Gambaran kadar trombosit dan hematokrit pada pasien diabetes tipe 2 dengan kaki diabetik di BLU RSUP Prof. Dr. R. D. Kandou Manado

Abstract: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin activity, or both. Uncontrolled DM will lead to chronic complication, such as microangiopathy, macroangiopathy. and neuropathy. Diabetic foot is one of the chronic complications. This complication is associated with abnormality of thrombocyte and hematocrit levels that influence the blood flow. This study aimed to find out the profile of thrombocyte and hematocrit levels in patients with type 2 DM with diabetic foot at Prof. Dr. R. D. Kandou Hospital Manado. There were 25 patients type 2 DM with diabetic foot as samples consisted of:10 males (40%) and 15 females (60%). The mean of hematocrit level in males was 35.20% and in females was 28.40%. The mean of thrombocyte level was 391.4 x 103/mm3.Keywords: diabetic foot, thrombocyte, hematocritAbstrak: Diabetes melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin atau keduannya. Hiperglikemi pada DM yang tidak terkontrol menyebabkan komplikasi kronis, seperti mikroangiopati,makroangiopati dan neuropati. Kaki diabetes merupakan salah satu komplikasi kronis. komplikasi ini berkaitan dengan kelainan kadar trombosit dan hematokrit yang mempengaruhi peredaran darah. Tujuan penelitian ini adalah untuk mengetahui gambaran kadar trombosit dan hematokrit pada pasien diabetes tipe 2 dengan kaki diabetik di BLU RSUP Prof. R. D. Kandou Manado. Terdapat 25 pasien dengan DM tipe 2 yang memiliki komplikasi kaki diabetes yang menjadi sampel penelitian ini. Berdasarkan distribusi jenis kelamin perempuan sebanyak 15 pasien (60%) dan pada pasien laki-laki sebanyak 10 pasien (40%). Rata-rata kadar hematokrit pasien laki-laki adalah 35.20% dan perempuan adalah 28.40%. Rata rata kadar trombosit pasien adalah 391,4 x 103/mm3.Kata kunci: kaki diabetes, trombosit, hematokrit

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The Improvement of Neuropathy and Balance after Combination of Indonesian Diabetic and Indonesian Diabetic Foot Exercise on Diabetic Peripheral Neuropathy

Indonesian Journal of Physical Medicine & Rehabilitation ◽

10.36803/ijpmr.v6i02.155 ◽

2017 ◽

Vol 6 (02) ◽

pp. 2

Author(s):

Putri Dyah Utami Ryadi ◽

Tertianto Prabowo ◽

Irma Ruslina Defi

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Neuropathy ◽

Diabetic Foot ◽

Diabetic Peripheral Neuropathy ◽

Diabetes Mellitus Type 2 ◽

Berg Balance Scale ◽

Type 2 Dm ◽

Quasi Experimental ◽

The Mean

Background: Half of people with Type 2 Diabetes Mellitus (Type 2 DM) developed diabetic neuropathyat 25 years after being diagnosed and around 75% of the neuropathy were diabetic peripheral neuropathy(DPN), that associated with balance disturbance. This study aimed to know the effect of combining Indonesiandiabetic exercise (Senam Diabetes Indonesia/SDI) and Indonesian diabetic foot exercise (Senam Kaki DiabetesIndonesia/SKDI) on improvement of diabetic neuropathy and balance score in people with Type 2 diabeticperipheral neuropathy.Methods: Design study was a quasi-experimental study with pre-posttest design. The participants were Type 2DM patients aged 40-65 years old, with DPN confirmed based on Indonesian version of Diabetic NeuropathySymptom (DNS-INA) >1 or Indones ian version of Diabetic Neuropathy Exmination (DNE-INA) >3, who didnot do exercise regularly. All participants had Berg Balance Scale (BBS) score within 41-55, and the randomperipheral blood glucose within 100-250mg/dL. The BBS, DNE-INA, and DNS-INA score were evaluatedbefore and after 12 weeks of excercise.Results: There were 6 women aged 52-65 years. The mean of BBS, DNS-INA, and DNE-INA scores beforeand after intervention were 54.33±1.032 and 55.16±1.329 (p=0.025), 2.50±1.048 and 1.50±0.836 (p=0.063),3.66±1.505 and 1.33±0.816 (p=0.041), respectively.Conclusion: There were improvement of Berg Balance Score and Diabetic Neuropathy Score after thecombination of Diabetic exercises.Keywords: Berg Balance Score, diabetic neuropathy score, Indonesian Diabetic Exercise, Indonesian FootDiabetic Exercise

