FORMULASI DAN UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SESEWANUA (Clerodendron squamatum Vahl.)

ABSTRACT Sesewanua Leaves (Clerodendron squamatum Vahl.) have the potential to be made as skin care cosmetic preparations but must be in the right formulation to achieve the desired effect. The aim of this study was to determine the physical stability of a cream from Sesewanua leaf extract. This study used a experimental method by making ethanol extract of Sesewanua leaves with a concentration of 0.5% and physical stability test. Physical evaluation was carried out before and after cycling test through organoleptic observation, homogenety test, pH test, dispersion test, adhesion test, viscosity test, centrifugation test and cream type determination. The results of the physical evaluation showed that F1 without Sesewanua leaf extract and F2 with Sesewanua leaf extract creams met the requirements of physical stability, so can be concluded that Sesewanua leaf extract can be formulated into cream preparations with concentration of 0.5% which is physically stable before and after cycling test. Keywords: Sesewanua Leaves, Cream, Physical Stability ABSTRAK Daun Sesewanua (Clerodendron squamatum Vahl.) berpotensi untuk dibuat sebagai sediaan kosmetik perawatan kulit namun harus dengan formulasi yang tepat agar mencapai efek yang diinginkan. Penelitian ini bertujuan untuk mengetahui stabilitas fisik sediaan krim ekstrak daun sesewanua. Penelitian ini menggunakan metode eksperimental dengan membuat krim ekstrak etanol daun Sesewanua dengan konsentrasi 0,5% dan uji stabilitas fisik. Evaluasi fisik dilakukan sebelum dan sesudah cycling test melalui pengamatan organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, uji viskositas, uji sentrifugasi dan penentuan tipe krim. Hasil evaluasi fisik menunjukkan krim F1 tanpa ekstrak daun Sesewanua dan F2 dengan ekstrak daun Sesewanua memenuhi persyaratan stabilitas fisik. Berdasarkan hasil penelitian dapat disimpulkan ekstrak daun sesewanua dapat diformulasi menjadi sediaan krim dengan konsentrasi 0,5% yang stabil secara fisik sebelum dan sesudah cycling test. Kata Kunci : Daun Sesewanua, Krim, Stabilitas Fisik

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FORMULASI DAN UJI EFEKTIVITAS ANTIFUNGI KRIM EKSTRAK ETANOL DAUN SALAM (Syzygium polianthum (Wight) Walp.) TERHADAP JAMUR Candida albicans

PHARMACON ◽

10.35799/pha.10.2021.34033 ◽

2021 ◽

Vol 10 (2) ◽

pp. 841

Author(s):

Sheren N. Lolowang ◽

Paulina V.Y. Yamlean ◽

Karlah L.R. Mansauda

Keyword(s):

Candida Albicans ◽

Antifungal Activity ◽

Leaf Extract ◽

Physical Stability ◽

Ethanol Extract ◽

Average Diameter ◽

Statistical Test ◽

Adhesion Test ◽

Physical Evaluation ◽

Dispersion Test

ABSTRACT Bay leaf (Syzygium polianthum (Wight) Walp.) are used as natural medicinal ingredients because contain compounds such as flavonoid, saponin and tannin that can inhibit the growth of fungal. The purpose of this study was to test the antifungal effectiveness of bay leaf ethanol extract cream and evaluate the preparation of physical stability. The research that was carried out was laboratory experimental. Bay leaf extract was obtained by maceration using 96% ethanol. The cream preparation was made with variations in the concentration of Bay leaf ethanol extract formula 1%; 3%; 6% and 9%. The method used to test the antifungal effectiveness is the well method. The result of the antifungal test showed an average diameter value for formula I (1%) 6.67 mm; formula II (3%) 9.5 mm; formula III (6%) 10.83 mm and formula IV (9%) 15 mm. Statistical test of ethanol extract cream of Bay leaf produced the largest inhibiton zone of 15 mm at a concentration of 9%. Physical evaluation showed that the cream preparations met organoleptic requirements, homogeneity, pH 4.83, dispersion test 5.30 cm, adhesion test 7.01 seconds. It can be concluded that the ethanol extract of bay leaf can be formulated into a cream preparation that is physically stable and has strong antifungal activity. Keywords: Bay Leaf, Antifungal Cream, Candida albicans ABSTRAK Daun Salam (Syzygium polianthum (Wight) Walp.) dimanfaatkan sebagai bahan obat alami karena memiliki kandungan senyawa flavonoid, saponin dan tannin yang dapat menghambat pertumbuhan jamur. Penelitian ini bertujuan menguji efektivitas antijamur sediaan krim ekstrak etanol daun salam dan mengevaluasi kestabilan fisik sediaan. Penelitian yang dilakukan bersifat eksperimental laboratorium. Ekstrak daun Salam diperoleh dengan cara maserasi menggunakan etanol 96%. Sediaan krim dibuat dengan variasi konsentrasi formula ekstrak daun Salam 1%; 3%; 6% dan 9%. Metode yang digunakan untuk uji efektivitas antijamur yaitu metode sumuran. Hasil pengujian antijamur menunjukkan nilai diameter rata-rata pada formula I (1%) 6.67 mm; formula II (3%) 9.5 mm; formula III (6%) 10.83 mm dan formula IV (9%) 15 mm. Uji statistika krim ekstrak etanol daun salam menghasilkan zona hambat terbesar yaitu 15 mm pada formula IV konsentrasi 9%. Evaluasi fisik menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptik, homogenitas, pH 4.83, daya sebar 5.30 cm, dan daya lekat 7.01 detik. Dapat disimpulkan bahwa ekstrak etanol daun salam dapat diformulasikan menjadi sediaan krim yang stabil secara fisik dan memiliki aktivitas antijamur yang kuat. Kata kunci: Daun Salam, Krim Antijamur, Candida albicans

