A STUDY ON EXPRESSION PROFILE OF BASAL MARKER CD44 AND LUMINAL MARKER CK20 IN UROTHELIAL NEOPLASM AND ITS CORRELATION WITH WHO GRADING AND STAGING OF TUMOUR

2021 ◽  
pp. 29-32
Author(s):  
Krishnendubikas Bag ◽  
Anish kumar Rakshit ◽  
Gopinath Barui
Keyword(s):  
Urothelial Carcinoma ◽  
West Bengal ◽  
Strong Association ◽  
Lower Grade ◽  
Tumour Grade ◽  
Cross Sectional ◽  
Over Expression ◽  
Medical College ◽  
Basal Marker ◽  
Luminal Marker

Aim: Histomorphological study of urothelial carcinoma on TRBT and Cystectomy specimen and its categorization on the basis of WHO grading & pTNM staging and to nd out the correlation between CK20 and CD44 exprression with tumour grade, pTNM staging. Material And Method: This descriptive cross sectional prospective study was conducted in the Department of Pathology, R G Kar Medical College & Hospital Kolkata in collaboration with Department of Urosurgery, R G Kar Medical College & Hospital, Kolkata, West Bengal. The present study is intended to nd out over expression of CD44 & CK20 in Urothelial Carcinoma of Bladder and correlate with tumour grade and clinical features. Result: There is strong association between CD44, CK20 expression and Stage of Urothelial Carcinoma cases and had a strong association between CD44 expressions and grade Urothelial Carcinoma cases. Conclusion: CK20 overexpression was seen more signicantly in High Grade tumours HGPUC (p < 0.05) as well as advanced stage pT2 and CD44 overexpression was more signicantly in lower grade tumours LGPUC (p<0.05) as well as lower stages pT1 in urothelial carcinoma. An inverse relasionship was noted in the staining patterns of CK20 and CD44 within individual cases as well as aggregate data,with (68.24%) of tumours with CD44 loss showing CK20 positivity.

SOCIODEMOGRAPHIC AND ANTHROPOMETRIC PROFILE OF DIABETIC PATIENTS ATTENDING IN A DIABETIC CLINIC IN A TERTIARY MEDICAL COLLEGE AND HOSPITAL, WEST BENGAL

2021 ◽  
pp. 12-15
Author(s):  
Smarajit Banik ◽  
Sandip Saha ◽  
Sudipan Mitra ◽  
Ujjwal Pattanayak ◽  
Rajib Sikder ◽  
...  
Keyword(s):  
West Bengal ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Diabetes Clinic ◽  
Cross Sectional ◽  
Medical College ◽  
Study Participants

Background: Diabetes mellitus is one of the important causes of morbidity and mortality. With a rise in non communicable diseases in India, diabetes has become a modern epidemic showing a rising trend in West Bengal also. A large number of diabetes patients come to the diabetes clinic of our tertiary care hospital in North Bengal Medical College and Hospital, Darjeeling, West Bengal. The large proportion of patients presenting with this condition prompted us to study the Sociodemographic and Anthropometric Prole of such patients. Methods: This was a descriptive hospital based cross sectional study involving a total of 344 diabetic patients enrolled in the diabetes clinic of a tertiary care teaching hospital from December 2019 to February 2020. A self-administered questionnaire was used to collect data and was analyzed in Microsoft excel sheet and using SPSS 20.0 software. Results: Among the 344 study participants, we found that 220 (63.95%) were males and 124 (36.05%) were females. Diabetes was more common among those aged 51-60 years 108 (31.40%). Family history was present among 188 (54.65%) of the diabetic patients. Almost 160 (46.51%) patients have diabetes 1.1 – 5 years. Hypertension was present among 216 (62.79%) patients. Almost 218 (63.37%) of the patients were overweight and 84 (24.42%) were obese. Conclusions: The diabetic patients presenting to this tertiary care hospital belong lower socioeconomic strata and having limited education in their age group. There is high proportion of obesity and hypertension among them.

scholarly journals Perception and Willingness towards Eye Donation in an urban community of West Bengal

2020 ◽  
Vol 12 (2) ◽  
pp. 290-297
Author(s):  
Shibaji Gupta ◽  
Seshadri Kole ◽  
Saikat Bhattacharya ◽  
Debjani Guchhait
Keyword(s):  
Higher Education ◽  
Mass Communication ◽  
West Bengal ◽  
Urban Community ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Economic Class ◽  
Medical College ◽  
Corneal Blindness ◽  
Eye Donation

