scholarly journals Modern possibilities of homeostatic reserves indication in bronchitis in children

2016 ◽  
Vol 97 (1) ◽  
pp. 41-47
Author(s):  
O I Pikuza ◽  
H M Vahitov ◽  
E V Generalova
Keyword(s):  
Oxidative Stress ◽  
Bacterial Infections ◽  
Acute Bronchitis ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Colonization Resistance ◽  
Non Invasive ◽  
Colonization Index ◽  
Buccal Epithelial Cells

Aim. To study the homeostatic reserves indicators in children with bronchitis by assessment of colonization resistance indicators and oxidative stress processes in the oral cavity.Methods. Clinical and instrumental examination of 115 children aged 5 to 14 years admitted to hospital with different variants of bronchitis was performed. The patients (main group) were divided into two subgroups according to the diagnosis: the first subgroup included 70 children with recurrent bronchitis, the second subgroup consisted of 45 children with acute bronchitis. The control group included 33 apparently healthy children of the same age. The examination complex included, in addition to conventional clinical and laboratory methods, special methods of examination - the oral cavity colonization resistance indicators identification (buccal epithelial cells colonization index and saliva anti-adhesive activity). In addition, oxidative stress indicators on oral neutrophils model - spontaneous and induced luminol-dependent chemiluminescence, were measured.Results. It was found that colonization index and saliva anti-adhesive activity was significantly lower in children of the main group than in control group. The lowest rates were characterstic for the first subgroup of patients. In children with acute bronchitis higher values of the induced and the spontaneous luminol-dependent chemiluminescence were registered as compared to control, whereas in recurrent bronchitis, by contrast, they were lower than in control (pConclusion. Patients with recurrent bronchitis extremely «vulnerable» in relation to recurrent bacterial infections (diseases) in connection with the mucosal protection system severe defects; they need to undergo aimed preventive and rehabilitation measures, the effectiveness control of which can be performed using the proposed non-invasive methods.

scholarly journals Роль материнских полиморфных вариантов гена HLA-G3'UTR 14-bp *ins/del в реализации генетического детерминирования риска формирования спорадических септальных врожденных пороков сердца без хромосомных болезней

2019 ◽  
Author(s):  
A.V. Shabaldin ◽  
A.V. Tsepokina ◽  
A.V. Ponasenko ◽  
E.V. Shabaldina
Keyword(s):  
Heart Defects ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Rt Pcr ◽  
Homozygous Genotype ◽  
Xenobiotic Biotransformation ◽  
Pcr Method ◽  
Mathematical Processing ◽  
Chromosomal Diseases