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PERBANDINGAN RETINAL GANGLION CELL THICKNESS DAN PERIMETRI PASIEN DIABETES MELITUS TIPE 2

Human Care Journal ◽

10.32883/hcj.v5i3.788 ◽

2020 ◽

Vol 5 (3) ◽

pp. 715

Author(s):

Sherly Muchlis Muchlis ◽

Ardizal Rahman ◽

Weni Helvinda

Keyword(s):

Diabetic Retinopathy ◽

Ganglion Cells ◽

P Value ◽

Retinal Ganglion ◽

Type 2 Dm ◽

Significant Difference ◽

The Mean ◽

Cell Thickness ◽

Diabetes Melitus

Diabetic retinopathy (RD) is a microvascular complication that often occurs in diabetes mellitus (DM). Retinal ganglion cells (RGC) are reduced in the early stages of DM, even before microvascular abnormalities are seen on the retina. Methods: Sample of 35 eyes of non RD RD type 2 patients and 35 mild non proliferative diabetic retinopathy (NPDR) eyes After examination of ophthalmological status, perimetry and optical coherence tomography (OCT) were examined. Results: The mean MD on non-RD type 2 DM -2.74 ± 3.5 mild NPDR -5.61 ± 4.5 with p value 0.414. The average non-RD type 2 PSD DM was -3.35 ± 3.3, mild NPDR was 4.16 ± 1.4 with a p value of 0.206. The mean RGC thickness of patients with non-RD type 2 DM was 83.8 ± 7.4 µm, mild NPDR 82.7 ± 8.1 μm. There was a decrease in the value of RGC thickness, MD and PSD in patients with type 2 DM, but it was not statistically significant . Conclusion: No significant difference was found in RGC thickness in DM patients between non-RD and mild NPDR. No significant difference was found between MD and PSD in DM patients between non-RD and mild NPDR. No significant relationship was found between RGC thickness and perimetry in DM patients between non-RD and mild NPDR.

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A Descriptive Study Of Diet In Family Of Patients With Diabetes Mellitus Type 2

Journal of Nursing Care ◽

10.24198/jnc.v1i1.15772 ◽

2018 ◽

Vol 1 (1) ◽

pp. 69

Author(s):

Citra Windani Mambang Sari ◽

Fitri Nurul Khotimah ◽

Sri Pratiwi Hartati

Keyword(s):

