scholarly journals Medical Equipment Cost Assessment in the Conditions of Intensive Technological Changes

2019 ◽  
Vol 9 (1) ◽  
pp. 5004-5009
Keyword(s):  
Biomedical Engineering ◽  
Medical Equipment ◽  
Scientific Literature ◽  
Rapid Development ◽  
Production Equipment ◽  
Industrial Enterprise ◽  
Cost Assessment ◽  
Technological Changes ◽  
Advantages And Disadvantages ◽  
Cost Factors

The purpose of the article is to consider the theoretical and methodological foundations of equipment assessment, in particular, the features of medical equipment assessment. The novelty of the study is associated with the fact that equipment assessment is considered by researchers, as a rule, as a stage in assessing the value of an industrial enterprise, that is, to a greater extent, production equipment is considered. Given the rapid development of biomedical engineering, the novelty of the study is related to the consideration of the features of medical equipment assessment. The article substantiates the relevance of medical equipment assessment and analyzes the use of different approaches to medical equipment assessment. Based on the analysis of scientific literature and expert survey, the characteristics of different approaches to medical equipment assessment are presented; cost factors, as well as advantages and disadvantages of various assessment methods, are indicated

An old friend is better than two new ones? Approaches to market research in the context of digital transformation for the antitrust laws enforcement

2020 ◽  
pp. 37-55 ◽  
Author(s):  
A. E. Shastitko ◽  
O. A. Markova
Keyword(s):  
Business Models ◽  
Rapid Development ◽  
Digital Transformation ◽  
Market Definition ◽  
Type I ◽  
Type Ii ◽  
Digital Platforms ◽  
Advantages And Disadvantages ◽  
Pass Through ◽  
Type Ii Errors

Digital transformation has led to changes in business models of traditional players in the existing markets. What is more, new entrants and new markets appeared, in particular platforms and multisided markets. The emergence and rapid development of platforms are caused primarily by the existence of so called indirect network externalities. Regarding to this, a question arises of whether the existing instruments of competition law enforcement and market analysis are still relevant when analyzing markets with digital platforms? This paper aims at discussing advantages and disadvantages of using various tools to define markets with platforms. In particular, we define the features of the SSNIP test when being applyed to markets with platforms. Furthermore, we analyze adjustment in tests for platform market definition in terms of possible type I and type II errors. All in all, it turns out that to reduce the likelihood of type I and type II errors while applying market definition technique to markets with platforms one should consider the type of platform analyzed: transaction platforms without pass-through and non-transaction matching platforms should be tackled as players in a multisided market, whereas non-transaction platforms should be analyzed as players in several interrelated markets. However, if the platform is allowed to adjust prices, there emerges additional challenge that the regulator and companies may manipulate the results of SSNIP test by applying different models of competition.

Recent Patents on the Angular Contact Ball Bearing of High-Speed Motorized Spindle

2020 ◽  
Vol 13 ◽  
Author(s):  
Yudong Bao ◽  
Linkai Wu ◽  
Yanling Zhao ◽  
Chengyi Pan
Keyword(s):  
High Speed ◽  
Ball Bearing ◽  
Rapid Development ◽  
Ceramic Materials ◽  
Development Trend ◽  
Numerical Control ◽  
Angular Contact Ball Bearing ◽  
Practical Applications ◽  
High Speed Cutting ◽  
Advantages And Disadvantages

Background:: Angular contact ball bearings are the most popular bearing type used in the high speed spindle for machining centers, The performance of the bearing directly affects the machining efficiency of the machine tool, Obtaining a higher value is the direction of its research and development. Objective:: By analyzing the research achievements and patents of electric spindle angular contact bearings, summarizing the development trend provides a reference for the development of electric spindle bearings. Methods:: Through the analysis of the relevant technology of the electric spindle angular contact ball bearing, the advantages and disadvantages of the angular contact ball bearing are introduced, and the research results are combined with the patent analysis. Results:: With the rapid development of high-speed cutting and numerical control technology and the needs of practical applications, the spindle requires higher and higher speeds for bearings. In order to meet the requirements of use, it is necessary to improve the bearing performance by optimizing the structure size and improving the lubrication conditions. Meanwhile, reasonable processing and assembly methods will also have a beneficial effect on bearing performance. Conclusion:: With the continuous deepening of bearing technology research and the use of new structures and ceramic materials has made the bearing's limit speed repeatedly reach new highs. The future development trend of high-speed bearings for electric spindles is environmental protection, intelligence, high speed, high precision and long life.