Introduction: Corneal blindness, though treatable, contributes largely to the burden of blindness. With 1.2 million existing cases of corneal blindness in India, the demand for cornea collection is increasing. 69349 corneas were collected in 2018-19 but it is much less than what is needed. Faulty perceptions and unwillingness are two major hurdles against a scenario favourable towards eye donation. The objectives of the study was to assess the perception and willingness towards eye donation and the socio-demographic variables that affect such perception and willingness, in an urban community of West Bengal. Materials and methods: In this cross-sectional study conducted among adult residents of the urban field practice area of Medical College Kolkata, data was collected from randomly selected eligible members, one each from all the available families by interviewing them using a validated pre tested schedule. Results: Eighty nine (52.3%) among 170 interviewed participants had Secondary level education or higher, 49.4% had outdoor engagement. 128 participants reported ocular morbidity in the family but only 126 had heard about eye donation. 98 (77.8%) of these 126, had favourable perception towards eye donation. Among these 98 participants, 40 were willing to pledge for eye donation. Higher education and outdoor engagement significantly predicted favourable perception, while willingness significantly increased with participants belonging to higher socio-economic class and with higher education. Conclusions: Compared to favourable perception, willingness of pledging eyes was lesser due to various false notions. Proper education through usage of means of mass communication and stress upon school education is needed to address these hurdles.

scholarly journals Anxiety and Academic Performance among Private Medical College Students

2018 ◽  
Vol 5 (2) ◽  
pp. 68-72 ◽  
Author(s):  
Shila Rani Das ◽  
Chinmay Biswas
Keyword(s):  
Academic Performance ◽  
Medical Students ◽  
Nuclear Family ◽  
Strong Association ◽  
Cross Sectional Study ◽  
Chi Square ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Chi Square Test

Background: Medical students are in a huge pressure due to their academic syllabus. Objective: The purpose of the present study was to assess the relationship between anxiety and academic performance among private medical college.Methodology: This cross sectional study was done in private medical College Hospital, Dhaka, Bangladesh and 3rd and 4th year medical student were included. Data was   collected by using semi structured Socio-demographic questionnaire and Burn Anxiety Inventory scale and Checklist. Finally all data and results were analyzed using latest version of SPSS software. For descriptive statistics means, medians, SD and range will be calculated as required. Data will be presented in frequency table, bar, pie and scattered diagram as per need.  Statistical test chi-square test were used and p<0.05 was consider to be statistically significant.Results: A total number of 200 medical students were studied after fulfilling the inclusion and exclusion criteria. Among them 87.0% were Muslim; 98.0% were unmarried; 83.0% were in nuclear family; family member of 42.5% respondents had 4 to 6 persons; monthly income of 64.7% respondents were less than 50,000 Taka; 47.0% of the respondents’ father occupation was businessman. In 1st profession examination 68.0% in Anatomy, 73% in Physiology, 76% in Biochemistry were passed in anatomy. In 1st professional exam, students suffered from moderate to extreme anxiety were passed 78% and referred 22% as well as suffered from minimal to mild anxiety were passed 43% and referred 57% in Physiology. So there was strong association between the two variables (p<0.05).Conclusion: Three fifth of the students are suffered from moderate anxiety level and those who are suffered moderate to extreme anxiety passed more and their class attendance are good.Journal of Current and Advance Medical Research 2018;5(2):68-72

scholarly journals Relation of BMI with Blood Glucose Level amongst Healthy Students of Ayub Medical College, Abbottabad

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nadia Haleem ◽  
Sarwat Abbasi ◽  
Mohammad Idress ◽  
Zahid Irfan Marwat ◽  
Saadia Sadiq ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Body Mass ◽  
Glucose Level ◽  
Strong Association ◽  
Cross Sectional ◽  
Random Blood Glucose ◽  
Medical College ◽  
Two Parameters