Diabetes Mellitus ◽

Sampling Technique ◽

Consumption Pattern ◽

Fat Intake ◽

Food Record ◽

Purposive Sampling ◽

Type 2 Dm ◽

The Family ◽

Diabetes Melitus

Diet is one of the main factors related to various diseases including Diabetes Mellitus (DM). High carbohydrate, fat, protein, and low fiber diets can increase the risk of type 2 DM occurrence, especially in the patient’s family as a risk group. Previous research on students with DM families in Central Java still had a high-calorie food consumption pattern. The diversity of population, culture, and age may affect the results. Therefore, this study aimed to describe the diet in the family of patients with type 2 DM in the working area of Puskemas (Community Health Center) Garuda Bandung.This research used a quantitative descriptive method by purposive sampling technique. The respondents in this study involved 46 people who were the children of type 2 DM patients in the working area of Puskesmas Garuda. Dietary data obtained from the food record sheet for 3 days and was calculated using Nutrisurvey software in kilocalories (kcal) as the unit of measurement then the results were categorized based on Consensus Perkeni 2015. Data analysis was using frequency distribution.The results showed that 39 (84.8%) respondents in the diet category less than body requirements, 37 (80.4%) respondents in the category of sufficient carbohydrate intake, 39 (84.6%) respondents in the category of excess fat intake, 45 (97.8%) respondents in the category of adequate protein intake, and 41 (89.1%) respondents in the category of less fiber.The conclusions from this study that almost all families of patients with type 2 DM in the work area of Puskesmas Garuda were in the diet category less than body requirement but with the excess fat intake and less fiber. Based on these results, the nurses in Puskesmas are expected to optimize the outreach programs by addressing families of DM patients to make the diet as an attempt to prevent the risk in the family of patients with type 2 DM.Key words: Diet, DM patients’ families, food record. Gambaran Diet pada Keluarga Pasien Diabetes Melitus Tipe 2AbstrakDiet adalah salah satu faktor utama yang berhubungan dengan berbagai penyakit termasuk Diabetes Melitus (DM). Diet tinggi karbohidrat, lemak, protein, serta rendah serat dapat meningkatkan risiko kejadian DM tipe 2 terutama pada keluarga pasien sebagai kelompok berisiko. Penelitian sebelumnya pada mahasiswa dengan keluarga DM di Jawa Tengah masih memiliki pola konsumsi makanan yang tinggi kalori. Perbedaan populasi, budaya, serta usia mungkin akan mempengaruhi hasil. Oleh karena itu, tujuan penelitian ini untuk menggambarkan diet pada keluarga pasien DM tipe 2 di wilayah kerja Puskemas Garuda Kota Bandung.Penelitian ini menggunakan metode deskriptif kuantitatif dengan teknik purposive sampling. Responden dalam penelitian ini berjumlah 46 orang yang merupakan anak kandung pasien DM tipe 2 di Wilayah Kerja Puskesmas Garuda. Data diet diperoleh melalui lembar food record selama 3 hari dihitung mengunakan software Nutrisurvey dengan hasil ukur dalam kilokalori (kcal) yang kemudian hasilnya dikategorikan berdasarkan Konsensus Perkeni 2015. Analisis data menggunakan distribusi frekuensi.Hasil penelitian menujukkan bahwa sebanyak 39 (84,8%) responden dalam kategori diet kurang dari kebutuhan, sebanyak 37 (80,4%) responden dalam kategori asupan karbohidrat cukup, sebanyak 39 (84,6%) responden dalam kategori asupan lemak berlebih, sebanyak 45 (97,8%) responden dalam kategori asupan protein cukup, dan 41 (89,1%) responden dalam kategori serat kurang.Simpulan dari penelitian ini bahwa hampir seluruh keluarga pasien DM tipe 2 di wilayah kerja Puskesmas Garuda berada pada kategori diet kurang dari kebutuhan tetapi dengan asupan lemak berlebih dan serat yang kurang. Berdasarkan hasil tersebut, maka perawat puskesmas diharapkan dapat mengoptimalkan program luar gedung dengan menyasar keluarga penderita DM untuk menjadikan diet sebagai upaya untuk mencegah risiko DM pada keluarga pasien DM tipe 2.Kata kunci : Diet, food record, keluarga pasien DM.

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The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes

Journal of Diabetes Research ◽

10.1155/2019/1973704 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9

Author(s):

Luuk A. de Wert ◽

Margot Geerts ◽

Sander van der Brug ◽

Laura Adriaansen ◽

Martijn Poeze ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Foot ◽

Shear Loading ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

Type 2 Dm ◽

Hyperaemic Response ◽

Skin Responses ◽

Healthy Participants

Background. Shear is a major risk factor in the development of diabetic foot ulcers, but its effect on the skin of patients with type 2 diabetes mellitus (DM) remains to be elucidated. The aim was to determine skin responses to shear in DM patients with and without diabetic polyneuropathy (DNP). Methods. The forearm skin was loaded with 14.5 N shear (+2.4 kPa pressure) and with 3.5 kPa pressure for 30 minutes in 10 type 2 DM patients without DNP, 10 type 2 DM patients with DNP, and 10 healthy participants. A Sebutape collected IL-1α (measure of tissue damage). A laser Doppler flowmeter measured cutaneous blood cell flux (CBF) as a measure of the reactive hyperaemic skin response. Findings. Reactive hyperaemia and IL-1α release was significantly increased after shear loading in all three groups and was higher compared to the responses to pressure loading. The reactive hyperaemic response after shear loading was impaired in patients with type 2 DM compared to healthy participants but did not differ between patients with and without DNP. The reactive hyperaemic response was negatively correlated with the blood glucose level but did not correlate with the DNP severity score. Interpretation. Shear is important in the development of tissue damage, but the reparative responses to shear are impaired in patients with type 2 DM. DNP was not associated with altered skin responses, suggesting that the loss of protective sensation to sense shear to skin remains a key factor in the development of diabetic foot ulcers in patients with DNP.

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Effectiveness of fast-track pathway for diabetic foot ulcerations

Acta Diabetologica ◽

10.1007/s00592-021-01721-x ◽

2021 ◽

Author(s):

Marco Meloni ◽

Jose Luis Lazaro Martinez ◽

Raju Ahluwalia ◽

Benjamin Bouillet ◽

Valentina Izzo ◽

...

