QUANTITATIVE ANALYSIS OF BIOCHEMICALAND HEMATOLOGICAL MARKERS IN COVID 19 PATIENTS AT DEDICATED COVID CARE HOSPITAL IN SOUTHERN RAJASTHAN

2021 ◽  
pp. 55-59
Author(s):  
Manju Lata Gupta ◽  
Namita Goyal ◽  
Dharmendra Garg ◽  
Anju Mishra ◽  
Priyanka Kumari ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Virus Disease ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Care Hospital ◽  
Rt Pcr ◽  
Icu Patients ◽  
Hematological Markers ◽  
High Dependency ◽  
D Dimer

Introduction: - Corona virus disease (COVID-19) is an emerging disease that threatens the biosecurity of all countries and spreading rapidly worldwide. Early diagnosis of the disease is essential because of high infectivity and mortality rates of COVID-19. Aims and objective: -The study was to observe and compare the clinical, biochemical and hematological proles between high dependency unit (HDU), Intensive care unit (ICU) and pregnant women with conrmed COVID 19 positive RT-PCR. Material and methods: - This study is conducted in COVID-19 dedicated Tertiary Care Hospital attached to RNT Medical College, Udaipur of Southern Rajasthan. Data of all patients with conrmed positive RT-PCR was collected during April 26, 2021 to May 31, 2021 from respective Lab Coordinator appointed for this purpose. SPSS statistics software was used for data statistics and mapping. Continuous variables were expressed as median and IQR (Inter Quarentile Range). Results:- Out of 428 patients 174 patients were in ICU, 235patients were in HDU and 19 patients were pregnant women. Mean age of 428 is 47.32 year ranging 18-86yrs. Among these 428 patients 267(62.38%) patients were males and 161(37.62%) patients were females. The biochemical, coagulation and hematological parameters such as Serum Ferritin, Lactate Dehydrogenase, C-Reactive Protein, Blood Sugar, D-Dimer, Prothrombin Time & INR, ESR, WBC, and Absolute Neutrophil Count were statistically signicant(p<0·05) across all comparisons(ICU,HDU and pregnant women). IL6 (Interleukin-6) and Hemoglobin were signicantly (p<0·05) lower in pregnant women as compare to ICU patients. Absolute lymphocyte count, Platelet, Platelet lymphocyte ratio were signicantly (p<0·05) lower in HDU patients as compare to ICU patients. Conclusion:- The present study has evaluated the clinical utility of biochemical parameter such as Ferritin, CRP, LDH, D-Dimer, and hematological markers like WBC, Neutrophils and Lymphocytes as signicant predictors of COVID-19 outcome.

scholarly journals Alteration of biomarkers of expired and cured COVID- 19 ICU patients in a tertiary care hospital

2021 ◽  
Vol 7 (2) ◽  
pp. 1031-1037
Author(s):  
Abu Hasan ◽  
Rummana Rahim ◽  
Mizanur Rahman
Keyword(s):  
Biochemical Parameters ◽  
Target Genes ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Care Hospital ◽  
Rt Pcr ◽  
C Reactive Protein ◽  
Protein Ratio ◽  
Reactive Protein ◽  
D Dimer

Coronavirus Disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2). This is a retrospective observational study aimed to find the alteration of some biochemical and hematological parameters of 121 COVID-19 patients admitted in intensive care unit (ICU) of Evercare Hospital Dhaka during May to December 2020. Methods: Retrospective biochemical, hematological and molecular (COVID-19 RT-PCR Ct value) markers were analyzed on COVID-19 patients in ICU and compared on those who died in the ICU and those cured. Results: Comparison of viral titer assessed by RT-PCR Ct values of target genes of SARS-CoV-2 among cured and expired patients did not show any significant differences. However, biochemical parameters such as CRP, Ferritin and hematological parameters such as WBC, absolute neutrophil, absolute lymphocyte, D-dimer showed significant differences among cured and expired patients. Patients who died in ICU mean CRP, Ferritin, D-dimer, WBC, absolute neutrophil were 10.39, 7694.30, 3196, 16.38, 15.12 respectively, compared to cured patients 0.93, 457.57, 773, 11.24, 8.86 respectively, with 95% confidence interval (95% CI). Platelets and absolute lymphocytes were observed decreased in expired patients compared to cured. Further, elevated level of neutrophil to lymphocyte ratio (NLR) and reduced level of lymphocyte to C-reactive protein ratio (LCR) has significant correlation with disease severity. Conclusion: These findings indicate that biochemical parameters such as CRP, Ferritin and hematological parameters such as CBC, D-Dimer, NLR, LCR can be monitored to identify severity and fatality of COVID-19 patients and thus, may help in improving disease outcome. Bioresearch Commu. 7(2): 1031-1037, 2021 (June)

