scholarly journals Immunochromatographic Technique for Seropositivity and PCR Based Molecular Diagnosis for Hepatis B and C Virus in a General Population of Mansehra Pakistan

Hepatitis B and C infections are known to be the major public health issue around the world. Our focus is to investigate the predominance of HBV and HCV infections in the general population of district Mansehra, Khyber Pakhtunkhwa, Pakistan. Blood samples were taken from 652 individuals and were shifted to Alkhedmat laboratory Mansehra and Department of Microbiology Hazara University Mansehra. Serum were isolated from blood samples and screen it by ICT device Kit (Accurate Diagnostics, Houston, Texas, USA). The ICT positive samples were then refined by PCR method. Total 652 individuals [males (368), females (284)] were screened for HBV and HCV infections in which total 37 (5.67%) [males (6.52%) and females (4.57%)] were found positive for HBsAg and 42 (6.44%) [males (7.33%) and females (5.28%)] were found positive for Anti HCV respectively. The ratio of these viral infections is more predominant as compare to other viral infections in Mansehra, Pakistan. The rate of HBV and HCV prevalence is increasing day by day in these areas. Communities with more than 5% HBV and HCV disease, mass vaccination and awareness programs should be undertaken as a matter of urgency.

2018 ◽  
Vol 100 (5) ◽  
pp. 413-416 ◽  
Author(s):  
BM Siddiqui ◽  
MS Patel ◽  
S Rudge ◽  
A Best ◽  
J Mangwani

Introduction Venous thromboembolism (VTE) remains a major public health issue around the world. Ethnicity is known to alter the incidence of VTE. To our knowledge, there are no reports in the literature investigating the incidence of VTE in British Indians. The aim of this study was to investigate the rates of symptomatic VTE in British Indian patients in the UK. Methods Patients referred to our institution between January 2011 and August 2013 with clinically suspected VTE were eligible for inclusion in the study. Those not of British Indian or Caucasian ethnicity were excluded. A retrospective review of these two cohorts was conducted. Results Overall, 15,529 cases were referred to our institution for suspected VTE. This included 1,498 individuals of British Indian ethnicity. Of these, 182 (12%) had confirmed VTE episodes. A further 13,159 of the patients with suspected VTE were coded as Caucasian, including 2,412 (16%) who had confirmed VTE events. VTE rates were a third lower in British Indians with clinically suspected VTE than in the equivalent Caucasian group. The British Indian cohort presented with VTE at a much earlier age than Caucasians (mean 57.0 vs 68.0 years). Conclusions This study suggests that British Indian patients have a lower incidence of VTE and are more likely to present at an earlier age than Caucasians. There was no significant difference in VTE type (deep vein thrombosis vs pulmonary embolism) among the ethnic groups. Clinicians should be aware of variations within ethnicities but should continue to adhere to existing VTE prevention guidance.


2021 ◽  
Author(s):  
Catharina Mello Barreto ◽  
Amanda Ferraz Arita ◽  
Ana Carolina Coutinho Engelhardt Bravin ◽  
Julia Surrage da Matta ◽  
Maria de Fatima Araujo da Fonseca ◽  
...  

Introduction: Stroke is a neurological syndrome resulting from a vascular injury that represents one of the main causes of morbidity and mortality in the world. Thus, cerebrovascular diseases are increasing in Brazilian statistics, especially the ischemic stroke, responsible for the highest incidence in cases, therefore characterizing a major public health issue. Methods: In this descriptive and ecological study we used data provided by DATASUS concerning hospitalizations and deaths due to stroke, not specified as hemorrhagic or ischemic, occurred between January 2008 and December 2020 in the region of Grande Vitória, Espírito Santo (GV – ES). Results: Overall, there were 10,199 hospitalizations due to stroke in the GV-ES. The prevalence was 57.2% in brown-skinned people, 26.2% between ages from 60 to 69 years old (26.2%) and 52% in Vitória. Among 2008 until 2014 there was an increase of 788.9% in stroke hospitalizations however between 2015 and 2020 there was a 30.5% reduction. In total there were 1,309 deaths, 64% were brown-skinned people, 29.2% above 80 years old and 51.3% in Vitoria. From 2008 to 2019, a 144.5% increase in the mortality rate was observed. In the analyzes there was no difference regarding the gender. Conclusion: Data analysis inferred that old age and brown skin are risk factors for stroke in GV-ES, thereby requiring greater attention for screening and preventing this disease in those groups. Moreover, there was an increase in the mortality rate, even with reduction in the number of cases, reinforcing the need for effective and resolute care in the region.


