scholarly journals FORMULASI SEDIAAN KRIM EKSTRAK ETANOL DAUN KALIANDRA (Calliandra surinamensis) DAN UJI AKTIVITAS ANTIBAKTERINYA TERHADAP BAKTERI Staphylococcus aureus

PHARMACON ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 809
Author(s):  
Gichella C. J. Somba ◽  
Hosea Jaya Edi ◽  
Jainer P. Siampa
Keyword(s):  
Leaf Extract ◽  
Physical Stability ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Physical Test ◽  
Sterility Testing ◽  
Cycling Test ◽  
Test Parameters ◽  
Before And After ◽  
Inhibitory Power

ABSTRACT This study aims to test the antibacterial effectiveness of ethanolic extract of Kaliandra leaf cream and evaluate the preparations using parameters of physical properties, physical stability, and sterility. Kaliandra leaf (Calliandra surinamensis) contains compounds such as flavonoid, saponins and tannins that can inhibit the growth of bacteria. This research uses laboratory experimental methods. Cream preparation formula is made with variations in the concentration of ethanol extract of Kaliandra leaves 2%, 3%, 4%, 5%, 6%. Kaliandra leaf extract was obtained by maceration using 96% ethanol solvent. The study of antibacterial test of ethanol extract of Kaliandra leaf extract using the method of Staphylococcus aures produced inhibitory power of 5.09 ± 0.88 mm at a concentration of 6%. The physical evaluation of the cream preparation includes organoleptic examination (odor, color, shape), homogeneity, pH testing, adhesion, dispersion, cycling test. All tests are carried out before and after the cycling test. The results obtained before and after the cycling test showed that the cream preparations met organoleptic requirements, homogeneity, cream pH 6.07 (4.5-6.5), cream adhesion 4.59 seconds (<4 seconds), cream dispersion  6.19 cm (5-7 cm). Cream sterility testing shows that the cream is sterile. It can be concluded that the ethanol extract of Kaliandra leaves cream meets the physical test parameters, is stable and has moderate antibacterial activity. Keywords : Kaliandra Leaf (Calliandra surinamensis), Cream, Antibacterial, Staphylococcous aureus.  ABSTRAK Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan krim ekstrak etanol daun Kaliandra dan mengevaluasi sediaan dengan menggunakan parameter uji sifat fisik, stabilitas fisik, dan sterilitas. Daun Kaliandra (Calliandra surinamensis) merupakan tanaman yang mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini menggunakan metode eksperimental laboratorium, Formula sediaan krim dibuat dengan variasi konsentrasi ekstrak etanol daun Kaliandra 2%, 3%, 4%, 5%, 6%. Ekstrak daun Kaliandra diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Penelitian uji antibakteri sediaan krim esktrak etanol daun Kaliandra menggunakan metode sumuran pada bakteri Staphylococcus aures menghasilkan daya hambat 5,09±0,88 mm pada konsentrasi 6%. Evaluasi fisik sediaan krim meliputi pemeriksaan organoleptis (bau, warna,  bentuk), homogenitas, pengujian pH, daya  lekat,  daya  sebar, uji cycling test. Semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian yang didapat sebelum dan sesudah cycling test menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptis, homogenitas, pH krim 6,07 (4,5-6,5), daya lekat krim 4,59 detik (<4 detik), daya sebar krim 6,19 cm (5-7 cm). Pengujian sterilitas krim menunjukan bahwa krim steril. Dapat disimpulkan bahwa sediaan krim ekstrak etanol daun Kaliandra memenuhi parameter uji fisik, stabil dan memiliki aktivitas  antibakteri yang sedang. Kata kunci : Daun Kaliandra (Calliandra surinamensis), Krim, Antibakteri, Staphlococcous aureus.

scholarly journals FORMULASI DAN UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SESEWANUA (Clerodendron squamatum Vahl.)

PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 261
Author(s):  
Meyla C. M. Pratasik ◽  
Paulina V. Y. Yamlean ◽  
Weny I Wiyono
Keyword(s):  
Experimental Method ◽  
Leaf Extract ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Adhesion Test ◽  
Cycling Test ◽  
Physical Evaluation ◽  
Before And After ◽  
Dispersion Test ◽  
The Right

ABSTRACT Sesewanua Leaves (Clerodendron squamatum Vahl.) have the potential to be made as skin care cosmetic preparations but must be in the right formulation to achieve the desired effect. The aim of this study was to determine the physical stability of a cream from Sesewanua leaf extract. This study used a experimental method by making ethanol extract of Sesewanua leaves with a concentration of 0.5% and physical stability test. Physical evaluation was carried out before and after cycling test through organoleptic observation, homogenety test, pH test, dispersion test, adhesion test, viscosity test, centrifugation test and cream type determination. The results of the physical evaluation showed that F1 without Sesewanua leaf extract and F2 with Sesewanua leaf extract creams met the requirements of physical stability, so can be concluded that Sesewanua leaf extract can be formulated into cream preparations with concentration of 0.5% which is physically stable before and after cycling test. Keywords: Sesewanua Leaves, Cream, Physical Stability  ABSTRAK Daun Sesewanua (Clerodendron squamatum Vahl.) berpotensi untuk dibuat sebagai sediaan kosmetik perawatan kulit namun harus dengan formulasi yang tepat agar mencapai efek yang diinginkan. Penelitian ini bertujuan untuk mengetahui stabilitas fisik sediaan krim ekstrak daun sesewanua. Penelitian ini menggunakan metode eksperimental dengan membuat krim ekstrak etanol daun Sesewanua dengan konsentrasi 0,5% dan uji stabilitas fisik. Evaluasi fisik dilakukan sebelum dan sesudah cycling test melalui pengamatan organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, uji viskositas, uji sentrifugasi dan penentuan tipe krim. Hasil evaluasi fisik menunjukkan krim F1 tanpa ekstrak daun Sesewanua dan F2 dengan ekstrak daun Sesewanua memenuhi persyaratan stabilitas fisik. Berdasarkan hasil penelitian dapat disimpulkan ekstrak daun sesewanua dapat diformulasi menjadi sediaan krim dengan konsentrasi 0,5% yang stabil secara fisik sebelum dan sesudah cycling test. Kata Kunci : Daun Sesewanua, Krim, Stabilitas Fisik

scholarly journals UJI EFEKTIVITAS FORMULASI SEDIAAN KRIM EKSTRAK KULIT BUAH PISANG GOROHO (Musa acuminafe L.) TERHADAP BAKTERI Staphylococcus aureus

PHARMACON ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 443
Author(s):  
Stephany P. Pangemanan ◽  
Hosea J. Edy ◽  
Erladys M. Rumondor
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Experimental Methods ◽  
Banana Peel ◽  
Physical Test ◽  
Cycling Test ◽  
Test Parameters ◽  
Peel Extract

