scholarly journals EFFICIENCY AND PERFORMANCE OF THE USE OF RECOMBINANT INTERFERON GAMMA IN COMPLEX THERAPY OF INFLUENZA A(H1N1)PDM09 PATIENTS

2017 ◽  
Vol 22 (2) ◽  
pp. 58-63
Author(s):  
T. V Sologub ◽  
A. S Midikari ◽  
V. N Agafonov ◽  
A. A Suzdalcev ◽  
V. V Tsvetkov
Keyword(s):  
Treatment Regimen ◽  
Interferon Gamma ◽  
Alternative Treatment ◽  
Influenza A ◽  
Economic Feasibility ◽  
Control Group ◽  
Recombinant Interferon ◽  
Treatment Regimens ◽  
Influenza A H1n1 ◽  
Complex Therapy

In the period of the epidemic rise in the incidence rate of influenza in 2015-2016 on the basis of infectious hospitals in Simferopol, Arkhangelsk and Samara, there performed a multicenter to evaluate the effectiveness and economic feasibility of two alternative treatment regimens for influenza A (H1N1) pdm09 patients. The study included 88 patients with a laboratory-confirmed diagnosis of influenza A (H1N1)pdm09. Patients of the main group (n = 46) received complex therapy with the use of antiviral (oseltamivir) and immunomodulating (interferon gamma) agents. Patients of the control group (n = 40) received only antiviral therapy (oseltamivir). To assess the effectiveness and economic feasibility of the two different treatment regimens, the outcome of the disease was analyzed: the discharge the hospital up to the 10th day of the illness and no symptoms of the disease by the 3-6th day of treatment. The supplementation of recombinant interferon gamma in the treatment regimen of influenza A (H1N1) pdm09 patients was found to promote the faster release of catarrhal and respiratory symptoms of the disease: the absence of dry cough by the 3-6th day of treatment (RR = 1.43, 95% CI: 0.86 - 2.38), rhinitis (RR 1.21, 95% CI 1.05-1.40) and dyspnea (RR= 1.28, 95% CI: 1.06-1.54). In addition, the supplementation of recombinant interferon gamma in the treatment regimen of patients with influenza A (H1N1)pdm09 promoted a significant shortening of time of the recovery and discharge from the hospital (RR =1.39, 95% CI: 0.97 - 2.00). Clinical and economic analysis of the use of two alternative treatment regimens has shown the supplementation of recombinant interferon gamma in the therapy of influenza A (H1N1) pdm09 patients to be economically favorable

Rituximab blocks protective serologic response to influenza A (H1N1) 2009 vaccination in lymphoma patients during or within 6 months after treatment

Blood ◽  
2011 ◽  
Vol 118 (26) ◽  
pp. 6769-6771 ◽  
Author(s):  
Olav Erich Yri ◽  
Dag Torfoss ◽  
Olav Hungnes ◽  
Anne Tierens ◽  
Kristian Waalen ◽  
...  
Keyword(s):  
Influenza A ◽  
Swine Flu ◽  
Control Group ◽  
Protective Antibody ◽  
Treatment Regimens ◽  
Non Hodgkin Lymphoma ◽  
Influenza A H1n1 ◽  
Antibody Titers ◽  
Humoral Responses ◽  
To Receive

Abstract Cancer patients are often encouraged to receive seasonal influenza vaccination. The monoclonal antibody rituximab is widely used in treatment of non-Hodgkin lymphoma. This results in a prolonged depletion of normal B cells, which might impair humoral responses. The aim of the present study was to investigate whether lymphoma patients undergoing rituximab-containing treatment regimens or having received such regimens within the past 6 months were able to mount protective antibody responses to the influenza A(H1N1) 2009 virus vaccine Pandemrix during the 2009 “swine flu” pandemic. Contrary to the control group, where 82% responded adequately to the vaccine, none of the 67 patients achieved protective antibody titers, suggesting that lymphoma patients receiving rituximab-containing regimens might not benefit from this vaccine. It is important that doctors who care for such patients are aware that they may fail to respond not only to the influenza vaccine, but also to other common vaccines.

scholarly journals Seroprevalence study in Vojvodina (Serbia) following 2009 pandemic influenza A(H1N1)v