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FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN KALIANDRA (Calliandra surinamensis Benth) SEBAGAI ANTIBAKTERI

PHARMACON ◽

10.35799/pha.8.2019.29356 ◽

2019 ◽

Vol 8 (4) ◽

pp. 801

Author(s):

Yulita Ni Nyoman Tri Sukartiningsih ◽

Hosea Jaya Edi ◽

Jainer P. Siampa

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Activity ◽

Physical Stability ◽

Homogeneity Test ◽

Adhesion Test ◽

Cycling Test ◽

Physical Evaluation ◽

Before And After ◽

Gel Preparation ◽

Ethanol Extracts

ABSTRACT Kaliandra Leaf (Calliandra surinamensis Benth) contains flavonoid compounds, saponins and tannins which are able to inhibit the antibacterial activity. This study aims to test the antibacterial effectiveness of gel preparation of ethanol extracts of kaliandra leaf to obtain the greatest formula, and prove the Kaliandra leaf gel preparation has good physical stability. This study uses a laboratory experimental method. Gel formula is made as many as 5 formulas with variations in the concentration of 2%, 3%, 4%, 5%, and 6% of w : v. Kaliandra leaf extraction was carried out by maceration method using 96% ethanol. The antibacterial test of the ethanol extracts of Kaliandra leaf gel using the method of welling against Staphylococcus aureus bacteria produced a moderate inhibition of 7.0 ± 0.63 mm at a concentration of 6%. The physical evaluation of the preparation includes organoleptic test, homogeneity test, syneresis test, scatter power test, adhesion test, pH test, cycling test, and sterility test. All tests are carried out before and after the cycling test. The results of the study on the preparation fulfilled the physical evaluation requirements before and after the cycling test. It can be concluded that the concentration of 6% of ethanol extracts of Kaliandra leaves could be formulated as a gel preparation that is physically stable and has moderate antibacterial activity. Keywords: Kaliandra (Calliandra surinamensis Benth), Gel preparations, Staphylococcus aureus antibacterial. ABSTRAK Daun Kaliandra (Calliandra surinamensus Benth) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas antibakteri. Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan gel ekstrak etanol daun Kaliandra untuk mendapatkan formula terbesar, serta membuktikan sediaan gel daun Kaliandra mempunyai stabilitas fisik yang baik. Penelitian ini menggunakan metode ekperimental laboratorium. Formula sediaan gel dibuat sebanyak 5 formula dengan variasi konsentrasi 2%, 3%, 4%, 5%, dan 6% b/v. Ekstraksi daun Kaliandra dilakukan dengan metode maserasi menggunakan etanol 96%. Penelitian uji antibakteri sediaan gel ekstrak etanol daun Kaliandra menggunakan metode sumuran pada bakteri staphylococcus aureus menghasilkan daya hambat yang sedang yaitu 7,0±0,63 mm pada konsentrasi 6%. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji sineresis, uji daya sebar, uji daya lekat, uji pH, uji cycling test, dan uji sterilitas. Semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian sediaan memenuhi persyaratan eveluasi fisik sebelum uji cycling test dan sesudah cycling test. Dapat disimpulkan pada kosentrasi 6% ekstrak etanol daun Kaliandra dapat diformulasi sebagai sediaan gel yang stabil secara fisik dan memiliki aktivitas antibakteri yang sedang. Kata kunci : Kaliandra (Calliandra surinamensis Benth), Sediaan Gel, Antibakteri Staphlococcous aureus.