ABSTRACT Goroho Banana Skin (Musa acuminafe L.) is a plant that contains flavonoid compounds, saponins and tannins that can inhibit bacterial growth. This study aims to test the antibacterial effectiveness of ethanol extract cream of goroho banana peel and evaluate the preparations using parameters of physical properties and physical stability. This research uses laboratory experimental methods. Cream formula is made with a variety of ethanol extract concentrations of Goroho Banana peel 2.5%, 5%, 7.5%, 10%, 12.5%. Goroho Banana peel extract was obtained by maceration using 96% ethanol solvent. The study of antibacterial test of ethanol extract of Goroho Banana peel using wells method on Staphylococcus aureus bacteria resulted in inhibition of 7.03 ± 3.29 mm at a concentration of 12.5%. All tests are carried out before and during the cycling test. The results obtained before and during the cycling testshowed that the cream preparations met organoleptic requirements, homogeneity, cream pH 6.807 (4.5-6.5), cream adhesion 9.63 seconds (<4 seconds), cream spread 4, 53 cm (5-7 cm). It can be concluded that the ethanol extract of Goroho Banana peel cream meets stable physical test parameters and has moderate antibacterial activity. Keywords: Goroho Banana Peel (Musa acuminafe L.), Antibacterial, Cream. ABSTRAK Kulit Buah Pisang Goroho (Musa acuminafe L.) merupakan tanaman yang mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan krim ekstrak etanol kulit buah pisang goroho dan mengevaluasi sediaan dengan menggunakan parameter uji sifat fisik dan stabilitas fisik. Penelitian ini menggunakan metode eksperimental laboratorium, Formula sediaan krim dibuat dengan variasi konsentrasi ekstrak etanol kulit buah Pisang Goroho 2,5%, 5%, 7,5%, 10%, 12,5%. Ekstrak kulit buah Pisang Goroho diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Penelitian uji antibakteri sediaan krim esktrak etanol kulit buah Pisang Goroho menggunakan metode sumuran pada bakteri Staphylococcus aureus menghasilkan daya hambat 7,03±3,29 mm pada konsentrasi 12,5%. Semua pengujian dilakukan sebelum dan selama cycling test. Hasil penelitian yang didapat sebelum dan selama cycling test menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptis, homogenitas, pH krim 6,807 (4,5-6,5), daya lekat krim 9,63 detik (<4 detik), daya sebar krim 4,53 cm (5-7 cm). Dapat disimpulkan bahwa sediaan krim ekstrak etanol kulit buah Pisang Goroho memenuhi parameter uji fisik stabil dan memiliki aktivitas  antibakteri yang sedang. Kata kunci : Kulit Buah Pisang Goroho (Musa acuminafe L.), Antibakteri, Krim.

scholarly journals FORMULASI SEDIAAN KRIM EKSTRAK ETANOL DAUN BAYAM MERAH (Amaranthus tricolor L.) DAN UJI AKTIVITAS ANTIOKSIDAN MENGGUNAKAN METODE DPPH (1.1-diphenyl-2-picrylhydrazyl)

PHARMACON ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 372
Author(s):  
Veronica O. Moilati ◽  
Paulina V. Y. Yamlean ◽  
Gerald Rundengan
Keyword(s):  
Antioxidant Activity ◽  
Vitamin C ◽  
Ethanol Extract ◽  
Amaranthus Tricolor ◽  
Physical Test ◽  
Cycling Test ◽  
Test Parameters ◽  
Dpph Method ◽  
Before And After ◽  
Spinach Leaves

ABSTRACT Red spinach leaves (Amaranthus tricolor L.) contain  flavonoid  compounds,  saponins  and  tannins which had antioxidant potential. This study aims to test the antioxidant activity of ethanol extracts of Red spinach (Amaranthus tricolor L.) leaves used to be DPPH method and evaluate cream preparations used physical test parameters. This study used a laboratory experimental method. The formulate of cream preparations and variations in the concentration of 0,25%, 0,5%, 0,75 %, 1%, 1,25%. The results obtained before and after the cycling test showed that cream preparations with 0,5% concentration met organoleptic requirements, homogeneity, cream pH 5,29 (4,5-6,5), cream adhesion 16,20 seconds (> 4 seconds ), the spreadability of the cream is 5,37 cm  (5-7 cm) and the antioxidant activity test produced value  2,82 ppm and vitamin C value of 0,22 ppm. It can be concluded that cream preparation of ethanol extract of Red spinach leaves meets physical test parameters, is stable and had very strong antioxidant activity.   Key words : Red spinach  (Amaranthus tricolor L.), Cream, Antioxidants, DPPH (1.1-diphenyl-2- picrylhydrazyl). ABSTRAK Daun Bayam merah (Amaranthus tricolor L.) mengandung senyawa flavonoid, saponin dan tannin yang memiliki potensial antioksidan. Penelitian ini bertujuan untuk menguji aktivitas antioksidan sediaan krim ekstrak etanol daun Bayam merah (Amaranthus tricolor L.) menggunakan metode DPPH dan mengevaluasi sediaan krim menggunakan parameter uji fisik. Penelitian ini menggunakan metode eksperimental laboratorium dan formulasi sediaan krim dibuat dengan variasi konsentrasi 0,25%, 0,5%, 0,75%%, 1%, 1,25%. Hasil penelitian yang didapat sebelum dan sesudah cycling test menunjukkan bahwa sediaan krim konsentrasi 0,5% memenuhi persyaratan organoleptis, homogenitas, pH krim 5,29 (4,5-6,5), daya lekat krim 16,20 detik (>4 detik), daya sebar krim  5,37 cm  (5-7 cm) serta uji aktivitas antioksidan menghasilkan nilai  2,82 ppm dan nilai   vitamin C 0,22 ppm. Dapat disimpulkan bahwa sediaan krim ekstrak etanol daun Bayam merah memenuhi parameter uji fisik, stabil dan memiliki aktivitas  antioksidan yang sangat kuat.  Kata kunci : Bayam merah (Amaranthus tricolor L.), Krim, Antioksidan, DPPH (1.1-diphenyl-2-picrylhydrazyl).