Врожденные пороки сердца (ВПС) являются ведущей патологией среди всех пороков и аномалий развития плода. Известно, что тератогенный эффект ксенобиотика будет максимально представлен при нарушенных иммунных взаимодействиях в системе мать-эмбрион . Неоднократно показано, что женский гомозиготный генотип HLA-G 3UTR 14-bp ins/ins ассоциирован с репродуктивными потерями. Цель исследования. Изучить распределение аллелей и генотипов генов биотрансформации ксенобиотиков у женщин, имеющих детей с ВПС, носительниц вариантных генотипов HLA-G 3UTR 14-bp ins/del. Материал и методы. Обследованы 103 женщины, у которых дети при рождении имели врожденный порок сердца без хромосомных заболеваний и родословной историей, а также 103 женщины (контрольная группа), родивших двух здоровых детей и более. Типирование полиморфных сайтов генов HLA-G 3UTR 14-bpins/del, GSTM1 (rs74837985), CYP1A1 (rs1048943) CYP1A2 (rs35694136, rs762551) GSTT1 (rs2266633, rs2266637, rs2234953) GSTP1 (rs6591256, rs1695, rs1871042, rs1793068), GATA 6 (rs10454095) проводили методом RT-PCR. Результаты. Показано, что у женщин основной группы, являющихся носительницами гомозиготного генотипа 14-bp ins/ins HLA-G 3UTR, статистически значимо чаще встречались гетерозиготные генотипы GSTP1 (rs6591256) A/G (р0,01 отношение шансов ОШ5,1, 2,5710,27), GSTP (rs1793068) G/T (р0,01 ОШ5,1, 2,5710,27), CYP1A2 (rs762551) A/C (р0,01 ОШ6,81, 3,3513,73) и гомозиготный минорный генотип GSTP1 (rs1871042) T/T (р0,001 ОШ7,32, 3,6214,76) по сравнению с группой контроля. В основной группе женщин G/G rs74837985 GSTM1 статистически значимо реже (р0,01 ОШ 0,20, 0,06-0,59) встречался у носительниц 14-bp ins/ins HLA-G 3UTR по сравнению с носительницами гетерозиготного генотипа 14-bp ins/del HLA-G 3UTR. Заключение. В ходе исследования установлено, что при одновременном носительстве мутантных аллелей HLA-G и генов системы транформации ксенобиотиков риски рождения детей с дефектом межжелудочковой перегородки выше, чем при носительстве изолированных мутаций.Congenital heart defects (CHD) are the leading pathologies among all congenital malformations and fetal development abnormalities. It is known that the teratogenic effect of xenobiotic will be maximally presented in the case of disturbed immune interactions in the mother-embryo system. It has been repeatedly shown that the female homozygous genotype HLA-G 3UTR 14-bp ins/ins is associated with reproductive losses. The purpose of this study was to study the distribution of alleles and genotypes of xenobiotic biotransformation genes in women with children with CHD, carriers of variant HLA-G 3UTR 14-bp ins/del genotypes. Material and method: It was examined 103 women whose children had a ventricular septal defect (VSD) without chromosomal diseases and a pedigree history at birth, and 103 women (control group) who gave birth to two or more healthy children. The typing of polymorphic sites of the genes HLA-G 3UTR 14-bp ins/del, GSTM1 (rs74837985), CYP1A1 (rs1048943) CYP1A2 (rs35694136, rs762551) GSTT1 (rs2266633, rs2266637, rs2234953) GSTP1 (rs6591256, rs1695, rs1871042, rs1793068), GATA 6 (rs10454095) was performed by the RT-PCR method. Mathematical processing was carried out using the application software STATISTICA 8.0 (StatSoftInc., USA) and SNPstats. Results: It was shown that the heterozygous genotypes GSTP1 (rs6591256) A / G (p0.01, OR5.1 (2.5710.27)), GSTP (rs1793068) G / T (p0.01, OR5.1 (2.5710.27)), CYP1A2 (rs762551) A/C (p0.01, OR6.81 (3.3513.73)) and the homozygous minor genotype GSTP1 (rs1871042) T/T (p0.001, OR7.32 (3.6214.76) ) were statistically significantly more frequent in the main group of women who are carriers of the homozygous genotype 14-bp ins/ins HLA-G 3UTR, in comparison with the control group. In the main group of women G/G rs74837985 GSTM1 statistically significantly less (p0.01, OR0.20 (0.060.59)) was found in carriers of 14-bp ins / ins HLA-G 3UTR, in comparison with carriers of the heterozygous genotype 14-bp ins/del HLA-G 3UTR. Conclusion: It was found that with the simultaneous carrier of the mutant alleles of HLA-G and the genes of the xenobiotics transformation system, the risk of having children with VSD is higher, compared with the carriage of isolated mutations.

Dynamic Analysis of Myocardial Enzymes and Electrocardiogram in Pediatric Pneumonia

2019 ◽  
Vol 9 (8) ◽  
pp. 1596-1599
Author(s):  
Yanling Wang ◽  
Li Sheng ◽  
Xuan Zhou
Keyword(s):  
Creatine Kinase ◽  
Myocardial Injury ◽  
Myocardial Damage ◽  
Control Group ◽  
Healthy Children ◽  
Dynamic Changes ◽  
Non Invasive ◽  
Pediatric Pneumonia ◽  
Electrocardiogram Ecg ◽  
Myocardial Enzymes

Objective: The condition of pediatric pneumonia changes rapidly. Non-invasive myocardial enzymes and electrocardiogram (ECG) can reflect the myocardial damage of patients noninvasively. The purpose of this study was to investigate the dynamic changes of myocardial enzymes and ECG in the pediatric pneumonia. Method: A total of 18 pediatric pneumonia cases in our hospital from April 2018 to February 2019 were chosen. Another 18 healthy children were chosen as control group. The activity of creatine kinase (CK), creatine kinase isoenzymes (CK-MB), lactate dehydrogenase (LDH), and Glutamic oxaloacetic transaminase (GOT) was collected, and the ECG were recorded in all subjects. Result: Before treatment, the CK, CK-MB, LDH and GOT in pneumonia group was higher than the data in control group. After treatment, the level decreased significantly, but still slight higher than the data in control group. Compare with control groups, the incidence of abnormal ECG increased significantly. There was no statistical difference of incidence between control group and the patients after treatment. Conclusion: The serum myocardial enzymes such as CK, CK-MB, LDH and GOT and ECG changes are useful markers for monitoring the myocardial injury in pediatric pneumonia.

