scholarly journals ANALYSIS OF NON-CELIAC GLUTEN SENSITIVITY IN PATIENTS WITH ENDOMETRIOSIS

2021 ◽  
Vol 7 (5) ◽  
Author(s):  
Giulienny Maria Antunes Gonçalves ◽  
Eduardo Euzieres Granzotto ◽  
Renato Mitsunori Nisihara ◽  
Jan Pawel Andrade Pachnicki ◽  
Lucas Marin Dall’Stella, ◽  
...  

Overview and Aims: Identify patients with surgically confirmed endometriosis and with gastrointestinal symptomatology by assessing whether there is clinical improvement of these from the adoption of gluten-free diet (GFD). Study design: They were invited to participate in the study by the researchers through telephone calls and instant messaging applications after selection in the clinics of attending physicians. Population: Through the GSRS (Gastrointestinal Symptom Rating Scale) questionnaire, the relationship of GFD adherence to symptomatology attenuation and benefit in the quality of life of 48 patients was analyzed. Methods: Inclusion criteria: female patients with surgical confirmation of endometriosis who agreed to participate in the study in accordance with the Informed Consent Form (ICF). Exclusion criteria: patients who already performed GFD, patients diagnosed with celiac disease, gluten allergy or non-celiac sensitivity to gluten, presence of gastrointestinal comorbidities, severe diseases or cognitive alterations that prevented the study from being performed. The patients who obtained the top 20 scores were invited to adopt GFD for one month, among those selected, only 12 proposed to participate in the diet. However, three of these presented personal complications that prevented the continuation of the same. After this period, a new questionnaire was applied to measure the impact of the diet on quality of life. Results: Nine patients finished the proposed period for the diet, with the average score obtained in the pre-diet questionnaire reducing from 57.2 to 36 in the post-diet. Conclusion: There was an improvement in gastrointestinal complaints of most patients and consequently in quality of life with GFD.

2020 ◽  
Vol 29 (4) ◽  
pp. 2097-2108
Author(s):  
Robyn L. Croft ◽  
Courtney T. Byrd

Purpose The purpose of this study was to identify levels of self-compassion in adults who do and do not stutter and to determine whether self-compassion predicts the impact of stuttering on quality of life in adults who stutter. Method Participants included 140 adults who do and do not stutter matched for age and gender. All participants completed the Self-Compassion Scale. Adults who stutter also completed the Overall Assessment of the Speaker's Experience of Stuttering. Data were analyzed for self-compassion differences between and within adults who do and do not stutter and to predict self-compassion on quality of life in adults who stutter. Results Adults who do and do not stutter exhibited no significant differences in total self-compassion, regardless of participant gender. A simple linear regression of the total self-compassion score and total Overall Assessment of the Speaker's Experience of Stuttering score showed a significant, negative linear relationship of self-compassion predicting the impact of stuttering on quality of life. Conclusions Data suggest that higher levels of self-kindness, mindfulness, and social connectedness (i.e., self-compassion) are related to reduced negative reactions to stuttering, an increased participation in daily communication situations, and an improved overall quality of life. Future research should replicate current findings and identify moderators of the self-compassion–quality of life relationship.


2020 ◽  
Vol 20 (2) ◽  
pp. 174-188
Author(s):  
Rómulo Jacobo González-garcía ◽  
Paloma Escamilla-Fajardo ◽  
Samuel López-Carril ◽  
Juan Nuñez-Pomar

