scholarly journals Konsumsi Kopi untuk Mencegah Penyakit Alzheimer

2020 ◽  
Vol 12 (2) ◽  
pp. 996-1002
Author(s):  
Bimo Husodo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Skills ◽  
Coffee Consumption ◽  
Brain Health ◽  
Literature Study ◽  
National Journal ◽  
Positive Effects ◽  
The Brain ◽  
Preventive Effects

Abstract. Coffee is one of the most consumed beverages in the world and most adults drink coffee every day. Coffee contains hundreds of bioactive compounds, including caffeine, chlorogenic acid, polyphenols, and small amounts of minerals and vitamins, which are known to have positive effects on brain health. Alzheimer's disease is a degenerative disease of the brain and the most common cause of dementia characterized by decreased memory, language, problem solving and other cognitive skills that affect a person's ability to perform daily activities. The purpose of this literature study is to determine the benefits of coffee consumption in preventing Alzheimer's disease. Method. This research is a literature study and library sources used involving 15 libraries from 1 national journal and 14 international journals. Result. Several studies have shown the preventive effects of coffee on Alzheimer's disease and cognitive decline through various mechanisms such as a role in lowering plasma Aβ levels, as well as an antioxidant that can reduce inflammation and protect against dementia. Conclusion. Coffee can have a protective effect on Alzheimer's disease and is safe to consume if it does not exceed the recommended dosage. Abstract. Kopi adalah salah satu minuman yang paling banyak dikonsumsi di dunia dan sebagian besar or ang dewasa minum kopi setiap hari. Kopi mengandung ratusan senyawa bioaktif, termasuk kafein, asam klorogenat, polifenol, dan sejumlah kecil mineral dan vitamin yang di antaranya diketahui memiliki efek positif bagi kesehatan otak. Penyakit Alzheimer adalah penyakit degeneratif pada otak dan penyebab paling umum dari demensia yang ditandai dengan penurunan daya ingat, bahasa, pemecahan masalah, dan keterampilan kognitif lain yang memengaruhi kemampuan seseorang untuk melakukan aktivitas sehari-hari. Tujuan dari studi literatur ini adalah untuk mengetahui manfaat konsumsi kopi untuk mencegah penyakit Alzheimer.  Metode. Penelitian ini merupakan studi literatur dan sumber pustaka yang digunakan melibatkan 15 pustaka yang berasal dari 1 jurnal nasional dan 14 jurnal internasional. Hasil. Beberapa studi menunjukkan efek pencegahan dari kopi pada penyakit Alzheimer dan penurunan kognitif melalui berbagai mekanisme misalnya berperan dalam penurunan kadar Aβ plasma,serta sebagai antioksidan yang dapat mengurangi peradangan dan melindungi dari demensia. Kesimpulan. Kopi dapat memberikan efek protektif pada penyakit alzheimer serta aman dikonsumsi apabila tidak melebihi dosis yang dianjurkan

scholarly journals Big data to smart data in Alzheimer's disease: The brain health modeling initiative to foster actionable knowledge

2016 ◽  
Vol 12 (9) ◽  
pp. 1014-1021 ◽  
Author(s):  
Hugo Geerts ◽  
Penny A. Dacks ◽  
Viswanath Devanarayan ◽  
Magali Haas ◽  
Zaven S. Khachaturian ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Big Data ◽  
Brain Health ◽  
Actionable Knowledge ◽  
Smart Data ◽  
The Brain

scholarly journals Microarray Profile of Long Noncoding RNA and Messenger RNA Expression in a Model of Alzheimer’s Disease

Life ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 64
Author(s):  
Linlin Wang ◽  
Li Zeng ◽  
Hailun Jiang ◽  
Zhuorong Li ◽  
Rui Liu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Skills ◽  
Messenger Rna ◽  
Noncoding Rna ◽  
Model Of Alzheimer’S Disease ◽  
Conserved Genes ◽  
Novel Biomarkers ◽  
The Brain ◽  
Ad Mouse Model

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by a deficiency in cognitive skills. Although long noncoding RNAs (lncRNAs) have been proposed as associated with AD, the aberrant lncRNAs expression and the co-expression of lncRNAs-mRNAs network in AD remains unclear. Therefore, in this study, lncRNA microarray was performed on the brain of APP/PS1 mice at different age, widely used as an AD mouse model, and on age-matched wide-type controls. Our results identified a total of 3306 lncRNAs and 2458 mRNAs as aberrantly expressed among AD mice at different age and their age-matched control. Gene Ontology and pathway analysis of the AD-related lncRNAs and mRNAs indicated that neuroinflammation-related and synaptic transmission signaling pathways represented the main enriched pathways. An lncRNA–mRNA–miRNA network between the differentially expressed transcripts was constructed. Moreover, an mRNA–miRNA network between both significantly dysregulated and highly conserved genes was also constructed, and among this network, the IGF1, P2RX7, TSPO, SERPINE1, EGFR, HMOX1, and NFE212 genes were predicted to play a role in the development of AD. In conclusion, this study illustrated the prognostic value of lncRNAs and mRNAs associated to AD pathology by microarray analysis and might provide potential novel biomarkers in the diagnosis and treatment of AD.

