EVALUATION OF THE EFFECTIVENESS OF TREATMENT AND PREVENTION OF DOG BABESIOSIS

2020 ◽  
Vol 15 (10) ◽  
pp. 1371-1378
Author(s):  
T.V. Alekseeva ◽  
◽  
M.A. Alekseeva ◽  
Keyword(s):  
Treatment Regimen ◽  
Healing Process ◽  
Clinical Signs ◽  
Individual Treatment ◽  
Control Group ◽  
Laboratory Diagnostics ◽  
Canine Babesiosis ◽  
Treatment Regimens ◽  
Treatment And Prevention ◽  
The Republic

With an increase in the incidence of babesiosis (piroplasmosis) in dogs, the development of effective methods for the prevention and treatment of this disease is one of the promising areas of veterinary science and practice. The article presents the research results obtained in assessing the effectiveness of various methods of treatment and prevention of canine babesiosis using domestically produced drugs. The studies were carried out on the basis of the Novoshakhtinsky branch of the State Budgetary Institution of the Republic of Belarus "Rostov Region SBBZh with PO", the object of the study was dogs of various breeds, diagnosed with babesiosis. Diagnosis of piroplasmosis was carried out on the basis of anamnesis, clinical signs and using laboratory diagnostics of blood tests. Hematological studies were performed on the 1st and 10th days of treatment on an automatic hematological analyzer URIT-3020 Vet Plus. For the experiment, 3 groups of animals were formed (5 dogs each): 1, 2 experimental and 3 control with individual treatment regimens. In 1 experimental group, Ringer-Locke's solution was used, in 2 - Reamberin, in animals of the control group, isotonic sodium chloride solution. After the end of the course of therapy, blood samples were taken to assess the results of the applied treatment regimen. The onset of recovery was judged by the change in the general condition of the animal, the absence of clinical signs and the results of hematological studies. Based on the studies conducted on the use of domestically produced drugs for the treatment and prevention of canine babesiosis, it was found that the use of the treatment regimen with the drug Reamberin 1 time per day at a dose of 100-200 ml infusion for 4-5 days turned out to be the most effective method and made it possible to speed up the healing process animals.

scholarly journals Canine Babesiosis: Where Do We Stand?

2018 ◽  
Vol 68 (2) ◽  
pp. 127-160 ◽  
Author(s):  
Bilić Petra ◽  
Kuleš Josipa ◽  
Barić Rafaj Renata ◽  
Mrljak Vladimir
Keyword(s):  
Species Recognition ◽  
Therapy Monitoring ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Canine Babesiosis ◽  
Treatment And Prevention ◽  
Clinicopathological Findings ◽  
Tick Borne Disease ◽  
Appropriate Therapy ◽  
Selection Of

Abstract Canine babesiosis is a tick-borne disease caused by protozoal haemoparasites of different Babesia species. Babesiosis is one of the most important globally extended and quickly spreading tick-borne infections of dogs. This comprehensive review gives an in-depth overview of Babesia species currently identified in dogs together with relevant vector tick species and their geographical distribution, life cycle and transmission of parasite. The main mechanisms in the pathogenesis of babesiosis are described and elucidated by recent literature overview. As Babesia infection causes a disease with very variable clinical manifestations, special attention is given to clinical signs, laboratory features and clinicopathological findings. The diagnosis of canine babesiosis by microscopy, serological and molecular methods is reviewed, together with recent advances in mass spectrometry based assays. Accurate detection and species recognition are important for the selection of the appropriate therapy, monitoring and prediction of the outcome of the disease. Finally, guidelines for the treatment and prevention of canine babesiosis are given.

scholarly journals Experimental study action autostrains Aerococcus viridans on the model Pseudomonas infection

2017 ◽  
Vol 8 (3) ◽  
pp. 313-316
Author(s):  
D. O. Stepanskyi ◽  
G. M. Kremenchutskyi ◽  
I. P. Koshova
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Clinical Signs ◽  
Solution Concentration ◽  
Control Group ◽  
Infection Model ◽  
Treatment And Prevention ◽  
Aerococcus Viridans ◽  
Group A ◽  
Recovery Dynamics ◽  
Experimental Group

