scholarly journals THE METHODOLOGY OF ANALYSIS OF J. JOYCE'S NOVEL "ULISSES" (EMPHASES OF DARIA VIKONSKA)

2021 ◽  
pp. 67-75
Author(s):  
M. Moklytsia
Keyword(s):  
Research Work ◽  
The Novel ◽  
Literary Forms ◽  
Literary Process ◽  
Self Knowledge ◽  
Ethical Norms ◽  
Almost All ◽  
First Time ◽  
School Curricula

The relevance of the study is due to the need to include the novel "Ulysses" by J. Joyce in university and, if possible, school curricula in foreign literature, as well as the need for its interpretation, despite the excessive complexity of the text and difficulty of perception. It is also important to return the legacy of D. Vikonska, a writer, critic, art critic and literary critic, to modern Ukrainian culture. Research methodology: a model of analysis of the modernist novel "Ulysses", created on the basis of the research work of D. Vikonska “James Joyce. The secret of his artistic face” (1934). Scientific novelty: for the first time the analysis of the novel "Ulysses" is carried out with the broad involvement of the half-forgotten studio of D. Vikonska, which has not lost its relevance, clearly articulates the modernist nature of the work, including surreal style. The purpose of the study: to draw attention to the outstanding figure of D. Vikonska as the founder of Ukrainian Joyce studies, to include her in the modern literary process, to show with her help the significant role of Joyce's novel "Ulysses". Conclusions. The answer to the question why Joyce's novel Ulysses is considered a landmark work of modernism should be concise but convincing, based on macro- and microanalysis of the text. First of all, it is a unique example of the author's self-expression, extreme subjectivism (the whimsy of Joyce's nature), transformed into universalism. No one is as subjective as Joyce is, no one is as universal as he is. Such can only be a conscious modernist who has passed the difficult path of search outside, in the world of culture, and inside, looking into the irrational depths of his own psyche. This is the most rational, intellectual and at the same time irrational, or visionary, according to K.G. Jung, type of creativity. Second: this is the boldest (revolutionary, in the words of Vikonska) challenge to tradition (or Cultural Canon, according to K.G. Jung), which manifested itself in the ironic parody of almost all known literary forms and narrative means, many moral and ethical norms. Third: it is a brilliant example of the author's style, a variant of surrealism, which grows out of naturalism and turns into neomythologism. Joyce's style is characterized by the following features: associative metaphorical writing, author's dictionary, which includes numerous innovations, narrative reception of the flow of consciousness; use of dreams, delusions, other boundary conditions; a bizarre intertwining of past and present, when dead and living characters are equal in meaning; consistent reflection of the external in the internal and vice versa; a labyrinth of human wanderings in search of pleasures, meaning, cognition and self-knowledge. Joyce modeled the next stage in the development of culture – the transition from modernism to postmodernism, from an ironic re-reading of tradition to playing with it.

THE ROLE OF KREMENETS UKRAINIAN GYMNASIUM NAMED AFTER IVAN STESHENKO IN THE FORMATION OF YOUNG PERSONALITY (BY THE NOVEL OF ULAS SAMCHUK "THE YOUTH OF VASYL SHEREMETA")

2019 ◽  
pp. 106-111
Author(s):  
Iryna Kominyarska ◽  
Olena Pasichnyk
Keyword(s):  
Young Person ◽  
Literary Analysis ◽  
Theoretical Interpretation ◽  
The Novel ◽  
The First World War ◽  
Literary Heritage ◽  
Literary Process ◽  
Cultural Code ◽  
First Time

