scholarly journals Роль материнских полиморфных вариантов гена HLA-G3'UTR 14-bp *ins/del в реализации генетического детерминирования риска формирования спорадических септальных врожденных пороков сердца без хромосомных болезней

2019 ◽  
Author(s):  
A.V. Shabaldin ◽  
A.V. Tsepokina ◽  
A.V. Ponasenko ◽  
E.V. Shabaldina
Keyword(s):  
Heart Defects ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Rt Pcr ◽  
Homozygous Genotype ◽  
Xenobiotic Biotransformation ◽  
Pcr Method ◽  
Mathematical Processing ◽  
Chromosomal Diseases

Врожденные пороки сердца (ВПС) являются ведущей патологией среди всех пороков и аномалий развития плода. Известно, что тератогенный эффект ксенобиотика будет максимально представлен при нарушенных иммунных взаимодействиях в системе мать-эмбрион . Неоднократно показано, что женский гомозиготный генотип HLA-G 3UTR 14-bp ins/ins ассоциирован с репродуктивными потерями. Цель исследования. Изучить распределение аллелей и генотипов генов биотрансформации ксенобиотиков у женщин, имеющих детей с ВПС, носительниц вариантных генотипов HLA-G 3UTR 14-bp ins/del. Материал и методы. Обследованы 103 женщины, у которых дети при рождении имели врожденный порок сердца без хромосомных заболеваний и родословной историей, а также 103 женщины (контрольная группа), родивших двух здоровых детей и более. Типирование полиморфных сайтов генов HLA-G 3UTR 14-bpins/del, GSTM1 (rs74837985), CYP1A1 (rs1048943) CYP1A2 (rs35694136, rs762551) GSTT1 (rs2266633, rs2266637, rs2234953) GSTP1 (rs6591256, rs1695, rs1871042, rs1793068), GATA 6 (rs10454095) проводили методом RT-PCR. Результаты. Показано, что у женщин основной группы, являющихся носительницами гомозиготного генотипа 14-bp ins/ins HLA-G 3UTR, статистически значимо чаще встречались гетерозиготные генотипы GSTP1 (rs6591256) A/G (р0,01 отношение шансов ОШ5,1, 2,5710,27), GSTP (rs1793068) G/T (р0,01 ОШ5,1, 2,5710,27), CYP1A2 (rs762551) A/C (р0,01 ОШ6,81, 3,3513,73) и гомозиготный минорный генотип GSTP1 (rs1871042) T/T (р0,001 ОШ7,32, 3,6214,76) по сравнению с группой контроля. В основной группе женщин G/G rs74837985 GSTM1 статистически значимо реже (р0,01 ОШ 0,20, 0,06-0,59) встречался у носительниц 14-bp ins/ins HLA-G 3UTR по сравнению с носительницами гетерозиготного генотипа 14-bp ins/del HLA-G 3UTR. Заключение. В ходе исследования установлено, что при одновременном носительстве мутантных аллелей HLA-G и генов системы транформации ксенобиотиков риски рождения детей с дефектом межжелудочковой перегородки выше, чем при носительстве изолированных мутаций.Congenital heart defects (CHD) are the leading pathologies among all congenital malformations and fetal development abnormalities. It is known that the teratogenic effect of xenobiotic will be maximally presented in the case of disturbed immune interactions in the mother-embryo system. It has been repeatedly shown that the female homozygous genotype HLA-G 3UTR 14-bp ins/ins is associated with reproductive losses. The purpose of this study was to study the distribution of alleles and genotypes of xenobiotic biotransformation genes in women with children with CHD, carriers of variant HLA-G 3UTR 14-bp ins/del genotypes. Material and method: It was examined 103 women whose children had a ventricular septal defect (VSD) without chromosomal diseases and a pedigree history at birth, and 103 women (control group) who gave birth to two or more healthy children. The typing of polymorphic sites of the genes HLA-G 3UTR 14-bp ins/del, GSTM1 (rs74837985), CYP1A1 (rs1048943) CYP1A2 (rs35694136, rs762551) GSTT1 (rs2266633, rs2266637, rs2234953) GSTP1 (rs6591256, rs1695, rs1871042, rs1793068), GATA 6 (rs10454095) was performed by the RT-PCR method. Mathematical processing was carried out using the application software STATISTICA 8.0 (StatSoftInc., USA) and SNPstats. Results: It was shown that the heterozygous genotypes GSTP1 (rs6591256) A / G (p0.01, OR5.1 (2.5710.27)), GSTP (rs1793068) G / T (p0.01, OR5.1 (2.5710.27)), CYP1A2 (rs762551) A/C (p0.01, OR6.81 (3.3513.73)) and the homozygous minor genotype GSTP1 (rs1871042) T/T (p0.001, OR7.32 (3.6214.76) ) were statistically significantly more frequent in the main group of women who are carriers of the homozygous genotype 14-bp ins/ins HLA-G 3UTR, in comparison with the control group. In the main group of women G/G rs74837985 GSTM1 statistically significantly less (p0.01, OR0.20 (0.060.59)) was found in carriers of 14-bp ins / ins HLA-G 3UTR, in comparison with carriers of the heterozygous genotype 14-bp ins/del HLA-G 3UTR. Conclusion: It was found that with the simultaneous carrier of the mutant alleles of HLA-G and the genes of the xenobiotics transformation system, the risk of having children with VSD is higher, compared with the carriage of isolated mutations.

