Reducing Effects of Anti-Epidemic (Quarantine) Measures during the COVID-19 Pandemic on the Incidence and Spread of Airborne Infectious Diseases (Based on the Example of Varicella)

2021 ◽  
pp. 55-62
Author(s):  
EP Lavrik ◽  
AG Kravchenko ◽  
GM Trukhina ◽  
АА Gerasimova ◽  
SA Vysotin ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Preventive Measures ◽  
Average Rate ◽  
Incidence Rates ◽  
Annual Data ◽  
Krasnodar Krai ◽  
Social Distancing ◽  
Restrictive Measures ◽  
Standard Techniques

Background. The coronavirus pandemic, also known as the COVID-19 pandemic, introduced significant changes in vital activities of the population and spread of airborne infectious diseases, the study of which enables ranking of preventive measures. The objective of our study was to assess the degree of influence of the lockdown and social distancing imposed in the Krasnodar Krai in 2020 due to the pandemic on the incidence of airborne communicable diseases based on the example of varicella. Materials and methods. We conducted a retrospective analysis of a 10-year incidence of varicella in the population of the Tuapse district, Krasnodar Krai using monthly and annual data on the incidence of infectious and parasitic diseases (Form No. 2) in the Tuapse district for 2011–2020 and the “Population Incidence” software, version 5, by applying standard techniques and methods of studying the epidemic process. Results. Stringent restrictive measures taken in the country in 2020 in the context of the COVID-19 pandemic caused a significant decrease (by 741 %) in the incidence of chickenpox among the population of the Tuapse district compared to the long-term average rate. In April – May and July – September 2020, varicella incidence rates were 30.98 and 7.75 per 100 thousand population or 7.4 and 18.8 times lower than the long-term average, respectively. The majority of chickenpox cases in the Tuapse district (as in the country as a whole) were pediatric – 94.02 % (RF – 94.3 %), with children aged 3 to 6 years making up 61 % of the total. Conclusion. The lockdown and social distancing imposed during the COVID-19 pandemic has a significant reducing effect on the incidence of airborne infectious diseases in the population in the absence of effective vaccination.

Updated picture of SARS-CoV-2 variants and mutations

Diagnosis ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Giuseppe Lippi ◽  
Camilla Mattiuzzi ◽  
Brandon M. Henry
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Preventive Measures ◽  
Definitive Treatment ◽  
Social Distancing ◽  
Viral Spread ◽  
Limited Efficacy ◽  
Highly Virulent ◽  
New Mutations

Abstract The worldwide burden of coronavirus disease 2019 (COVID-19) is still unremittingly prosecuting, with nearly 300 million infections and over 5.3 million deaths recorded so far since the origin of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic at the end of the year 2019. The fight against this new highly virulent beta coronavirus appears one of the most strenuous and long challenges that humanity has ever faced, since a definitive treatment has not been identified so far. The adoption of potentially useful physical preventive measures such as lockdowns, social distancing and face masking seems only partially effective for mitigating viral spread, though efficacy and continuation of such measures on the long term is questionable, due to many social and economic reasons. Many COVID-19 vaccines have been developed and are now widely used, though their effectiveness is challenged by several aspects such as low uptake and limited efficacy in some specific populations, as well as by continuous emergence of new mutations in the SARS-CoV-2 genome, accompanying the origin and spread of new variants, which in turn may contribute to further decrease the effectiveness of current vaccines and treatments. This article is hence aimed to provide an updated picture of SARS-CoV-2 variants and mutations that have emerged from November 2019 to present time (i.e., early December 2021).

