CLINICAL PROFILE OF YOUNG ADULTS (18-24 YEARS) WITH POLYCYSTIC OVARY SYNDROME

2021 ◽  
pp. 1-3
Author(s):  
Sheila Balakrishnan ◽  
MKC Nair ◽  
Babu George ◽  
Jaysree L ◽  
Leena ML
Keyword(s):  
Young Adults ◽  
Nursing Students ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Overweight And Obesity ◽  
Study Group ◽  
Continuous Variables ◽  
Ovary Syndrome ◽  
Chi Square ◽  
Chi Square Test

Background: Polycystic Ovary Syndrome is a common endocrine problem with a heterogenous clinical picture. Early identication is essential to prevent metabolic problems and infertility. To estimate the prevalence of Objective: Polycystic Ovary Syndrome and depict the clinical prole of young adults (18-24 years) with Polycystic Ovary syndrome. A cross- Methods: sectional study of all the nursing students aged 18-24 years in Thiruvananthapuram District was conducted to self-screen for Polycystic Ovary Syndrome and Rotterdam criteria were applied. The study group comprised 529 subjects who were diagnosed to have the syndrome. The clinical and ultrasonographic characteristics and anthropometric variables of the study group were estimated and compared with 399 young adults without Polycystic Ovary Syndrome. Variables were expressed in terms of frequenci Statistical Analyses: es for categorical and mean (± SD) for continuous variables. Chi-square test was used for categorical and t- test for continuous variables. The prevalence of Polycystic Ovary Results: Syndrome was 13.1%. Irregular periods was seen in 74.7%, hirsutism in 57.1%, acne in 37.1%, acanthosis nigricans in 51% and alopecia in 2.5%. Overweight and obesity were found in 30.8%, increased waist circumference in 16.1% and hypertension in 27.8%. Polycystic Conclusion: Ovary Syndrome is a clinically heterogenous condition with an increased prevalence of irregular periods, hirsutism, acne and acanthosis. Overweight and obesity are signicantly increased. A younger age group of late adolescents or young adults is ideal to screen for the syndrome and institute lifestyle intervention to prevent metabolic problems.

scholarly journals THYROID DISORDER AMONG LEAN AND OBESE POLYCYSTIC OVARY SYNDROME PHENOTYPES

2021 ◽  
pp. 55-57
Author(s):  
Priya Agarwal ◽  
Varuna Pathak ◽  
Tripti Saxena
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Comparison Group ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Categorical Variables ◽  
Thyroid Disorder ◽  
Continuous Variables ◽  
Ovary Syndrome ◽  
Chi Square ◽  
Normally Distributed

Context: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among females in reproductive age and is associated with metabolic disorders,cardiovascular conditions and anovulatory infertility.Thyroid disorders share many overlapping features with PCOS,but their relation with PCOS is still controversial. Aim:To evaluate the prevalence of thyroid disorders among the patients with PCOS,and its relative prevalence among the lean and obese phenotypes of PCOS. Materials and methods: A prospective and observational study involving 89 females with PCOS as per the Rotterdam's/ESHRE criteria and 93 non-PCOS females as comparison group was carried out.All participants underwent history,clinical,anthropometry,ultrasonography and serum thyroid profile evaluation.A cut-off body mass index (BMI) 2 of 23 kg/m was used for classification of lean and obese phenotypes.Mann-Whitney U test and independent samples ttest were used to compare the non-normally distributed and normally distributed continuous variables, respectively. Pearson's chi-square ( 2) test was used for comparison of categorical variables. Results:The PCOS group showed higher proportion of hypothyroidism (21.34%) than the comparison group (8.6%) (P = 0.015). Higher prevalence of hypothyroidism (33.33%; P = 0.009) and higher mean serum TSH values (3.8 mIU/L; P < 0.001) were seen in obese PCOS females in comparison to the lean PCOS phenotype (10.67% and 2.14 mIU/L, respectively). Conclusion: There is higher prevalence of hypothyroidism in females with PCOS than the non-PCOS. Also, the obese PCOS have higher proportion of females with hypothyroidism than the lean PCOS subgroup.