scholarly journals Analysis of the interconnection of the GSTP1, CYP1A2, CYP1A1 genes in children with congenital heart diseases

2020 ◽  
Vol 65 (3) ◽  
pp. 39-43
Author(s):  
A. V. Tsepokina ◽  
A. V. Ponasenko ◽  
A. V. Shabaldin
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Heart Defects ◽  
Congenital Heart Diseases ◽  
Genotype Distribution ◽  
Healthy Children ◽  
Rt Pcr ◽  
Locus Model ◽  
Healthy Donors ◽  
Pcr Method

The article presents data on the study of gene interconnections between the xenobiotics detoxification genes in various phases.Materials and methods. The study involves 131 children with congenital heart diseases (CHD) and 103 conditionally healthy children. The genotyping was performed by RT-PCR method using TaqMan probes. Intergenic bonds were analyzed via MDR v.3.0.2.Results and conclusion. We discovered no statistically significant differences in the genotype distribution in children with CHD and conditionally healthy donors. The analysis of intergenic interactions helped to develop a five-locus model characterized by the highest reproducibility, sensitivity and specificity: GSTP1 rs1793068 – GSTP1 rs6591256 – GSTP1 rs1871042 – CYP1A1 rs1048943 – CYP1A2 rs762551. This model was used to determine a number of protective and risky combinations of congenital heart defects-associated genotypes in children.

scholarly journals Clinical significance of expression of the marker of adaptation to hypoxia HIF-1α in pregnant women with initial forms of venous disease

2020 ◽  
Author(s):  
E. Iu. Iupatov ◽  
L. I. Maltseva ◽  
T. P. Zefirova ◽  
R. S. Zamaleeva ◽  
I. M. Ignatiev ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Pregnant Women ◽  
Hypoxia Inducible Factor ◽  
Perinatal Outcomes ◽  
Main Group ◽  
Control Group ◽  
Adaptation To Hypoxia ◽  
Venous Disease ◽  
Healthy Children ◽  
Venous Valves

Aim: to study the activity of the hypoxia marker HIF-1α (hypoxia-inducible factor-1α) in pregnant women with phlebopathy.Materials and Methods. We examined 70 women with phlebopathy in the dynamics of pregnancy. The main group consisted of 30 patients whose newborns had signs of hypoxia; the control group consisted of 40 women with healthy children. All women underwent ultrasound examinations of the veins of the lower extremities and pelvis with an assessment of vascular patency, the condition of the venous valves, and the phenomenon of platelet sludge. The expression of the HIF-1α transcription factor at 18–20 and 36 weeks was performed by real-time PCR.Results. Disorder of veins functional state was found in all pregnant women of the main group, which was accompanied by the formation of platelet sludge of varying degrees in the area of the venous valves in the majority, signs of endothelial dysfunction and venous hypoxia – an increase in the expression of the hypoxia gene HIF1-α by 2.18 times. In the women of the control group the indicators were not violated.Conclusion. The transcription factor HIF1-α can be considered a marker of unfavorable perinatal outcomes in pregnant women with signs of phlebopathy.

scholarly journals Modern possibilities of homeostatic reserves indication in bronchitis in children