scholarly journals FORMULASI DAN UJI ANTIBAKTERI SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL DAUN ALPUKAT (Persea americana Mill.) TERHADAP BAKTERI Staphylococcus epidermidis SEBAGAI ANTIJERAWAT

PHARMACON ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 860
Author(s):  
Esterlina A. Puluh ◽  
Hosea Jaya Edi ◽  
Jainer P. Siampa
Keyword(s):  
Antibacterial Activity ◽  
Leaf Extract ◽  
Physical Stability ◽  
Antibacterial Properties ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Persea Americana ◽  
Physical Test ◽  
Test Parameters ◽  
Test Requirements

ABSTRACT Avocado leaves contain the compounds such as saponins, alkaloids, flavonoids, polyphenols, and quercetin which are as antibacterial properties. This study aims to obtain the best concentration of the formula of peel off gel mask preparation of avocado leaf ethanol extract (Persea americana Mill.) Based on antibacterial activity test and prove the quality preparation based on the test parameters of physical properties, physical stability and sterility.This study used a laboratory experimental methods, the formula for the preparation of avocado leaf extract peel off gel mask was made with a concentration variation of 0.1%; 0.15%; 0.2%; 0.25% and 0.3%. Avocado leaf extract is obtained by maceration using 96% of ethanol solvent. The largest diameter of inhibition zone of antibacterial testing with wells method is at a concentration of 0.3% with a diameter of the inhibition zone 3 mm ± 0.32 and the ability of inhibition is categorized as weak. The physical test and the stability of the preparation meet the evaluation parameters of the physical preparation before storage, but after storage the preparation does not meet the test requirements when drying. It can be concluded that the preparation of the extract of avocado leaf peel off gel mask meets the physical test parameters, is stable and has weak antibacterial activity. Keywords: Avocado Leaf (Persea americana Mill.), Peel off mask, Antibacterial, Sterility Test. ABSTRAK Daun Alpukat memiliki kandungan antara lain saponin, alkaloid, flavonoid, polifenol, quersetin yang bersifat sebagai antibakteri.  Penelitian ini bertujuan untuk mendapatkan konsentrasi terbaik dari formula sediaan masker gel peel off ekstrak etanol daun alpukat (Persea americana Mill.) berdasarkan uji aktivitas antibakteri serta membuktikan sediaan yang berkualitas berdasarkan parameter uji sifat fisik, stabilitas fisik dan sterilitas. Penelitian ini menggunakan metode ekperimental laboratorium, formula sediaan masker gel peel off ekstrak daun Alpukat dibuat dengan variasi konsentrasi 0,1%; 0,15%; 0,2%; 0,25% dan 0,3%. Ekstrak tanaman daun alpukat diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Pengujian antibakteri dengan metode sumuran diameter zona hambat yang paling besar yaitu pada konsentrasi 0,3% dengan diameter zona hambat 3 mm ± 0,32 dan kemampuan daya hambat dikategorikan lemah.  Pada uji fisik dan stabilitas sediaan memenuhi parameter evaluasi sediaan fisik sebelum penyimpanan, tapi setelah penyimpanan sediaan tidak memenuhi persyaratan uji waktu mengering. Dapat disimpulkan bahwa sediaan masker gel peel off ekstrak etanol daun alpukat memenuhi parameter uji fisik, stabil dan memiliki aktivitas antibakteri yang lemah. Kata kunci: Daun Alpukat (Persea americana Mill.), Masker peel off, Antibakteri, Uji Sterilitas.