scholarly journals Clinical significance of expression of the marker of adaptation to hypoxia HIF-1α in pregnant women with initial forms of venous disease

2020 ◽  
Author(s):  
E. Iu. Iupatov ◽  
L. I. Maltseva ◽  
T. P. Zefirova ◽  
R. S. Zamaleeva ◽  
I. M. Ignatiev ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Pregnant Women ◽  
Hypoxia Inducible Factor ◽  
Perinatal Outcomes ◽  
Main Group ◽  
Control Group ◽  
Adaptation To Hypoxia ◽  
Venous Disease ◽  
Healthy Children ◽  
Venous Valves

Aim: to study the activity of the hypoxia marker HIF-1α (hypoxia-inducible factor-1α) in pregnant women with phlebopathy.Materials and Methods. We examined 70 women with phlebopathy in the dynamics of pregnancy. The main group consisted of 30 patients whose newborns had signs of hypoxia; the control group consisted of 40 women with healthy children. All women underwent ultrasound examinations of the veins of the lower extremities and pelvis with an assessment of vascular patency, the condition of the venous valves, and the phenomenon of platelet sludge. The expression of the HIF-1α transcription factor at 18–20 and 36 weeks was performed by real-time PCR.Results. Disorder of veins functional state was found in all pregnant women of the main group, which was accompanied by the formation of platelet sludge of varying degrees in the area of the venous valves in the majority, signs of endothelial dysfunction and venous hypoxia – an increase in the expression of the hypoxia gene HIF1-α by 2.18 times. In the women of the control group the indicators were not violated.Conclusion. The transcription factor HIF1-α can be considered a marker of unfavorable perinatal outcomes in pregnant women with signs of phlebopathy.

scholarly journals Evaluation of the state of the pro-oxidant/antioxidant system in children with hereditary spherocytosis

2021 ◽  
pp. 55-61
Author(s):  
E. F. Mitsura ◽  
I. A. Novikova ◽  
T. S. Petrenko ◽  
K. S. Makeeva ◽  
L. I. Volkova
Keyword(s):  
Oxidative Stress ◽  
Antioxidant System ◽  
Antioxidant Status ◽  
Hereditary Spherocytosis ◽  
The State ◽  
Control Group ◽  
Healthy Children ◽  
Gender And Age ◽  
Severity Of The Disease

Objective: to assess the state of the pro-oxidant/antioxidant system in children with hereditary spherocytosis (HS) depending on its severity.Material and methods. The study involved 44 HS patients at the age from 1 to 17 who were divided into 2 groups depending on the disease severity: mild course (n = 24) and moderate or severe course (n = 20). The control group included 23 practically healthy children who were comparable with the main group by gender and age. The state of the pro-oxidant/antioxidant balance of blood plasma was assessed by the method of luminol-dependent chemiluminescence (LDCL) with the determination of the maximum luminescence intensity (Imax, %) and the light sum of chemiluminescence (S, %). The activity of superoxide dismutase (SOD) and catalase was determined in the erythrocytes of the examined children.Results. On average, the parameters of the pro-oxidant/antioxidant status in the HS patients significantly differed from those of the control group (p <0.05), which corresponded to moderately pronounced oxidative stress. The activity of SOD and catalase in the erythrocytes of the patients was higher as compared with that of the control group (p = 0.0001 and p <0.0001, respectively). The comparison of the severity of oxidative stress depending on HS severity has determined that the degree of stress was more pronounced in patients with moderate or severe course of the disease (p <0.05).Conclusion. HS patients develop oxidative stress (decreased activity of the antioxidant system associated with increased accumulation of prooxidant substances), the degree of which is higher in patients with a severe course of the disease. This allows of considering plasma LDCL indicators as an additional marker for the assessment of the severity of the disease and of justifying the necessity to include antioxidants in the HS treatment regimen.