2016 ◽  
Vol 97 (1) ◽  
pp. 41-47
Author(s):  
O I Pikuza ◽  
H M Vahitov ◽  
E V Generalova
Keyword(s):  
Oxidative Stress ◽  
Bacterial Infections ◽  
Acute Bronchitis ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Colonization Resistance ◽  
Non Invasive ◽  
Colonization Index ◽  
Buccal Epithelial Cells

Aim. To study the homeostatic reserves indicators in children with bronchitis by assessment of colonization resistance indicators and oxidative stress processes in the oral cavity.Methods. Clinical and instrumental examination of 115 children aged 5 to 14 years admitted to hospital with different variants of bronchitis was performed. The patients (main group) were divided into two subgroups according to the diagnosis: the first subgroup included 70 children with recurrent bronchitis, the second subgroup consisted of 45 children with acute bronchitis. The control group included 33 apparently healthy children of the same age. The examination complex included, in addition to conventional clinical and laboratory methods, special methods of examination - the oral cavity colonization resistance indicators identification (buccal epithelial cells colonization index and saliva anti-adhesive activity). In addition, oxidative stress indicators on oral neutrophils model - spontaneous and induced luminol-dependent chemiluminescence, were measured.Results. It was found that colonization index and saliva anti-adhesive activity was significantly lower in children of the main group than in control group. The lowest rates were characterstic for the first subgroup of patients. In children with acute bronchitis higher values of the induced and the spontaneous luminol-dependent chemiluminescence were registered as compared to control, whereas in recurrent bronchitis, by contrast, they were lower than in control (pConclusion. Patients with recurrent bronchitis extremely «vulnerable» in relation to recurrent bacterial infections (diseases) in connection with the mucosal protection system severe defects; they need to undergo aimed preventive and rehabilitation measures, the effectiveness control of which can be performed using the proposed non-invasive methods.

Increased susceptibility to gingival colonization by specific HACEK microbes in children with congenital heart disease

2001 ◽  
Vol 25 (1) ◽  
pp. 91-94 ◽  
Author(s):  
Robert Steelman ◽  
Stanley Einzig ◽  
Arpy Balian ◽  
John Thomas ◽  
David Rosen ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Heart Defects ◽  
Control Group ◽  
Healthy Children ◽  
Normal Children ◽  
Exact Test ◽  
Inflammatory Index ◽  
Significant Difference ◽  
Experimental Group ◽  
Increased Susceptibility

It is well established that infective endocarditis (IE) involving the HACEK (Hemophilus, Actinobaccillus, Cardiobacter, Eikenella, Kingella) group of microbes occurs in patients with congenital heart defects (CHD) and in those with prosthetic grafts. Dental caries and gingival disease have been presumed to be the focus of microbial shedding. The purpose of this study was to determine if children with CHD had a more severe gingival inflammatory condition and harbored the HACEK group of microbes to a greater extent than normal children. Two groups of 12 age and sex matched children were selected for this study. The experimental group consisted of twelve children with CHD, 1-1/2 to 8 years of age. The control group consisted of 12 healthy children 2 to 8 years of age. Each child had a gingival index score recorded as described by Massler. Subgingival cultures were obtained. Gingival samples were cultured for HACEK microbes and total Streptococcus (spp) using standard techniques. Fisher's exact test was performed with significance defined at P<0.05. Children with CHD had more severe gingival inflammatory index than the control group (P<0.05). 8/12 CHD patient had Actinobacillus actinomycetemcomitans (A.a.) as compared with 2/12 controls (P<0.05). Furthermore, all cyanotic CHD patients (4/4) had A.a. whereas, only 2/12 controls did (P<0.05). 4/12 CHD patients harbored Eikenella corrodens (E.c.) compared to 1/12 controls (N.S.). There was no significant difference in colonization with E.c. or A.a. between cyanotic and acyanotic patients. No significant difference in total Streptococcus (spp) was found between the two groups. This study suggests that children with CHD have a more severe gingival inflammatory index and are colonized with specific HACEK microbes more so than normal children.

scholarly journals Influence of Nature of Infant Nutrition on Formation of Body Resistance