“Brain-Specific” Nutrients: A Memory Cure?

2002 ◽  
Vol 3 (1) ◽  
pp. 12-38 ◽  
Author(s):  
Mark A. McDaniel ◽  
Steven F. Maier ◽  
Gilles O. Einstein
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Animal Studies ◽  
Memory Decline ◽  
Memory Tests ◽  
Positive Effects ◽  
Age Related ◽  
Per Se ◽  
The Brain

We review the experimental evaluations of several widely marketed nonprescription compounds claimed to be memory enhancers and treatments for age-related memory decline. We generally limit our review to double-blind placebo-controlled studies. The compounds examined are phos-phatidylserine (PS), phosphatidylcholine (PC), citicoline, piracetam, vinpocetine, acetyl-L-carnitine (ALC), and antiox-idants (particularly vitamin E). In animals, PS has been shown to attenuate many neuronal effects of aging, and to restore normal memory on a variety of tasks. Preliminary findings with humans, though, are limited. For older adults with probable Alzheimer's disease, a single study failed to demonstrate positive effects of PS on memory performance. For older adults with moderate cognitive impairment, PS has produced consistently modest increases in recall of word lists. Positive effects have not been as consistently reported for other memory tests. There is one report of consistent benefits across a number of memory tests for a subset of normal adults who performed more poorly than their peers at baseline. The choline compounds PC and citicoline are thought to promote synthesis and transmission of neurotransmitters important to memory. PC has not proven effective for improving memory in patients with probable Alzheimer's disease. The issue remains open for older adults without serious degenerative neural disease. Research on citicoline is practically nonexistent, but one study reported a robust improvement in story recall for a small sample of normally aging older adults who scored lower than their peers in baseline testing. Animal studies suggest that piracetam may improve neuronal efficiency, facilitate activity in neurotransmitter systems, and combat the age-related decrease in receptors on the neuronal membrane. However, for patients with probable Alzheimer's disease, as well as for adults with age-associated memory impairment, there is no clear-cut support for a mnemonic benefit of piracetam. Vinpocetine increases blood circulation and metabolism in the brain. Animal studies have shown that vinpocetine can reduce the loss of neurons due to decreased blood flow. In three studies of older adults with memory problems associated with poor brain circulation or dementia-related disease, vinpocetine produced significantly more improvement than a placebo in performance on global cognitive tests reflecting attention, concentration, and memory. Effects on episodic memory per se have been tested minimally, if at all. ALC participates in cellular energy production, a process especially important in neurons, and in removal of toxic accumulation of fatty acids. Animal studies show that ALC reverses the age-related decline in the number of neuron membrane receptors. Studies of patients with probable Alzheimer's disease have reported nominal advantages over a range of memory tests for ALC-treated patients relative to placebo groups. Significant differences have been reported rarely, however. Whether ALC would have mnemonic benefits for aging adults without brain disease is untested as far as we know. Antioxidants help neutralize tissue-damaging free radicals, which become more prevalent as organisms age. It is hypothesized that increasing antioxidant levels in the organism might retard or reverse the damaging effects of free radicals on neurons. Thus far, however, studies have found that vitamin E does not significantly slow down memory decline for Alzheimer's patients and does not produce significant memory benefits among early Parkinson's patients. Neither did a combination of vitamins E and C significantly improve college students' performance on several cognitive tasks. In sum, for most of the “brain-specific” nutrients we review, some mildly suggestive effects have been found in preliminary controlled studies using standard psychometric memory assessments or more general tests designed to reveal cognitive impairment. We suggest that future evaluations of the possible memory benefits of these supplements might fruitfully focus on memory processes rather than on memory tests per se.

