scholarly journals DIET INFLUENCES THE GUT MICROBIOTA: A MINIREVIEW

2021 ◽  
Vol 4 (2) ◽  
pp. e247
Author(s):  
Manish Soni
Keyword(s):  
Gut Microbiota ◽  
External Environment ◽  
Complex Interaction ◽  
Human Gut ◽  
Dietary Fibres ◽  
The World ◽  
Host Health ◽  
Genetic Makeup ◽  
Diet Intake

The human gut ecosystem is dynamic in nature which harbors trillions of microorganisms. These microorganisms constituting the gut microbiota are highly diverse and abundant having multiple implications on wellbeing and health of a person. There is a complex interaction between diet and microorganisms which can lead to beneficial or detrimental outcomes to host health. Each individual harbors specific and diverse microbiota depending upon his diet intake, genetic makeup, medication, metabolic regulations, external environment and his way of living the life. Among all these factors, diet plays a major role in deciding and influencing the microbiota of any person. The effects of diet on the gut microbiota are mostly temporary in nature. The microbiota of a person can be modulated by consumption of dietary fibres and prebiotics. This review focuses on the role of diet in influencing the gut microbiota of varied populations in different regions of the world.

Gastrointestinal Microbiota and Colon Cancer

2016 ◽  
Vol 34 (3) ◽  
pp. 244-250 ◽  
Author(s):  
Georgina L. Hold
Keyword(s):  
Gut Microbiota ◽  
Good Health ◽  
Cancer Development ◽  
Gastrointestinal Microbiota ◽  
Human Gut ◽  
Microbial Biofilms ◽  
Functional Capabilities ◽  
Health Burden ◽  
Host Health

The human gut microbiota plays a major role in the development and maintenance of good health. Many recent studies have attempted to define links between microbiota residents, their function and the development of colorectal cancer (CRC). Gut microbiota drive the development of inflammation within the colon and such inflammation is implicated in colonic neoplastic development. Although the precise mechanisms through which the microbiota is involved in cancer development remain elusive, the message is clear: the microbiota contributes to cancer risk by influencing a number of key host processes. It is also recognized that we have the ability to influence the role of the gut microbiota by considering our nutritional intake. We have always known that ‘we are what we eat' but it is also true that ‘they (our gut microbiota) are what we eat'. We therefore have a huge opportunity to positively influence our health through microbial manipulation. There is now a clear need to move past defining the constituents of the gastrointestinal microbiota and to focus more on understanding the functional capabilities of the resident microbial community and how this impacts on host health. One such emerging concept is the development of microbial biofilms which can form in the gut in conjunction with CRC tissue. By better understanding of the interaction between the host and its resident microbiota, in the context of health and cancer development, we will open new therapeutic and diagnostic opportunities for reducing the CRC global health burden.

scholarly journals Sulfoquinovose is a select nutrient of prominent bacteria and a source of hydrogen sulfide in the human gut

2020 ◽  
Author(s):  
Buck Hanson ◽  
Kerim Kits ◽  
Jessica Löffler ◽  
Anna Burrichter ◽  
Alexander Fiedler ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Gut Microbiota ◽  
Additional Source ◽  
Human Gut ◽  
Health States ◽  
Host Health ◽  
Gut Microorganisms ◽  
H2s Production ◽  
Active Contribution

Abstract Diet selectively shapes the human gut microbiota and fuels production of diverse metabolites that influence host health. Responses of the microbiota to diet are highly personalized, yet mechanistically not well understood because the metabolic capabilities of human gut microorganisms remain largely unknown. Here we show that sulfoquinovose (SQ), an omnipresent monosaccharide in green vegetables, is a selective substrate for few but ubiquitous bacteria in the human gut. In anoxic incubations of human feces and in defined co-culture, Eubacterium rectale and Bilophila wadsworthia both use previously unrecognized pathways to cooperatively catabolize SQ to hydrogen sulfide (H2S), a key intestinal metabolite with disparate effects on host health. We find SQ degradation capability encoded in almost half of E. rectale genomes but otherwise sparsely distributed among microbial species in the human intestine. Re-analysis of fecal metatranscriptome datasets of four human cohorts showed that SQ degradation (mostly from E. rectale and Faecalibacterium prausnitzii) and H2S production (mostly from B. wadsworthia) pathways were expressed abundantly across various health states, suggesting their active contribution to gut functioning. The discovery of green diet-derived SQ as an exclusive microbial nutrient and an additional source of H2S in the human gut highlights the role of individual dietary compounds and organosulfur metabolism on microbial activity and has implications for precision editing of the gut microbiota by dietary and prebiotic interventions.