2021 ◽  
Vol 65 (6) ◽  
pp. 145-154
Author(s):  
T. G. Malanicheva ◽  
E. V. Agafonova ◽  
N. V. Ziatdinova ◽  
I. N. Skidan
Keyword(s):  
Incidence Rate ◽  
Respiratory Diseases ◽  
Comparison Group ◽  
Resistance Index ◽  
Community Acquired Pneumonia ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Acute Respiratory Diseases ◽  
Body Resistance

Purpose of the Study: Assessment of the influence of the type of the adapted infant milk formula in infants on the formation of the body resistance. Children Characteristics and Study Methods. 105 virtually healthy children were examined, as follows: 35 children were breastfed (control group), 70 children were formula fed including 35 children that received NENNY with prebiotics formula based on the goat milk (main group), 35 children – formulas based on the cow milk with probiotics and prebiotics (comparison group). The incidence rate of the acute respiratory diseases (ARD) as well as the number of the pneumonia histories in the infants were assessed, and the body resistance index was calculated. The laboratory assessment of the child body immunoresistance was carried out using the method of imprint smears from the nasal mucous membranes and the method of nasal washes. Results. It was determined that there were 2 times more children of the main group with no history of the acute respiratory diseases when infant than in the comparison group. In general, the good resistance (were sick 0-3 times a year) in the main group was registered in 82.9% of the children, while it was only 60% in the comparison group. The average number of the ARD cases per year was 2.3 ± 0.02 in the main group, which is 1.5 times less than in the comparison group – 3.6 ± 0.04 (p <0.05), and in 1, 3 times more than that in the control group – 1.8 + 0.03 (p<0.05). In average, the resistance index was 0.28 ± 0.02 in the main group, while it was 0.36 ± 0.03 in the comparison group, and 0.25 ± 0.02 in the control group. When studying the incidence rate of the community-acquired pneumonia in the infants, it was revealed that 2.8% of them were ill in the control group, 5.7% of them in the main group, and 8.5% in the comparison group. When feeding the child with formulas based on the goat’s milk, the level of mucosal immunity of the nasal mucosa and enzyme systems of the intraleukocyte microbicidal system is assured, which is virtually indistinguishable from the level of immunity achieved with breastfeeding. Conclusion. Adapted NENNY with prebiotics formulas can be recommended for children who are formula fed when infant in order to increase the body’s resistance and to reduce the incidence rate of the acute respiratory diseases and community-acquired pneumonia.

scholarly journals Telomere lengths in women with early reproductive losses

2019 ◽  
Vol 24 ◽  
pp. 202-207
Author(s):  
N. I. Huleyuk ◽  
D. V. Zastavna ◽  
M. Tyrka
Keyword(s):  
Older Women ◽  
Reproductive Function ◽  
Peripheral Blood Lymphocytes ◽  
Control Group ◽  
Healthy Children ◽  
Rt Pcr ◽  
Reproductive Loss ◽  
Reproductive Losses ◽  
History Of ◽  
Polymerase Chain

Aim. Study of the relative telomere lengths in women with a history of early reproductive losses. Methods. Relative Telomere Length (RTL) was studied in the peripheral blood lymphocytes using a real time polymerase chain reaction (RT-PCR). Results. RTL was studied in 281 women, among which 169 - with early reproductive losses (ERL) (surveyed group) and 112 - have healthy children and no reproductive losses in history (control group). For women under the age of 35, the average RTL value is significantly higher than that of older women, P = 0.003597. In women with ERL, RTL is significantly lower than that of women with a preserved reproductive function, P = 0.0000001. The value of RTL is significantly lower in women with ERL under 35 years compared with control, P = 0.0000001, and is similar to value of RTL in women in the control group at the age of 36, P> 0.05. Conclusions. The telomere lengths is significantly lower in both older women and women with ERL. The similarity of RTLvalue in women with ERL up to 35 years of age and in women with a preserved reproductive function at the age of 36 years testifies to the telomeric theory of reproductive aging. Keywords: telomeres, RT-PCR, women, age, early reproductive loss.

scholarly journals Study of the FUT2 gene association with infection and clinical manifestations of Helicobacter pylori infection

2021 ◽  
pp. 27-32
Author(s):  
A. S. Klimova ◽  
E. V. Shrayner ◽  
A. I. Khavkin ◽  
N. V. Kokh ◽  
G. I. Lifshits ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Polymorphic Locus ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Significant Difference ◽  
Taqman Pcr ◽  
Pcr Method ◽  
H Pylori ◽  
Fut2 Gene