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FORMULASI SEDIAAN KRIM EKSTRAK ETANOL DAUN KALIANDRA (Calliandra surinamensis) DAN UJI AKTIVITAS ANTIBAKTERINYA TERHADAP BAKTERI Staphylococcus aureus

PHARMACON ◽

10.35799/pha.8.2019.29357 ◽

2019 ◽

Vol 8 (4) ◽

pp. 809

Author(s):

Gichella C. J. Somba ◽

Hosea Jaya Edi ◽

Jainer P. Siampa

Keyword(s):

Leaf Extract ◽

Physical Stability ◽

Ethanolic Extract ◽

Ethanol Extract ◽

Physical Test ◽

Sterility Testing ◽

Cycling Test ◽

Test Parameters ◽

Before And After ◽

Inhibitory Power

ABSTRACT This study aims to test the antibacterial effectiveness of ethanolic extract of Kaliandra leaf cream and evaluate the preparations using parameters of physical properties, physical stability, and sterility. Kaliandra leaf (Calliandra surinamensis) contains compounds such as flavonoid, saponins and tannins that can inhibit the growth of bacteria. This research uses laboratory experimental methods. Cream preparation formula is made with variations in the concentration of ethanol extract of Kaliandra leaves 2%, 3%, 4%, 5%, 6%. Kaliandra leaf extract was obtained by maceration using 96% ethanol solvent. The study of antibacterial test of ethanol extract of Kaliandra leaf extract using the method of Staphylococcus aures produced inhibitory power of 5.09 ± 0.88 mm at a concentration of 6%. The physical evaluation of the cream preparation includes organoleptic examination (odor, color, shape), homogeneity, pH testing, adhesion, dispersion, cycling test. All tests are carried out before and after the cycling test. The results obtained before and after the cycling test showed that the cream preparations met organoleptic requirements, homogeneity, cream pH 6.07 (4.5-6.5), cream adhesion 4.59 seconds (<4 seconds), cream dispersion 6.19 cm (5-7 cm). Cream sterility testing shows that the cream is sterile. It can be concluded that the ethanol extract of Kaliandra leaves cream meets the physical test parameters, is stable and has moderate antibacterial activity. Keywords : Kaliandra Leaf (Calliandra surinamensis), Cream, Antibacterial, Staphylococcous aureus. ABSTRAK Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan krim ekstrak etanol daun Kaliandra dan mengevaluasi sediaan dengan menggunakan parameter uji sifat fisik, stabilitas fisik, dan sterilitas. Daun Kaliandra (Calliandra surinamensis) merupakan tanaman yang mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini menggunakan metode eksperimental laboratorium, Formula sediaan krim dibuat dengan variasi konsentrasi ekstrak etanol daun Kaliandra 2%, 3%, 4%, 5%, 6%. Ekstrak daun Kaliandra diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Penelitian uji antibakteri sediaan krim esktrak etanol daun Kaliandra menggunakan metode sumuran pada bakteri Staphylococcus aures menghasilkan daya hambat 5,09±0,88 mm pada konsentrasi 6%. Evaluasi fisik sediaan krim meliputi pemeriksaan organoleptis (bau, warna, bentuk), homogenitas, pengujian pH, daya lekat, daya sebar, uji cycling test. Semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian yang didapat sebelum dan sesudah cycling test menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptis, homogenitas, pH krim 6,07 (4,5-6,5), daya lekat krim 4,59 detik (<4 detik), daya sebar krim 6,19 cm (5-7 cm). Pengujian sterilitas krim menunjukan bahwa krim steril. Dapat disimpulkan bahwa sediaan krim ekstrak etanol daun Kaliandra memenuhi parameter uji fisik, stabil dan memiliki aktivitas antibakteri yang sedang. Kata kunci : Daun Kaliandra (Calliandra surinamensis), Krim, Antibakteri, Staphlococcous aureus.