The article deals with the literary analysis of Ulas Samchuk's novel «The youth of Vasyl Sheremeta». It explores the proper concept of the philosophical and theoretical interpretation of the significance and role of the Kremenets Gymnasium named after Ivan Steshenko in the formation of a young person by the novel of Ulas Samchuk «The youth of Vasyl Sheremeta». The authors of the article note that the significance of Ulas Samchuk's creative work in the complex literary process lies in its key role in the formation of a new active hero in the Ukrainian prose of the twentieth century. The life and creative path of the prose writer, his literary heritage is a vivid phenomenon in world-wide Ukrainian society, which more clearly reveals the "character of the nation-creating factor" (R. Gromiak). It was investigated that Ulas Samchuk wrote an autobiographical essay-novel in the two volumes "Youth of Vasily Sheremety" about the life of Kremenets and the gymnasium of the 20's. "This book, - says the author, - violates a small part of the problem of our Ukrainian sector. This is a series of questions from the youth environment of the first years after the First World War of one of our provinces. I wanted to lighten them with the ones my eyes saw them, and the way they heard them, my soul. Without special colors, without special "educational trends", without "for" and without "against". My only tendency was to see everything, even my insignificant heroes from a distant provincial town, co-authors of their era. I wanted to show people who later created the content of what we had just experienced in their first time. Do not force the reader and the critic "to be satisfied." I would have liked more to be true. It is proved that in the artistic means of the novel "The youth of Vasyl Sheremeta" the main feature of his outlook is clearly and consistently traced. The language and cultural code of the national identity of the heroes is represented as a phenomenon of Ukrainianity and the formation of a young Ukrainian person. Ulas Samchuk closely connects language and history as an inseparable unity.

scholarly journals PLOT ELEMENTS AND MOTIVES OF THE NOVEL “CHEVENGUR” IN PLATONOV’S SHORT STORY “POTUDAN RIVER”

2021 ◽  
Vol 26 (1) ◽  
pp. 44-55
Author(s):  
N. Mikhaylovna Malygina ◽  
Keyword(s):  
Short Story ◽  
The Novel ◽  
Love Story ◽  
Planetary Scale ◽  
The Family ◽  
Analytical Review ◽  
Eugene Onegin ◽  
Intertextual Connections ◽  
First Time

The relevance of the article is determined by the researcher of the semantic poetics of Platonov’s story “Potudan River”. We carry out an analytical review of the lifetime criticism and articles of modern researchers about the story, on the basis of which we formulate the purpose of the study, due to the need for a new approach to the interpretation of the work and the identification of the principles of its poetics. The novelty of the article is determined by the identification of the multilayered symbolism of the title of the story, which allows to establish the insufficiency of the conclusions that the content of the “Potudan River” is limited to the family theme. At the level of micropoetics we reveal symbolic details that connect the content of the story with the motive of love for the distant, medical and construction subjects and revealing the planetary scale of the author’s thinking. For the first time, it was established that Platonov’s story “Potudan River” was written based on part of the plot of the novel “Chevengur” – the love story of Alexander Dvanov and Sonya Mandrova. We show that the heroes of the story “Potudan River” Nikita Firsov, Lyuba Kuznetsova and Nikita’s father are doubles of the characters in the novel “Chevengur” by Sasha Dvanov, Sonya Mandrova, and Zakhar Pavlovich. The connection of the image of Lyuba with the archetype of the bride is considered. The paper reveals for the first time the intertextual connections of the story “Potudan River” with the poem “The Bronze Horseman” and the novel in verse “Eugene Onegin” by A. Pushkin, in the texts of which the writer found material for modeling the ordinary fate of the hero. Multi-level connections of the content of the story “Potudan River” with Platonov’s artistic world, which is a complete metatext, are found, which opens up new opportunities for determining the role of the editing technique and the principles of returning to the plots and motives of the works of the 1920s, as well as their transformation in the writer’s work of the 1930s.

scholarly journals Role of RBC membrane protein palmitoylation in regulation of molecular topology and susceptibility to Plasmodium falciparum invasion

2020 ◽  
Author(s):  
Soumya Pati ◽  
Preeti Yadav ◽  
Geeta Kumari ◽  
Rex D.A.B ◽  
Sangam Goswami ◽  
...  
Keyword(s):  
The Novel ◽  
Molecular Topology ◽  
Parasite Invasion ◽  
Rbc Membrane ◽  
Protein Pool ◽  
Depth Analysis ◽  
Protein Palmitoylation ◽  
Specific Receptors ◽  
First Time