scholarly journals FORMULASI DAN UJI EFEKTIVITAS KRIM ANTIBAKTERI EKSTRAK DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP BAKTERI Staphylococcus aureus

PHARMACON ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 225
Author(s):  
Nurul S Majid ◽  
Paulina V. Y. Yamlean ◽  
Gayatri Citraningtyas
Keyword(s):  
Staphylococcus Aureus ◽  
Leaf Extract ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Quality Test ◽  
Antibacterial Compounds ◽  
Artocarpus Heterophyllus ◽  
Test Parameters

ABSTRACT Jackfruit leaves contain saponins, flavonoids and tannins. Which are know to have antibacterial compounds. The purpose of this study is to make cream of jackfruit leaf extract with a concentration of 5%, 10% and 15% and test the quality of preparations of  jackfruit leaf extract cream and  there is antibacterial effectiveness against Staphylococcus aureus bacteria. The method used is the ethanol extract of Jackfruit leaves by formulating it as an M/A type cream. The results showed the cream of  jackfruit leaf extract fulfilled all the physical stability tests of the cream and in the antibacterial testing of cream of Jackfruit leaf extract could inhibit the effectiveness of Staphylococcus aureus bacteria. As concluded, the Jackfruit leaf extract Conclusions obtained by jackfruit leaf extract can be formulated as a cream with a concentration of 5%, 10% and 15%, and cream preparations meet the cream quality test parameters, for testing the effectiveness of antibacterial to the biggest inhibition zone Staphylococcus aureus is 10.5 mm at 15% concentration. Keywords: Jackfruit leaves, cream antibacterial, Staphylococcus aureus. ABSTRAK Daun Nangka memiliki kandungan saponin, flavonoid dan tannin yang berperan sebagai senyawa antibakteri. Tujuan penelitian ini yaitu membuat krim ekstrak daun Nangka dengan konsentrasi 5%, 10% dan 15%, menguji mutu  dan efektivitas antibakteri krim ekstrak daun Nangka terhadap bakteri Staphylococcus aureus. Metode yang digunakan yaitu ekstrak etanol daun Nangka dengan memformulasikan sebagai krim dengan tipe M/A. Hasil penelitian menunjukkan krim ekstrak daun Nangka memenuhi semua uji kestabilan fisik krim dan dalam pengujian antibakteri krim ekstrak daun Nangka dapat menghambat efektivitas bakteri Staphylococcus aureus. Kesimpulan yang diapat ekstrak daun Nangka dapat diformulasikan sebagai krim dengan konsentrasi 5%, 10% dan 15%, dan  sediaan krim memenuhi parameter uji kualitas krim, untuk pengujian efektivitas antibakteri terhadap Staphylococcus aureus zona hambat terbesar yaitu 10,5 mm pada konsentrasi 15%. Kata kunci: Daun Nangka, krim antibakteri, Staphylococcus aureus.

scholarly journals Uji Formulasi dan Uji Efektivitas Repelan Lotion Ekstrak Daun Tembakau (nicotiana tabacum. L) Terhadap Nyamuk Aedes Aegypti