Features of the Current Epidemic Process of Infectious Mononucleosis in the Nizhny Novgorod Region

2021 ◽  
pp. 79-86
Author(s):  
MI Popkova ◽  
OV Utkin
Keyword(s):  
Infectious Mononucleosis ◽  
Average Rate ◽  
Disease Incidence ◽  
Age Groups ◽  
Incidence Rates ◽  
Epidemiological Surveillance ◽  
Epidemic Process ◽  
Tract Infections ◽  
Nizhny Novgorod Region

Introduction: Today, we are witnessing the process of forming a fundamentally new epidemiological situation on infectious mononucleosis. Over the past decade, a general increase in the incidence of infectious mononucleosis, its proportion in the structure of respiratory tract infections, and economic importance was noted in Russia. Information about the epidemic process of infectious mononucleosis in different areas is limited. Our objective was to study the features of the epidemic process of infectious mononucleosis in the Nizhny Novgorod Region in 2010–2019. Methods: We conducted a retrospective epidemiological analysis of the incidence of infectious mononucleosis in the Nizhny Novgorod Region for 2010–2019 based on official statistics using standard statistical approaches. Results and discussion: The long-term incidence rate of infectious mononucleosis in the Nizhny Novgorod Region was stable (+0.6 %) with the long-term average rate of 12.6 ± 0.6 ‰оо. An autumn-winter-spring seasonality with two distinct peaks (in November–December and May) was revealed. The majority of cases were children aged 0–14 years (72.8 ± 2.2 %). The highest incidence rates were regis�tered in the age groups of 1–2 and 3-6 years. We established a reverse trend in the disease incidence among children aged 0–6 (decrease) and 7 years and older (increase). Adolescents aged 15–17 demonstrated the most pronounced growth rate (+7.5 %). The typical annual dynamics in adults was distinguished by a clear spring-summer seasonality, the absence of a characteristic growth in the autumn months, and a low rate in December. The identified features of the epidemic process in different age groups require clarification and detailing. Conclusions: We established recent patterns and features of the epidemic process of infectious mononucleosis in the Nizhny Novgorod Region. This work is an important component of epidemiological surveillance of infection and a scientific basis for improving the existing system of preventive and anti-epidemic measures.

Effect of Prevention Strategies on Survival and Quality-Adjusted Survival of Women With BRCA1/2 Mutations: An Updated Decision Analysis

2002 ◽  
Vol 20 (10) ◽  
pp. 2520-2529 ◽  
Author(s):  
Victor R. Grann ◽  
Judith S. Jacobson ◽  
Dustin Thomason ◽  
Dawn Hershman ◽  
Daniel F. Heitjan ◽  
...  
Keyword(s):  
Cancer Incidence ◽  
Preventive Measures ◽  
Prophylactic Mastectomy ◽  
Incidence Rates ◽  
Sensitivity Analyses ◽  
Prophylactic Surgery ◽  
Markov Modeling ◽  
Prophylactic Oophorectomy ◽  
Quality Adjustment

PURPOSE: This study updates findings regarding the effects of prophylactic surgery, chemoprevention, and surveillance on the survival and quality-adjusted survival of women who test positive for BRCA1/2 mutations. MATERIALS AND METHODS: Markov modeling of outcomes was performed in a simulated cohort of 30-year-old women who tested positive for BRCA1/2 mutations. The model incorporated breast and ovarian cancer incidence rates from the literature and mortality rates from the Surveillance, Epidemiology, and End Results Program. Quality adjustment of survival estimates were obtained from a survey of women aged 33 to 50 years. Sensitivity analyses were performed of varied assumptions regarding timing and effects of preventive measures on cancer incidence and adverse effects. RESULTS: A 30-year-old woman could prolong her survival beyond that associated with surveillance alone by use of preventive measures: 1.8 years with tamoxifen, 2.6 years with prophylactic oophorectomy, 4.6 years with both tamoxifen and prophylactic oophorectomy, 3.5 years with prophylactic mastectomy, and 4.9 years with both surgeries. She could prolong her quality-adjusted survival by 2.8 years with tamoxifen, 4.4 years with prophylactic oophorectomy, 6.3 years with tamoxifen and oophorectomy, and 2.6 years with mastectomy, or with both surgeries. The benefits of all of these strategies would decrease if they were initiated at later ages. CONCLUSION: Women who test positive for BRCA1/2 mutations may derive greater survival and quality adjusted survival benefits than previously reported from chemoprevention, prophylactic surgery, or a combination. Observational studies and clinical trials are needed to verify the results of this analysis of the long-term benefits of preventive strategies among BRCA1/2-positive women.

scholarly journals Management of the Incidence of Infectious Diseases by Applying Preventive Measures in the Weakest Period in Its Cyclicity