CORRELATION BETWEEN CT CHEST SEVERITY SCORE AND CLINICAL PARAMETERS AND BIOCHEMICAL MARKERS IN COVID 19 PATIENTS

2021 ◽  
pp. 25-28
Author(s):  
Pramodh Kumar ◽  
Konduru Aneesha ◽  
Ch. Radhika ◽  
Elaya Kumar ◽  
R. Srinivasan
Keyword(s):  
Severity Score ◽  
Biochemical Markers ◽  
Tamil Nadu ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Parameters ◽  
Care Hospital ◽  
Rt Pcr ◽  
The Relationship ◽  
D Dimer

AIM: To correlate between CT chest severity score in COVID 19 patients with Clinical [SpO2, RR, PaO2/FiO2] and Biochemical parameters [NLR ratio, CRP, D- Dimer values]. METHODS: A Retrospective, observational study was conducted in a tertiary care hospital in Kanchipuram, Tamil Nadu. 110 patients were admitted to the hospital with COVID 19 [RT PCR swab for COVID 19 positive and radiologically positive] between March 2021 to June 2021. The patient was clinically, radiologically, and biochemically evaluated. CT chest severity score was used to differentiate the patients into mild, moderate, and severe groups. The relationship between CT Severity score and Clinical parameters such as SpO2, RR, PaO2/FiO2 and Biochemical markers [ NLR ratio, CRP, D-Dimer] were studied. RESULTS: CT chest severity score was found to be positively correlated with decreased SpO2 levels, decreased PaO2/ FiO2, increased RR and elevated NLR ratio, D Dimer and CRP levels(P < 0.001). CONCLUSION: The 25 CT Severity score scores well with the Clinical parameters and biochemical markers. Our data suggest that CT Chest Severity Score correlates well with clinical parameters and biochemical markers.

scholarly journals A Cross Sectional Study to Assess the Status of Hemoglobin and Other Blood Indices among Pregnant Women Attending Tertiary Care Hospital of Vadodara

2021 ◽  
pp. 106-111
Author(s):  
Vruti Patel ◽  
J. D. Lakhani
Keyword(s):  
Pregnant Women ◽  
Leucocyte Count ◽  
Tertiary Care Hospital ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Haematological Parameters ◽  
Moderate Degree ◽  
Care Hospital ◽  
Cross Sectional ◽  
Blood Indices