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FORMULASI DAN UJI ANTIBAKTERI GEL EKSTRAK ETANOL DAUN KEDONDONG (Spondias dulcis) TERHADAP BAKTERI Pseudomonas aeruginosa

PHARMACON ◽

10.35799/pha.9.2020.27404 ◽

2020 ◽

Vol 9 (1) ◽

pp. 8

Author(s):

Kevin Yosua Pakpahan ◽

Paulina V. Y. Yamlean ◽

Imam Jayanto

Keyword(s):

Pseudomonas Aeruginosa ◽

Ethanol Extract ◽

Homogeneity Test ◽

Cycling Test ◽

Physical Evaluation ◽

Before And After ◽

Dispersion Test ◽

Gel Preparation ◽

Ethanol Extracts ◽

Weak Antibacterial Activity

ABSTRACT Kedondong leaves (Spondias dulcis) contain flavonoid compounds, saponins and tannins that inhibit bacterial activity. This study aims to formulate, evaluate, and test the antibacterial effectiveness of the ethanol extracts gel of the Kedondong leaves (Spondias dulcis) at a concentration of 6%, 8%, 10%, respectively. This study uses an experimental method by testing the physical evaluation requirements of gel preparations. Physical evaluation of preparations includes organoleptic test, homogeneity test, pH test, dispersion test, adhesion test and cycling test, all tests are carried out before and after the cycling test. The results of the study on the gel dispersion test did not meet the physical evaluation requirements before the cycling test and after the cycling test there was a synergetic and did not meet the requirements. Antibacterial test of ethanol extracts gel of Kedondong leaves against Pseudomonas aeruginosa produced weak inhibitory properties. It can be concluded that the gel concentration of 6%, 8%, 10% of ethanol extract of Kedondong leaves cannot be formulated as a gel preparation because it is less physically stable and has weak antibacterial activity. Keywords: Antibacterial, HPMC Gel, Kedondong (Spondias dulcis), Pseudomonas aeruginosa ABSTRAK Daun Kedondong (Spondias dulcis) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan gel ekstrak etanol daun Kedondong (Spondias dulcis) pada kosentrasi 6%, 8%, 10%. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik sediaan gel. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian pada uji daya sebar sediaan gel tidak memenuhi persyaratan eveluasi fisik sebelum uji cycling test dan setelah cycling test terjadi sineresis dan tidak memenuhi syarat. Penelitian uji antibakteri sediaan gel ekstrak etanol daun Kedondong pada bakteri Pseudomonas aeruginosa menghasilkan daya hambat yang lemah. Dapat disimpulkan pada gel kosentrasi 6%, 8%, 10% ekstrak etanol daun Kedondong tidak dapat diformulasi sebagai sediaan gel karena kurang stabil secara fisik dan memiliki aktivitas antibakteri yang lemah. Kata kunci : Antibakteri, Gel HPMC, Kedondong (Spondias dulcis), Pseudomonas aeruginosa

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FORMULASI DAN EFEK ANTIBAKTERI MASKER PEEL-OFF EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphlococcous epidermidis

PHARMACON ◽

10.35799/pha.8.2019.29393 ◽

2019 ◽

Vol 8 (3) ◽

pp. 686

Author(s):

Regita Daimunon ◽

Paulina V. Y. Yamlean ◽

Imam Jayanto

Keyword(s):

Staphylococcus Epidermidis ◽

Ethanol Extract ◽

Homogeneity Test ◽

Power Test ◽

Cycling Test ◽

Physical Evaluation ◽

Before And After ◽

Time Test ◽

Ethanol Extracts ◽

Muntingia Calabura

ABSTRACT Kersen leaf (Muntingia calabura L.) contains flavonoids, saponins and tannins, which could inhibit bacterial activity. This study aimed to formulate, evaluate, and to test the effectiveness of antibacterial preparations for the Kersen leaf ethanol extracts mask. This study uses the experimental method by testing the parameters of the physical evaluation requirements for the masker. Physical evaluation of preparations included organoleptic test, homogeneity test, pH test, scattering power test, dry time test, sticky test and cycling test, all tests were carried out before and after cycling test. The results of the preparation study meet the requirements of physical evaluation before the cycling test but after the cycling test is is not in accordance to the requirements for the preparation of the peel-off mask. The antibacterial test of mask peel-off ethanol extract of Kersen's leaves on Staphylococcus epidermidis bacteria produced a moderate inhibition. So it can be concluded that the ethanol extracts of Kersen leaves at a concentration of 20%. can be formulated as a peel-off mask that is physically stable and has moderate antibacterial activity.Keywords: Kersen, Peel-off mask, Antibacterial, Staphlococcous epidermidis ABSTRAK Daun Kersen (Muntingia calabura L.) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan masker peel-off ekstrak etanol daun Kersen. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik masker peel-off. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji waktu sediaan mengering, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian sediaan memenuhi persyaratan eveluasi fisik sebelum uji cycling test namun setelahnya tidak sesuai dengan persyaratan sediaan masker peel-off. Penelitian uji antibakteri masker peel-off ekstrak etanol daun Kersen pada bakteri staphylococcus epidermidis menghasilkan daya hambat yang sedang. Dapat disimpulkan pada kosentrasi 20% ekstrak etanol daun Kersen dapat diformulasi sebagai sediaan masker peel-off yang stabil secara fisik dan memiliki aktivitas antibakteri yang sedang .Kata kunci : Kersen, Masker peel-off, Antibakteri, Staphlococcous epidermidis

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FORMULASI DAN UJI EFEKTIVITAS ANTIOKSIDAN SEDIAAN MASKER PEEL-OFF EKSTRAK ETANOL DAUN SESEWANUA (Cleodendron squamatum Vahl.)