2021 ◽  
Vol 76 (1) ◽  
pp. 20-27
Author(s):  
Evgeny D. Savilov
Keyword(s):  
Infectious Diseases ◽  
Preventive Measures ◽  
Self Regulation ◽  
Cost Effective ◽  
Risk Groups ◽  
Disease Occurrence ◽  
Long Term Trends ◽  
Marked Decline ◽  
Positive Effect

Existing preventive measures have not been entirely efficient. Mainly they are aimed at solving social and economic issues, which demands both time and money. Considering this, it is necessary to find and sustain additional effective measures, based on patterns of development of infectious diseases, which could be more cost-effective. One of such approaches could be based on the theory of self-regulation of parasitic systems, which directs epidemiologists to conducting preventive measures before the rise of the number of cases to prevent increase in the agents virulence. Yet this theory does not provide the optimum time for preventive measures. Based on the main statements of the theory of self-regulation of parasitic systems and analysis of annual and/or long-term cyclicity, the article provides substantiation of the theory that the lowest level of incidence is the weakest period in its development. Epidemiological experiments, using bacterial dysentery as an example, showed that preventive administration of polyvalent dysenteric bacteriophage in risk groups (children going to preschool institutions) during two months of the lowest incidence level of the disease appeared to be effective. The positive effect took place in the stages of cyclic increase and decrease of long-term trends. The effect appeared in the groups of children and population in general with most marked decline in disease occurrence in its seasonal peak. The hypothesis that the lowest incidence level is directly related to seasonal climbs of the disease was proved by our earlier studies when we investigated influence of technogenic pollution of the environment on annual incidence rate of more than ten most common infectious diseases with different ways of transmission. Thus, the lowest incidence level of infectious diseases defines their future growth and/or decline, and, therefore, it can be used to conduct preventive measures.

scholarly journals Study of Susceptibility of Staphylococcosis and Streptococcosis Causative Agents to Medicinal Preparations

2021 ◽  
Vol 7 (6) ◽  
Author(s):  
S. Abbasov
Keyword(s):  
Infectious Diseases ◽  
Preventive Measures ◽  
Medicinal Preparations ◽  
Causative Agents

The article gives consideration to the determination of the susceptibility of causative agents of staphylococcosis and streptococcosis to antibiotics. Long-term use of medicinal preparations, including antibiotics, leads to the emergence of generations of microorganisms that are resistant to causative agents of infectious diseases, and this is the reason for the decrease in the effectiveness of medical and preventive measures. Considering all this, the susceptibility degree of cultures of causative agents of staphylococcosis and streptococcosis to drugs such as enroline, colistin, gentamicin, tilazine, furazalidone and neomycin was studied. The susceptibility of Staphylococcus pyugenes cultures to enroline, gentamicin and colistin by 22.2%, and to furasilidone by 74.0%, and Streptococcus feccalus cultures by 38.0% to enolin, by 33.3% to gentamicin, by 19.0% to colistin and by 33.3% to furazalidone were investigated. On the basis of findings of investigations, the highest sensitivity of Staphylococcus pyugenes to furazalidone by 74.0% was revealed. And from the preparations we studied, it was found that Streptococcus feccalus is susceptible to enroline by 38.0%.

scholarly journals Association of Mental Fatigue due to Long-term Restrictive Measures with Reasoning: A COVID-19 Study

2021 ◽  
Author(s):  
Majid Manoochehri ◽  
Jakub Šrol ◽  
Fatemeh Asgharian Asl ◽  
Mona Mehdinasab ◽  
Zakiya Akhoundi
Keyword(s):  
Preventive Measures ◽  
Mental Fatigue ◽  
Reasoning Ability ◽  
Psychological Consequences ◽  
Cognitive Reflection ◽  
The World ◽  
Psychopathological Disorders ◽  
Restrictive Measures ◽  
The Impact

Coronavirus Disease 2019 broke out in China at the end of 2019 and spread rapidly around the world. In response, many countries have adopted social distancing and lockdown measures. But restrictive measures resulted in many unwanted psychological consequences, including mental fatigue. Mental fatigue in turn is very likely to cause psychopathological disorders and cognitive malfunctions. A cognitive ability that is likely to be affected by mental fatigue is reasoning, while high reasoning ability is a prerequisite for compliance with restrictive measures. The present study aims to explore the association between mental fatigue and reasoning under the impact of long-term restrictive measures. The findings indicated that mental fatigue correlates negatively with cognitive reflection, while it has no significant association with general reasoning. The results also showed that mental fatigue correlates positively with the misperception of the preventive measures and negatively with the incomprehension of the restrictive measures. The implications of the results have been discussed.