El sector del turismo deportivo recibe cada vez una mayor atención por parte de los distintos agentes sociales, teniendo un alto impacto en distintas esferas de la sociedad. El turismo no sólo afecta a las actitudes de los residentes hacia su desarrollo, sino también a su calidad de vida en general. Una vez que una comunidad o población se convierte en un destino turístico, la calidad de vida de los residentes locales se ve afectada por el desarrollo del mismo. Por consiguiente, es relevante conocer cuáles son las percepciones de los residentes respecto al impacto que causa el turismo deportivo. Por ello, el objetivo del presente estudio es analizar las percepciones de los residentes de Gran Canaria hacia los efectos del turismo deportivo, en ámbitos como su impacto, la calidad de vida y el apoyo al sector. Los resultados del estudio indican que, a mayores niveles de percepción positivos de los residentes sobre los impactos sociales, culturales, ambientales y económicos, hay un mayor apoyo hacia el desarrollo del turismo. Por otra parte, también se produce un efecto mediador significativo de la variable calidad de vida de los residentes, entre la relación de impactos percibidos y el apoyo al desarrollo del turismo activo y deportivo en Gran Canaria. Estos resultados posibilitan un mejor entendimiento de la perspectiva que los residentes tienen hacía el sector turístico deportivo, algo que puede ayudar a orientar futuras decisiones sobre la práctica, desarrollo y planificación del turismo deportivo. The sports tourism sector is receiving increasing attention from different social actors, having a high impact on different spheres of society. Tourism not only affects residents' attitudes towards their development, but also their quality of life in general. Once a community or population becomes a tourist destination, the quality of life of local residents is affected by its development. It is therefore important to know what residents' perceptions are of the impact of sports tourism. Therefore, the aim of this study is to analyse the perceptions of the residents of Gran Canaria towards the effects of sports tourism, in areas such as its impact, quality of life and support for the sector. The results of the study indicate that, at higher levels of positive perception by residents of the social, cultural, environmental and economic impacts, there is greater support for the development of tourism. On the other hand, there is also a significant mediating effect of the variable quality of life of the residents, between the relationship of perceived impacts and the support for the development of active and sports tourism in Gran Canaria. These results make it possible to better understand the perspective that residents have towards the sports tourism sector, something that can help guide future decisions on the practice, development and planning of sports tourism. O sector do turismo desportivo está a receber cada vez mais atenção por parte de diferentes actores sociais, tendo um elevado impacto em diferentes esferas da sociedade. O turismo não afecta apenas as atitudes dos residentes em relação ao seu desenvolvimento, mas também a sua qualidade de vida em geral. Uma vez que uma comunidade ou população se torna um destino turístico, a qualidade de vida dos residentes locais é afectada pelo seu desenvolvimento. Por conseguinte, é importante conhecer a percepção que os residentes têm do impacto do turismo desportivo. Portanto, o objectivo deste estudo é analisar as percepções dos residentes da Gran Canária sobre os efeitos do turismo desportivo, em áreas como o seu impacto, qualidade de vida e apoio ao sector. Os resultados do estudo indicam que, em níveis mais elevados de percepção positiva dos residentes sobre os impactos sociais, culturais, ambientais e econômicos, há maior apoio para o desenvolvimento do turismo. Por outro lado, existe também um efeito mediador significativo da variável qualidade de vida dos residentes, entre a relação de impactos percebidos e o apoio ao desenvolvimento do turismo ativo e desportivo na Gran Canária. Estes resultados permitem compreender melhor a perspectiva que os residentes têm em relação ao sector do turismo desportivo, algo que pode ajudar a orientar futuras decisões sobre a prática, desenvolvimento e planeamento do turismo desportivo. Il settore del turismo sportivo sta ricevendo un'attenzione crescente da parte di diversi attori sociali, con un forte impatto sulle diverse sfere della società. Il turismo influenza non solo l'atteggiamento dei residenti nei confronti del loro sviluppo, ma anche la loro qualità di vita in generale. Una volta che una comunità o una popolazione diventa una destinazione turistica, la qualità della vita dei residenti locali è influenzata dal suo sviluppo. È quindi importante sapere quali sono le percezioni dei residenti sull'impatto del turismo sportivo. Pertanto, l'obiettivo di questo studio è quello di analizzare le percezioni degli abitanti di Gran Canaria nei confronti degli effetti del turismo sportivo, in settori quali l'impatto, la qualità della vita e il sostegno al settore. I risultati dello studio indicano che, a livelli più elevati di percezione positiva da parte dei residenti degli impatti sociali, culturali, ambientali ed economici, vi è un maggiore sostegno allo sviluppo del turismo. D'altra parte, c'è anche un significativo effetto mediatore della variabile qualità della vita dei residenti, tra la relazione degli impatti percepiti e il sostegno allo sviluppo del turismo attivo e sportivo a Gran Canaria. Questi risultati permettono di comprendere meglio la prospettiva che i residenti hanno nei confronti del settore del turismo sportivo, cosa che può aiutare a guidare le future decisioni sulla pratica, lo sviluppo e la pianificazione del turismo sportivo.