The aim of the pilot study of a group of adolescents with H. pylori infection was to study the preliminary data obtained on the rs602662 locus of the FUT2 gene and to establish its role in the realization of clinical manifestations of chronic gastritis, gastric ulcer and duodenal ulcer associated with H. pylori.Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a Real-Time CFX96 Touch amplifier. The duration of the study was 6 months.Results: The main group included 25 adolescents aged 16 to 17 years 11 months, the control group included 20 patients. Patients infected with H. pylori more often noticed symptoms of dyspepsia - in 36%, compared with the control group - 9.7%. The presence of a family history in the main group for associated diseases had a significant difference, χ2 = 4.97, p <0.05.To assess the contribution of the genotype of the rs602662 locus of the FUT2 gene to the risk of clinical manifestations in H. pylori infection, the main group was divided into subgroups. In the distribution of alleles in these groups, statistically significant differences were revealed.Allele “A” has a protective effect against the onset of clinical symptoms of dyspepsia. The odds ratio (OR) with the carriage of allele “A” (genotypes A / A and G / A versus G / G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI = [0.049-0.625] chi2 = 7.79 p = 0.0053).Conclusion. As a result of the study, we were unable to identify a significant association of alleles and genotypes of the rs602662 locus of the FUT2 gene with clinical manifestations of H. pylori infection. At the same time, carriers of the A allele have a pronounced association with the absence of clinical symptoms in patients with a positive H. pylori infection status of 0.175 (C.I. = [0.049-0.625] chi2 = 7.79 p = 0.0053).

scholarly journals Change in the aortic pulse wave velocity in children with familial hypercholesterolemia

2021 ◽  
Vol 26 (6) ◽  
pp. 640-647
Author(s):  
L. F. Galimova ◽  
D. I. Sadykova ◽  
E. S. Slastnikova ◽  
D. I. Marapov
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Total Cholesterol ◽  
Familial Hypercholesterolemia ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Aortic Pulse Wave Velocity ◽  
Main Group ◽  
Control Group ◽  
Healthy Children

Background. Familial hypercholesterolemia (FH) is the genetic disease characterized by an increase in the levels of total cholesterol and low density lipoproteins since childhood. The aim of the study was to assess arterial stiffness in children with heterozygous FH by measuring pulse wave velocity (PWV) in the aorta. Design and methods. The study involved 118 children. Of these, 60 healthy children were in the control group and 58 children with the diagnosis of heterozygous FH were included in the main group. Both groups were divided into 3 age subgroups: from 5 to 7 years old, from 8 to 12 years old and from 13 to 17 years old. The diagnosis of FH was made according to the British criteria by Simon Broome. The lipid profile was determined for all children, blood pressure was monitored daily with the estimate of the minimum, average and maximum PWV (PWVmin, PWVav, PWVmax) in aorta using oscillometric method. Results. In the younger age subgroup (5–7 years), there were no significant differences in PWV between main and control groups. In children aged 8–12 years, the main group was characterized by significantly higher values of maximum PWV compared to healthy peers — 5,1 [4,7–5,8] and 4,6 [4,45–5,05] m/s, respectively (p = 0,041). In group of children with FH aged 13–17 years, compared to the control group, a significant increase in the minimum PWV was observed — 4,7 [4,1–5,1] and 3,9 [3,5–4,1] m/s, respectively (p = 0,009), average PWV — 5,5 [4,8–6,4] and 4,5 [4,2–4,9] m/s, respectively (p = 0,009), and maximum PWV — 6,2 [5,7–7,55] and 5,4 [5,05–5,6] m/s, respectively (p = 0,007). Correlation analysis in patients with FH showed direct correlation between PWVmin, PWVav and PWVmax with total cholesterol (r = 0,46, r = 0,46 and r = 0,464, respectively, p < 0,001). Conclusions. Our study demonstrates an increase in the PWV in the aorta in children with FH compared with healthy peers from 8–12 years of age. There is a further progression of arterial stiffness with an increase in the minimum, average and maximum PWV most significant in the group of 13–17 years.

scholarly journals FITNESS DANCE FOR DEVELOPING BASIC MOVEMENT QUALITIES IN PRESCHOOL CHILDREN AND IMPROVING THEIR PSYCHIC STATUS