2273-PUB: Long-Term Incidence Rates of Complications in Patients with Type 2 Diabetes in Sweden

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2273-PUB
Author(s):  
ANN-MARIE SVENSSON ◽  
STEFAN FRANZÉN ◽  
ROGIER M. KLOK ◽  
TRACEY WEISS ◽  
SWAPNIL RAJPATHAK ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Incidence Rates

Comprehending and Executing Aacharrasayana in the context of COVID 19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1099-1104
Author(s):  
Priti Desai ◽  
Anita Wanjari ◽  
Deepali Giri
Keyword(s):  
Preventive Measures ◽  
Code Of Conduct ◽  
Spiritual Health ◽  
Social Health ◽  
Human Being ◽  
Global Level ◽  
Social Distancing ◽  
Global Population

The COVID 19 pandemic had disrupted the lives of all socio-economic groups of the global population. The lockdowns, social distancing, financial adversities, continuous fear of being a victim to the virus had left every individual desperate with a feeling of vulnerability. Irrespective of all possible efforts at the global level, no ultimate solution to get rid of this virus is available till date except for the preventive measures. Various medicines and formulations are into practice, which may boost one’s immunity to fight against the virus. This catastrophic scenario had resulted in an impact on the human being in all aspects, physical, mental, emotional, social and behavioural. Ayurveda, the science of life has encompassed all these aspects through its preventive and curative principles. Aacharrasayana, code of conduct or behavioural discipline is one such modality that entails perfect mental, physical, social and spiritual health of the human being. The execution of Aacharrasayana in this situation can immensely contribute in restoring mental, spiritual and social health. This review aims to interpret the implementation of various aspects of Aacharrasayanain context of COVID 19 and its utility in combatting the dreadful crisis.

Differentiation of endemic areas by incidence rates of tick-borne infectious diseases as the basis for choosing prevention strategy and tactics

2019 ◽  
pp. 56-61
Author(s):  
N.V. Rudakov ◽  
N.A. Penyevskaya ◽  
D.A. Saveliev ◽  
S.A. Rudakova ◽  
C.V. Shtrek ◽  
...  
Keyword(s):  
High Risk ◽  
Infectious Diseases ◽  
Population Based ◽  
Preventive Therapy ◽  
Incidence Rates ◽  
Prevention Strategy ◽  
Individual Risk ◽  
The Individual ◽  
Integral Assessment ◽  
Very High

Research objective. Differentiation of natural focal areas of Western Siberia by integral incidence rates of tick-borne infectious diseases for determination of the strategy and tactics of their comprehensive prevention. Materials and methods. A retrospective analysis of official statistics for the period 2002-2018 for eight sub-federal units in the context of administrative territories was carried out. The criteria of differentiation were determined by means of three evaluation scales, including long-term mean rates of tick-borne encephalitis, tick-borne borreliosis, and Siberian tick-borne typhus. As a scale gradation tool, we used the number of sample elements between the confidence boundaries of the median. The integral assessment was carried out by the sum of points corresponding to the incidence rates for each of the analyzed infections. Results. The areas of low, medium, above average, high and very high risk of tick-borne infectious diseases were determined. Recommendations on the choice of prevention strategy and tactics were given. In areas of very high and high incidence rates, a combination of population-based and individual prevention strategies is preferable while in other areas a combination of high-risk and individual strategies is recommended. Discussion. Epidemiologic zoning should be the basis of a risk-based approach to determining optimal volumes and directions of preventive measures against natural focal infections. It is necessary to improve the means and methods of determining the individual risk of getting infected and developing tick-borne infectious diseases in case of bites, in view of mixed infection of vectors, as well as methods of post-exposure disease prevention (preventive therapy).