2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Rodolfo Castro ◽  
Hugo Perazzo ◽  
Beatriz Grinsztejn ◽  
Valdilea G. Veloso ◽  
Chris Hyde

Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are estimated to be infected by HCV in Brazil representing a major public health issue. The aim of this paper was to review the epidemiology and management of chronic hepatitis C from a Brazilian perspective. The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed.


2021 ◽  
Author(s):  
Bader Y Alhatlani ◽  
Waleed A Aljabr ◽  
Mohammed S Almarzouqi ◽  
Sami M Alhatlani ◽  
Rayan N Alzunaydi ◽  
...  

Aim: Hepatitis E virus (HEV) transmission through blood transfusion is a major public health issue worldwide. We aimed to determine the seroprevalence of HEV in blood donors in the Qassim region of Saudi Arabia. Materials & methods: Serum samples (n = 1078) were collected from volunteer blood donors and tested for the presence of anti-HEV IgG and IgM by indirect ELISA. Results: The seroprevalence of anti-HEV IgG among the blood donors was 5.7% overall. Anti-HEV IgG and IgM seropositivity were significantly higher in non-Saudi donors than in Saudi donors (22.1 vs 3 and 7.8 vs 0.2% for anti-HEV IgG and IgM, respectively). Conclusion: The seroprevalence of HEV among blood donors in the Qassim region was lower than previous estimates for other regions of the country and neighboring countries.


2016 ◽  
Vol 14 (4) ◽  
Author(s):  
Yuan Yuh Leong ◽  
Louis Tong

Dry eye, a visually disabling disease that has been reported to be a major public health issue in many countries, is known to induce a significant decrease in quality of life. In this report, we aim to compile information on the investigators of dry eye that published most frequently in peer reviewed scientific journals and the publications in Asia and Europe.


Author(s):  
Faisal Suliman Algaows ◽  
Nader Marzouq AlOtaibi ◽  
Salma Mousa Hakami ◽  
Omar Abdrabalrasoul Alkhabaz ◽  
Bandar Owaidh ALJohani ◽  
...  

Neck pain is a prevalent ailment that affects many people around the world. Neck pain is linked to a high level of disability and is usually regarded as a serious public health issue. Pain between the superior nuchal line and the spinous process of the first thoracic vertebra is referred to as neck pain. The pain in the neck might refer to the head, trunk, and upper limbs in some cases. This article seeks to offer a summary of the existing evidence on the prevalence, costs, diagnosis, prognosis, risk factors, prevention, and management of neck pain patients.


Author(s):  
Sukhwinder Sahota ◽  
Tahir Mahmood

Obesity is a complex multifactorial disorder, which has reached epidemic proportions worldwide. It affects all aspects of an individual’s life: physical, social, emotional, and psychological. Although it is largely preventable, obesity is now a major public health issue and has a significant impact on the health and well-being of an individual throughout their lifespan. Obesity is associated with multiple adverse outcomes not only during the reproductive phase of a woman’s life but during the post-reproductive era as well. Obesity also increases risks for non-obstetrical and gynaecological illnesses such as diabetes mellitus, hypertension, metabolic syndrome, cardiovascular disease, and non-gynaecological cancers. Obesity thus is a cause of major societal economic burden.


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