Keyword(s):

Diabetic Foot ◽

Fast Track ◽

Independent Predictor ◽

Major Amputation ◽

Healing Time ◽

Early Referral ◽

The Mean ◽

Late Referral

Abstract Aim To investigate the effectiveness of fast-track pathway (FTP) in the management of diabetic foot ulceration (DFU) after 2 years of implementation. Methods The study group was composed of patients who referred to a specialized DF centre due to DFUs. Those were divided in two groups: early referral (ER) and late referral (LR) patients. According to FTP, ER were considered patients who referred after 2 weeks in the case of uncomplicated non-healing ulcers (superficial, not infected, not ischemic), within 4 days in the case of complicated ulcers (ischemic, deep, mild infection) and within 24 h in the case of severely complicated ulcers (abscess, wet gangrene, fever). Healing, healing time, minor and major amputation, hospitalization, and survival were evaluated. The follow-up was 6 months. Results Two hundred patients were recruited. The mean age was 70 ± 13 years, 62.5% were male, 91% were affected by type 2 diabetes with a mean duration of 18 ± 11 years. Within the group, 79.5% had ER while 20.5% had LR. ER patients showed increased rates of healing (89.9 vs. 41.5%, p = 0.001), reduced healing time (10 vs. 16 weeks, p = 0.0002), lower rates of minor (17.6 vs. 75.6%, p < 0.0001) and major amputation (0.6 vs. 36.6%, p < 0.0001), hospitalization (47.1 vs. 82.9%, p = 0.001), and mortality (4.4 vs. 19.5%, p = 0.02) in comparison to LR. At multivariate analysis, ER was an independent predictor of healing, while LR was an independent predictor for minor and major amputation and hospitalization. Conclusion After the FTP implementation, less cases of LR were reported in comparison to ER. ER was an independent predictor of positive outcomes such as healing, healing time, limb salvage, hospitalization, and survival.

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Evaluation of Serum Uric Acid, Serum Magnesium and Lipid Profiles in Type 2 Diabetes Mellitus Patients for the Risk Factor of Cardiovascular Disease

International Journal of Biochemistry Research & Review ◽

10.9734/ijbcrr/2020/v29i730201 ◽

2020 ◽

pp. 10-17

Author(s):

Sonal Sogani ◽

Navendru Kumar Gupta ◽

Suman Jain

Keyword(s):

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Serum Magnesium ◽

Lipid Profiles ◽

Healthy Controls ◽

Mean Values ◽

Type 2 Dm ◽

The Mean

Background and Objective: Dyslipidemia is one of the common disorders which are seen in most of the diabetes patients, which causes cardio vascular diseases. However, serum uric acid and lipid profiles are considered as the potential risk factor for developing diabetes, hypertension, stroke and cardiovascular diseases. Also the direct association of trace elements such as serum magnesium and hs-CRP in type 2 diabetes has been observed. The aim of the present study is to evaluate serum uric acid, serum magnesium and lipid profiles in type 2 diabetes mellitus patients for the risk factor of cardiovascular disease and its comparison with non diabetic subjects. Materials and Methods: This case-control study was conducted in the Department of Biochemistry, PIMS, Udaipur. The study included 100 patients with type 2 Diabetes Mellitus (both males and females) who were recruited from the institute’s medicine OPD and wards and 100 healthy controls (both males and females) with normal plasma glucose and with no symptoms suggestive of DM were included in the study. All the Biochemical parameters analysis was done on fully automated analyzer-ERBA 360 EM. Results: The mean values of serum lipid profiles (serum cholesterol, serum triglycerides, VLDL, LDL) were compared between healthy controls and patients with type 2 DM, showed highly significant difference in patients with type 2 DM as compared with healthy controls (p<0.001). However, on comparing HDL between healthy controls and patients with type 2 DM, the difference seems to be significant (p<0.05). The mean values of RBS, HbA1c, uric acid and hs-CRP were highly significant in patients with type 2 DM as compared with healthy controls (p<0.001). The mean values of serum magnesium showed significant difference between healthy controls and patients with type 2 DM p<0.05). Interpretation and Conclusion: The common lipid abnormalities seen during diabetes induce dyslipidemia causing the development of CVD’s among diabetic patients. Also elevated levels of hs-CRP, hyperuricemia, hypomagnesium suggest that it could be a better prognosis for CVD’s and stroke in diabetic patients.