The paper presents the results of a study of the action of Aerococcus autostrains on the model of a chronic blue pus infection. For the study of the action of Aerococcus autosymbiont strains on Pseudomonas aeruginosa, three of the most biochemically and antagonistically active isolates were selected: 1) 5m2015 (isolated from mice); 2) 3k2015 (isolated from rats); 3) 3ch2015 (isolated from humans). Experiments were conducted on 84 white outbred mice weighing 16–17 g, 60 were used as the experimental, and 24 as the control group. In the experimental group of animals, infected wounds were treated by Aerococcus autosymbiont strains once daily (0.2 billion ml–1) till recovery. The drug was administered under the eschar with a syringe. In the control animals the wound was treated by isotonic sodium chloride solution (concentration 0.9%) with the same route of administration and for the same period of time. It was found that from the very first days of application of Aerococci autosymbiont strains, perifocal inflammation was less severe in most animals in the research group compared with the control group. Starting from the fourth day of usage of Aerococcus autosymbiont strains the number of pseudomonades, contained in secretions from wounds in the experimental group of mice was significantly lower than in the control animals. It was revealed that in case of application of Aerococcus strain (5m2015) isolated from mice, the animals had better indicators of recovery, dynamics of local clinical signs of inflammation and the number of pseudomonades contained in the wound in comparison with other Aerococcus autostrains isolated from rats and humans. The wounds purified from pus and covered with dry eschar faster. For example, wounds completely healed with dry eschar rejection by the 11th day of observation in 44 of 58 surviving mice (75.9%). In the control group a similar pattern was observed in only 3 of 17 mice (17.6%) by the that period. The number of Pseudomonas aeruginosa (equivalent to 1 ml of secretions wounds), expressed in logarithms, was 5.00 ± 0.16 on average on the 4th day in the treated mice, while the control group had the same amount of pseudomonades detected in the wounds (lg 5.22 ± 0.38; lg 5.12 ± 0.30) only on the 13–14th days of observation. We found different activity of strains, depending on the origin of microorganism and type host. Aerococcus viridians autosymbionts showed higher rates in the study of their activity in terms of the blue pus infection model in the treatment of the host and lower activity in treatment.of other species. The obtained data may warrant further study of application of Aerococcus autostrains for treatment and prevention of wound infection caused by pseudomonades. 

scholarly journals Collagen quantification in rabbit dermal wounds treated with heterologous platelet-rich plasma gel

2017 ◽  
Vol 38 (1) ◽  
pp. 249 ◽  
Author(s):  
Maria Elisa Marin Marques ◽  
Cecília Braga Laposy ◽  
Mariana Lucas Dos Santos Silva ◽  
Maria Rosa Santos Breda ◽  
Mayara Mascaro Matsumoto ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adverse Reactions ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Clinical Signs ◽  
Polarized Light ◽  
Clinical Aspects ◽  
Control Group ◽  
Wound Healing Process ◽  
Prp Gel

Platelet-rich plasma (PRP) has been extensively studied as a biomaterial for wound treatment, and the heterologous PRP is usefulin the event that obtaining the patient’s own blood is impossible. This study aimed to evaluate and compare wound healing in rabbits and quantify the collagen in experimentally induced wounds in a control group and in a group treated with heterologous PRP gel. We hypothesize that this gelis capable of promoting proper healing with no adverse reactions, increased collagen content. The clinical aspects of coloring, edema, hyperemia, exudation, crust, granulation, pain sensitivity, and retraction index of the wounds were measuredon days 7, 14, and 17 after the injury. Collagen quantification by Picrosirius staining and evaluation under polarized light was performed on the 17th day. Crust was present in both groups at all evaluated time points, with the absence of other clinical signs. The wound contraction rate and collagen quantity did not differ between groups. In conclusion, the suggested hypothesis was partially confirmed; the heterologous PRP gel was unable to increase the amount of collagen and accelerate the wound healing process, however, wound healing was efficient and similar in both groups and there was no local adverse reaction. Thus, despite the scarcity of studies in the literature, the heterologous PRP gel is an effective alternative treatment for wounds in the absence of other sources of PRP.

ANALYSIS OF THE EFFECTIVENESS OF PREVENTIVE MEASURES IN THE POSTNATAL PERIOD IN COWS

2020 ◽  
pp. 128-133
Author(s):  
S. V. Polyakov ◽  
◽  
N.Yu. Terentyeva ◽  
S. N. Ivanova ◽  
◽  
...  
Keyword(s):  
Preventive Measures ◽  
White Blood Cells ◽  
Reproductive Function ◽  
Postnatal Period ◽  
Drug Prevention ◽  
Control Group ◽  
Treatment Regimens ◽  
Treatment And Prevention ◽  
Ulyanovsk Region ◽  
Methodological Guidelines