2018 ◽  
Vol 12 (3) ◽  
pp. 220-232 ◽  
Author(s):  
Elizabeth Karol ◽  
Dianne Smith

Aim:The objective of this article is to identify and analyze what is known about characteristics in and around the home that support well-being for those with cognitive impairment. This could provide direction for designers of homes in general, but specifically for designers trying to meet the needs of people with cognitive impairment.Background:It has been established that there is a relationship between psychological well-being and a person’s environment. Research also shows that particular design aspects can reduce the impact of cognitive impairment. However, there is limited design expertise in the Australian housing market to create supportive spaces which will help to reduce the impact of the disability for those with cognitive impairment.Method:A literature review was carried out to determine the extent and details of what is known about the relationship of home design and its impact on emotional, psychological, or social well-being for people with cognitive impairment.Conclusions:The study indicates that researchers in various disciplines understand that pragmatic design inputs such as thermal comfort and adequate lighting are important for people with cognitive impairment. In addition, some researchers have shown or surmise that there are other “intangible” designer-controlled elements that have beneficial impacts on people with cognitive impairment. Details of these intangible elements are sparse, and how much they might improve the quality of life for a person with cognitive impairment is not well understood. Further research is required to meet a growing need.


Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Yongcan Wu ◽  
Caixia Pei ◽  
Xiaomin Wang ◽  
Mingjie Wang ◽  
Demei Huang ◽  
...  

Abstract Background Extended exposure to high concentrations of PM2.5 changes the human microbiota profile, which in turn may increase morbidity and mortality due to respiratory system damage. A balanced microecosystem is crucial to human health, and certain health-related problems may be addressed by effective microecosystem regulation. Recent studies have confirmed that probiotics may reduce the incidence of respiratory diseases. However, few studies have investigated probiotic treatment outcomes in subjects exposed to high concentrations of PM2.5. Methods This study is designed as a prospective, randomized, participants- and assessor-blinded, placebo-controlled trial. One hundred and twenty eligible volunteers recruited from October 2019 to July 2020 in downtown Chengdu, China, will be treated with either probiotics or placebo over 4 consecutive weeks. The primary outcome will be 16SrRNA sequencing assay data from nasal and intestinal secretions. Secondary outcomes will be pulmonary function, score on a gastrointestinal symptom rating scale, COOP/WONCA charts, and the Short-Form Health Survey 36 for quality of life. Results will be analyzed to assess differences in clinical efficacy between groups. Six-month follow-up examinations will evaluate the long-term value of probiotics on cardiovascular and respiratory disease end-point events. Discussion We will explore the characteristics of nasal and intestinal microbiota in a population with high exposure to PM2.5. Probiotics and placebo interventions will be tested for efficacy in microbial balance regulation, effects on lung and physical functions, and quality of life improvement. This study is expected to provide reliable evidence to support the widespread promotion of probiotics in clinical practice for the protection of individuals with high exposure to PM2.5. Trial registration Chinese Clinical Trial Registry ChiCTR1900025469. Registered on 27 August 2019.