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102 Jurnal Kesehatan Andalas. 2015; 4(1) Pola Komplikasi Kronis Penderita Diabetes Melitus Tipe 2 Rawat Inap di Bagian Penyakit Dalam RS. Dr. M. Djamil Padang Januari 2011 - Desember 2012

Jurnal Kesehatan Andalas ◽

10.25077/jka.v4i1.207 ◽

2015 ◽

Vol 4 (1) ◽

Author(s):

Dwi Amelisa Edwina ◽

Asman Manaf ◽

Efrida Efrida

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Medical Record ◽

Macrovascular Complications ◽

Chronic Complications ◽

Microvascular And Macrovascular Complications ◽

Type 2 Diabetic ◽

Diabetes Melitus

AbstrakDiabetes Melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia. DM tipe 2 adalah yang paling sering ditemukan. Komplikasi kronis DM tipe 2 yaitu mikrovaskular dan makrovaskular yang dapat menurunkan kualitas hidup penderita. Tujuan penelitian ini adalah untuk memperoleh gambaran tentang insidensi penderita DM tipe 2 dengan komplikasi kronis. Penelitian deskriptif ini dilakukan dengan mengambil data pada rekam medik penderita DM tipe 2 dengan komplikasi kronis yang dirawat inap di bagian Penyakit Dalam RS.Dr. M. Djamil, Padang Januari 2011-Desember 2012. Penelitian dilakukan dari Februari 2013-April 2013 di bagian rekam medik RS. Dr. M. Djamil Padang. Data didapatkan sebanyak 261 pasien, dari jumlah tersebut didapatkan 197 pasien memiliki komplikasi kronis DM tipe 2. Data dikategorikan berdasarkan jenis komplikasi makrovaskular dan mikrovaskular. Hasil penelitian menunjukkan bahwa penderita dengan komplikasi kronis makrovaskular (66,5%) dan mikrovaskular (81,7%). Terdapat perubahan insidensi dalam dua tahun yaitu dari tahun 2011 dengan 2012. Komplikasi kronis yang paling sering terjadi adalah nefropati diabetik (42,6%) pada perempuan <60 tahun.Kata kunci: diabetes melitus, komplikasi mikrovaskular, komplikasi makrovaskularAbstractDiabetes mellitus is a group of metabolic diseases with characterized by hyperglycemia. Type 2 diabetes is the most common disease in the world. Chronic complications of type 2 diabetes are microvascular and macrovascular complications that can reduce the quality of life of patients. The objective of this study was to obtain a picture of the incidence of type 2 diabetic chronic complications. This descriptive study was conducted by taking medical record data of hospitalized type 2 diabetic patients with chronic complications inInternal Medicine Department Dr. M. Djamil hospital, Padang on January 2011-December 2012. The study was conducted from February 2013-April 2013 at the hospital medical record Dr. M. Djamil, Padang. This study was conducted on 261 patients, from that number 197 patients have chronic complications of type 2 diabetes mellitus. Data were categorized by type of macrovascular and microvascular complications.The results showed that patients with chronic complications of macrovascular (66,5%) and microvascular (81,7%). There is a change in incidence from 2011 to 2012. The most common of chronic complications is diabetic nephropathy (42.6%). Chronic microvascular and macrovascular complications are different incidence in two years, the most common is diabetic nephropathy which often occurs in women <60 years.Keyword: diabetes mellitus, microvascular complication, macrovacular complication.

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Gambaran hematologi rutin dan hubungannya dengan rerata gula darah pada pasien diabetes melitus tipe 2 di Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou Manado

e-CliniC ◽

10.35790/ecl.4.2.2016.14769 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Gita C. Kekenusa ◽

Karel Pandelaki ◽

Harlinda Haroen

Keyword(s):