2021 ◽  
Vol 1 ◽  
pp. 1968-1976
Author(s):  
Rojiah Batsah ◽  
W Wirasti ◽  
F Fitriyani
Keyword(s):  
Aedes Aegypti ◽  
Leaf Extract ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Tobacco Leaves ◽  
Tobacco Leaf ◽  
Nicotiana Tabaccum ◽  
Cycling Test ◽  
Significant Difference ◽  
One Way Anova

AbstractTobacco leaves (Nicotiana tabaccum. L) have great potential as a pesticide or insect repellent, especially the Aedes aegypti mosquito. Maceration method was used to obtain tobacco leaf extract as much as 127.86 grams from the dried simplicia of tobacco leaves (Nicotiana tabaccum. L) 827 grams (yield 15.46%). The tobacco extract was made in the form of lotio with a concentration of 1%, 2%, and 3%, having repellant effectiveness of 90%, 96% and 100%, respectively. Physical stability test was carried out on the lotion 0%, 1%, 2%, and 3% as follows; organoleptic test (brownish color, typical tobacco aroma and homogeneity), spreadability test (6.1cm; 6.1cm; 6.2cm; 6.4cm), adhesion test (3.06sec; 2.8sec; 2.75sec; 2.61sec), cycling test (brownish color, thick consistency, homogeneity, and distinctive aroma of tobacco), pH test (7; 7; 7; 6,3), and viscosity test (4.708cPs, 4.575cPs, 4.465cPs, 4.403cPs). The results of One Way ANOVA analysis showed that there was a significant difference in each concentration of tobacco leaf extract lotio and Tukey's test showed that the repellant ability of 3% concentration had 100% percent repelance. It can be concluded that the ethanol extract lotion of tobacco leaves (Nicotiana tabaccum. L) has repellant effectiveness.Keywords: tobacco leaves, extract, lotion, repellant, ANOVA AbstrakDaun tembakau (Nicotiana tabaccum. L) memiliki potensi besar sebagai pestisida atau pengusir serangga khususnya nyamuk Aedes aegypti. Metode maserasi digunakan untuk mendapatkan ekstrak daun tembakau sebanyak 127,86 gram dari simplisia kering daun tembakau (Nicotiana tabaccum. L) 827 gram (rendemen 15,46%). Ekstrak tembakau dibuat dalam bentuk lotio dengan konsentrasi 1%, 2%, dan 3% memiliki efektivitas repelan berturut-turut adalah 90%, 96% dan 100%. Dilakukan uji stabilitas fisik terhadap lotio 0%,1%, 2%, dan 3% sebagai berikut; uji organoleptis (warna kecoklatan, aroma khas tembakau dan homogen), uji daya sebar (6,1cm; 6,1cm; 6,2cm; 6,4cm), uji daya lekat (3,06detik; 2,8detik; 2,75detik; 2,61detik), uji cycling test (warna kecoklatan, konsistensi kental, homogen, dan aroma khas tembakau), uji pH (7;7;7;6,3), dan uji viskositas (4.708cPs, 4.575cPs, 4.465cPs, 4.403cPs). Hasil analisis One Way ANOVA menunjukkan adanya perbedaan yang signifikan pada setiap konsentrasi lotio ekstrak daun tembakau dan uji Tukey menunjukkan kemampuan repelan konsentrasi 3% memiliki persen repelansi 100%. Hal ini dapat disimpulkan bahwa lotio ekstrak etanol daun tembakau (Nicotiana tabaccum. L) memiliki efektivitas repelan.Kata kunci: : daun tembakau; ekstrak; lotion; repelan; ANOVA

scholarly journals FORMULATION AND EVALUATION OF PHARMACEUTICALY STABLE SERUM OF DUCHESNEA INDICA (ARBENAN)

2021 ◽  
Author(s):  
A. Mumtihanah Mursyid ◽  
Risda Waris
Keyword(s):  
Peer Review ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Initial Stage ◽  
Unique System ◽  
Duchesnea Indica ◽  
Leaf Powder ◽  
Review Reports ◽  
Stable Leaf