2012 ◽  
Vol 140 (11-12) ◽  
pp. 751-755
Author(s):  
Vladimir Petrovic ◽  
Zorica Seguljev ◽  
Jasminka Nedeljkovic ◽  
Mioljub Ristic
Keyword(s):  
Pandemic Influenza ◽  
Hemagglutination Inhibition ◽  
Influenza A ◽  
Herd Immunity ◽  
Age Groups ◽  
Immunization Coverage ◽  
Control Group ◽  
Study Objective ◽  
Seroprevalence Study ◽  
Influenza A H1n1

Introduction. The seroprevalence study was performed in Vojvodina during May and June 2010 in order to asses the effects of the 2009 pandemic influenza A(H1N1)v epidemic on herd immunity. It was a part of the Serbian Ministry of Health funded nationwide study. Objective. Prevalence of antibodies against 2009 pandemic influenza A(H1N1)v was determined in a 1% sample of the population monitored for influenza-like illness and acute respiratory infections in Vojvodina through sentinel surveillance system. Methods. The study sample involved a total of 1004 inhabitants of Vojvodina. The control group consisted of randomly selected and age-adjusted 1054 sera collected in the pre-pandemic period. Sera were tested by the reaction of hemagglutination inhibition using influenza A/California/7/2009 (H1N1) antigen in dilution from 1:8 to 1:256. Antibody titers ?1:32 and ?1:8 were considered protective and diagnostic, respectively. Results. The differences between control and study sera in all age groups were significant for both diagnostic ?1/8 and protective titres ?1/32 of hemagglutination inhibition antibodies (chi square test, p<0.001). The highest percentage of seropositive subjects was registered in the age group 15-19 years followed by children aged 5-14 years. Both diagnostic and protective titres were about twice higher in the vaccinated as compared to the non-vaccinated group. There were no statistically significant differences in seroprevalence between seven districts of Vojvodina. Conclusion. The 2009 pandemic influenza A(H1N1)v epidemic significantly influenced the herd immunity in our population regardless of low immunization coverage with highest immunity levels in adolescents aged 15-19 years and with similar herd immunity levels in all the regions in the province six months after the outbreak.

scholarly journals Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection

2011 ◽  
Vol 52 (4) ◽  
pp. 447-456 ◽  
Author(s):  
Ivan FN Hung ◽  
Kelvin KW To ◽  
Cheuk-Kwong Lee ◽  
Kar-Lung Lee ◽  
Kenny Chan ◽  
...  
Keyword(s):  
Intensive Care ◽  
Viral Load ◽  
Treatment Group ◽  
Respiratory Tract ◽  
Plasma Treatment ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Control Group ◽  
Severity Scores ◽  
Influenza A H1n1

Background. Experience from treating patients with Spanish influenza and influenza A(H5N1) suggested that convalescent plasma therapy might be beneficial. However, its efficacy in patients with severe pandemic influenza A(H1N1) 2009 virus (H1N1 2009) infection remained unknown. Methods. During the period from 1 September 2009 through 30 June 2010, we conducted a prospective cohort study by recruiting patients aged ≥18 years with severe H1N1 2009 infection requiring intensive care. Patients were offered treatment with convalescent plasma with a neutralizing antibody titer of ≥1:160, harvested by apheresis from patients recovering from H1N1 2009 infection. Clinical outcome was compared with that of patients who declined plasma treatment as the untreated controls. Results. Ninety-three patients with severe H1N1 2009 infection requiring intensive care were recruited. Twenty patients (21.5%) received plasma treatment. The treatment and control groups were matched by age, sex, and disease severity scores. Mortality in the treatment group was significantly lower than in the nontreatment group (20.0% vs 54.8%; P =  .01). Multivariate analysis showed that plasma treatment reduced mortality (odds ratio [OR], .20; 95% confidence interval [CI], .06-.69; P =  .011), whereas complication of acute renal failure was independently associated with death (OR, 3.79; 95% CI, 1.15-12.4; P =  .028). Subgroup analysis of 44 patients with serial respiratory tract viral load and cytokine level demonstrated that plasma treatment was associated with significantly lower day 3, 5, and 7 viral load, compared with the control group (P &lt;  .05). The corresponding temporal levels of interleukin 6, interleukin 10, and tumor necrosis factor α (P &lt;  .05) were also lower in the treatment group. Conclusions. Treatment of severe H1N1 2009 infection with convalescent plasma reduced respiratory tract viral load, serum cytokine response, and mortality.

scholarly journals The role of the CD27/CD70 signalling pathway in development of systemic inflammatory response in patients with influenza A/H1N1 virus-associated pneumonia