scholarly journals Metabolic functions of the human gut microbiota: the role of metalloenzymes

2019 ◽  
Vol 36 (4) ◽  
pp. 593-625 ◽  
Author(s):  
Lauren J. Rajakovich ◽  
Emily P. Balskus
Keyword(s):  
Gut Microbiota ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Metabolic Functions ◽  
Host Health ◽  
Health And Disease

Metalloenzymes play central roles in metabolic functions of the human gut microbiota that are associated with host health and disease.

scholarly journals Influence of pig farming on human Gut Microbiota: role of airborne microbial communities

Gut Microbes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1-13
Author(s):  
Julia Moor ◽  
Tsering Wüthrich ◽  
Suzanne Aebi ◽  
Nadezda Mostacci ◽  
Gudrun Overesch ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Microbial Communities ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Pig Farming

scholarly journals Sex differences in the phylum‐level human gut microbiota composition

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alexander Koliada ◽  
Vladislav Moseiko ◽  
Mariana Romanenko ◽  
Oleh Lushchak ◽  
Nadiia Kryzhanovska ◽  
...  
Keyword(s):  
Sex Differences ◽  
Gut Microbiota ◽  
Age Groups ◽  
Microbiota Composition ◽  
Human Gut ◽  
Cross Sectional ◽  
Total N ◽  
Human Gut Microbiota ◽  
Gut Microbiota Composition

Abstract Background Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbiota in the sexual dimorphism of human diseases. To date, sex differences in fecal microbiota were demonstrated primarily at lower taxonomic levels, whereas phylum-level differences between sexes were reported in few studies only. In the present population-based cross-sectional research, sex differences in the phylum-level human gut microbiota composition were identified in a large (total n = 2301) sample of relatively healthy individuals from Ukraine. Results Relative abundances of Firmicutes and Actinobacteria, as determined by qRT-PCR, were found to be significantly increased, while that of Bacteroidetes was significantly decreased in females compared to males. The Firmicutes to Bacteroidetes (F/B) ratio was significantly increased in females compared to males. Females had 31 % higher odds of having F/B ratio more than 1 than males. This trend was evident in all age groups. The difference between sexes was even more pronounced in the elder individuals (50+): in this age group, female participants had 56 % higher odds of having F/B ratio > 1 than the male ones. Conclusions In conclusion, sex-specific differences in the phylum-level intestinal microbiota composition were observed in the Ukraine population. The F/B ratio was significantly increased in females compared to males. Further investigation is needed to draw strong conclusions regarding the mechanistic basis for sex-specific differences in the gut microbiota composition and regarding the role of these differences in the initiation and progression of human chronic diseases.

scholarly journals Role of Microbiome in Rheumatic Diseases

2017 ◽  
Vol 17 (2) ◽  
pp. 58-63 ◽  
Author(s):  
Chi Kit Au ◽  
Tin Lok Lai ◽  
Cheuk Wan Yim
Keyword(s):  
Rheumatoid Arthritis ◽  
Gut Microbiota ◽  
Immune Responses ◽  
Rheumatic Diseases ◽  
Pivotal Role ◽  
Human Gut ◽  
Future Role ◽  
Human Gut Microbiota ◽  
Rheumatic Manifestations

AbstractMajority of rheumatic diseases are complex and multifactorial in etiology. Emerging studies has suggested that the change of human microbiota, especially in the gut, play a pivotal role in its pathogenesis. Dysequilibrium of the gut microbiota triggers the imbalance between pro- and anti- inflammatory immune responses and results in different rheumatic manifestations, such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). In this article, current and future role of the human gut microbiota in rheumatic diseases are discussed.

scholarly journals Role of Biological Sex in the Cardiovascular-Gut Microbiome Axis