Objective: Arbenan (Duchesnea indica) plants contain saponins, flavonoids, and tannins which have antioxidant activity. The purpose of this research is to perform formulation and evaluation extract ethanol of Arbenan leaves in the form of serum which is pharmaceutically stable. Method: Arbenan leaf powder was macerated with ethanol solvent, and then left for 3-4 days while stirring repeatedly, and then filtering. Furthermore, the liquid ethanol extract that has been obtained is evaporated using a Rotary Vacum Evaporator was used to evaporate the extract. Prepared extract was used to evaluate various parameters like organoleptics, homogeneity, viscosity, and pH. Result: All formulations were having typical smell, light brown color and a little thick consistency. Formulations of leaf extract of Arabenan with four variations bases have shown to have good stability after stress condition. It can be seen from the evaluation result are organoleptics, homogeneity, viscosity, rheology, and pH. Conclusion: Study concludes that a stable leaf extract of Arabenan can be effectively formulated into a serum by the means of various bases.                                     Peer Review History: Received 8 January 2021; Revised 13 February; Accepted 4 March, Available online 15 March 2021 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Marwa A. A. Fayed,  University of Sadat City, Egypt, [email protected] Prof. Dr. Ali Gamal Ahmed Al-kaf,  Sana'a university, Yemen, [email protected] Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected] Similar Articles: PHYTOCHEMICAL, ANTI-INFLAMMATORY, ANALGESIC, ANTIPYRETIC AND ACUTE TOXICITY OF PSIADIA PUNCTULATA GROWING IN YEMEN ANTIHYPERLIPIDEMIC EFFECT OF THE ETHANOLIC EXTRACT OF SCAEVOLA TACCADA (GAERTN) ROXB. LEAVES ETHNOBOTANY, PHYTOCHEMISTRY AND PHARMACOLOGY OF OCHNA SCHWEINFURTHIANA: A REVIEW

Gynura divaricata Effect on Blood Glucose Levels in Alloxan-Induced Diabetes Mice

2019 ◽  
Vol 13 (01) ◽  
pp. 27-33
Author(s):  
Evi Sovia ◽  
Dian Anggraeny ◽  
Ris Kristiana ◽  
Firhan Hamdi Maulida ◽  
Mutia Susparini
Keyword(s):  
Blood Glucose ◽  
Histological Examination ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Antidiabetic Activity ◽  
Phytochemical Analysis ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetes Mice ◽  
Before And After

Gynura divaricata (GD) also known as Dewa leaf is one of the Indonesian medicinal plants which are also native to India, Thailand and China. GD is widely used as antidiabetic, antihypertensive and other diseases including several tumors. However, research on the effects of GD as antidiabetic is still not widely practiced, especially in Indonesia. The aim of this research is to investigate the effect of GD ethanolic extract on blood glucose levels of alloxan-induced diabetes mice. This research is an experimental research with pre- and post-test design using 24 male DDY strain mice. Animals experiment is divided into four groups, that are one normal group and three alloxan-induced diabetes mice group that give 1% CMC (control), 400[Formula: see text]mg/kg GD ethanolic extract and 0.65[Formula: see text]mg/kg glibenclamide, respectively. Treatment was given for 14 days. Blood glucose levels were measured before and after inducing alloxan, and after 14 days treatment. At the end of study, all of animals experiment were sacrificed for histological examination. Phytochemical analysis revealed that polyphenols, flavonoids, steroids, triterpenoids, terpenoids and and quinones were present in ethanol extract of GD. The results of this study showed significant ([Formula: see text]) decrease of blood glucose levels after GD ethanolic extract and glibenclamide treatment. The results of histological examination showed improvement in pancreas damage and significant increase in the number of beta cells in GD and glibenclamide groups. The results indicate that dewa leaf ethanolic extract has antidiabetic activity and the effectiveness is the same as glibenclamide. GD also could repair damage of pancreas caused by alloxan induction.