scholarly journals Evaluation of vitamin D3 in patients of polycystic ovary syndrome and their correlation

2017 ◽  
Vol 6 (5) ◽  
pp. 2010
Author(s):  
Rooplekha Chauhan ◽  
Sonal Sahani ◽  
Ankita Garg
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Vitamin D3 ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Chi Square ◽  
Exact Test ◽  
Young Females ◽  
Vitamin D3 Deficiency

Background: Polycystic ovary syndrome (PCOS) is enigma faced by young females since the onset of urbanization. As on day, PCOS is the most common endocrine disorder in the women of reproductive age affecting 4-10%. This study done to measure serum vitamin D3 levels of PCOS patients and to identify its association with factors associated with various symptoms and signs in PCOS.Methods: Institutional based prospective observational study conducted on 70 patients of PCOS, both suspected and already diagnosed, attending gynecology OPD of Department of obstetrics and gynecology of NSCB Medical College Jabalpur from 1 March 2015 to 31 August 2016. Diagnosis of PCOS was made by Rotterdam 2003 criteria. A detailed assessment was done and preformed proforma was filled. Serum Vitamin D3 levels were estimated by standard lab technique ‘Liquid Chromatography Tandem Mass Spectrometry’ and categorized into vitamin D3 sufficient >30ng/dl, insufficient 20-29ng/dl and deficient <20ng/dl. Categorical data was coded numerically before the analysis. For comparison of frequency distribution chi square test or fisher’s exact test were applied as appropriate.Results: Prevalence of Vitamin D3 deficiency in patients of PCOS was found to be 84.3%.Conclusions: The present study concludes that there is correlation between vitamin D3 and PCOS, screening and correction of vitamin D3 deficiency may prevent PCOS and its manifestations. Hence, it is speculated that improvement of vitamin D3 levels at a younger age can contribute to prevention of PCOS.

scholarly journals ADULT ACNE: A CLINICAL STUDY WITH SPECIAL REFERENCE TO POLYCYSTIC OVARY SYNDROME

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shivani Yadav ◽  
Srishti Tripathi ◽  
Soumya Agarwal ◽  
Titiksha Hans ◽  
Anshul Choudhary ◽  
...  
Keyword(s):  
Young Adults ◽  
Polycystic Ovary Syndrome ◽  
Late Onset ◽  
Polycystic Ovary ◽  
Age Groups ◽  
Clinical Profile ◽  
Age Group ◽  
Ovary Syndrome ◽  
Female Patients ◽  
Rotterdam Criteria

Background: According to Global Burden of Skin Disease study data, 2013, Acne affects nearly 85% of adolescents and young adults in the age group 12-25 years.1 traditionally it was considered to be a transitory disease of teenagers and young adults; however recent study reports indicate it to be a disease affecting all age groups in adults. Aims: To study the clinical profile of adult acne, grade the severity using global acne grading system (GAGS) and to determine the proportion of Polycystic Ovary Syndrome (PCOS) in women with adult acne. Material and Methods: Patients with acne in the age group of 25-60 years were included in the study. A detailed examination of clinical profile of acne was done along with grading of severity of acne using GAGS. Also, documentation of hyperandrogenism using Ferriman Gallwey score for hirsutism and diagnosis of PCOS using Rotterdam criteria was done in all female patients of acne. Results: A total of 105 patients were included in the study. Among these, 82.9% were women and 17.1% were men. The mean age of the patients was 28.04±3.60 years. Persistent acne was observed in 85.7%, while late onset in 14.3%. Most common site of involvement was cheek (98%), followed by chin (76%), and forehead (64.7%). Mild grade acne was observed in 93.3% patients. Hyperpigmentation was seen in 78.1% while scarring was observed in 52.4% patients. A total of 8% female patients had PCOS according to Rotterdam criteria. Conclusion: We found a predominance of females and persistent acne. Although the prevalence of PCOS was low in adult female acne patients, they were affected by more severe grades of acne and risk of hyperpigmentation and scarring was higher as compared to non-PCOS patients.