2021 ◽  
Vol 6 ◽  
pp. 70-73
Author(s):  
A.V. Malyarchikov ◽  
◽  
K.G. Shаpovаlov ◽  
Keyword(s):  
Plasma Level ◽  
Inflammatory Response ◽  
Influenza A ◽  
Severe Pneumonia ◽  
Community Acquired Pneumonia ◽  
Systemic Inflammatory Response ◽  
Signalling Pathway ◽  
Control Group ◽  
Influenza A H1n1

Aim of study. To evaluate the role of the CD27/CD70 signalling pathway in development of systemic inflammatory response in patients with pneumonia associated with influenza A (H1N1). Material and methods. A total of 85 patients with pneumonia associated with influenza A (H1N1) were examined. Among them, 30 patients had severe pneumonia and 55 patients had non-severe pneumonia. The patients’ age was 48±15 years. Men accounted for 47.8% and women 52.2% of the sample. The exclusion criteria were: unstable haemodynamics, BMI>30, diabetes mellitus, HIV, tuberculosis, oncopathology. The control group was constituted by 15 healthy donors. The diagnosis of influenza A (H1N1) was confirmed by a positive PCR test. The CURB / CRB-65 scales were used to diagnose and assess the severity of pneumonia; SMART-COP as well as the Federal Clinical Guidelines of the Ministry of Health of the Russian Federation «Community-acquired pneumonia in adults» 2019 and the IDSA / ATS criteria (in the presence of one «major» or three «minor» criteria, the pneumonia was regarded as «severe»). The plasma level of CD27 was evaluated via flow cytometry using the Beckman Coulter analyser (USA) using the LEGENDplex™ HU Immune Checkpoint Panel 1 Beckman Coulter (USA) kit for multiplex analysis. Results. It has been established that the plasma level of CD27 increased 1.8-fold in patients with severe pneumonia and underlying influenza A (H1N1) and 1.5-fold in patients with non-severe pneumonia compared to the control group, which is associated with the severity of the condition and the mortality rate. Conclusion. The CD27/CD70 signalling pathway is actively involved in the cascade of innate and adaptive immunity reactions in patients with pneumonia associated with influenza A (H1N1). CD27 activity is associated with the severity of the disease and the increase in mortality

scholarly journals METHOD FOR TREATING CHRONIC GENERALIZED PERIODONTITIS OF LIGHT AND MEDIUM GRAPES

2020 ◽  
Vol 16 (2) ◽  
pp. 53-58
Author(s):  
Karen Karakov ◽  
Emilia Khachaturyan ◽  
Marat Uzdenov ◽  
Laura Uzdenoba ◽  
Nelli Vanchenko ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Treatment Regimen ◽  
Treatment Time ◽  
Periodontal Diseases ◽  
Periodontal Pocket ◽  
Control Group ◽  
Moderate Severity ◽  
Affected Area ◽  
Periodontal Tissues ◽  
Complex Therapy

Subject. The article presents the data of a comparative analysis of the traditional method of treating chronic generalized periodontitis of mild to moderate severity and with the use of periodontal dressings in combination with an antibacterial photodynamic system. The goal is to study the effectiveness of the methodology of complex therapy for the treatment of periodontal diseases using periodontal dressings and antibacterial photodynamic therapy. Methodology. We observed 120 patients with inflammatory periodontal diseases aged 18 to 55 years (men ― 52, women ― 68), who were divided into the control and main groups. In the control group, treatment was carried out according to the traditional scheme of drug therapy, in the main ― according to the method of complex therapy. The treatment regimen according to this technique included the use of periodontal dressings and an antibacterial photodynamic therapy system: photosynthesis was applied to the affected area of the periodontal pocket, after which the pathogenic microorganisms were stained for 1-3 minutes, then the liquid was thoroughly washed from the periodontal pockets and the laser affected the affected area for 60 seconds. Results. The proposed treatment regimen using an antibacterial photodynamic system in combination with periodontal dressings allows to achieve a pronounced and prolonged anti-inflammatory effect in periodontal tissues without local and systemic use of antibiotics, reduces treatment time for mild periodontitis by 29, average ― by 57 %, reduces the likelihood recurrence, lengthens the duration of remission. Findings. The use of complex treatment of periodontitis of mild to moderate severity allows the method to accelerate the restoration of periodontal tissues, relieve inflammation, saturate the tissues with oxygen, reduce the rate of relapse by 2.6 times and reduce the duration of relapse of this disease within 24 months. Our data allow us to implement this treatment regimen in practical healthcare.