2019 ◽  
Vol 39 (2) ◽  
pp. 112-118 ◽  
Author(s):  
Osasuyi Iyasere ◽  
Edwina Brown ◽  
Fabiana Gordon ◽  
Helen Collinson ◽  
Richard Fielding ◽  
...  

Background In-center hemodialysis (HD) has been the standard treatment for older dialysis patients, but reports suggest an associated decline in physical and cognitive function. Cross-sectional data suggest that assisted peritoneal dialysis (aPD), an alternative treatment, is associated with quality of life (QoL) outcomes that are comparable to in-center HD. We compared longitudinal changes in QoL between modalities. Methods We enrolled 106 aPD patients, matched with 100 HD patients from 20 renal centers in England and Northern Ireland. Patients were assessed quarterly for 2 years using the Hospital Anxiety and Depression Scale (HADS), SF-12 physical and mental scores, symptom score, Illness Intrusiveness Rating Scale (IIRS), Barthel's score, and the Renal Treatment Satisfaction Questionnaire (RTSQ). Mixed model analysis was used to assess the impact of dialysis modality on these outcomes during follow-up. P values were adjusted for multiple significance testing. Results Multivariate analysis showed no difference in any of the outcome measures between aPD and HD. Longitudinal trends in outcomes were also not significantly different. Higher age at baseline was associated with lower IIRS and RTSQ scores during follow-up. One-hundred and twenty-five (60.6%) patients dropped out of the study: 59 (28.6%) died, 61 (29.6%) withdrew during follow-up, and 5 (2.5%) were transplanted. Conclusions Quality of life outcomes in frail older aPD patients were equivalent to those receiving in-center HD. Assisted PD is thus a valid alternative to HD for older people with end-stage kidney disease (ESKD) wishing to dialyze at home.


2017 ◽  
Vol 98 (5) ◽  
pp. 709-713
Author(s):  
S V Tarasenko ◽  
A A Natal’skiy ◽  
O V Zaytsev ◽  
S N Sokolova ◽  
A Yu Bogomolov ◽  
...  

Aim. Comparative analysis of the long-term results of surgical treatment of patients with chronic pancreatitis. Methods. The study included patients with complicated clinical forms of chronic pancreatitis including: ductal pancreatic hypertension, main pancreatic duct concrements, marked fibrous restructuring of the pancreatic parenchyma and presence of calcifications, presence of biliary hypertension, portal hypertension syndrome, duodenostasis syndrome, chronic abdominal pain syndrome, retention and post-necrotic cysts. Patients were divided into 3 groups: group 1 included patients with chronic pancreatitis receiving conservative treatment (n=32), group 2 - patients who underwent the Frey pancreatic resection (n=24) and group 3 - Beger pancreatic resection (n=9). The assessment was performed according to the most spread specific questionnaire in gastroenterology GSRS (Gastrointestinal Symptom Rating Scale). Results. The quality of life of patients who underwent both Frey and Beger pancreatic resection was significantly higher than the quality of life of patients in whom chronic pancreatitis was treated conservatively. Quality of life of patients who underwent Frey or Beger pancreatic resection did not differ significantly. Malabsorption syndrome has a significant effect on the quality of life of patients who underwent surgical treatment of chronic pancreatitis. The GSRS questionnaire demonstrated low sensitivity in detecting malabsorption syndrome. Conclusion. Quality of life of patients who underwent surgical treatment of chronic pancreatitis is statistically significantly higher than in patients receiving conservative treatment; correction of existing quality of life questionnaires is required in order to identify malabsorption syndrome.