AbstractSqueezability of biconcave RBC raises a fundamental query, about, how it can restructure its bendable cytoskeleton for efficient micro-circulation. We report for the first time, the existence of dynamic palmitoylome in RBC composed of 118 palmitoylated proteins that reduced to 42 upon treatment with 2BP, a generic inhibitor of palmitoylation. In-depth analysis revealed that Semaphorin7A, CR1 and ABCB6, the known RBC receptors for P. falciparum were reduced to negligible in 2BP-treated RBCs, suggesting palmitoylation-dependent recruitment of parasite-specific receptors. Interestingly, Kell, a single disulphide-linked co-partner in Kell-Kx complex was undetected in 2BP-treated RBCs, while Kx remained intact. RBCs-blocked with anti-Kell antibody demonstrated signficant reduction in parasite invasion, thus suggesting it as a receptor proto-type for P. falciparum invasion. Finally, reduced expression of Kell in palmitoylated protein pool of sickle-cell RBC ghost, with its diminished surface representation in these RBCs, proposed Kell, as one of the novel receptor-prototype for P. falciparum invasion.

scholarly journals Search of an ideal language in Friedrich Schlegel’s novel “Lucinde”

2019 ◽  
Vol 4 (4) ◽  
pp. 100-111
Author(s):  
Ekaterina A. Shikhanova ◽  
Alexander V. Belobratov
Keyword(s):  
Cognitive Abilities ◽  
The Novel ◽  
Ideal Language ◽  
Self Knowledge ◽  
Theory Creation

The study investigates the speech organization of Carl Wilhelm Friedrich Schlegel’s novel “Lucinde” (1799), which was written at the time of “universal poetry” theory creation and became its true embodiment. One of the key problems of the text is thinking and self-knowledge of the speaking subject. It is also connected with the role of language and dialogic speech in these processes. In this respect the important things are interaction of the speaker with “nameless”, definition and denomination of phenomena (all of them are necessary stages of knowledge), narrative itself, and plot deploying the speech canvas. In the course of these processes the expressive and cognitive abilities of the language are “tested”, its imperfections are revealed, and attempts are made to overcome them. Thus, “Lucinde” appears as a work typical for Early Romanticism with its search for a genuine language, pronounced self-reflexivity and the “socratic” dialogism of the novel form.

scholarly journals Ageing, Cellular Senescence and Neurodegenerative Disease

2018 ◽  
Vol 19 (10) ◽  
pp. 2937 ◽  
Author(s):  
Marios Kritsilis ◽  
Sophia V. Rizou ◽  
Paraskevi Koutsoudaki ◽  
Konstantinos Evangelou ◽  
Vassilis Gorgoulis ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurodegenerative Disease ◽  
Cellular Senescence ◽  
Biological Process ◽  
The Novel ◽  
Cell Type ◽  
Age Related ◽  
Cell Type Specific ◽  
First Time

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular senescence is a homeostatic biological process that has a key role in driving ageing. There is evidence that senescent cells accumulate in the nervous system with ageing and neurodegenerative disease and may predispose a person to the appearance of a neurodegenerative condition or may aggravate its course. Research into senescence has long been hindered by its variable and cell-type specific features and the lack of a universal marker to unequivocally detect senescent cells. Recent advances in senescence markers and genetically modified animal models have boosted our knowledge on the role of cellular senescence in ageing and age-related disease. The aim now is to fully elucidate its role in neurodegeneration in order to efficiently and safely exploit cellular senescence as a therapeutic target. Here, we review evidence of cellular senescence in neurons and glial cells and we discuss its putative role in Alzheimer’s disease, Parkinson’s disease and multiple sclerosis and we provide, for the first time, evidence of senescence in neurons and glia in multiple sclerosis, using the novel GL13 lipofuscin stain as a marker of cellular senescence.