Currently, many issues related to therapy and prophylaxis have not been solved in the problem of afterbirth detention. There is a high percentage of complications of this pathology with endometritis, which leads to a decrease in the productivity and reproductive function of animals. Based on the above, the aim of our work was to determine the effectiveness of two treatment regimens for the retention of the afterbirth in cows. Scientific research was carried out in IAPC “New Life” of the Cherdaklinsky district of the Ulyanovsk region. Before the diagnosis was made, an obstetric study was performed according to the”Methodological guidelines for the diagnosis, treatment and prevention of obstetric and gynecological diseases of cows”. Morpho-biochemical parameters of blood were studied according to generally accepted methods. To determine the effectiveness of conservative treatment of afterbirth retention in animals of the experimental and control groups, different schemes of drug prevention were used. The results of studies show that after calving, the number of white blood cells and total protein increases. A higher indicator in the control group indicated the development of the inflammatory process. Clinical studies have confirmed the assumption. A decrease in the level of alkaline phosphatase and phosphorus with an increase in the content of calcium indicates the risk of developing osteodystrophic processes. As a result of preventive measures in the experimental group, complications in the form of postnatal endometritis were not observed, although cases of subinvolution were recorded (15 %). In the control group of cows, postpartum endometritis (15 %) occurred along with uterine subinvolution (15 %). Thus, the inclusion in the scheme of prevention of a preparation “Uterotsev” reduces the risk of postpartum complications in cows.

scholarly journals A Comparison between Multimedia and Traditional Education in Encouraging Adherence to Treatment Regimen in Patients with Hypertension

2020 ◽  
Vol 12 (1) ◽  
pp. 1-6
Author(s):  
Mostafa Bijani ◽  
Banafsheh Tehranineshat ◽  
Fatemeh Ahrari ◽  
Najimeh Beygi
Keyword(s):  
Patient Education ◽  
Treatment Regimen ◽  
Treatment Plan ◽  
Healthcare Providers ◽  
Control Group ◽  
Adherence To Treatment ◽  
Educational Approach ◽  
Convenience Sample ◽  
Treatment Regimens ◽  
The Difference

Background: Adherence to treatment regimen plays a crucial part in the prevention of the consequences of hypertension, thus identification and employment of effective educational methods to enhance patients' adherence to their treatment plans is important. Objective: The present study compares the effectiveness of multimedia and traditional methods of patient education in persuading patients with hypertension to stick to their treatment regimens. Methods: Conducted in 2019, the present study is an experimental work of research which lasted for 5 months. A convenience sample of 160 patients who visited the clinic and cardiac sections of a hospital located in the south-west of Iran was selected and then randomly divided into an intervention and a control group. The intervention consisted of multimedia education provided in 6 sessions and telephone follow-ups. The control group was given the traditional care. The research instruments were a demographics questionnaire and a medication adherence scale. Data were collected before, immediately after, and one month after the intervention. The collected data were analyzed using SPSS v. 19, independent t-test, and chi-square test. Results: The difference between the adherence to treatment regimen scores of the two groups as calculated immediately after and one month after the intervention was found to be statistically significant (P<0.001). Conclusion: Patient education via multimedia can significantly increase patients' adherence to their treatment regimens. Accordingly, it is recommended that nurses and other healthcare providers utilize this new educational approach to facilitate patient education and enhance adherence to treatment plan in patients with hypertension.

Use of Multilayer Thin-Film Coatings for Complete Restoration of Integument in Its Deep Damage (Experimental Study)

2012 ◽  
Vol 19 (2) ◽  
pp. 65-70
Author(s):  
I. E Nikityuk ◽  
V. V Petrash ◽  
V. A Kubasov
Keyword(s):  
Thin Film ◽  
Normal Skin ◽  
Healing Process ◽  
Clinical Signs ◽  
Control Group ◽  
Wound Healing Process ◽  
Multilayer Coatings ◽  
Multilayer Thin Film ◽  
Skin Damage ◽  
Complete Restoration

The effect of multilayer thin-film wound coatings upon regeneration of skin in its deep damage was studied 18 Chinchilla rabbits. Full-layer skin wounds 40 x 40 mm were inflicted on the back of the animals. In experimental group of animals the wounds were closed by multilayer coatings consisting of 50 aluminum metalized lavsan films. In control group one layer coating with thin aluminum plate was used. In all control animals the pyonecrotic wound processes developed within 1 — 2 weeks after intervention. In experimental rabbits the wound healing process showed no clinical signs of inflammation. In 6 weeks a full value regenerate in the zone of deep skin damage was formed. Its thickness and structure was typical of normal skin. Principle of multilayer coatings is perspective for the elaboration of coatings at treatment of deep and small wounds of various etiology when high quality of dermal regenerate is required.