Background: Obesity is a global challenge all over the world. Body mass index is a good marker to measure the adiposity. Obesityis one of the important risk factors for type 2 diabetes mellitus. Normal random blood glucose levels are closely regulated in healthwith a normal range of 4.4-7.8mmol/l (79-140mg/dl), despite the varying demands of food, exercise and fasting. Many diabeticpatients are obese and studies suggest a strong association between the two.Objective: To find an association of BMI with blood glucose level in undergraduate healthy students of Ayub Medical CollegeMaterial and Methods: This cross-sectional study was carried out in 2018, capillary blood samples were collected from 152students of Ayub Medical College Abbottabad to evaluate blood glucose level by Accu chek softclix® lancing device and Accu chekglucometer®, BMI was calculated by the formula (weight in kg/ height in meters squared). Data was collected and analyzed bySPSS version 23.Results: Total 152 (100%) healthy participants with 84 (55.3%) males and 68 (44.7%) females included in this study. Their ageswere ranged from 18-25 with a mean age of 21.02 years (min 17 max 26) having a standard deviation of 1.75. By taking thecorrelation between two parameters i.e. body mass index and serum random blood glucose level by Pearson product of moment(p=.214, r=101) a non-significant result was found.Conclusion: It is concluded that there is no significant association found between two parameters (BMI and serum BGL) in healthyyoung adults.

scholarly journals HER2 / neu Overexpression in Urothelial Carcinoma and Its Association with Tumour Grading - A Cross Sectional Study from a Tertiary Care Hospital in Kerala

2021 ◽  
Vol 8 (9) ◽  
pp. 497-501
Author(s):  
Sebina Asmi A.T ◽  
Suma Madathiveetil
Keyword(s):  
Urothelial Carcinoma ◽  
Growth Factor Receptor ◽  
Cross Sectional Study ◽  
Low Grade ◽  
High Grade ◽  
Sectional Study ◽  
Tumour Grade ◽  
Cross Sectional ◽  
Epidermal Growth ◽  
Papillary Urothelial Carcinoma

BACKGROUND Human epidermal growth factor receptor-2 HER2 / neu, is a trans membrane tyrosine kinase receptor of epidermal growth factor receptor (EGFR) family and is involved in the pathogenesis of urinary bladder cancer. In this study we attempted to evaluate the HER2 / neu expression in urothelial carcinoma of bladder and its association with tumour grading. METHODS This was a cross sectional study with a sample size of 75. Routine 4 micrometre thick sections of formalin fixed paraffin embedded tissue blocks stained with haematoxylin & eosin were reviewed. Tumour grade was determined by using the World Health Organization (WHO) / International Society of Urological Pathologist criteria (ISUP). Immunohistochemistry was done by using HER2 / neu monoclonal antibody and its expression were observed. The membrane staining intensity and pattern were studied and scored. RESULTS In our study 75 cases of urothelial carcinoma were studied, of which 49 cases were papillary urothelial carcinoma low grade, 26 cases were papillary urothelial carcinoma high grade. Among these, 19 cases were infiltrating urothelial carcinoma. HER2 / neu positivity were observed in 27 (36 %) cases and overexpression in 8 (10 %) cases. Low grade urothelial carcinoma showed HER2 / neu positivity in 11 (22 %) cases and overexpression in 1 (2 %) case. High grade urothelial carcinoma showed HER2 / neu positivity in 16 (64 %) cases, among which 7 (28 %) cases showed overexpression. HER2 / neu positivity was seen in 13 (68 %) cases of infiltrating urothelial carcinoma with 4 (21 %) cases showing overexpression. A statistically significant difference in HER2 / neu expression was noted in high grade and invasive urothelial carcinoma compared to low grade and non-invasive urothelial carcinoma. CONCLUSIONS Urothelial carcinomas show overexpression of HER2 / neu and this over expression increases with increasing grade of tumour and muscle invasiveness. KEYWORDS Urothelial Carcinoma, HER2 / neu, Overexpression, Tumour Grade, Trastuzumab

scholarly journals A cross sectional study on adequacy of blood transfusion and transfusion related infections in thalassemic patients attending a medical college hospital, West Bengal

2018 ◽  
Vol 5 (8) ◽  
pp. 3596
Author(s):  
Tarun Kumar Sarkar ◽  
Pulak Kumar Jana ◽  
Jasmine M. ◽  
Timiresh Kumar Das ◽  
Mrinmoy Adhikary ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
West Bengal ◽  
Ferritin Level ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
College Hospital ◽  
Cross Sectional ◽  
Blood Samples ◽  
Medical College ◽  
Study Participants