EVALUATION OF THE EFFECTIVENESS OF TREATMENT AND PREVENTION OF DOG BABESIOSIS

2020 ◽  
Vol 15 (10) ◽  
pp. 1371-1378
Author(s):  
T.V. Alekseeva ◽  
◽  
M.A. Alekseeva ◽  
Keyword(s):  
Treatment Regimen ◽  
Healing Process ◽  
Clinical Signs ◽  
Individual Treatment ◽  
Control Group ◽  
Laboratory Diagnostics ◽  
Canine Babesiosis ◽  
Treatment Regimens ◽  
Treatment And Prevention ◽  
The Republic

With an increase in the incidence of babesiosis (piroplasmosis) in dogs, the development of effective methods for the prevention and treatment of this disease is one of the promising areas of veterinary science and practice. The article presents the research results obtained in assessing the effectiveness of various methods of treatment and prevention of canine babesiosis using domestically produced drugs. The studies were carried out on the basis of the Novoshakhtinsky branch of the State Budgetary Institution of the Republic of Belarus "Rostov Region SBBZh with PO", the object of the study was dogs of various breeds, diagnosed with babesiosis. Diagnosis of piroplasmosis was carried out on the basis of anamnesis, clinical signs and using laboratory diagnostics of blood tests. Hematological studies were performed on the 1st and 10th days of treatment on an automatic hematological analyzer URIT-3020 Vet Plus. For the experiment, 3 groups of animals were formed (5 dogs each): 1, 2 experimental and 3 control with individual treatment regimens. In 1 experimental group, Ringer-Locke's solution was used, in 2 - Reamberin, in animals of the control group, isotonic sodium chloride solution. After the end of the course of therapy, blood samples were taken to assess the results of the applied treatment regimen. The onset of recovery was judged by the change in the general condition of the animal, the absence of clinical signs and the results of hematological studies. Based on the studies conducted on the use of domestically produced drugs for the treatment and prevention of canine babesiosis, it was found that the use of the treatment regimen with the drug Reamberin 1 time per day at a dose of 100-200 ml infusion for 4-5 days turned out to be the most effective method and made it possible to speed up the healing process animals.

scholarly journals A Comparison between Multimedia and Traditional Education in Encouraging Adherence to Treatment Regimen in Patients with Hypertension

2020 ◽  
Vol 12 (1) ◽  
pp. 1-6
Author(s):  
Mostafa Bijani ◽  
Banafsheh Tehranineshat ◽  
Fatemeh Ahrari ◽  
Najimeh Beygi
Keyword(s):  
Patient Education ◽  
Treatment Regimen ◽  
Treatment Plan ◽  
Healthcare Providers ◽  
Control Group ◽  
Adherence To Treatment ◽  
Educational Approach ◽  
Convenience Sample ◽  
Treatment Regimens ◽  
The Difference

Background: Adherence to treatment regimen plays a crucial part in the prevention of the consequences of hypertension, thus identification and employment of effective educational methods to enhance patients' adherence to their treatment plans is important. Objective: The present study compares the effectiveness of multimedia and traditional methods of patient education in persuading patients with hypertension to stick to their treatment regimens. Methods: Conducted in 2019, the present study is an experimental work of research which lasted for 5 months. A convenience sample of 160 patients who visited the clinic and cardiac sections of a hospital located in the south-west of Iran was selected and then randomly divided into an intervention and a control group. The intervention consisted of multimedia education provided in 6 sessions and telephone follow-ups. The control group was given the traditional care. The research instruments were a demographics questionnaire and a medication adherence scale. Data were collected before, immediately after, and one month after the intervention. The collected data were analyzed using SPSS v. 19, independent t-test, and chi-square test. Results: The difference between the adherence to treatment regimen scores of the two groups as calculated immediately after and one month after the intervention was found to be statistically significant (P<0.001). Conclusion: Patient education via multimedia can significantly increase patients' adherence to their treatment regimens. Accordingly, it is recommended that nurses and other healthcare providers utilize this new educational approach to facilitate patient education and enhance adherence to treatment plan in patients with hypertension.