PHARMACON ◽

10.35799/pha.8.2019.29305 ◽

2019 ◽

Vol 8 (2) ◽

pp. 388

Author(s):

Ferrna Rompis ◽

Paulina V. Y. Yamlean ◽

Widya A. Lolo

Keyword(s):

Ethanol Extract ◽

Homogeneity Test ◽

Analytic Method ◽

Drying Time ◽

Power Test ◽

Cycling Test ◽

Physical Evaluation ◽

Antioxidant Effectiveness ◽

Before And After ◽

Time Test

ABSTRACT Sesewanua leaves (Cleodendron squamatum Vahl.) contain alkaloids and flavonoids which are efficacious as antioxidants. This study aimed to fomulate, evaluate, and test the effectiveness of antioxidants in the form of peel-off mask of ethanol extract from the Sesewanua leaves. This study used descriptive-analytic method with the treatment of variations in concentrations of PVA 12 % , 14% and 16 %, respectively. Physical evaluation of preparations included organoleptic observation, homogeneity test, pH test, scattering power test, drying time test, and cycling test, all tests were carried out before and after the cycling test. The results showed that all preparations met the requirements of physical evaluation before the cycling test while after the cycling test only preparations with 12% PVA concentrations met the requirement, whereas preparations with 14% and 16% of PVA did not met the requirement after the cycling test and after testing antioxidant effectiveness using the DPPH (1,1-diphenyl-2-pikrilhidrazil) method were obtained. The value of IC50 before cycling test was 179.120 mg/L and after cycling test was 504.74mg/L. Based on the results of the study it can be concluded that the ethanol extract of Sesewanua leaves can be formulated into a peel-off mask with 12% PVA concentration which is physically stable and has moderate antioxidant effectiveness before the cycling test, while after cycling test the preparation of peel-off mask ethanol extract of Sesewanua leaves is less effective as an antioxidant. Keywords: Sesewanua leaves (Cleodendron squamatum Vahl.), peel-off mask, antioxidantsABSTRAK Daun Sesewanua (Cleodendron squamatum Vahl.) mengandung alkaloid dan flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antioksidan sediaan masker peel-off ekstrak etanol daun Sesewanua. Penelitian ini menggunakan metode deskriptif-analitik dengan perlakuan variasi konsentrasi PVA 12%, 14% dan 16%. Evaluasi fisik sediaan meliputi pengamatan organoleptik, uji homogenitas, uji pH, uji daya sebar, uji waktu mengering dan uji cycling test semua pengujian dilakukan sebelum dan sesudah uji cycling test. Hasil penelitian menunjukkan bahwa semua sediaan memenuhi persyaratan evaluasi fisik sebelum uji cycling test sedangkan setelah uji cycling test hanya sediaan dengan konsentrasi PVA 12% yang memenuhi persyaratan sedangkan sediaan dengan konsentrasi PVA 14% dan 16% tidak memenuhi persyaratan setelah uji cycling test, dan setelah dilakukan uji efektivitas antioksidan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil) diperoleh nilai IC50 sebelum uji cycling test sebesar 179,120 mg/L dan sesudah cycling test sebesar 504,74 mg/L. Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak etanol daun Sesewanua dapat diformulasi menjadi sediaan masker peel-off dengan konsentrasi PVA 12% yang stabil secara fisik dan memiliki efektivitas antioksidan yang sedang sebelum uji cycling test sedangkan setelah cycling test sediaan masker peel-off ektrak etanol daun sesewanua kurang efektif sebagai antioksidan. Kata Kunci : Sesewanua (Cleodendron squamatum Vahl.), masker peel-off, Antioksidan.

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Uji Stabilitas Fisik Formula Sediaan Gel Ekstrak Daun Kelor (Moringa Oleifera Lamk.)