2013 ◽  
Vol 94 (3) ◽  
pp. 406-408 ◽  
Author(s):  
I V Barkhatov

Aim. To assess the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire as an ambulatory screening test for early diagnosis of abdominal angina. Methods. An assessment of abdominal symptoms severity and quality of life was performed using the GSRS questionnaire in 110 patients with abdominal angina. No sings of abdominal angina and no vascular abnormalities were found at Doppler sonography in 39 (35.5%) of patients (main group). In 71 (64.5%) patients distributed to the second group signs of insufficient blood flow (including vascular wall calcification and thickening, medium and small arteries compression and narrowing up to 40-70%, and inadequate blood flow after exercise. Results. There were no statistically significant differences found in prevalence of abdominal pain, reflux and diarrhea between two groups. Dyspepsia was noted in 29 (74.4%) patients of first group and in 71 (100%) patients of the second group. Average GSRS scores were 3.67±0.51 and 5.07±0.32 accordingly in those patients. Constipation was present in 16 (41%) patients of first group and in 54 (76.1%) patients of the second group, with the GSRS score 1.33±0.31 and 3.04±0.32 accordingly in those patients. Average total GSRS score was significantly higher in patients with abdominal angina - 13.51±0.84 points versus 9.94±1.13 in patients without signs of abdominal angina on Doppler sonography. Conclusion. The use of GSRS questionnaire allows to detect syndromes characteristic for abdominal angina.


2017 ◽  
Vol 46 ◽  
pp. 42-47 ◽  
Author(s):  
A. Hofer ◽  
Y. Mizuno ◽  
F. Wartelsteiner ◽  
W. Wolfgang Fleischhacker ◽  
B. Frajo-Apor ◽  
...  

AbstractBackground:Health-related quality of life (HRQOL) is significantly affected in individuals with schizophrenia or bipolar I disorder (BD-I). The current study investigated whether symptomatic remission and resilience might differently impact HRQOL in these patients.Methods:Fifty-two patients with schizophrenia and 60 patients suffering from BD-I from outpatient mental health services as well as 77 healthy control subjects from the general community were included into a cross-sectional study. HRQOL and resilience were assessed using the WHOQOL-BREF and the Resilience Scale. In patients, psychopathology was quantified by the Positive and Negative Syndrome Scale or the Montgomery Asberg Depression Rating Scale and the Young Mania Rating Scale, respectively.Results:Notably, both patient groups showed lower HRQOL and resilience compared to control subjects, non-remitted patients indicated lower HRQOL than remitted ones. The effect of remission on HRQOL was significantly larger in patients with BD-I than in those with schizophrenia but did not explain the difference in HRQOL between groups. Resilience predicted HRQOL in all three groups. When accounting for the effect of resilience among remitted patients, only the difference in HRQOL between schizophrenia patients and control subjects was significant.Conclusion:These findings demonstrate the impact of symptomatic remission and resilience on HRQOL of both patients suffering from schizophrenia and BD-I and indicate that these factors are especially relevant for HRQOL of patients with BD-I.


Dermatology ◽  
2019 ◽  
Vol 236 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Alejandro Molina-Leyva ◽  
Carlos Cuenca-Barrales

Background: Patients with hidradenitis suppurativa (HS) suffer from symptoms such as pruritus and malodour which can significantly impair their quality of life. Objectives: (1) To analyse the impact of pruritus and malodour on the quality of life of patients with HS and (2) to explore the potential association between clinical features and the severity of these symptoms. Patients and Methods: This is a cross-sectional study. The Numeric Rating Scale (NRS) was used to assess pruritus and malodour. Quality of life was assessed by means of the Dermatology Life Quality Index (DLQI). Results: Two hundred and thirty-three patients were included in the study. Both pruritus and malodour positively correlated with worse quality of life (p < 0.05). Pruritus intensity was associated with the number of regions affected by HS, female sex, the intensity of suppuration, and the presence of comorbid Crohn’s disease. Statin use was associated with lower levels of pruritus. Malodour intensity was associated with higher body mass index, disease duration, the number of regions affected, Hurley stage, and intensity of suppuration. Conclusions: The results of our study show that pruritus and malodour are key symptoms in patients with HS which have a great impact on their quality of life. We have identified clinical features potentially associated with the intensity of these symptoms which could be useful to identify higher-risk patients and may influence treatment decisions.


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