scholarly journals EVALUATION OF THE RELATIONSHIP BETWEEN DENTAL CARIES AND OXIDATIVE STRESS AND ANTIOXIDANT CAPACITY

2021 ◽  
Author(s):  
Ahmet Güzelçiçek ◽  
Mahmut Demir ◽  
Adnan Kirmit ◽  
MEHMET DOGAN
Keyword(s):  
Oxidative Stress ◽  
Dental Caries ◽  
Patient Group ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Control Group ◽  
Healthy Children ◽  
Markers Of Oxidative Stress ◽  
The Relationship ◽  
And Oxidative Stress

Background Dental caries can be affected or altered by the body’s oxidant / antioxidant balance and oxidative stress. Aim/Hypothesis To examine the relationship between dental caries and Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI). Design The study group consisted of 52 children with dental caries (DMFS/dfs ≥ 5), and the control group consisted of 42 healthy children (DMFS/dfs = 0). The saliva samples, unstimulated and mid-morning, were collected from all children. Participants’ saliva samples were acquired by spitting for 5 minutes, after which the samples were frozen and stored at 4 ° C and kept at -80 ° C until analysis. NCSS (Number Cruncher Statistical System) 2007 (Kaysville, Utah, USA) was used for the statistical analysis. Results TOS of the patient group cases were statistically significantly higher than those of the control group (p=0,004; p<0,01). OSI values of the patient group cases were statistically significantly higher than those of the control group (p=0,008; p<0,01). Conclusion OSI and TOS as markers of oxidative stress levels were found to be significantly higher in the group of patients with dental caries than in the healthy group.

Plasma and Erytrocyte Oxidative Stress Markers in Children with Frequent Breath-Holding Spells

2021 ◽  
Author(s):  
Beril Dilber ◽  
Ulas Emre Akbulut ◽  
Hepsen Mine serin ◽  
Ahmet Alver ◽  
Ahmet Menteşe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Enzyme Activities ◽  
Protein Carbonyl ◽  
Deficiency Anemia ◽  
Breath Holding ◽  
Control Group ◽  
Antioxidant Enzyme Activities ◽  
Healthy Children ◽  
Antioxidant Parameters ◽  
Nitrite Nitrate

Abstract Background Breath-holding spells (BHS) are common non-paroxysmal events with unknown pathophysiology. BHS have been associated not only with iron deficiency anemia (IDA) but also with oxidant/antioxidant imbalance and erythrocyte injury induced by hypoxia. The present study was designed to investigate the contribution of IDA in BHS and the oxidant/antioxidant balance in children with or without IDA in BHS and compare them with healthy controls.Additionally, the study also aimed to examine the effect of the frequency of BHS attacks (mild or severe) on the oxidant/antioxidant balance and to determine the best predictive oxidant and antioxidant markers. Materials and Methods The study included 66 children with BHS aged 6–48 months who had been followed up for a minimum period of one year between 2014 and 2018. A control group of 30 age- and gender-matched healthy children was included in the study. The patient group was divided into 2 groups (IDA and non-IDA) and these groups were compared between each other and also with the control group. The IDA group was divided into subgroups based on the frequency of BHS attacks. Blood samples were obtained within a maximum period of 24 h following the spell. Levels of protein carbonyl, nitrite, nitrate, TOS, TAS, OSI, MDA, enzyme activities of GPx, CAT,enzyme activities of erythrocyte SOD, CAT, and GPx, and the level of MDA were measured. Results In patients with IDA, the oxidant levels increased while the antioxidant enzyme activities decreased. In all patients, the levels of MDA, carbonyl, TOS, OSI increased and the levels of TAS, activities SOD, and CAT decreased, whereas the enzyme activities of erythrocyte SOD, CAT, GPx decreased significantly compared to those of control group. Increased of erythrocyte MDA levels had 10.32, decreased enzyme activities of erythrocyte SOD levels had a 10.25, and decreased enzyme activities of erythrocyte CAT had a 5.33 times greater risk for spell. Conclusion The results indicated that the oxidant/antioxidant balance in children with BHS was impaired in favor of oxidants at both levels, regardless of the presence of IDA and the increased frequency of BHS attacks per day. Moreover, the presence of IDA was found to be associated with increased oxidative stress in children with BHS, particularly at the erythrocyte level. Erythrocyte level; among the erythrocyte MDA oxidant parameters, erythrocyte SOD and antioxidant parameters, they are the biomarkers that show the best probability of having a BHS attack and an increase in the frequency of apnea attacks.

scholarly journals Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis?