O1-10-06: Internet-based recruitment of subjects for prodromal and secondary prevention Alzheimer's disease trials using the brain health registry

2015 ◽  
Vol 11 (7S_Part_3) ◽  
pp. P156-P156
Author(s):  
Rachel L. Nosheny ◽  
Derek Flennkiken ◽  
Philip S. Insel ◽  
Shannon Finley ◽  
Scott Mackin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Secondary Prevention ◽  
Brain Health ◽  
Health Registry ◽  
The Brain

Increase your Brainability—and Reduce your Risk of Dementia

2021 ◽  
Author(s):  
Charles Alessi ◽  
Larry W. Chambers ◽  
Muir Gray
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Health Service ◽  
Brain Tissue ◽  
Blood Supply ◽  
Medical Profession ◽  
Brain Health ◽  
The Mind ◽  
The Brain

Our experience is that many people including many members of the medical profession are confused about what happens to our brains and minds as we live longer. Consistently, they overestimate the effects of ageing and underestimate the potential for improving the ability of the brain and the mind no matter what age you may be. Linked to this is the fact that, although Alzheimer’s disease cannot be prevented, the risk of dementia can be reduced by at least a third because there are many other causes of dementia than Alzheimer’s disease having to do with healthy brain tissue, blood supply to the brain and ability to interact with people and ideas. With this knowledge, we outline steps individuals can take themselves, with family and friends, their community and the health service to improve brain health.

scholarly journals Growth Hormone (GH) Administration Increases the Metabolic Activity of the left Hippocampus in an Elder Patient with Cognitive Disorders

2018 ◽  
Author(s):  
Jesús Devesa ◽  
Iria Núñez ◽  
Carlos Agra ◽  
Alejandro Bejarano ◽  
Pablo Devesa
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Hormone ◽  
Metabolic Activity ◽  
Verbal Learning ◽  
Pet Scan ◽  
Cognitive Test ◽  
Positive Effects ◽  
Left Hippocampus ◽  
The Brain

1) Background: We analyzed, by PET-SCAN, how growth hormone (GH) might act on the brain of a not GH-deficient elder woman who suspected that she was developing Alzheimer's disease; 2) Methods: After performing a first psychometric study (TAVEC verbal learning test), the metabolic activity of brain structures related to cognition, memory and behavior was analyzed by 18-F Fluorodeoxyglucose PET-SCAN. The patient was then treated with GH (0.4 mg/day) during three weeks and the last day under this treatment a new PET-SCAN was carried out. One month after commencing the treatment with GH a new TAVEC test was performed; 3) Results: GH administration normalized the cognitive deficits observed in the first cognitive test and significantly (p < 0.025) increased (Voxel-Based Morphometry) the metabolic activity in the left hippocampus, left amygdala and left parahippocampus, but also in practically all brain cortical areas; 4) Conclusions: This is the first study in which the effects of GH on the brain have been visualized in images. Our data confirm the positive effects of this hormone on cognition and memories; although they do not allow us to conclude whether GH administration may be useful in the early stages of Alzheimer's disease, they seem to be promising.

scholarly journals Effects of Acupuncture on Alzheimer’s Disease in Animal-Based Research

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Sunjung Park ◽  
Jun-Hwan Lee ◽  
Eun Jin Yang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Studies ◽  
Sufficient Evidence ◽  
Therapeutic Effects ◽  
Functional Deficits ◽  
Positive Effects ◽  
Therapeutic Benefits ◽  
Preclinical And Clinical Studies ◽  
The Brain

Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles, and severe functional deficits in the brain. The pathogenesis and treatment of AD remain topics of investigation and significant global socioeconomic issues. The effect of complementary medicine has been investigated in managing AD. Acupuncture, a form of therapy practiced for more than 3000 years, has shown positive effects on several neurological disorders including AD. Animal studies have evaluated the specific utility and neuropathological mechanisms addressed by acupoint manipulation; however, no study has summarized the relationships among different acupoints and their therapeutic effects in the context of AD. Therefore, we reviewed the effects of acupuncture at different acupoints in animal models of AD. In general, acupuncture produced therapeutic benefits in rodent models of AD. Studies demonstrate the utility of GV20 as a valuable acupoint for electroacupuncture and manual acupuncture. GV20 stimulation suppresses Aβ generation, improves glucose metabolism, and attenuates neuropathological features in various disease models. However, a lack of sufficient evidence in preclinical and clinical studies makes these results controversial. Additional studies are required to confirm the exact utility of specific acupoints in clinically managing AD.

Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Aging ◽  
Brain Aging ◽  
Elderly Subjects ◽  
Additional Increase ◽  
Longitudinal Changes ◽  
Novel Method ◽  
The Brain

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.

The Weak Combined Magnetic Fields Reduce the Brain β-Amyloid in an Animal Model of Sporadic Alzheimer's Disease

PIERS Online ◽  
2009 ◽  
Vol 5 (4) ◽  
pp. 311-315 ◽  
Author(s):  
Natalia V. Bobkova ◽  
Vadim V. Novikov ◽  
Natalia I. Medvinskaya ◽  
Irina Yu. Aleksandrova ◽  
Eugenii E. Fesenko
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Magnetic Fields ◽  
Sporadic Alzheimer’S Disease ◽  
Combined Magnetic Fields ◽  
The Brain
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