Jurnal Ilmiah Kesehatan ◽

10.48144/jiks.v13i2.260 ◽

2020 ◽

Vol 13 (2) ◽

pp. 115-122

Author(s):

S Slamet ◽

Bibah Dewi Anggun ◽

Dwi Bagus Pambudi

Keyword(s):

Leaf Extract ◽

Moringa Oleifera ◽

Physical Stability ◽

Stability Test ◽

Stability Parameters ◽

Cycling Test ◽

Dispersion Test ◽

Gel Preparation ◽

The Stability ◽

Moringa Leaf Extract

Abstrak. Tanaman kelor mempunyai khasiat sebagai antibakteri. Penambahan ekstrak daun kelor (Moringa oleifera Lamk.) di dalam sediaan gel diperkirakan dapat mempengaruhi stabilitas fisik sediaan tersebut. Penelitian ini bertujuan menguji stabilitas fisik sediaan gel yang mengandung ekstrak daun kelor (Moringa oleifera Lamk.) pada berbagai konsentrasi (1%, 3% dan 5%). Uji stabilitas fisik sedian gel dilakukan setelah penyimpanan selama 14 hari pada suhu ruangan dan uji cycling test (2o±40o C). Parameter stabilitas adalah organoleptis, uji daya sebar, uji daya lekat, pH, viskositas dan cycling test. Hasil ketiga formulasi menunjukkan stabilitas yang sesuai persyaratan sediaan gel diuji pada pengamatan organoleptis, daya sebar, daya lekat, pH, viskositas dan hasil uji cycling test. Kata kunci : Gel, Kelor, Stabilitas Fisik Physical Stability Test Formula Ready Gel Moringa Leaf Extract (Moringa Oleifera Lamk.) Abstract. Moringa plants have efficacy as an antibacterial. The addition of moringa leaf extract (Moringa oleifera Lamk.) preparation required to affect the physical stability of the preparation. The study aims to test the physical stability of gel preparations containing Moringa oleifera Lamk. Leaf extract at various concentrations (1%, 3% and 5%). gel formula physical stability test was carried out after storage for 14 days at room temperature and the cycling test (2o ± 40o C). The stability parameters are organoleptic, dispersion test, adhesion test, pH, viscosity, cycling test. The results of the three formulations showed that stability according to the requirements of the gel preparation. Gel preparation tested on observations of organoleptic, spreadability, adhesion, pH, viscosity, and cycling test results. Keyword: Gel, Moringa, Physical Stability

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Uji Formulasi dan Uji Efektivitas Repelan Lotion Ekstrak Daun Tembakau (nicotiana tabacum. L) Terhadap Nyamuk Aedes Aegypti

Prosiding Seminar Nasional Kesehatan ◽

10.48144/prosiding.v1i.958 ◽

2021 ◽

Vol 1 ◽

pp. 1968-1976

Author(s):

Rojiah Batsah ◽

W Wirasti ◽

F Fitriyani

Keyword(s):

Aedes Aegypti ◽

Leaf Extract ◽

Physical Stability ◽

Ethanol Extract ◽

Tobacco Leaves ◽

Tobacco Leaf ◽

Nicotiana Tabaccum ◽

Cycling Test ◽

Significant Difference ◽

One Way Anova

AbstractTobacco leaves (Nicotiana tabaccum. L) have great potential as a pesticide or insect repellent, especially the Aedes aegypti mosquito. Maceration method was used to obtain tobacco leaf extract as much as 127.86 grams from the dried simplicia of tobacco leaves (Nicotiana tabaccum. L) 827 grams (yield 15.46%). The tobacco extract was made in the form of lotio with a concentration of 1%, 2%, and 3%, having repellant effectiveness of 90%, 96% and 100%, respectively. Physical stability test was carried out on the lotion 0%, 1%, 2%, and 3% as follows; organoleptic test (brownish color, typical tobacco aroma and homogeneity), spreadability test (6.1cm; 6.1cm; 6.2cm; 6.4cm), adhesion test (3.06sec; 2.8sec; 2.75sec; 2.61sec), cycling test (brownish color, thick consistency, homogeneity, and distinctive aroma of tobacco), pH test (7; 7; 7; 6,3), and viscosity test (4.708cPs, 4.575cPs, 4.465cPs, 4.403cPs). The results of One Way ANOVA analysis showed that there was a significant difference in each concentration of tobacco leaf extract lotio and Tukey's test showed that the repellant ability of 3% concentration had 100% percent repelance. It can be concluded that the ethanol extract lotion of tobacco leaves (Nicotiana tabaccum. L) has repellant effectiveness.Keywords: tobacco leaves, extract, lotion, repellant, ANOVA AbstrakDaun tembakau (Nicotiana tabaccum. L) memiliki potensi besar sebagai pestisida atau pengusir serangga khususnya nyamuk Aedes aegypti. Metode maserasi digunakan untuk mendapatkan ekstrak daun tembakau sebanyak 127,86 gram dari simplisia kering daun tembakau (Nicotiana tabaccum. L) 827 gram (rendemen 15,46%). Ekstrak tembakau dibuat dalam bentuk lotio dengan konsentrasi 1%, 2%, dan 3% memiliki efektivitas repelan berturut-turut adalah 90%, 96% dan 100%. Dilakukan uji stabilitas fisik terhadap lotio 0%,1%, 2%, dan 3% sebagai berikut; uji organoleptis (warna kecoklatan, aroma khas tembakau dan homogen), uji daya sebar (6,1cm; 6,1cm; 6,2cm; 6,4cm), uji daya lekat (3,06detik; 2,8detik; 2,75detik; 2,61detik), uji cycling test (warna kecoklatan, konsistensi kental, homogen, dan aroma khas tembakau), uji pH (7;7;7;6,3), dan uji viskositas (4.708cPs, 4.575cPs, 4.465cPs, 4.403cPs). Hasil analisis One Way ANOVA menunjukkan adanya perbedaan yang signifikan pada setiap konsentrasi lotio ekstrak daun tembakau dan uji Tukey menunjukkan kemampuan repelan konsentrasi 3% memiliki persen repelansi 100%. Hal ini dapat disimpulkan bahwa lotio ekstrak etanol daun tembakau (Nicotiana tabaccum. L) memiliki efektivitas repelan.Kata kunci: : daun tembakau; ekstrak; lotion; repelan; ANOVA