scholarly journals FORMULATION OF SERUM GEL CONTAINING ANGELICA KEISKEI LEAF EXTRACT AS AN ANTIOXIDANT AND TYROSINASE ENZYME INHIBITOR

2020 ◽  
pp. 108-111
Author(s):  
DIAH LIA AULIFA ◽  
RIZKA Y. NOERFITRI ◽  
DEBY TRISTIYANTI ◽  
ARIF BUDIMAN
Keyword(s):  
Antioxidant Activity ◽  
Leaf Extract ◽  
Enzyme Inhibitor ◽  
Physical Stability ◽  
Ic50 Value ◽  
Angelica Keiskei ◽  
Inhibitory Activities ◽  
Tyrosinase Enzyme ◽  
Inhibitory Power ◽  
Skin Lightening

Objective: The aim of this study was to formulate and evaluate the efficacy of Angelica keiskei (AK) leaf extract in serum gel as an antioxidant and tyrosinase enzyme inhibitor. Methods: The leaves of AK were extracted using the maceration method, while the antioxidant and tyrosinase enzyme inhibitory activities were determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and L-Tyrosine as assay and substrate, respectively. Subsequently, the extract was formulated into serum gel and evaluated for physical stability, antioxidant and inhibitory activity to tyrosinase enzyme. Results: The results showed that AK leaf extract has antioxidant activity, with an IC50 value = 7.73 mg/ml, while the tyrosinase enzyme inhibitory power had an IC50 value = 500 mg/ml. Based on physical stability, the serum gel was stable after 28 d of storage. The serum gel of AK leaf extract also showed antioxidant activity and tyrosinase enzyme inhibition with IC50 value of 16.68 mg/ml and 741.62 mg/ml, respectively. Conclusion: This study demonstrated that the serum gel of AK leaf extract has potential as a skin lightening agent and is safe for use as a topical preparation.

scholarly journals The Inhibitory Power Extract Of Balsamica Plant (Impatiens balsamica L) on Aeromonas hydrophila Bacteria Growth

2014 ◽  
Vol 2 (2) ◽  
pp. 40
Author(s):  
Galih Arif Kusuma ◽  
Sammy N. J. Longdong ◽  
Reiny A. Tumbol
Keyword(s):  
Antibacterial Activity ◽  
Aeromonas Hydrophila ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Inhibitory Effect ◽  
Bacteria Growth ◽  
Activity Test ◽  
Inhibitory Power

This research aimed to assess the potential use of extracts of leaves, flowers, and stems of the balsamica plant increase inhibitory effect on the growth of Aeromonas hydrophila. The content of the plant contains a compound balsamica naphthoquinone, coumarin derivatives, tannins, flavonoids, and steroids. The active compounds have the ability as an antimicrobial. A hidrophyla bacteria, including opportunistic pathogens are almost always found in water and often cause disease when the fish in adverse conditions. Antibacterial activity test in this research using the spread plate method. Data obtained in the form of the extract, the results of bacterial inoculation, and the inhibition test results, will be analyzed, displayed with pictures and described descriptively. The result of the process of maceration extraction using ethanol 70% was obtained three extracts are concentrated leaf extract: 28.75 g, flower: 12.82 g, and rods: 29.48 g. The result of antibacterial extracts of leaves, stems, and flowers balsamica plant showed inhibitory activity on the A hydrophila bacteria that seems to be indicated by a clear zone around the paper disc. Based on the classification of leaf extract and extract of the stem can be classified in the class of strong, because the inhibition zone formed by the leaf extract is equal to 11.2 mm, and extract stem with 13.7 mm inhibition zone. Ability flower extract in inhibiting the growth of A hidrophila bacteria with 21.4 mm inhibition zone showed that the extract was included in a very strong class. Keywords: The ethanol extract balsamica, Impatiens balsamica L, Aeromonas hydrophila, antibacterial activity test.

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