Blood Glucose ◽

Pancreatic Beta Cells ◽

Metabolic Diseases ◽

Hemoglobin Concentration ◽

Type 2 Dm ◽

Average Blood Glucose ◽

Spearman’S Correlation ◽

Average Glucose ◽

Diabetes Melitus

Abstract: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia due to a defect in insulin action, insulin secretion by pancreatic beta cells or both. In patients with type 2 diabetes (T2DM), trombopoiesis acceleration and increased turnover and increased hematocrit occur resulting in impaired blood flow velocity. This increased blood viscosity causes vasoconstriction due to thickening of blood vessel walls.This study was aimed to obtain the profile of hematology and its correlation with average blood glucose in type 2 DM patients. This was a descriptive analytical study using patients’ medical record in the Endocrine Clinic of Prof. Dr. R. D. Kandou Hospital Manado from August to October 2016. The results of Spearman’s correlation test were as follows: correlation between average blood glucose and hemoglobin concentration with r = 0.083 and p = 0.272; correlation between average blood glucose and levels of hematocrit with r = 0.123 and p = 0.184; correlation between the average glucose blood and levels of erythrocyte with r = 0.121 and p = 0.187; correlation between average blood glucose and platelet with r = 0.052 and p = 0.353; and correlation between average blood glucose and levels of leukocytes with r = 0.247 and p = 0.033. Conclusion: Among type 2 DM patients, there were no significant correlations between average blood glucose level and hemoglobin, hematocrit, and erythrocyte levels, as well as platelet levels. However, there was a significant correlation between average blood glucose and leukocyte level.Keywords: T2 DM, average blood glucose, hemoglobin, hematocrit, platelets Abstrak: Diabetes Melitus (DM) merupakan suatu kelompok penyakit metabolik yang ditandai oleh hiperglikemia akibat defek pada kerja insulin, sekresi insulin oleh sel beta pancreas, atau keduanya. Pada pasien DM tipe 2 (DMT2) terjadi percepatan trombopoiesis serta peningkatan pergantian trombosit dan hematokrit yang dapat berakibat terhadap kecepatan aliran darah. Viskositas darah yang meningkat dapat menyebabkan terjadinya vasokonstriksi akibat penebalan dinding pembuluh darah. Penelitian ini bertujuan untuk mengetahui gambaran hematologi dan hubungannya dengan rerata gula darah pada pasien DM tipe 2. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado periode Agustus-Oktober 2016. Hasil uji korelasi Spearman memperlihatkan nilai hubungan antara rerata gula darah dan kadar hemoglobin r = 0,083 dan p = 0,272; nilai hubungan antara rata-rata gula darah dan kadar hematocrit r = 0,123 dan p = 0,184; nilai hubungan antara rata-rata gula darah dan kadar eritrosit r = 0,121 dan p = 0,187; nilai hubungan antara rata-rata gula darah dan trombosit r = 0,052 dan p = 0,353, serta nilai hubungan antara rata-rata gula darah dan kadar leukosit r = 0,247 dan p = 0,033. Simpulan: Pada pasien DMT 2 tidak dijumpai hubungan bermakna antara rerata gula darah dengan kadar hemoglobin, kadar hematokrit, kadar eritrosit, dan kadar trombosit namun terdapat hubungan bermakna antara rerata gula darah dan leukosit.Kata kunci: DMT2, rerata gula darah, hemoglobin, hematokrit, trombosit

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Perbaikan Sensitivitas Insulin Diabetes Melitus Tipe 2 oleh Media Terkondisi Sel Punca Mesensimal

PRAXIS ◽

10.24167/praxis.v1i2.1629 ◽

2019 ◽

Vol 1 (2) ◽

pp. 180

Author(s):

Bernadia Branitamahisi

Keyword(s):