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1097
Author(s):  
Izabela Kokot ◽  
Agnieszka Piwowar ◽  
Marcin Jędryka ◽  
Ewa Maria Kratz
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Total Bilirubin ◽  
Redox Homeostasis ◽  
Curve Analysis ◽  
Control Group ◽  
Roc Curve Analysis ◽  
Non Invasive ◽  
Gynecological Disorders ◽  
Significant Difference

Can redox homeostasis indicators be potential non-invasive markers, crucial in the diagnosis and treatment of endometriosis? We checked if the differences in levels of serum oxidative-antioxidant balance parameters (TAS, FRAP, albumin, total bilirubin, uric acid, iron, SIRT3, SIRT5, SIRT6, telomerase, AOPP) are significant between patients with advanced endometriosis (E), healthy women (control group, C) and non-endometriosis women, but with other gynecological disorders (NE). The FRAP concentrations were significantly higher in E and NE group than in the control group (p = 0.015 and p = 0.017, respectively). The telomerase concentrations were significantly higher in the endometriosis group than in the control group (p = 0.004). Significantly higher concentrations of AOPP were observed in E (p < 0.001) and NE groups (p = 0.028) in comparison to the control subjects. Between stages III and IV of endometriosis, a significant difference existed only in concentration of iron (p = 0.013). There were no significant differences between the studied groups in the values of the remaining parameters. Based on the results of ROC curve analysis, we can conclude that the levels of serum FRAP, telomerase and AOPP may be taken into account as promising diagnostics markers that reflect the degree of oxidative stress accompanying advanced endometriosis.

scholarly journals The maternal effect in infantile autism: elevated DNA damage degree in patients and their mothers

2016 ◽  
Vol 62 (4) ◽  
pp. 466-470 ◽  
Author(s):  
L.N. Porokhovnik ◽  
S.V. Kostyuk ◽  
E.S. Ershova ◽  
S.M. Stukalov ◽  
N.N. Veiko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Maternal Effect ◽  
Infantile Autism ◽  
Reproductive Age ◽  
Control Group ◽  
Healthy Children ◽  
Tail Moment ◽  
Autistic Children ◽  
Comet Tail

Infantile autism is a common disorder of mental development, which is characterized by impairments in the communicative, cognitive and speech spheres and obsessional stereotyped behaviour. Although in most cases, pathogenic factors remain unclear, infantile autism has a significant hereditary component, however, its etiology is also under the influence of environmental factors, including the condition of the mother's body during pregnancy (“maternal effect”). Oxidative stress is assumed to play a key role in the pathogenesis of infantile autism. It is known that oxidative stress has a prominent genotoxic effect, which is realized through inducing single and double strand breaks of the nuclear DNA. We evaluated the degree of DNA damage in patients with infantile autism and their mothers using DNA comet assay. The comet tail moment and DNA per cent ratio in the tail were assessed for each individual. The two parameters appeared to be strongly correlated (r=0.90). Mean and median values of both parameters were considerably higher in the sample of autistic children, than in age-matching healthy controls. Interestingly, these parameters were also elevated in healthy mothers of autistic children, with no difference from the values in the group of autistic children. The control group of healthy women of reproductive age, who had no children with autism, differed by the DNA comet tail moment from the group of mothers of autistic children, but did not differ significantly from the control group of healthy children. The results suggest that there are genotoxic factors in mentally healthy mothers of autistic children, which can determine the pathological process in the foeti via environmental “maternal effect” during gestation.

scholarly journals Parameters of lipid and oxidative-antioxidant status in persons aged 18-23 from radiation-contaminated areas under conditions of moderate physical activity

2020 ◽  
Vol 24 (5) ◽  
pp. 293-303
Author(s):  
Vadym L. Sokolenko ◽  
Svitlana V. Sokolenko
Keyword(s):  
Oxidative Stress ◽  
Physical Training ◽  
Main Group ◽  
Stress Index ◽  
Control Group ◽  
Moderate Physical Activity ◽  
Oxidative Stress Index ◽  
Physical Exercises ◽  
Radiation Zone ◽  
Experimental Group