Design process for serious activities inspired by play and games: a problem solving with a board game from disengamement and gamification processes (Preprint)

2020 ◽  
Author(s):  
Stéphane Goria ◽  
Louise Dupet ◽  
Maëva Négroni ◽  
Gabriel Sega ◽  
Philippe Arnoux ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Serious Games ◽  
Diagnostic Method ◽  
Scientific Literature ◽  
Imaging Techniques ◽  
Point Of View ◽  
Board Game ◽  
Advantages And Disadvantages ◽  
Design Result

BACKGROUND most serious games and other game-based tools are designed as digital games or escape games. They are designed for learning or sometimes in the field of medicine as an aid to care. However, they can also be seen as an aid to research, in our case, to evaluate the advantages and disadvantages of imaging techniques for cancer detection. OBJECTIVE we present a case study of action research on the design of a serious board game intended to consider the advantages and weaknesses of a diagnostic method in a different ways. The goal was to better understand the principles of designing a tool using game or play. METHODS we explicitly implemented another process than gamification to develop a structure reminiscent of the game to highlight the strengths and weaknesses of different imaging techniques from the point of view of the respondents (in this case specialists not directly involved in the project). Based on this feedback and the scientific literature on this subject, we detail the main categories of games and games developed for serious use in order to understand their differences. Concerning the cancer research part to which game contributes, our method is based on questions asked to experts and practitioners of this specialty. RESULTS an expert point of view translation tool in the form of a game has been realized to apprehend a research in a different way. CONCLUSIONS we show with the help of a diagram, some possible design paths leading to this type of design result including two hidden dimensions to consider (the awareness of the game or play by the "player" and his role as a contributor or recipient).

scholarly journals Artificial Cardiac Muscle with or without the Use of Scaffolds

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Yifei Li ◽  
Donghui Zhang
Keyword(s):  
Tissue Engineering ◽  
Cardiovascular Diseases ◽  
Cardiac Tissue ◽  
Contractile Function ◽  
Rapid Development ◽  
Treatment Options ◽  
Cardiac Tissue Engineering ◽  
Hydrogel Scaffold ◽  
Fibrous Matrix ◽  
Advantages And Disadvantages

During the past several decades, major advances and improvements now promote better treatment options for cardiovascular diseases. However, these diseases still remain the single leading cause of death worldwide. The rapid development of cardiac tissue engineering has provided the opportunity to potentially restore the contractile function and retain the pumping feature of injured hearts. This conception of cardiac tissue engineering can enable researchers to produce autologous and functional biomaterials which represents a promising technique to benefit patients with cardiovascular diseases. Such an approach will ultimately reshape existing heart transplantation protocols. Notable efforts are accelerating the development of cardiac tissue engineering, particularly to create larger tissue with enhanced functionality. Decellularized scaffolds, polymer synthetics fibrous matrix, and natural materials are used to build robust cardiac tissue scaffolds to imitate the morphological and physiological patterns of natural tissue. This ultimately helps cells to implant properly to obtain endogenous biological capacity. However, newer designs such as the hydrogel scaffold-free matrix can increase the applicability of artificial tissue to engineering strategies. In this review, we summarize all the methods to produce artificial cardiac tissue using scaffold and scaffold-free technology, their advantages and disadvantages, and their relevance to clinical practice.

scholarly journals High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

2021 ◽  
pp. 247255522098504
Author(s):  
Jeffrey R. Simard ◽  
Linda Lee ◽  
Ellen Vieux ◽  
Reina Improgo ◽  
Trang Tieu ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Degradation ◽  
Protein Interactions ◽  
Fluorescent Protein ◽  
De Novo ◽  
Rapid Development ◽  
Dependent Manner ◽  
Western Blots ◽  
Advantages And Disadvantages ◽  
Degradation Rates