Introduction: A number of adaptations happen in the anatomy, physiology and metabolic processes within the mother which aids in successful progression of the pregnancy. The different blood indices such as haemoglobin concentration, packed cell volume (PCV), red blood cell count; total WBC count etc. can be measured to evaluate haematological status in a pregnant woman. The hematological profile of the pregnant women has an impact on both pregnancy and its outcome. Anaemia in pregnancy can be leads to morbidity and mortality in mother and fetus. The current study was designed to determine the variation in status of hemoglobin and other blood indices in anemic and non-anemic pregnant women. Aims ans Objectives: 1. To study the hematological and other blood indices among pregnant women, 2. To assess the degree of anemia in pregnant women, 3. To compare the Various hematological parameters between anemic and non -anemic pregnant women. Materials and Methods: A Cross-sectional comparative descriptive survey design and quantitative approach was adopted to achieve the goal of the study. The study was conducted at the tertiary care hospital of Vadodara, Gujarat. Total 300 pregnant women were recruited and socio demographic information was collected. Hemoglobin concentration (Hb), total leucocyte count (TLC), differential leucocyte count (DLC), and platelet count, blood indices of the recruited samples were studied.Mean and SD of Haematological parameters were calculated and unpaired t-test was used to compare the pregnant anaemic women data with non-anaemic pregnant women. Results: Out of 300, 204 pregnant women were found anemic and most of the pregnant women 84% belonged to rural area. In accordance with severity of anemia, Moderate degree of anemia was found to be highest (41%) in anemic pregnant women. Comparison of non - anaemic pregnant women with anaemic pregnant women shows significant changes in haematological parameters (p <0.05). Conclusion: It can be concluded that there is significant changes in hematological parameters in each trimesters of pregnancy as well compare to non-anemic to anemic pregnant women. Most of the hematological changes occur in order to physiological adaptation of pregnancy but abnormal status of Haemoglobin and other blood indices cause adverse outcome of the pregnancy.

scholarly journals MO842SARS-COV-2 INFECTION AMONG PATIENTS RECEIVING MAINTENANCE HAEMODIALYSIS: SINGLE HAEMODIALYSIS CENTER EXPERIENCE FROM BANGLADESH

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Mohammad Mehfuz E Khoda ◽  
Muhammad Abdur Rahim ◽  
Ishrat Jahan Shimu ◽  
Md Golzar Hossain ◽  
Md Abul Mansur
Keyword(s):  
Blood Group ◽  
Virus Disease ◽  
Tertiary Care ◽  
Health Care Facilities ◽  
Care Hospital ◽  
Rt Pcr ◽  
Case Record ◽  
Maintenance Haemodialysis ◽  
Corona Virus ◽  
Increased Risk

Abstract Background and Aims Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infections emerged in Wuhan, China in December 2019 and rapidly became pandemic. Unfortunately, there is lack of evidence about the optimal management of corona virus disease-2019 (COVID-19) and even less is available in patients on maintenance haemodialysis. Patient receiving maintenance haemodialysis are at increased risk for infection by SARS-CoV-2 with poor outcome. So, the purpose of this study was to identify the incidence of SARS-CoV-2 infection among end-stage kidney disease (ESKD) patients on maintenance haemodialysis. Method A cross-sectional study was conducted at a haemodialysis unit of tertiary care hospital of Bangladesh from April to August 2020. All patients, who were on maintenance haemodialysis, twice or thrice weekly, were screened by reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV-2, irrespective of symptoms. All data were collected in case record forms and patients were followed-up over phone. Results During the study period, a total of 133 patients (males 70, 52.6%) were on regular maintenance haemodialysis in the study centre. Most patients were in 5th and 6th decades of life. Twenty-one (15.8%) patients tested positive for SARS-CoV-2 by RT-PCR with female (16, 76.2%) predominance. Eighteen (18/21, 85.7%) patients had symptoms suggestive of SARS-CoV-2 infection and rest three (3/21, 14.3%) patients were diagnosed during routine screening. Common presentations were fever (42.9%), cough (66.7%) and respiratory distress (66.7%) and most had multiple symptoms. The incidence of SARS-CoV-2 infection in blood group A was 8(38%) and blood group O was 8(38%). There were no significant differences of mortality rate among blood groups. Most patients (16/21, 76.2%) infected by SARS-CoV-2 were referred to COVID-dedicated hospitals, five (5/21, 23.8%) were shifted to intensive care unit (ICU). Outcome was poor; 17 (17/21, 89%) patients died in hospitals and four (4/21, 19%) patients became free of SARS-CoV-2 infection. Caregivers/relative of our patients acquired COVID-19 in course of disease. Conclusion One-sixth of patients on maintenance haemodialysis acquired SARS-CoV-2 infection with nearly ninety percent fatality rates. Despite having risk factors for severe infection by SARS-CoV-2, patients on dialysis must visit health care facilities. So, utmost care should be taken to reduce risk of COVID-19 among such vulnerable group of patients.