Background and Study Aim. There is a significant amount of data on the stressful effects of exercise, which contain conflicting results. Some publications testify to the adaptive processes and the benefits of optimized exercise for various physiological systems, some deny such an effect. Much controversial is the question of combination the physical exercises of different intensity with other stressors. The purpose of the study: to analyze the parameters of lipid metabolism and oxidative-antioxidant system in persons aged 18-23 who lived in territories with different radioecological status, under conditions of moderate physical activity during exercise. Material and Methods. There were examined 50 students from relatively ecologically clean areas (control group) and 50 students from the IV radiation zone (experimental group). The radiation zone is selected by the dosimetry of soil contamination with 137Cs isotopes after the Chornobyl catastrophe. Age of the examined is 18-23 years. Within the framework of the experimental group there were formed two subgroups: the main group for physical training classes (without signs of morphological-functional disorders) and the group for therapeutic physical training classes (TPTC, persons with signs of vegetative-vascular dystonia syndrome). For the control and experimental main group, classes contained all the planned exercises due to the standard curriculum. The program included a combination of aerobic and strength exercises of moderate intensity. For students with signs of vegetative-vascular dystonia, teachers used specially designed therapeutic exercise complexes. The first analysis of parameters was carried out the day before physical training classes, the second one – immediately after the class. Results. Higher levels of total cholesterol and its lipoprotein fractions (LDL-C and HDL-C), triglycerides, oxidative stress index are detected in the experimental group compared to the control group. At the same time lower levels of sulfhydryl groups (SH) were marked. The absence of statistically significant changes in the analyzed parameters in the control group and the experimental therapeutic group after physical exercises is shown in the study. There were evident tendencies of ceruloplasmin level increase in the control along with the absence of such trends in persons with signs of vegetative-vascular dystonia syndrome. This led to the formation of a significant difference between groups for this antioxidant. There is a significant increase in cortisol level and oxidative stress index in the main group of students from radiation contaminated areas. Conclusions. Potentiation of various stress factors in persons who experienced the prolonged exposure to Chornobyl accident reduces the adaptive potential of homeostatic systems. This eliminates the optimization of lipid metabolism and oxidative-antioxidant system through moderate exercise. Exercise therapy does not cause a pronounced stress effect.

scholarly journals Influence of Nature of Infant Nutrition on Formation of Body Resistance

2021 ◽  
Vol 65 (6) ◽  
pp. 145-154
Author(s):  
T. G. Malanicheva ◽  
E. V. Agafonova ◽  
N. V. Ziatdinova ◽  
I. N. Skidan
Keyword(s):  
Incidence Rate ◽  
Respiratory Diseases ◽  
Comparison Group ◽  
Resistance Index ◽  
Community Acquired Pneumonia ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Acute Respiratory Diseases ◽  
Body Resistance

Purpose of the Study: Assessment of the influence of the type of the adapted infant milk formula in infants on the formation of the body resistance. Children Characteristics and Study Methods. 105 virtually healthy children were examined, as follows: 35 children were breastfed (control group), 70 children were formula fed including 35 children that received NENNY with prebiotics formula based on the goat milk (main group), 35 children – formulas based on the cow milk with probiotics and prebiotics (comparison group). The incidence rate of the acute respiratory diseases (ARD) as well as the number of the pneumonia histories in the infants were assessed, and the body resistance index was calculated. The laboratory assessment of the child body immunoresistance was carried out using the method of imprint smears from the nasal mucous membranes and the method of nasal washes. Results. It was determined that there were 2 times more children of the main group with no history of the acute respiratory diseases when infant than in the comparison group. In general, the good resistance (were sick 0-3 times a year) in the main group was registered in 82.9% of the children, while it was only 60% in the comparison group. The average number of the ARD cases per year was 2.3 ± 0.02 in the main group, which is 1.5 times less than in the comparison group – 3.6 ± 0.04 (p <0.05), and in 1, 3 times more than that in the control group – 1.8 + 0.03 (p<0.05). In average, the resistance index was 0.28 ± 0.02 in the main group, while it was 0.36 ± 0.03 in the comparison group, and 0.25 ± 0.02 in the control group. When studying the incidence rate of the community-acquired pneumonia in the infants, it was revealed that 2.8% of them were ill in the control group, 5.7% of them in the main group, and 8.5% in the comparison group. When feeding the child with formulas based on the goat’s milk, the level of mucosal immunity of the nasal mucosa and enzyme systems of the intraleukocyte microbicidal system is assured, which is virtually indistinguishable from the level of immunity achieved with breastfeeding. Conclusion. Adapted NENNY with prebiotics formulas can be recommended for children who are formula fed when infant in order to increase the body’s resistance and to reduce the incidence rate of the acute respiratory diseases and community-acquired pneumonia.

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