scholarly journals INFLUENCE OF LIFESTYLE ON THE PROGNOSIS OF POLYCYSTIC OVARY SYNDROME

2021 ◽  
Keyword(s):  
Quality Of Life ◽  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Overweight And Obesity ◽  
Lifestyle Changes ◽  
Ovary Syndrome ◽  
Pubmed Database

Polycystic Ovary Syndrome (PCOS) is the most common endocrine-metabolic pathology among women at reproductive age. It has a multifactorial character, and its etiology has not yet been precisely explained. The pathogenesis of PCOS is related to metabolic issues such as hyperandrogenism and insulin resistance, and is also associated with obesity, type 2 diabetes and increased cardiovascular risk. Manifestations such as irregular menstruation, acne, hisurtism and androgenic alopecia are common in addition to the consequent psychological and quality of life impacts. Thus, knowing that the adoption of healthy habits have therapeutic impacts in the face of various signs and symptoms of PCOS, there is a need to analyze the influence of lifestyle on the prognosis of PCOS. The present study carried out its searches in the PUBMED database, using the descriptors "polycystic ovary syndrome", "life style" and "prognosis", using the Boolean operator "and". Inclusion criteria were used: articles written in Portuguese, English and Spanish, published in the last 5 years. 19 results were obtained, 5 of which were excluded, resulting in 14 articles chosen for theoretical reference. The influence of lifestyle on the prognosis of PCOS is notorious, especially in patients with overweight and obesity. Thus, healthy behaviors have the potential to improve pathological conditions and bad habits demonstrate that they can induce clinical manifestations of PCOS in predisposed people. Lifestyle changes, mainly associated with weight loss, show improvements in aspects such as insulin resistance, free testosterone, acne, hirsutism and reproductive function, reduced cardiovascular risk, in addition to positively influence to the psychic and quality of life in analyzed patients. Therapeutic strategies that combine lifestyle changes and drug interventions have been shown to be more effective, as well as strategies structered with the monitoring of professionals tend to increase adherence to treatment.

Efficacy of Vitamin D Combined with Metformin and Clomiphene in the Treatment of Patients with Polycystic Ovary Syndrome Combined with Infertility

2020 ◽  
Author(s):  
Lili ZHUANG ◽  
Wei CUI ◽  
Jianxiang CONG ◽  
Yinghong ZHANG
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Pregnancy Rate ◽  
Polycystic Ovary ◽  
Uterine Wall ◽  
Control Group ◽  
Study Group ◽  
Ovary Syndrome ◽  
Ovarian Volume ◽  
Before And After

Background: We aimed to explore the clinical efficacy of vitamin D combined with metformin and clomiphene in the treatment of patients with polycystic ovary syndrome combined with infertility. Methods: Overall, 396 cases of polycystic ovarian syndrome combined with infertility in Yantai Yuhuangding Hospital, Yantai, China were prospectively analyzed. Among them, 204 cases treated with vitamin D combined with metformin and clomiphene were set as the study group; 192 cases treated with only metformin and clomiphene were set as the control group. The ovarian volume and thickness of uterine wall before and after treatment were recorded. Levels of fasting insulin (FINS), luteinizing hormone (LH), testosterone (T), folliclestimulating hormone (FSH), and estradiol (E2) before and after treatment were recorded. Results: There was no difference in body weight, BMI, ovarian volume, thickness of ovarian wall, FINS, LH, T, FSH and E2 between the study group and the control group; there was no significant difference in FSH, E2 and the thickness of uterine wall between the two groups. After treatment, the BMI, FINS, LH, and T in the study group were significantly lower than those in the control group (P<0.05); the incidence rates of oligomenorrhea, facial acne and hairy symptoms in the study group were significantly lower than those in the control group (P<0.05); after treatment, the ovulation rate and pregnancy rate in 36 cycles in the observation group were significantly higher than those of the control group (P<0.05). Conclusion: Our challenge could significantly improve clinical symptoms and endocrine conditions, and greatly enhance the ovulation rate and pregnancy rate.

scholarly journals Minimal difference in phenotype between adolescents and young adults with polycystic ovary syndrome