scholarly journals Real Time-PCR (RT-PCR) Positivity for SARS-CoV-2 in Suspected COVID-19 Patients Presented in a Tertiary Care Hospital

2020 ◽  
pp. 67-70 ◽  
Author(s):  
Sarmistha Biswas ◽  
Khan Abul Kalam Azad ◽  
Mohammad Mahfuzul Hoque ◽  
Syed Ghulam Mogni Mowla ◽  
Sultana Shahana Banu ◽  
...  
Keyword(s):  
Virus Disease ◽  
Tertiary Care ◽  
Early Period ◽  
High Rate ◽  
World Health ◽  
Care Hospital ◽  
Rt Pcr ◽  
College Hospital ◽  
Cross Sectional ◽  
Male Predominance

Introduction: Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a newly emergent virus. World Health Organization declared COVID-19 as pandemic on March 11, 2020 for its rapid spreading. Not only to diagnose the disease (confirm case) but also to control and contain the transmission; test, trace and isolation are fundamental. RT-PCR for SARS-CoV-2 is used to detect and diagnose COVID-19 which started in Dhaka Medical College Hospital (DMCH) on 2nd April 2020. In this study we described our observation of RT-PCR done in patients presented in DMCH in the first month after starting the test. Methods: This observational, cross sectional study was done to find out the rate of RT-PCR positivity in suspected COVID -19 patients presented to DMCH from 2nd April to 3rd May, 2020 by the Department of Medicine in association with the Department of Virology. Data was collected from the registry book of the Department of Virology. The rate of RT-PCR for SARS-CoV-2 positivity among the suspected COVID-19 patients and demographical variable was observed. Results: Among the total studied patients (n=3206), 58.8% (n=1886) was male and mean age was 37.7(±14.38784) years. RT-PCR for SARS- CoV-2 was positive in 26.9% (n=864). Mean age was higher in patients positive for test (39.6± 15.9 year vs. 37±14.4 year). Male predominance was more marked in patients with positive PCR test (68.4 vs. 55.9). Conclusion: High rate of positivity of RT PCR for SARSCoV- 2 among the suspected patient for COVID 19 indicated high disease burden and transmission in this highly populated area in the early period of pandemic which should be considered as was alarming. J Bangladesh Coll Phys Surg 2020; 38(0): 67-70

scholarly journals Clinical and laboratory parameters of confirmed and probable COVID-19 patients: experience from a tertiary care hospital of Bangladesh

2020 ◽  
pp. 6-11
Author(s):  
Hasna Fahmima Haque ◽  
AKM Shaheen Ahmed ◽  
Samira Humaira Habib ◽  
Maliha Sulzana ◽  
Rahul Prasad Ghosh ◽  
...  
Keyword(s):  
Urban Areas ◽  
Tertiary Care Hospital ◽  
Virus Disease ◽  
Tertiary Care ◽  
Disease Classification ◽  
Care Hospital ◽  
Laboratory Parameters ◽  
Male Predominance ◽  
Corona Virus ◽  
D Dimer