scholarly journals EFFICIENCY AND PERFORMANCE OF THE USE OF RECOMBINANT INTERFERON GAMMA IN COMPLEX THERAPY OF INFLUENZA A(H1N1)PDM09 PATIENTS

2017 ◽  
Vol 22 (2) ◽  
pp. 58-63
Author(s):  
T. V Sologub ◽  
A. S Midikari ◽  
V. N Agafonov ◽  
A. A Suzdalcev ◽  
V. V Tsvetkov
Keyword(s):  
Treatment Regimen ◽  
Interferon Gamma ◽  
Alternative Treatment ◽  
Influenza A ◽  
Economic Feasibility ◽  
Control Group ◽  
Recombinant Interferon ◽  
Treatment Regimens ◽  
Influenza A H1n1 ◽  
Complex Therapy

In the period of the epidemic rise in the incidence rate of influenza in 2015-2016 on the basis of infectious hospitals in Simferopol, Arkhangelsk and Samara, there performed a multicenter to evaluate the effectiveness and economic feasibility of two alternative treatment regimens for influenza A (H1N1) pdm09 patients. The study included 88 patients with a laboratory-confirmed diagnosis of influenza A (H1N1)pdm09. Patients of the main group (n = 46) received complex therapy with the use of antiviral (oseltamivir) and immunomodulating (interferon gamma) agents. Patients of the control group (n = 40) received only antiviral therapy (oseltamivir). To assess the effectiveness and economic feasibility of the two different treatment regimens, the outcome of the disease was analyzed: the discharge the hospital up to the 10th day of the illness and no symptoms of the disease by the 3-6th day of treatment. The supplementation of recombinant interferon gamma in the treatment regimen of influenza A (H1N1) pdm09 patients was found to promote the faster release of catarrhal and respiratory symptoms of the disease: the absence of dry cough by the 3-6th day of treatment (RR = 1.43, 95% CI: 0.86 - 2.38), rhinitis (RR 1.21, 95% CI 1.05-1.40) and dyspnea (RR= 1.28, 95% CI: 1.06-1.54). In addition, the supplementation of recombinant interferon gamma in the treatment regimen of patients with influenza A (H1N1)pdm09 promoted a significant shortening of time of the recovery and discharge from the hospital (RR =1.39, 95% CI: 0.97 - 2.00). Clinical and economic analysis of the use of two alternative treatment regimens has shown the supplementation of recombinant interferon gamma in the therapy of influenza A (H1N1) pdm09 patients to be economically favorable

scholarly journals Frequency of inflammatory complications following surgical tooth extraction and the efficiency of postoperative protocols for their prevention

2020 ◽  
Vol 71 (2) ◽  
pp. 14-20
Author(s):  
Tamara Đurić ◽  
Ana Tadić
Keyword(s):  
Tooth Extraction ◽  
Oral Surgery ◽  
Healing Process ◽  
Clinical Signs ◽  
Surgical Site Infections ◽  
Control Group ◽  
Treatment Type ◽  
Significant Difference ◽  
Alveolar Osteitis ◽  
The Impact

Introduction: Surgical tooth extraction is one of the most common surgical procedures in oral surgery nowadays. The post-extraction period is usually uneventful, however, in some cases, the healing process may be affected by the extraction trauma or by the impact of bacteria at the surgical site. Aim: The aim of this paper is to establish the frequency of inflammatory complications, specifically surgical site infections and alveolar osteitis, after surgical extractions, and to explore the impact of antiseptics and antibiotics regarding the prevention of these complications. Material and methods: A number of 60 patients was included in this research, divided into three research groups according to the post-operative treatment type prescribed. The first group consisted of the patients who had been prescribed antibiotics, while the second group consisted of the patients who had been instructed to rinse their mouth with 0.12% chlorhexidine digluconate rinse postoperatively. Control group consisted of the patients who had not been prescribed any treatment. The postoperative check-ups were done on the second and the seventh day after the surgery, where it was checked if there were any clinical signs of infection or alveolar osteitis at the surgical site. Results: The study consisted of 60 patients, out of which a total of 67 teeth were extracted. Two patients were diagnosed alveolar osteitis, while four patients were diagnosed postoperative infection Conclusion: Statistically significant difference between the participant groups regarding the frequency of postoperative complications has not been noticed. There is insufficient evidence to justify the routine use of antibiotics or antiseptics after surgical tooth extractions.