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FORMULASI DAN UJI STABILITAS FISIK SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL DAUN MIANA (Coleus Scutelleroides (L.) Benth.) DENGAN BERBAGAI BASIS

Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) ◽

10.35799/pmj.4.1.2021.34523 ◽

2021 ◽

Vol 4 (1) ◽

pp. 36

Author(s):

Indriyani Arman,Hosea Jaya Edy, Karlah L.R Mansauda

Keyword(s):

Physical Stability ◽

Ethanol Extract ◽

Homogeneity Test ◽

Adhesion Test ◽

Physical Quality ◽

Test Parameters ◽

Different Types ◽

Time Test ◽

Dispersion Test ◽

The Stability

AbstractMiana leaves (Coleus Scutelleroides (L.) Benth.) contained flavonoid compounds that has antioxidants properties. This study aimed to formulate peel-off gel mask ethanol extract from Miana leaves became peel-off gel mask that is physically stable and to knows the type of base that form a formulation with good physical quality based on the test parameters of physical properties and the stability of preparation. Formulation of peel-off gel mask ethanol extract of miana leaves used three different types of base, they are HPMC, Carbopol, and Na.CMC. Each formula is differentiated based on base of concentration which were HPMC 4%, carbopol 1%, and Na.CMC 3%. Evaluation to predict the physical stability of the preparation included organoleptic test, homogeneity test, pH test, dispersion test, adhesion test and dry time test. In stability test, each formula is placed at temperature 27 oC for 28 days and made observation on the 1st, 7th, 14th, 21th, and 28th day. Based on the result, the ethanol extract of Miana leaves can be formulated into a peel-off mask and formulation with HPMC and Carbopol base has a good physical quality and physically stable compared to Na.CMC base.Keywords: Miana Leaves, Peel-Off Gel Mask, Stability Teh AbstrakDaun Miana (Coleus Scutelleroides (L.) Benth.) memiliki kandungan senyawa flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk memformulasikan ekstrak etanol daun Miana menjadi masker gel peel-off yang stabil secara fisik serta mengetahui jenis basis yang membentuk formulasi sediaan masker dengan mutu fisik yang baik berdasarkan parameter uji sifat fisik dan stabilitas sediaan. Formulasi sediaan masker gel peel-off ekstrak etanol daun Miana dibuat dengan menggunakan tiga jenis basis yang berbeda yaitu HPMC, karbopol, dan Na.CMC. Masing-masing formula dibedakan berdasarkan basis konsentrasi yaitu HPMC 4%, karbopol 1%, dan Na.CMC 3%. Evaluasi yang dilakukan terhadap stabilitas fisik sediaan masker gel peel-off meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, dan uji waktu mengering. Uji stabilitas dilakukan pada suhu kamar (27 oC) selama 28 hari dan dilakukan pengamatan pada hari ke 1, 7, 14, 21, dan 28. Hasil uji stabilitas fisik sediaan masker gel peel-off ekstrak etanol daun Miana dapat diformulasikan dalam bentuk sediaan masker gel peel-off , dan formula masker dengan basis HPMC dan karbopol memiliki mutu fisik yang baik dan stabil secara fisik dibandingkan dengan basis Na.CMC.Kata kunci: Daun Miana, Masker gel peel-off, Uji Stabilitas.