Background: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which was previously known as novel corona virus 2019 (2019-nCoV), causes corona virus disease 2019 (COVID-19). Since 8 March 2020, COVID -19 emerged in Dhaka city and rapidly spread throughout the country. This study evaluated the sociodemographic, clinical and laboratory parameters of confirmed and probable COVID-19 patients in a tertiary care hospital. Methods: This cross-sectional study was conducted in BIRDEM General Hospital, Dhaka, Bangladesh from May to October 2020. Adult (>18 years) patients having clinical symptoms and signs of COVID-19, irrespective of sex were included in this study. Diagnosis was confirmed by positive reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2 from nasopharyngeal samples of patients and the disease classification was done following national guidelines. Results: Total patients were 141with a mean age of 59.74±11.0 years; majority was from urban areas and there was male predominance. Diabetes mellitus (91.5%) and hypertension (75.2%) were common co-morbidities. Common clinical presentations were fever (100%), cough (97.2%), fatigue (88.7%) and shortness of breath (61.7%). Laboratory investigations revealed lymphopenia (73.8%), elevated level of C-reactive protein (94.3%) and positive D-dimer (99.4%). Chest x-ray showed bilateral shadows in 73.8% cases and 42.6% had COVID pneumonia in high-resolution computed tomography (HRCT) scan of chest. Nearly three-fifths (58.9%) of the study subjects had moderate COVID-19 and 70.92% patients were shifted to the COVID-dedicated hospitals. Conclusions: COVID-19 affects mostly the older males. Majority was diabetic and hypertensive. Common symptoms were fever, cough and respiratory distress. Common laboratory findings were lymphopenia, high CRP, positive D-dimer and bilateral shadows on lung imaging. Birdem Med J 2020; 10, COVID Supplement: 6-11

scholarly journals Asymptomatic Bacteriuria among Pregnant Women Attending Tertiary Care Hospital in Lucknow, India

2021 ◽  
pp. 1-8
Author(s):  
Naimshree Sonkar ◽  
Malay Banerjee ◽  
Suman Gupta ◽  
Absar Ahmad
Keyword(s):  
Haemoglobin Level ◽  
Pregnant Women ◽  
Antimicrobial Susceptibility ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Asymptomatic Bacteriuria ◽  
Care Hospital ◽  
Gram Positive ◽  
Gram Negative ◽  
E Coli

Introduction: Asymptomatic bacteriuria (ASB) is the presence of actively multiplying bacteria within the urinary tract with absence of any symptoms, resulting in adverse pregnancy outcomes. This research study was done in order to review prevalence, antimicrobial susceptibility profile, and factors associated with ASB occurring in female patients who are pregnant and being treated at a tertiary care hospital in Lucknow, India. Method and Materials: This is a cross-sectional study done among 216 pregnant women attending a hospital for antenatal check-ups. Clean catch midstream urine samples were collected and examined microscopically, and semi-quantitative culture was done on blood agar and MacConkey agar. Isolates were identified by colony morphology and biochemical tests, and antimicrobial susceptibility testing was done by using the Kirby-Bauer method. Results: Of the 216 pregnant women, 36 (16.7%) tested positive for ASB. The female gestational period, haemoglobin level, and BMI were significantly associated with ASB. Logistic regression also showed that higher haemoglobin level was less likely to ASB (AOR = 0.42, 95% confidence interval: 0.202–0.88, p = 0.021). The predominant and usual isolates were E. coli (n = 22, 61.1%), followed by Cons (n = 6, 16.7%), and S. aureus (3, 8.3%). All Gram-negative isolates were mostly sensitive to most of the drugs like piperacillin-tazobactam, cefepime, nitrofurantoin, and meropenem but were 100% resistant to ampicillin. Similarly, Gram-positive isolates were sensitive to ampicillin, vancomycin, linezolid, and nitrofurantoin but 100% resistant to co-trimoxazole. Conclusion: The present study shows the existence of ASB was 16.7% among women who are pregnant. Pregnancy duration, haemoglobin level, and BMI were significantly associated with ASB. The isolates identified more frequently were E. coli (61.16%), Cons (16.7%), and S. aureus (8.3%). All isolates which were Gram-negative were mostly sensitive to most of the drugs but were 100% resistant to ampicillin. Similarly, Gram-positive isolates were sensitive to most of the drugs but 100% resistant to co-trimoxazole.

scholarly journals Iatrogenic anaemia and transfusion thresholds in ICU patients with COVID-19 disease at a tertiary care hospital

2021 ◽  
pp. 103068
Author(s):  
Ivo Beverina ◽  
Erika Borotto ◽  
Chiara Novelli ◽  
Danilo Radrizzani ◽  
Bruno Brando
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Icu Patients
Sign in / Sign up

Export Citation Format

Share Document