scholarly journals Myocardial contractility dysfunction in patients with chronic lymphocytic leukemia receiving chemotherapy and their treatment with enalapril

2020 ◽  
Vol 25 (2) ◽  
pp. 90-97 ◽  
Author(s):  
I. L. Davydkin ◽  
T. P. Kuzmina ◽  
I. A. Zolotovskaya ◽  
O. V. Tereshina ◽  
O. E. Danilova ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Treatment Regimen ◽  
Global Longitudinal Strain ◽  
Clinical Signs ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Lymphocytic Leukemia ◽  
Control Group ◽  
Early Assessment ◽  
Converting Enzyme Inhibitors ◽  
Experimental Group

Aim. To assess eft ventricular (LV) contractility dysfunction in patients with chronic lymphocytic leukemia (CLL) receiving chemotherapy with fludarabine, cyclophosphamide, and rituximab (FCR), and to determine the enalapril.effectiveness for their treatment.Material and methods. The study included 49 patients with newly diagnosed Binet stage B CLL in combination with class I-II stable angina, stage 1-2 hypertension and LV ejection fraction (EF) >50%. All subjects did not take angiotensin converting enzyme inhibitors (ACE inhibitors), had no clinical signs of heart failure (HF), and all had indications for FCR combination use before study start. Patients underwent two-dimensional echocardiography initially, before starting chemotherapy (period V1) and after three (84±5 days) (V2) and six (168±7 days) (V3) courses of chemo therapy (enalapril) was added to the treatment regimen in the experimental group.Results. After the third course of chemotherapy, a relative percentage decrease in global longitudinal strain (GLS) was noted in the experimental and control groups — by 16,16±0,80 and 16,2±0,79, respectively (p=0,764). These changes are considered a cardiotoxicity predictor. At the same time, LVEF values remained within the normal range: 63,4% [65; 68] in the experimental group and 63,9% [61,6; 67] in the control group (p=0,960). After the sixth course, LVEF values significantly differed (p=0,002): in the control group, five patients (21%) had cardiotoxicity; in experimental group, there were no patients with cardiotoxicity.Conclusion. A clinically significant decrease in GLS is a marker of subclinical LV contractile dysfunction and is a cardiotoxicity predictor in CLL patients receiving chemotherapy with FCR. The timely addition of enalapril to the treatment regimen can prevent cardiotoxicity in such patients. The need for early assessment of GLS during FCR courses for the detection and prevention of cardiotoxicity has been proved.

TREATMENT OF CHRONIC SUPPURATIVE-CATARRHAL ENDOMETRITIS OF COWS PREPARATION MASTOMETRIN

2016 ◽  
Vol 1 (4) ◽  
pp. 83-85
Author(s):  
Минюк ◽  
Lyudmila Minyuk ◽  
Гришина ◽  
Darya Grishina
Keyword(s):  
Economic Evaluation ◽  
Cost Effectiveness ◽  
Treatment Regimen ◽  
Recovery Time ◽  
Research Evidence ◽  
Clinical Signs ◽  
Control Group ◽  
Chronic Endometritis ◽  
The Cost ◽  
Experimental Group

The aim of the work is to improve the effectiveness of treatment of cows with chronic endometritis using homeopathic Mastometrin drug. In this work given economic evaluation of the treatment of chronic purulent-catarrhal endometritis in cows using Mactometpin drug in a comparative perspective with the treatment regimen adopted in the economy. The material for the research were the cows of black-motley breed of dairy complex SEC Kuibyshev district Kinel Samara region. Before the start of the experimental work was performed obstetric clinical examination of the animals are not pregnant. Among the cows with chronic purulent-catarrhal endometritis it was formed on the basis of approximate analogs of two groups of cows (control, experimental) on 10 goals each. In the control group of cows treatment of chronic endometritis was performed under the scheme adopted in the farm. The animals of the experimental group were treated with the drug Mastometrin. To determine the cost-effectiveness of Mastometrin drug in the treatment of chronic endometritis, the duration of the analysis of the treatment was carried out in cows; treatment costs compared with the treatment regimen used in the farm. Based on what has been defined income per head. Research evidence that the use of the drug Mastometrin reduces the waning of clinical signs of chronic endometritis and recovery time than with the scheme of treatment used in the farm. Shown Mastometrin economic efficiency of the drug, whereby the drug Mastometrin proposed to use a dose of 5 ml intramuscularly at intervals of 12 hours daily for 7-14 days.

Sign in / Sign up

Export Citation Format

Share Document