INFORMATION SUPPORT FOR MAKING MANAGEMENT DECISIONS IN THE FIELD OF PREVENTION OF EYE DISEASES AT STUDENTS BASED ON MULTI-VARIANT SIMULATION AND FORECASTING

2020 ◽  
pp. 147-153
Author(s):  
Юлия Владимировна Татаркова ◽  
Татьяна Николаевна Петрова ◽  
Олег Валериевич Судаков ◽  
Александр Юрьевич Гончаров ◽  
Ольга Николаевна Крюкова
Keyword(s):  
Preventive Measures ◽  
Influential Factors ◽  
Eye Diseases ◽  
Information Support ◽  
Factor Space ◽  
Factors Affecting ◽  
Eye Fatigue ◽  
Modeling And Forecasting ◽  
Medical Examinations

В настоящей статье представлен обзор основных решений, доступных сегодня для формирования как краткосрочных, так и долгосрочных проекций заболеваемости болезней глаза и его придаточного аппарата в студенческой среде. С другой стороны, существует ряд проблем, связанных с многообразием факторов, влияющих на заболеваемость, статистической необоснованностью и противоречивостью имеющихся результатов анализа данных. Представлены результаты математического моделирования зависимости показателя заболеваемости от наиболее влиятельных факторов образовательной и социальной среды. Перечислены важнейшие направления разработки математических моделей распространения заболеваемости. С помощью разработанного программного комплекса проведена серия вычислительных экспериментов по оценке и прогнозированию заболеваемости обучающихся в вузах разного профиля. Показана эффективность применения методики многовариантного моделирования и прогнозирования, указаны их ограничения и возможности практического применения. По расположению обобщенной области благоприятного прогноза в факторном пространстве можно определить время воздействия неблагоприятных для зрения факторов, которое должно составлять не более 10 ... 11 часов в сутки, количество профилактических мероприятий должно составлять не менее 3 ... 4. При этом риск развития миопии составит не более 0,4, вероятность усталости глаз за компьютером составит не более 0,4, вероятность дискомфорта глаз на занятиях составит не более 0,15. Исходя из характера прогноза, определяется длительность диспансерного наблюдения, а также потребность профилактических мероприятий по устранению или ослаблению действия неблагоприятно влияющих социально-гигиенических и медико-биологических факторов конкретного больного. Использование прогностической матрицы в практическом здравоохранении позволяет существенно улучшить работу по профилактике офтальмологической заболеваемости и является одним из эффективных мероприятий диспансеризации студенческой молодежи, так как дает возможность выделить из числа обучающихся группу с высоким риском неблагоприятного исхода заболевания This article provides an overview of the main solutions available today for the formation of both short-term and long-term projections of the incidence of eye diseases and its adnexa in the student environment. On the other hand, there are a number of problems associated with a variety of factors affecting the incidence, statistical unreasonability and inconsistency of the available data analysis results. The results of mathematical modeling of the dependence of the incidence rate on the most influential factors of the educational and social environment are presented. The most important areas of developing mathematical models for the spread of morbidity are listed. With the help of the developed software package, a series of computational experiments was carried out to assess and predict the incidence of students in universities of various profiles. The effectiveness of the application of multivariate modeling and forecasting methods is shown, their limitations and practical application possibilities are indicated. By the location of the generalized region of favorable prognosis in the factor space, it is possible to determine the exposure time of factors unfavorable for vision, which should be no more than 10 ... 11 hours a day, the number of preventive measures should be at least 3 ... 4. At the same time, the risk of development myopia will be no more than 0.4, the probability of eye fatigue at the computer will be no more than 0.4, the likelihood of eye discomfort in the classroom will be no more than 0.15. Based on the nature of the forecast, the duration of the follow-up observation is determined, as well as the need for preventive measures to eliminate or weaken the action of adverse social, hygienic and biomedical factors of a particular patient. The use of the prognostic matrix in practical health care can significantly improve the work on the prevention of ophthalmic morbidity and is one of the effective medical examinations for students, since it makes it possible to distinguish among the students a group with a high risk of an unfavorable outcome of the disease

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