Differential diagnosis of spontaneous intracranial hemorrhage in young

2021 ◽  
Vol 22 (1) ◽  
pp. 83-86
Author(s):  
O. A. Kicherova ◽  
◽  
L. I. Reikhert ◽  
O. N. Bovt ◽  
◽  
...  

In recent years, cerebral vascular diseases have been increasingly detected in young patients. It is due not only to better physicians’ knowledge about this pathology, but also to the improvement of its diagnosis methods. Modern neuroimaging techniques allow us to clarify the nature of hemorrhage, to determine the volume and location of intracerebral hematoma, and to establish the degree of concomitant edema and dislocation of the brain. However, despite the high accuracy of the research, it is not always possible to establish the cause that led to a brain accident, which greatly affects the tactics of management and outcomes in this category of patients. A special feature of the structure of cerebrovascular diseases of young people is the high proportion of hemorrhagic stroke, the causes of which are most often arterio-venous malformations. Meanwhile, there are a number of other causes that can lead to hemorrhage into the brain substance. These include disorders of blood clotting, and various vasculitis, and exposure to toxic substances and drugs, and tumor formations (primary and secondary). All these pathological factors outline the range of diagnostic search in young patients who underwent hemorrhagic stroke. Diagnosis of these pathological conditions with the help of modern visualization techniques is considered to be easy, but this is not always the case. In this article, the authors give their own clinical observation of a hemorrhagic stroke in a young patient, which demonstrates the complexity of the diagnostic search in patients with this pathology.

1971 ◽  
Vol 34 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Larry K. T. Ng ◽  
Gabriel Schwarz ◽  
Mark M. Mishkin

✓ Two patients with a history of progressive unilateral neurological symptoms and signs, and evidence of obstructive hydrocephalus from a mass lesion adjacent to the third ventricle as demonstrated by pneumography, were each found to have an intracerebral hematoma secondary to remote hemorrhage from a small vascular malformation. One patient died shortly after surgical exploration and the other after ventriculography. The pathophysiology of hydrocephalus associated with a vascular malformation is discussed and the need for considering a benign cause for obstructive hydrocephalus from a mass deep in the brain substance is emphasized.


2020 ◽  
Vol 11 (10) ◽  
pp. 33-36
Author(s):  
Jui V Gundo ◽  
Ashish A Thatere ◽  
Vaishali K Gajbhiye ◽  
Shweta P Deolekar ◽  
Prakash R Kabra

Cerebrovascular diseases include some of the most common and devastating disorders; ischemic stroke and hemorrhagic stroke. Intracranial hemorrhage usually results from rupture of blood vessel within the brain parenchyma but may also occur in patients with subarachnoid haemorrhage, if the artery ruptures into the brain substance as well as into the subarachnoid space. It produces neurological symptoms by producing mass effect on neural structures, from the toxic effects of blood itself or by increasing intracranial pressure. According to Ayurved hemorrhagic stroke can be linked with Urdhva Raktapitta. Chikitsa of Urdhva Raktapitta was Virechana and Adho Raktapitta was Vamana as stated by Charak. So initial management was planned to stabilize Prakupit Dosha and hence Basti and Nasya were selected in these 5 patients of pilot study. Observations and results obtained were encouraging and assessed on different parameters which are presented in full paper. The patients of acute hemorrhagic stroke (not less than 1yr) were selected on the basis of CT/ MRI of brain and sign- symptoms of stroke. Observation and results are mention by applying appropriate statistical tests. Clinically encouraging results were observed on signs and symptoms. Statistically significant results were observed on parameters. These results are presented in full paper in details. Combination of this Ayurvedic treatment can be helpful in treating the cases of hemorrhagic stroke however the study on the larger compound will be helpful to validate its effect on hemorrhagic stroke.


2018 ◽  
pp. 50-55
Author(s):  
E. V. Kostenko ◽  
M. A. Eneeva

The article presents a modern view of the pathogenic mechanisms of cerebrovascular diseases was Observed that currently available data indicate the existence of different variants of ischemic lesions of the brain and their clinical manifestations. Based on the available data and the results of our own studies, it is concluded that therapeutic strategies in patients with CVD should take into account the variety of clinical manifestations, the existence of various options for ischemic lesions of the brain substance, especially the course of the disease, heterogeneity of pathogenetic mechanisms and risk factors, as well as multi-morbidity of patients. Discusses the use of the drug Vazobral in CVD.


Author(s):  
Sergii Stadnik ◽  
Oleksii Saiko

The most severe and disabling among various types of cerebrovascular accidents are hemorrhages. High mortality in hemorrhagic stroke is due to the possible development of a generalized convulsive syndrome, accompanied by respiratory failure; a cascade of irreversible biological reactions (dislocation syndrome with wedging, ventricular system hemotamponade with the formation of acute obstructive hydrocephalus); the development of complications associated with forced immobilization of the patient or connecting to a ventilator. The diagnosis of cerebral stem strokes is highly relevant due to the increase in their prevalence in the structure of cerebrovascular diseases. With stem strokes, the prognosis of the disease is worse than with strokes of any other localization, which is explained by the location of many vital centers in these structures. The paper highlights the classification and clinical manifestations of hemorrhages in the brain stem, substantiates the feasibility of rehabilitation measures at all periods of the disease. The use of early individual rehabilitation complex treatment can improve the results of therapy of deeply located hematomas, reducing disability and mortality of patients. The article presents the clinical case of a patient with a stem hemorrhagic stroke, in which, against the background of drug therapy and rehabilitation measures developed according to an individual program, self-care skills and working capacity were fully restored. Key words: hemorrhagic stroke (hemorrhage), stem stroke, hemorrhage in pons, rehabilitation


2021 ◽  
Vol XXX (3-4) ◽  
pp. 54-55
Author(s):  
М. Ya. Berdichevsky ◽  
S. A. Karmiryan ◽  
I. I. Geiko ◽  
L. А. Aristova ◽  
S. G. Kalustov ◽  
...  