Analysis of high-dose methotrexate with rituximab versus other treatment regimens for primary central nervous system (CNS) lymphoma.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 2090-2090
Author(s):  
Scott Michael Lindhorst ◽  
Frances McSherry ◽  
Annick Desjardins ◽  
Henry S. Friedman ◽  
Katherine B. Peters
Keyword(s):  
Treatment Regimen ◽  
Alternative Treatment ◽  
Survival Rates ◽  
Primary Cns Lymphoma ◽  
Cns Lymphoma ◽  
P Value ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Treatment Regimens ◽  
Dose Methotrexate

2090 Background: The most effective and least toxic treatment regimen for primary CNS lymphoma is a matter of debate. Most current regimens utilize various doses of high-dose methotrexate combined with other agents. The utility of deferred radiation is also under study. Methods: We evaluated 28 patients with primary CNS lymphoma treated with methotrexate 3.5 g/m2 and rituximab, as well as alternative regimens. Median, 12-month, and 24-month survival were compared for the various treatment regimens, as well as for patients who received radiation and those who did not. Results: Survival rates were significantly better in the methotrexate-rituximab treatment cohort than the other regimens examined (Log-Rank p-value 0.0437). 12-month survival for the methotrexate-rituximab cohort was 72.7% (95% CI, 37.1% to 90.3%) versus the alternative treatment cohort 12-month survival of 49.4% (95% CI, 23.7% to 70.8%). 24-month survival for the methotrexate-rituximab cohort was 72.7% (95% CI, 37.1% to 90.3%) versus the alternative treatment cohort 24-month survival of 39.5% (95% CI, 14.9% to 63.6%). Median survival for the alternative treatment cohort was 11 months (95% CI, 2.2 to 28.6), while the median survival for the methotrexate-rituximab regimen was not reached. Stratified by radiation, survival rates were significantly better in the radiation cohort than the cohort without radiation (Log-Rank p-value 0.0040). 12-month survival for the radiation cohort was 90% (95% CI, 47.3% to 98.5%) versus the cohort without radiation 12-month survival of 40.5% (95% CI, 17.7% to 62.3%). 24-month survival for the radiation cohort was 90% (95% CI, 47.3% to 98.5%) versus the cohort without radiation 24-month survival of 33.7% (95% CI, 12.9% to 56.1%). Median follow-up for all patients was 21.5 months (95% CI, 16 to 42.1). Conclusions: The combination of methotrexate at 3.5 g/m2 with rituximab is a valid treatment regimen for primary CNS lymphoma. Patients may be spared toxicity by using a methotrexate dose of 3.5 g/m2 rather than 8 g/m2. The addition of radiation provided a significant survival advantage in this observational study, however, radiation deferred until progression may be a viable alternative.

Pregnancy and influenza: pathological manifestations of the infection caused by virus A/H1N1

2014 ◽  
Vol 63 (3) ◽  
pp. 26-35
Author(s):  
Sergey Anatolyevich Gladkov
Keyword(s):  
Pregnant Women ◽  
Respiratory System ◽  
Influenza A ◽  
Morphological Changes ◽  
Influenza Infection ◽  
High Risk Group ◽  
Morphological Data ◽  
Control Group ◽  
Limited Information ◽  
Influenza A H1n1

Background. Pregnant women are a high-risk group for severe complications and mortality from influenza. There is limited information on the detection of specific pathological signs of viral injury of the organs outside the respiratory system, as well as of the placenta and fetus by transplacental passage. Purpose. In this paper clinicopathologic peculiarities of lung lesion and associated morphological changes outside the respiratory system have been studied. Materials and methods. The author has analyzed 4 fatal outcomes of influenza A/H1N1 which occurred at hospitals of the Arkhangelsk region in women who become ill on the third trimester of pregnancy in 2009 and 2011. The analyses of patient cards, autopsy data and postmortem histological examination have been performed. The results were compared with clinical and morphological data of influenza A/H1N1 fatal outcomes in 8 non-pregnant adults (control group). Microscopic changes in the placenta and lungs of antenatal deceased fetus have been investigated in one case. Results. The clinical presentation and morphological findings in respiratory system in pregnant women were not different from those of the other patients died from total viral pneumonia. However, morphological signs of generalized influenza infection with brain and heart involvement were observed in three of the four pregnant women, while in the control group outside respiratory specific changes, characteristic for infection caused by the flu virus, were not detected. In one case with identified morphological signs of generalized infection in the mother’s body a similar changes in the placenta and lungs of antenatal deceased fetus were confirmed.

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