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

Blood ◽  
2006 ◽  
Vol 108 (4) ◽  
pp. 1402-1405 ◽  
Author(s):  
Jeanne-Claire Lesbordes-Brion ◽  
Lydie Viatte ◽  
Myriam Bennoun ◽  
Dan-Qing Lou ◽  
Guillemette Ramey ◽  
...  
Keyword(s):  
Iron Overload ◽  
Negative Regulator ◽  
Iron Release ◽  
Coding Region ◽  
Targeted Disruption ◽  
Excess Iron ◽  
Almost All ◽  
Parenchymal Cells ◽  
First Time

Abstract We previously reported that mice made deficient for the transcriptional factor USF2 fail to express hepcidin 1 and hepcidin 2 genes as a consequence of targeted disruption of the Usf2 gene lying just upstream in the locus. These mice developed an iron overload phenotype with excess iron deposition in parenchymal cells and decreased reticuloendothelial iron. At that time, although the role of USF2 was still confounding, we proposed for the first time the role of hepcidin as a negative regulator of iron absorption and iron release from macrophages. Accordingly, we subsequently demonstrated that hyperexpression of hepcidin 1, but not hepcidin 2, resulted in a profound hyposideremic anemia. To analyze the consequences of hepcidin 1 deletion on iron metabolism without any disturbance due to USF2 deficiency, we disrupted the hepcidin 1 gene by targeting almost all the coding region. Confirming our prior results, Hepc1–/– mice developed early and severe multivisceral iron overload, with sparing of the spleen macrophages, and demonstrated increased serum iron and ferritin levels as compared with their controls.

scholarly journals The essence оf the Christian dogma by Erich Fromm

2015 ◽  
pp. 116-126
Author(s):  
N. B. Buriak
Keyword(s):  
Comparative Analysis ◽  
Old Testament ◽  
Historical Evolution ◽  
Erich Fromm ◽  
Complex Issue ◽  
Man And Nature ◽  
Evolution Of Ideas ◽  
Almost All ◽  
First Time

The essence оf the Christian dogma by Erich Fromm. In the article is widely considered the dynamics of religious beliefs Erich Fromm. For the first time a comparative analysis of all Fromm’s work relating to the theme of religion. Fromm devoted to the search itself and society in faith quite a lot of time because such research is very important and requires a recess in the nature of some of the world’s religions, including Christianity. Questions and countermeasures manifestations of humanism and authoritarian Christianity, its historical evolution and ideals throw a kind of challenge to the outstanding philosopher, and forced him to work on this complex issue almost all his life. Dogma Erich Fromm developed so that initially there was an idea of the man who became God, and turned on the idea of God became man. The concept of the Old Testament prophets world extend beyond relationships between people, harmony should prevail between man and nature. Peace between man and nature is harmony between them. Erich Fromm permanently broke with Judaism in ‘26 and has since considered himself a Christian. But Christianity Fromm, his understanding of God, the role of Christ in history, the interpretation of the evolution of ideas and Savior is surprising for its boldness.

scholarly journals MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils

2021 ◽  
Vol 12 ◽  
Author(s):  
Ewelina Dobosz ◽  
Marta Wadowska ◽  
Marta Kaminska ◽  
Mateusz Wilamowski ◽  
Mohsen Honarpisheh ◽  
...  
Keyword(s):  
Potent Inhibitor ◽  
Early Event ◽  
The Novel ◽  
Resolution Of Inflammation ◽  
Monocyte Chemoattractant ◽  
Gm Csf ◽  
Binding Partners ◽  
Potential Binding ◽  
First Time