2019 ◽  
Vol 19 (1) ◽  
pp. 86-92
Author(s):  
I Izarovskaia ◽  
L Smirnova ◽  
E Sumak ◽  
O Izarovskaia
Keyword(s):  
Preschool Children ◽  
Interpersonal Relationships ◽  
Body Mass ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Psychological Traits ◽  
Body Weight Index ◽  
General Physical ◽  
Basic Movement

Aim. The article deals with developing a set of fitness dance exercises to improve basic movement qualities and psychic status in preschool children. Materials and methods. We studied two equal groups of apparently healthy children aged 5-6. All children frequent preschool educational establishments and a BABY CLUB education center (2 times per week, 20 people).  We analysed the morphological and psychophysiological traits of pre-schoolers during their lessons. Results. This study demonstrates the results for the correction of individual psychological traits, interpersonal relationships, coordination abilities, endurance, and speed-strength qualities in preschool children by means of fitness dance. Additional lessons resulted in a significant increase of physical preparedness in children from the main group. We registered better results in children from the main group compared to the control group in the following tests: ball throwing, 3×10 shuttle run, hand grip test, 500 m and 30 m run. We established that a set of fitness dance exercises improved significantly the following parameters of children from the main group: body mass, body length, body mass/body weight index, behavioural deviations, self-esteem, anxiety index, general physical preparedness. Conclusion. This study proves that negative trends in children of a new generation tend to increase, in particular in preschool children. The existing programs and methods aimed at children’s health within educational establishments usually lack their comprehensiveness. Physical exercises in a dance form are usually better perceived and possess greater health-improving effect. The diagnostics of movement abilities and skills revealed that children possess limited movement arbitrariness, cramped muscles, limited emotional and inner freedom. These factors decrease health-improving effect and prevents the improvement  of psychological and physical health.

scholarly journals CLINICAL AND INSTRUMENTAL CHARACTERISTICS OF NEUROSONOGRAPHIC CHANGES DETECTED IN DYNAMICS IN CHILDREN WITH CONGENITAL CHLAMIDIA INFECTION

2020 ◽  
Vol 20 (3) ◽  
pp. 36-40
Author(s):  
M. Yе. Fesenko ◽  
N. V. Shaposhnikiva ◽  
M. M. Fastovets ◽  
L. A. Zhuk ◽  
O.O. Kalyuzhka
Keyword(s):  
Chlamydial Infection ◽  
Clinical Signs ◽  
Intrauterine Infection ◽  
Main Group ◽  
Chlamydia Infection ◽  
Control Group ◽  
Healthy Children ◽  
Pathological Changes ◽  
Group Iii ◽  
The Central Nervous System

Introduction. The problem of congenital chlamydial infection is still remaining relevant due to the difficulties in its diagnosis and peculiarities of the course. The aim of this study was to clarify the dynamics of the severity and nature of the affection of the central nervous system in the case of congenital chlamydial infection. Materials and methods. 103 newborns were examined. Catamnestic observations were performed during a year. Specific diagnosis was made by polymerase chain reaction with the detection of chlamydia DNA in the blood serum of newborns. The main group included 80 children; the second control group consisted of 23 healthy children. The group III involved 36 children assessed as having satisfactory health status at birth, whose mothers had Chlamydia infection. Results and discussion. Analysis of the results showed that visceral forms with congenital chlamydial pneumonia were diagnosed in almost 50% of newborns; localized forms (congenital conjunctivitis) were diagnosed in 7.5% of children. 45% of newborns of the main group had no clinical signs of the disease. Neurosonography was performed in dynamics. It demonstrated that lenticular vasculopathy, areas of increased echogenicity, thickening of the ventricular walls, both alone and in combination were found only in the children of the main group and could be regarded as markers of intrauterine infection. Neurosonographic examination during the 1 year of life of the children in the main group indicated the presence of pathological changes. In the children of the control group markers of intrauterine infection were not detected. Thus, the obtained neurosonographic data confirm the long-term and damaging effects of chlamidia infection in the children of the main group. Conclusion. Pathological changes detected by neurosonography persisted during the first year of life and correlated with the formation of stato-kinetic developmental delay, muscular dystonia syndrome, and cerebral palsy in children.

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