Background: Thalassemia is more prevalent in India. The main treatment of Thalassemia is blood transfusion. But the transfusion of blood has many side effects like iron overload, transfusion related infections etc. The objectives of the study were to assess the adequacy of blood transfusion for thalassemic patients and to determine the magnitude of transfusion transmitted infections among those patients.Methods: A cross sectional study was conducted in Murshidabad Medical College and Hospital, West Bengal for 1 month with the sample size of 116. The blood samples from the patients were taken from the patients attending for blood transfusion in transfusion centre of Murshidabad Medical College and Hospital for two weeks dated from 24.04.2017 to 05.05.2017 to check for the hemoglobin, ferritin level and hepatitis B, C and HIV infection.Results: Among the 116 patients, even after transfusion, 94% of the study participants have their hemoglobin levels below 7 gm/dl. Only 2 individuals got their hemoglobin levels more than 9 gm/dl and only 1 patient got HIV infection post transfusion which accounts for 0.9% of study population.Conclusions: Frequent Hb estimation will help to maintain the adequacy of blood transfusion and proper screening of the blood before transfusion can help in reducing these transfusion transmitted infections.

scholarly journals Haematocrit Value in Preeclampsia

2016 ◽  
Vol 30 (2) ◽  
pp. 80-85 ◽  
Author(s):  
Sankar Kumar Basak ◽  
Kohinoor Begum ◽  
Maliha Rashid ◽  
Nahid Yasmin ◽  
Hasina Begum
Keyword(s):  
Pregnant Women ◽  
Strong Association ◽  
Cross Sectional Study ◽  
P Value ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Group A ◽  
The Mean ◽  
Group B

Objective(s): To assess the association between the haematocrit value and severity of preeclampsia.Materials & Methods: This cross sectional study was conducted in the department of Obstetrics & Gynaecology of Dhaka Medical College Hospital, Dhaka during the period of January 2012 to December 2013. Total of 100 patients were studied and they were divided into two groups – group-A and group-B. Fifty preeclamptic patients were included in the group-A and 50 normal pregnant women were included in the group-B.Results: Majority of preeclamptic women (68%) and normal pregnant women (76%) were in the age group of 20-30 years with the mean ages of group-A and group-B subjects were 26.50±5.71 and 26.26±4.91 years respectively. Eighty six percent of group-A and 70% of group-B women were of lower socioeconomic status. Majority of the study subjects (74% of group-A and 80% of group-B) were housewife. More than half (54%) of the preeclamptic women were primigravid and 60% of normal pregnant women were multigravid. Among the preeclamptic subjects 16 (32%) had mild hypertension (DBP<110mmHg) and 34 (68%) had severe hypertension (DBP ? 110 mmHg). Out of 50 preeclamptic subjects 45 (90%) had severe proteinuria (+++) and only 5 (10%) had moderate (++) proteinuria.The mean haematocrit value of preeclamptic patients was 34.881±3.03 and that of normal pregnant women was 31.94±1.2. It was statistically significant (P value 0.001). The mean haematocrit value of normal pregnant, mild and severe preeclamptic women were 31.94±1.2, 33.31±2.57 and 35.62±2.95 respectively. It was also statistically significant (P value 0.001).Conclusion: This study shows that haematocrit value of preeclamptic patients is significantly higher compared to that of the normal pregnant women (P<0.05). There is a strong association of increasead haematocrit and preeclampsia.Bangladesh J Obstet Gynaecol, 2015; Vol. 30(2) : 80-85

scholarly journals Estimation of Perceived Stress among Doctors in a Peripheral Tertiary Government Medical College of West Bengal: A Cross-sectional Study

2021 ◽  
Author(s):  
Ranjan Das ◽  
Nazrul Mallick ◽  
Ashis Debnath ◽  
Bijit Biswas ◽  
Sumit Mukherjee
Keyword(s):  
Logistic Regression ◽  
Perceived Stress ◽  
West Bengal ◽  
Tertiary Care ◽  
Moderate Level ◽  
Government Medical College ◽  
Cross Sectional ◽  
Medical College ◽  
Family Problem ◽  
The Impact

Introduction: Doctors working in a tertiary care teaching hospital suffers higher symptoms of psychological distress. The impact of excessive stress may affect the individual employee and the organisation in terms of productivity and performance. Aim: To estimate the perceived stress among doctors and to find out the sources of their stress in a peripheral Government Medical College of West Bengal. Materials and Methods: This was an observational study, cross-sectional in design, conducted to assess the perceived stress and specific stressors among 95 doctors who were posted in a peripheral Government Medical College from June to November 2019. A Perceived Stress Scale (PSS 10) questionnaire was used to assess the perceived stress. Psycho-social and Environmental stressors were assessed using 11 items questionnaire. Data were analysed using the IBM statistical package for social sciences, (SPSS) software program (version 20.0) (Chicago, USA). Results: The majority of the participant (80%) had moderate level of stress, while 10.5% had low stress and 9.5% had severe stress. The mean PSS score in this study was 20.49±5.61. In univariate logistic regression analysis, significant association was found with loneliness {Odds Ratios (OR) 9.3; 95% Confidence Interval (CI)= 2.9-29.9}, family problem (OR 2.7; 95% CI=1.1-6.6) and quality of food (OR 2.9: 95% CI=1.2-7.0). Finally, loneliness (AOR 9.6; 95% CI=2.7-34.1) and family problem (AOR 3.7; 95% CI=1.3-10.1) came out to be statistically significant predictors of stress in multivariable logistic regression. Conclusion: Majority of doctors had moderate level of stress and they felt upset, nervous and stressed in last one month of preceding the survey. Professional counseling for the doctors to improve their coping and resilience behaviours is highly recommended.