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Formulasi Sediaan Krim Dari Ekstrak Kulit Pisang Kapas (Musa paradisiaca Linn).

Prosiding Seminar Nasional Kesehatan ◽

10.48144/prosiding.v1i.786 ◽

2021 ◽

Vol 1 ◽

pp. 1035-1045

Author(s):

D Dananirroh ◽

Urmatul Waznah ◽

W Wirasti ◽

S Slamet

Keyword(s):

Ethanol Extract ◽

Banana Peel ◽

Homogeneity Test ◽

Herbaceous Plant ◽

Test Results ◽

Adhesion Test ◽

Banana Plant ◽

Musa Paradisiaca ◽

Physical Evaluation ◽

Dispersion Test

AbstractMusa paradisiaca Linn, also known as the banana plant in Indonesia, is a herbaceous plant that belongs to the Musaceaa family. Cotton banana peel (Musa paradisiaca Linn.) can be used as a wound medicine. For use, it is still simple, namely by applying the inside of the banana peel to the injured body part, and by scraping the banana peel from the inside to bandage the wound. For this reason, it is necessary to develop a dosage form of this cotton banana peel so that it is easier and provides comfort in its use. Purpose: To find out the skin of cotton banana (Musa paradisiaca Linn) is formulated in cream preparations. The method in this study was experimental, the sample was extracted by maceration using 96% ethanol as solvent. The viscous extract obtained was used at concentrations of 0.08%, 0.10%, and 0.12%. The results showed that cotton banana peel extract (Musa paradisiaca Linn) could be made as a cream and fulfilled the physical evaluation of the preparation. The results of the homogeneity test were that the preparations were made homogeneous, the pH of the cream was obtained at pH 5-7 still fulfilling the skin pH range of 4-7, the adhesion test results obtained more than 5 seconds, the dispersion test results obtained 6-7 cm, the viscosity test at formula I is 3564 – 4253 cPas, Formula II is 4042 – 4746 cPas, Formula III is 4466 – 5254 cPas. The conclusion of this study, the formulation of the ethanol extract cream of cotton banana peel (Musa paradisiaca Linn) met the requirements for physical evaluation of the preparation including homogeneity test, pH test, organoleptic test, dispersibility test, adhesion test, viscosity test and stability test.Keywords: Formulation, banana peel, cream, evaluation. AbstrakMusa paradisiaca Linn atau dikenal dengan nama tumbuhan pisang di Indonesia adalah tumbuhan herba yang termasuk dalam keluarga Musaceaa. Kulit buah pisang kapas (Musa paradisiaca Linn.) dapat digunakan sebagai obat luka. Untuk penggunaan masih sederhana yaitu dengan mengoleskan bagian dalam dari kulit buah pisang pada bagian tubuh yang luka, dan dengan cara mengorek kulit buah pisang dari dalam untuk membalut luka. Untuk itu perlu adanya pengembangan bentuk sediaan dari kulit pisang kapas ini sehingga lebih memudahkan dan memberikan kenyamanan dalam penggunaannya. Tujuan Untuk mengetahui kulit buah pisang kapas (Musa paradisiaca Linn) diformulasikan dalam sediaan krim. Metode pada penelitian ini dilakukan secara eksprimental, sampel di ekstraksi dengan cara maserasi dengan menggunakan pelarut etanol 96%. Ekstrak kental yang diperoleh digunakan pada konsentrasi 0.08%, 0.10%, dan 0.12%. Hasil penelitian menunjukkan bahwa ekstrak kulit pisang kapas (Musa paradisiaca Linn) dapat dibuat sebagai krim dan memenuhi evaluasi fisik sediaan. Hasil uji homogenitas bahwa sediaan yang dibuat homogen, pH krim diperoleh pH 5-7 masih memenuhi kisaran pH kulit 4-7, uji daya lekat hasil yang diperoleh lebih dari 5 detik, uji daya sebar hasil yang diperoleh 6 – 7 cm, uji viskositas pada formula I yaitu 3564 – 4253 cPas, Formula II yaitu 4042 – 4746 cPas, Formula III yaitu 4466 – 5254 cPas. Kesimpulan pada penelitian ini, formulasi sediaan krim ekstrak etanol kulit pisang kapas (Musa paradisiaca Linn) memenuhi syarat evaluasi fisik sediaan meliputi uji homogenitas , uji pH, uji organoleptis, uji daya sebar, uji daya lekat, uji viskositas dan uji stabilias.Kata kunci: Formulasi, kulit pisang, krim, evaluasi.

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