, which connect to the trigeminal ganglion and the spinal trigeminal nucleus. They are found around vessels and seromucinous glands in the submucosa. When the nasal mucosa receives a noxious stimulus, SP is released and acts orthodromically as a comediator of nasal pain, while antidromically it induces vasodilatation, plasma extravasation, mucosal edema, and rhinorrhea. Its antidromic effects have been implicated in vasomotor rhinitis and can be blocked by topical intranasal capsaicin application. Wolf and others have demonstrated in human subjects that vasomotor rhinitis can be blocked up to 1 year by a series of intranasal capsaicin applications. It has not yet been demonstrated that nasal mucous SP levels following noxious nasal stimulus change after intranasal capsaicin pretreatment. Consequently, a project was designed to determine whether intranasal capsaicin pretreatment would affect nasal substance P release measured in nasal secretion. Nasal secretion SP levels were measured before and after noxious nasal stimulus in controls and in capsaicin pretreated rats. The difference in measured nasal secretion SP levels were significant (p < 0.05).

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