Insulin Sensitivity ◽

T Test ◽

Diabetic Rat ◽

Control Group ◽

Sprague Dawley ◽

Type 2 Dm ◽

Significant Difference ◽

Type 2 Diabetic ◽

Diabetes Melitus

Abstract: Type 2 diabetes mellitus is the highest prevalence among diabetes types, but there is no treatment that overcome obstacle in the process of surgery, rejection reactions, and increased complications that occur. The aim of this study was to investigate the insulin sensitivity improvement by Mesenchymal Stem Cell-Conditioned Medium(MSC-CM) through increased IRS-1 tyrosine phosphorylation (IRS-1tyr612) on the type 2 diabetic rat with and without treatment. This experimental study is purely laboratory Posttest Control Group using male Sprague Dawley rat, 7 weeks old and 150-200gram weight. Rat is divided into 3 research groups, K(-): normal control; K(+): diabetic control; P:treatment, type 2 DM rat+MSC-CM 0,1ml/200gBW ip. Giving MSC-CM is done every 3 days 10 times. On day 30 after therapy, an IRS-1tyr612 expression analysis was performed with skeletal muscle immunohistochemistry (IHC). Data analysis was performed by Kruskal-Wallis and Independent Sample T-test at 95% significance. Percentage of positive score of IRS-1tyr612 expression K(-)(75%)> P(62,5%)> K(+)(12,5%). Average expression of IRS-1tyr612 P(45,46±9,15)> K(-)(44,41±4,61)> K(+)(21,29±3,49) with significant difference of K(-)-K(+) and P-K(+). Giving MSC-CM may increase the expression of IRS-1tyr612 on type 2 diabetic animal model rat. Keywords: MSC-CM, insulin sensitivity, IRS-1tyr612, type 2 DM Abstrak: Diabetes melitus tipe 2 merupakan tipe diabetes dengan prevalensi tertinggi, namun belum ada pengobatan yang dapat mengatasi hambatan dalam proses operasi, reaksi rejeksi, dan banyaknya komplikasi yang terjadi. Penelitian ini bertujuan untuk mengetahui perbaikan sensitivitas insulin oleh Media Terkondisi Sel Punca Mesensimal (MT-SPM) melalui peningkatan fosforilasi tirosin 612 IRS-1(IRS-1tyr612) pada tikus model DM tipe 2 dengan dan tanpa terapi. Penelitian ini eksperimental murni laboratorium Posttest Control Group menggunakan hewan uji tikus Sprague Dawley jantan usia 7 minggu dan berat badan 150-200gram. Tikus dibagi menjadi 3 kelompok penelitian, yaitu K(-): kontrol normal; K(+): kontrol diabetik; P: perlakuan, tikus DM tipe 2 + MT-SPM 0,1ml/200g bb ip. Pemberian MT-SPM dilakukan setiap 3 hari sebanyak 10 kali. Pada hari ke-30 setelah terapi, dilakukan analisis ekspresi IRS-1tyr612 dengan IHC otot skelet. Analisis data dilakukan dengan Independent Sample T-test dan Kruskal Wallis pada signifikansi 95%. Prosentase skor positif ekspresi IRS-1tyr612 K(-)(75%) > P(62,5%) > K(+)(12,5%). Rerata ekspresi IRS-1tyr612 P(45,46±9,15) > K(-)(44,41±4,61) > K(+)(21,29±3,49) dengan perbedaan yang bermakna secara statistik pada K(-)–K(+) dan P–K(+). Pemberian MTSPM dapat meningkatkan ekspresi IRS-1tyr612 pada tikus model DM tipe 2. Kata kunci: MT-SPM, sensitivitas insulin, IRS-1tyr612,DM tipe 2

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Frequency of Chronic Kidney Disease in Type 2 Diabetic Patients Presenting with Diabetic Foot Ulcer

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd9-1/011 ◽

2020 ◽

Author(s):

Ghazala Usman

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Diabetic Foot ◽

Foot Ulcer ◽

Diabetic Foot Ulcer ◽

P Value ◽

Diabetic Patients ◽

Type 2 Dm ◽

Significant Difference

Background: Recent evidence states that about a quarter of all diabetic patients will experience an ulcer on foot at some point in their lifetime and 15-25% of these will require foot amputation. In the present study, we aimed to evaluate the incidence of chronic kidney disease (CKD) in Type 2 diabetes mellitus (T2DM) patients presenting with Diabetic foot ulcer. Methods: The present study was carried out at Jinnah Postgraduate Medical Center (JPMC), Sindh from February-August 2017. Over 100 Type 2 - DM patients, aged between 35-60 years who presented with diabetic foot ulcer took part in this study. Data was collected and documented in pre-approved pro-forma, subsequently, entered and analyzed via SPSS version 19. Chi-square was applied to test any significant difference between the categories with a p-value of ≤0.05 considered as significant. Results: The mean serum creatinine (mg/dl) value was reported to be 1.17 ± 0.45. Frequency of CKD in Type 2 - DM patients presenting with diabetic foot ulcer was 31%. Male gender was affected more from CKD. Frequency distribution of chronic kidney disease among duration of DM groups 10-15 years = 35.5% and >15 years = 64.5%. The characteristics of HbA1c (g/dl) of study population was 8.34 ± 0.59. Conclusion: Occurrence of CKD in Type 2 - DM patients presenting with diabetic foot ulcer was much higher as compared to national and international studies. Therefore, special attention should be given on regular screening of diabetic patients with a complaint of a foot ulcer.

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