The aberrant regulation of protein expression and function can drastically alter cellular physiology and lead to numerous pathophysiological conditions such as cancer, inflammatory diseases, and neurodegeneration. The steady-state expression levels of endogenous proteins are controlled by a balance of de novo synthesis rates and degradation rates. Moreover, the levels of activated proteins in signaling cascades can be further modulated by a variety of posttranslational modifications and protein–protein interactions. The field of targeted protein degradation is an emerging area for drug discovery in which small molecules are used to recruit E3 ubiquitin ligases to catalyze the ubiquitination and subsequent degradation of disease-causing target proteins by the proteasome in both a dose- and time-dependent manner. Traditional approaches for quantifying protein level changes in cells, such as Western blots, are typically low throughput with limited quantification, making it hard to drive the rapid development of therapeutics that induce selective, rapid, and sustained protein degradation. In the last decade, a number of techniques and technologies have emerged that have helped to accelerate targeted protein degradation drug discovery efforts, including the use of fluorescent protein fusions and reporter tags, flow cytometry, time-resolved fluorescence energy transfer (TR-FRET), and split luciferase systems. Here we discuss the advantages and disadvantages associated with these technologies and their application to the development and optimization of degraders as therapeutics.

scholarly journals Multi-Criteria Decision-Making (MCDM) for the Assessment of Renewable Energy Technologies in a Household: A Review

Energies ◽  
2020 ◽  
Vol 13 (5) ◽  
pp. 1164 ◽  
Author(s):  
Indre Siksnelyte-Butkiene ◽  
Edmundas Kazimieras Zavadskas ◽  
Dalia Streimikiene
Keyword(s):  
Decision Making ◽  
Renewable Energy ◽  
Scientific Literature ◽  
Renewable Energy Sources ◽  
Multiple Criteria Decision Making ◽  
Energy Sources ◽  
Renewable Energy Technologies ◽  
Advantages And Disadvantages ◽  
Energy Technologies ◽  
Depth Analysis

Different power generation technologies have different advantages and disadvantages. However, if compared to traditional energy sources, renewable energy sources provide a possibility to solve the climate change and economic decarbonization issues that are so relevant today. Therefore, the analysis and evaluation of renewable energy technologies has been receiving increasing attention in the politics of different countries and the scientific literature. The household sector consumes almost one third of all energy produced, thus studies on the evaluation of renewable energy production technologies in households are very important. This article reviews the scientific literature that have used multiple-criteria decision-making (MCDM) methods as a key tool to evaluate renewable energy technologies in households. The findings of the conducted research are categorized according to the objectives pursued and the criteria on which the evaluation was based are discussed. The article also provides an overview and in-depth analysis of MCDM methods and distinguishes the main advantages and disadvantages of using them to evaluate technologies in households.

Research on Applied-Information Technology with Application of Data Mining in Analysis of Consumer Behavior

2014 ◽  
Vol 1003 ◽  
pp. 230-234
Author(s):  
Feng Long Fan ◽  
Xu Li ◽  
Xu Sheng Yu ◽  
Li Wang
Keyword(s):  
Computer Technology ◽  
System Analysis ◽  
Computer Network ◽  
Rapid Development ◽  
Daily Consumption ◽  
School Students ◽  
Customer Data ◽  
Advantages And Disadvantages ◽  
Depth Analysis ◽  
Database Technology

With the development of computer technology, especially the rapid development and extensive application of database technology and computer network technology, the data quantity increases sharply, the accumulation of a large number of data in various fields, and rising fast. Enterprise database or data warehouse has stored a large number of customer data, these data include many aspects of the information of customers, but also contains the advantages and disadvantages of the enterprise operation. If we can use these data quickly, efficiently in-depth analysis and research, to find the rules and modes, to obtain the necessary knowledge from it, will help enterprises to better decision making. The system can successfully excavate students and staff of the tendency of consumption and consumption habits, analyze their satisfaction with each restaurant. The results of system analysis to a certain role for school students and teachers to understand and analyze the condition of daily consumption, so the establishment of this system has great practical value.