Vascular diseases of the brain are widespread and largely determine such indicators of public health as life expectancy, morbidity, and mortality. In the overall structure of mortality, cerebral strokes rank second after heart disease.


2021 ◽  
Vol 22 (15) ◽  
pp. 7847
Author(s):  
Anthony Fringuello ◽  
Philip D. Tatman ◽  
Tadeusz Wroblewski ◽  
John A. Thompson ◽  
Xiaoli Yu ◽  
...  

Background: A major contributor to disability after hemorrhagic stroke is secondary brain damage induced by the inflammatory response. Following stroke, global increases in numerous cytokines—many associated with worse outcomes—occur within the brain, cerebrospinal fluid, and peripheral blood. Extracellular vesicles (EVs) may traffic inflammatory cytokines from damaged tissue within the brain, as well as peripheral sources, across the blood–brain barrier, and they may be a critical component of post-stroke neuroinflammatory signaling. Methods: We performed a comprehensive analysis of cytokine concentrations bound to plasma EV surfaces and/or sequestered within the vesicles themselves. These concentrations were correlated to patient acute neurological condition by the Glasgow Coma Scale (GCS) and to chronic, long-term outcome via the Glasgow Outcome Scale-Extended (GOS-E). Results: Pro-inflammatory cytokines detected from plasma EVs were correlated to worse outcomes in hemorrhagic stroke patients. Anti-inflammatory cytokines detected within EVs were still correlated to poor outcomes despite their putative neuroprotective properties. Inflammatory cytokines macrophage-derived chemokine (MDC/CCL2), colony stimulating factor 1 (CSF1), interleukin 7 (IL7), and monokine induced by gamma interferon (MIG/CXCL9) were significantly correlated to both negative GCS and GOS-E when bound to plasma EV membranes. Conclusions: These findings correlate plasma-derived EV cytokine content with detrimental outcomes after stroke, highlighting the potential for EVs to provide cytokines with a means of long-range delivery of inflammatory signals that perpetuate neuroinflammation after stroke, thus hindering recovery.


1994 ◽  
Vol 10 (4-5) ◽  
pp. 561-571
Author(s):  
Gunnar Heuser ◽  
Ismael Mena ◽  
Francisca Alamos

Exposures to neurotoxic chemicals such as pesticides, glues, solvents, etc. are known to induce neurologic and psychiatric symptomatology. We report on 41 patients 16 young patients (6 males, 10 females, age 34 8 yrs.) and 25 elderly patients (9 males, 16 females, age 55 7 yrs). Fifteen of them were exposed to pesticides, and 29 to solvents. They were studied with quantitative and qualitative analysis of regional cerebral bood flow (rCBF), performed with 30 mCi of Xe-133 by inhalation, followed by 30 mCi of Tc-HMPAO given intravenously. Imaging was performed with a brain dedicated system, distribution of rCBF was assessed with automatic ROI definition, and HMPAO was normalized to maximal pixel activity in the brain. Results of Xe rCBF are expressed as mean and S.D. in ml/min/100g, and HMPAO as mean and S.D. uptake per ROI, and compared with age-matched controls 10 young and 20 elderly individuals. Neurotoxics HMPAO Uptake Young Elderly R. Orbital frontal R. Dorsal frontal .70 .66 p < 0.05 R. Temporal .64 p < 0.001 R. Parietal .66 .66 We conclude that patients exposed to chemicals present with diminished CBF, worse in the right hemisphere, with random presentation of areas of hypoperfusion, more prevalent in the dorsal frontal and parietal lobes. These findings are significantly different from observations in patients with chronic fatigue and depression, suggesting primary cortical effect, possibly due to a vasculitis process.


Stroke ◽  
1973 ◽  
Vol 4 (1) ◽  
pp. 80-84 ◽  
Author(s):  
AKIRA ITO ◽  
TERUO OMAE ◽  
SHIBANOSUKE KATSUKI

2021 ◽  
Vol 2 (12) ◽  
pp. 32-35
Author(s):  
E. V. Usenkova ◽  
◽  
P. S. Kulakova ◽  

The article discusses the rehabilitation process of persons who have suffered from cerebro-vascular diseases, traumatic brain injuries, brain tumors within the framework of a multidisciplinary approach in a rehabilitation center. Emphasis is placed on the importance and timeliness of team work of specialists, setting goals, tasks for optimal improvement of the patient's quality of life and social adaptation.


1927 ◽  
Vol 23 (4) ◽  
pp. 475-479

Meeting of February 24Prof. M. N. Cheboksarov: Adrenal lipase, its relation to poisons and clinical significance. The report was printed in issue 3 of "K.M. Journal". In the debate Prof. P.P. Vasiliev pointed out that microscopic examination of the adrenal glands of dead B., mentioned by the reporter, revealed the existence of changes both in the cortical and in the brain substance of them. Proff. С. С. Zimnitskii and P. N. Nikolaev, noting the practical importance and interest of the reporter's work, pointed out that it would be especially interesting to trace the content of adrenal lipase in such diseases as typhoid and typhoid, as well as in animals with artificial damage to their adrenal glands.


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