scholarly journals An assessment of the learning styles of first year medical and dental students of North Bengal Medical College, Darjeeling, West Bengal, India

2020 ◽  
Vol 8 (4) ◽  
pp. 1414
Author(s):  
Sumana Panja ◽  
Pratibha Rao Lahiri ◽  
Aditi Lahiri
Keyword(s):  
Learning Styles ◽  
Learning Strategies ◽  
Learning Style ◽  
West Bengal ◽  
Sensory Modality ◽  
Dental Students ◽  
First Year ◽  
Cross Sectional ◽  
Medical College ◽  
North Bengal

Background: Learning is the act of acquiring, modifying and reinforcing existing knowledge, behavior, skills and values. This phenomenon of learning is dominated by an individual’s learning style. Learning style is a popular concept in psychology and education, and it refers to how a person learns best. This study aims to identify the Learning Styles of the first year MBBS and BDS students at NBMC by administering the questionnaire of the VARK model.Methods: This cross-sectional study was performed in the Department of Physiology at North Bengal Medical College, West Bengal after. The VARK questionnaire 7.8 version was administered to 180 first year MBBS and BDS students from the 2017-2018 batch who had volunteered for the study. The Questionnaire consisted of 16 questions, along with a scoring chart. Students were allowed to choose more than one option. If in majority of the questions they opted for a single sensory modality they were considered as unimodal learners and if they chose multiple options, they were recognized as multimodal learners.Results: The study showed 57% of the students to be multimodal learners and 43% to be unimodal learners. Read/Write was the most preferred (31.22%) sensory modality followed by kinesthetic mode (29.57%).Conclusions: As majority of our students are multimodal learners teachers should incorporate active teaching and learning strategies to cater to all types of learners. Also, as the most preferred method is Read/Write which includes googling and the use of internet to browse for information, we must try and incorporate e-learning into our curriculum.

scholarly journals A study on traditional practice of squeezing of breasts in newborn care among mothers in a tertiary care centre in Malda, West Bengal, India

2021 ◽  
Vol 8 (4) ◽  
pp. 1710
Author(s):  
Sushama Sahoo ◽  
Arpita Singh
Keyword(s):  
West Bengal ◽  
Tertiary Care ◽  
Newborn Care ◽  
Integrated Approach ◽  
Cross Sectional Study ◽  
Mustard Oil ◽  
Tertiary Care Centre ◽  
Traditional Practice ◽  
Cross Sectional ◽  
Medical College

Background: Newborn care is culturally and traditionally sensitive in every society. India is a vast country with different communities having their own traditional practices of newborn care. Squeezing of breasts in newborn period is one such unique traditional practice prevalent among population of rural background of West Bengal. This study was conducted to explore the traditional practice of squeezing of neonatal breasts and to highlight its related morbidities following the procedure among newborns.Methods: This was a descriptive, cross-sectional study conducted at triage of Special Newborn Care Unit (SNCU) of Malda Medical College and Hospital among 352 mothers who presented to us with their sick newborns following squeezing of neonatal breasts. After obtaining proper informed consent, mothers were interviewed. The data were collected using pre-designed questionnaires. Statistical analyses of the data were done using SPSS version 21.Results: In the present study, majority (33.52%) of mothers were 18-21 years old and 92.90% were Muslims. Squeezing of neonatal breasts was usually done on 10th day of life (40.34%) and on 4th day of life (27.27%). Local application following squeezing was done with hot turmeric paste (31.25%) and mustard oil (27.56%). Majority of newborns presented with features of mastitis (39.49%), 15.91% with breast abscess and 35.51% with sepsis.Conclusions: This study highlights the harmful aspects of traditional practice of breasts-squeezing among newborns prevalent in rural Bengal. This practice must be condemned by everyone through an integrated approach of proper health education and counseling of mothers and family members.

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