scholarly journals Place of Transport in the Sales Policy of the Industrial Enterprise

2021 ◽  
pp. 5-11
Author(s):  
О. A Hodoskina ◽  
О. Y Moiseienkova
Keyword(s):  
Continuous Process ◽  
Industrial Enterprise ◽  
Production Structure ◽  
Functional Dependencies ◽  
Advantages And Disadvantages ◽  
Marketing Policy ◽  
Different Types ◽  
Marketing Activities ◽  
Weak Points ◽  
Mode Of Transport

Purpose. Currently, the organization of sales at the enterprise is the main and continuous process that provides the enterprise with its economic efficiency and bringing the goods to the consumer. The purpose of this work is to analyze and compare modes of transport and its role in the marketing of products by an enterprise. Methodology. To build a model for the marketing activity of an enterprise, as well as when modeling the mechanism of functioning of its organizational, economic and production structure and the place of transport in the structure of an industrial enterprise, elements of economic and mathematical modeling were used. Analysis of the data obtained allows you to choose the best method of transportation, which is extremely important to ensure that the needs of the enterprise, as well as the needs of consumers, are met. Findings. Marketing and logistics services of the enterprise need, having studied all the advantages and disadvantages of all types of transport, to choose the most optimal mode of transport when transporting goods. For the sale of its products, the enterprise should take into account that over time, the costs of different types of transport may change, and the transportation schemes should be revised. The paper compares the modes of transport and the structure of freight turnover by mode of transport (as a percentage of the total). Originality. The use of a mathematical apparatus in the construction of functional dependencies that make up a general economic and mathematical model that characterizes the organization of the marketing activities of an enterprise will allow not only to identify «weak» points, but also to adjust the marketing policy of the enterprise accordingly, relying not on abstract conclusions, but on the obtained clear dependencies. Practical value. The result is, first of all, a reduction in costs in the marketing policy of the enterprise and an increase in competitiveness, an increase in profits and maximum satisfaction of consumer requirements.

scholarly journals Closest and long-term prospects of 3D-printing for obstetrics and gynecology

2021 ◽  
Vol 20 (1) ◽  
pp. 76-81
Author(s):  
E. V. Kudryavtseva ◽  
V. V. Kovalev ◽  
E. S. Zakurinova ◽  
G. Muller-Kamskii ◽  
V. V. Popov
Keyword(s):  
3D Printing ◽  
Scientific Literature ◽  
Simulation Models ◽  
Surgical Instruments ◽  
Obstetrics And Gynecology ◽  
Scientific Review ◽  
Advantages And Disadvantages ◽  
The Creation ◽  
Dimensional Printing

Introduction. Despite the notable and rapid progress in the development of medical 3D printing in recent years, not much is known about the use of this technology in obstetrics and gynecology.The purpose of our review of scientific literature was to determine the current level of 3D printing development, discuss the closest and long term prospects for using this technology in obstetrics and gynecology, and analyze its potential advantages and disadvantages.Materials and methods. We searched for scientific literature. 378 papers passed a three-step screening, as a result of which 42 sources were selected for the final scientific review.Results and discussion. The main areas in which dimensional printing can be used in this area of medicine is the creation of simulation models and training for students, the creation of anatomical models for preoperative preparation, the surgical instruments, the creation of new dosage drug forms (including transvaginal ones), and bioprinting of organs and tissues.Conclusion. The presented literary review allows us to conclude that 3D printing the obstetrics and gynecology is a current rapidly developing direction. The organization of 3D modeling and printing laboratories can significantly increase the efficiency of teaching students and residents. In addition, obstetricians-gynecologists and surgeons should be informed about the possibility of 3D printing surgical instruments according to an individual design. It can inspire them to implement their own ideas and develop domestic innovative developments. Three-dimensional printing of dosage forms and bioprostheses requires more complex technological solutions, and is not yet used in clinical practice. However, given the enormous prospects for these areas, various grants should be envisaged for their development in Russia

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