2019 ◽  
Vol 111 (2) ◽  
pp. 389-396 ◽  
Author(s):  
Temeka Zore ◽  
Daria Lizneva ◽  
Soumia Brakta ◽  
Walidah Walker ◽  
Larisa Suturina ◽  
...  
Keyword(s):  
Young Adults ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Adolescents And Young Adults ◽  
Ovary Syndrome ◽  
Minimal Difference

scholarly journals A review of maternal overweight and obesity and its impact on cardiometabolic outcomes during pregnancy and postpartum

2021 ◽  
Vol 15 ◽  
pp. 263349412098654
Author(s):  
Jessica A. Grieger ◽  
Melinda J. Hutchesson ◽  
Shamil D. Cooray ◽  
Mahnaz Bahri Khomami ◽  
Sarah Zaman ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Gestational Weight Gain ◽  
Polycystic Ovary ◽  
Overweight And Obesity ◽  
Ovary Syndrome ◽  
Cardiometabolic Diseases ◽  
Gestational Weight ◽  
Maternal Overweight

The rates of maternal overweight and obesity, but also excess gestational weight gain, are increasing. Pregnancy complications, including gestational diabetes mellitus, gestational hypertension, pre-eclampsia and delivery of a preterm or growth restricted baby, are higher for both women with overweight and obesity and women who gain excess weight during their pregnancy. Other conditions such as polycystic ovary syndrome are also strongly linked to overweight and obesity and worsened pregnancy complications. All of these conditions place women at increased risk for future cardiometabolic diseases. If overweight and obesity, but also excess gestational weight gain, can be reduced in women of reproductive age, then multiple comorbidities associated with pregnancy complications may also be reduced in the years after childbirth. This narrative review highlights the association between maternal overweight and obesity and gestational weight gain, with gestational diabetes, pre-eclampsia, polycystic ovary syndrome and delivery of a preterm or growth restricted baby. This review also addresses how these adverse conditions are linked to cardiometabolic diseases after birth. We report that while the independent associations between obesity and gestational weight gain are evident across many of the adverse conditions assessed, whether body mass index or gestational weight gain is a stronger driving factor for many of these is currently unclear. Mechanisms linking gestational diabetes mellitus, gestational hypertension, pre-eclampsia, preterm delivery and polycystic ovary syndrome to heightened risk for cardiometabolic diseases are multifactorial but relate to cardiovascular and inflammatory pathways that are also found in overweight and obesity. The need for post-partum cardiovascular risk assessment and follow-up care remains overlooked. Such early detection and intervention for women with pregnancy-related complications will significantly attenuate risk for cardiovascular disease.

scholarly journals Association of SNP rs700519 in CYP19A1 Gene with Polycystic Ovary Syndrome (PCOS) Among Females of Quetta, Pakistan

2021 ◽  
Vol 21 (03) ◽  
Author(s):  
Rozeena Shaikh
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Control Group ◽  
Ovary Syndrome ◽  
Chi Square ◽  
Cross Sectional ◽  
Significant Difference ◽  
Reproductive Disorder ◽  
Pcos Group

ABSTRACT Polycystic Ovary Syndrome (PCOS) is endocrine reproductive disorder which causes oligomenorrhea/ amenorrhea, infertility, type II diabetes. The present study aims in CYP19A1 polymorphism rs700519 (C/T) identification that elevates androgen among PCOS females in Quetta, Pakistan. Cross-sectional study involved enrollment of 100 control and 100 affected females. Blood samples were collected for genetic and hormonal analysis. The samples were amplified via ARMS PCR and analyzed by sequencing. The frequency of CC genotype in control and PCOS group was 48 percent and 33 percent. For CT, it was 52 percent and 67 percent. In control group, the allele frequency for C and T was 0.74 and 0.26. In PCOS group, it was 0.67 and 0.33 for C and T, respectively. The Pearson Chi-Square p=0.031 (p<0.05) at 95% Confidence Interval inferred a significant difference between the observed genotypes. The study inferred that CT genotype is a risk factor for PCOS progression in the population of Quetta.

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