Monocyte chemoattractant protein-induced protein-1 (MCPIP-1) is a potent inhibitor of inflammatory response to pathogens. Acting as endonuclease against transcripts of inflammatory cytokines or transcription factors MCPIP-1 can significantly reduce the cytokine storm, thus limiting the tissue damage. As the adequate resolution of inflammation depends also on the efficient clearance of accumulated neutrophils, we focused on the role of MCPIP-1 in apoptosis and retention of neutrophils. We used peritoneal neutrophils from cell-specific MCPIP-1 knockout mice and showed prolonged survival of these cells. Moreover, we confirmed that MCPIP-1-dependent degradation of transcripts of antiapoptotic genes, including BCL3, BCL2A1, BCL2L1, and for the first time MCL-1, serves as an early event in spontaneous apoptosis of primary neutrophils. Additionally, we identified previously unknown miRNAs as potential binding partners to the MCPIP-1 transcript and their regulation suggest a role in MCPIP-1 half-life and translation. These phenomena may play a role as a molecular switch that balances the MCPIP-1-dependent apoptosis. Besides that, we determined these particular miRNAs as integral components of the GM-CSF-MCPIP-1 axis. Taken together, we identified the novel anti-inflammatory role of MCPIP-1 as a regulator of accumulation and survival of neutrophils that simultaneously promotes an adequate resolution of inflammation.

scholarly journals The adhan in the Bosniak population in Serbia

2020 ◽  
Vol 68 (3) ◽  
pp. 533-554
Author(s):  
Naka Niksic
Keyword(s):  
High Schools ◽  
Music Education ◽  
Seventh Century ◽  
Religious School ◽  
15Th Century ◽  
First Time ◽  
Over Time ◽  
School Curricula

The adhan (?the call to ritual prayer?) originated in Mecca in the seventh century, when it was, by order and instruction of the prophet Muhammad, for the first time, in an exceptionally lovely voice, melodiously performed by Bilal ibn Rebbah, also known as Bilal the Ethiopian. Over time, it became the symbol of testifying to the belief that there is only one god, Allah, and that Muhammad his prophet calls to Islam, as a sign of establishing power over a newly-conquered territory. With the spreading of Islam, the practice of salat, and thus the adhan, has been performed today, in addition to the salat, it is also performed when ritually naming newborns. In the areas which are dominantly inhabited by the Bosniaks in Serbia it still continues to be performed from the beginning of the 15th century. Viewed from the aspect of music, during the performance of an adhan we note the prevalence of various melodious patterns, depending on whether the Turkish or Arabic religious school predominates. The aim of this paper is to point at the importance and role of the adhan in the culture of Bosniaks, and thus argue for its inclusion in the school curricula for music education teaching in elementary and high schools. For this purpose, I use the existing scholarship on this topic recordings of interlocutors, ethnomusicological recordings of performances, as well as the analysis of curricula. I hope that this research will provide a contribute to expanding knowledge of the role of adhan among Bosniaks and understanding this form of Islamic spiritual music.

scholarly journals The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis

2021 ◽  
Vol 90 (3) ◽  
pp. e560
Author(s):  
Dženan Kovačić ◽  
Jovana Jotanović ◽  
Jasmina Laković
Keyword(s):  
Molecular Mimicry ◽  
Causative Factor ◽  
Organ Damage ◽  
Peptide Sequence ◽  
Autoimmune Response ◽  
The Novel ◽  
Autoimmune Conditions ◽  
First Time

Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), persists as a threat to global health and continues to be a rapidly evolving condition. Although COVID19 is negatively correlated with the existing comorbidities in terms of the clinical outcome, the ability of SARS-CoV-2 to mediate the novel, or to exacerbate the existing autoimmune conditions, has generated considerable interest, due to its potential implications both with regard to patients suffering from autoimmune conditions, as well as to the long-term consequences of the disease. However, although molecular mimicry has been postulated as a potential causative factor in post-COVID19 autoimmunity and multi-organ damage, a substantial body of research needs to emerge in order to achieve a more definitive conclusion. We investigated the possibility of SARS-CoV-2 peptide sequences behaving as molecular mimics with a potential to trigger an autoimmune response. Thus, on the basis of analysis in silico, we were able to develop a plausible case for the molecular mimicry as a potential aetiological mechanism of SARS-CoV-2-mediated autoimmunity, both in a multi-organ damage context or outside of the viral phase of infection. Interestingly, this is the first time that the peptide sequence of MACROD1 has been implicated in the COVID-19 autoimmunity. Additionally, we also confirm that PARP9 and PARP14 may be involved in the process.

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