2022 ◽  
Vol 8 ◽  
Author(s):  
Shuangyue Li ◽  
Georgios Kararigas
Keyword(s):  
Gut Microbiota ◽  
Gut Microbiome ◽  
Microbial Composition ◽  
Biological Sex ◽  
Technological Advances ◽  
Host Health ◽  
Health And Disease ◽  
And Function ◽  
Insight Into

There has been a recent, unprecedented interest in the role of gut microbiota in host health and disease. Technological advances have dramatically expanded our knowledge of the gut microbiome. Increasing evidence has indicated a strong link between gut microbiota and the development of cardiovascular diseases (CVD). In the present article, we discuss the contribution of gut microbiota in the development and progression of CVD. We further discuss how the gut microbiome may differ between the sexes and how it may be influenced by sex hormones. We put forward that regulation of microbial composition and function by sex might lead to sex-biased disease susceptibility, thereby offering a mechanistic insight into sex differences in CVD. A better understanding of this could identify novel targets, ultimately contributing to the development of innovative preventive, diagnostic and therapeutic strategies for men and women.

A enfermagem militar no enfrentamento à COVID-19 em comunidades indígenas

2021 ◽  
Vol 11 (34) ◽  
pp. 318-323
Author(s):  
Jessica Bernardes Almeida Borges da Silva dos Reis ◽  
Camila Bento Silva ◽  
Bianca Rafaela Correia ◽  
Vanessa De Almeida Ferreira Corrêa ◽  
Renata Flavia Abreu da Silva
Keyword(s):  
Health Care ◽  
Indigenous Health ◽  
Armed Forces ◽  
Military Nurses ◽  
Professional Performance ◽  
Immunological Tests ◽  
The World ◽  
Host Health ◽  
Military Nursing

Descrever a experiência de enfermeiras militares na Operação Xavante no enfrentamento ao novo Coronavírus. Trata-se de um relato de experiência sobre a atuação de enfermeiras militares na Operação Xavante. Como parte de uma equipe multidisciplinar, a enfermagem militar na Operação Xavante foi primordial em várias frentes de atuação, as quais permitiram, dentro do contexto proposto, o adequado cumprimento da missão e o sucesso das ações de saúde planejadas, destacando-se nos seguintes aspectos: recepção e triagem; acolhimento; educação em saúde e realização de testes imunológicos para a COVID-19. Enfatiza-se que estas ações fazem parte da atuação profissional das enfermeiras integrantes das Forças Armadas, atuando em diferentes situações e contextos, possibilitando reafirmar as práticas de enfermagem na atenção à saúde indígena, em meio a um momento de extremo desafio vivenciado pela população mundial.Descritores: Enfermagem Militar, Infecções por Coronavirus, Saúde de Populações Indígenas, Grupos Populacionais. Military nursing in the fight against COVID-19 in indigenous communitiesAbstract: To describe the experience of military nurses in Operation Xavante in coping to the new Coronavirus. This is an experience report on the role of military nurses in Operation Xavante. As part of a multidisciplinary team, military nursing in Operation Xavante was primordial on several fronts of action, which allowed, within the proposed context, the proper fulfillment of the mission and the success of the planned health actions, standing out in the following aspects: reception and screening; host; health education and immunological tests for COVID-19. It ends by emphasizing that these actions are part of the professional performance of nurses who are members of the Armed Forces, working in different situations and contexts, making it possible to reaffirm nursing practices in indigenous health care, amid a moment of extreme challenge experienced by the world population.Descriptors: Military Nursing, Coronavirus Infections, Health of Indigenous People, Population Groups. La enfermería militar en la lucha contra el COVID-19 en comunidades indígenasResumen: Describir la experiencia de las enfermeras militares en la Operación Xavante frente al nuevo Coronavirus. Este es un informe de experiencia sobre el papel de las enfermeras militares en la Operación Xavante. Como parte de un equipo multidisciplinario, la enfermería militar en la Operación Xavante fue primordial en varios frentes de acción, lo que permitió, dentro del contexto propuesto, el adecuado cumplimiento de la misión y el éxito de las acciones de salud planificadas, destacándose en los siguientes aspectos: recepción y selección; acogida; educación en salud y realización de pruebas inmunológicas para COVID-19. Finalizase enfatizando que estas acciones son parte del desempeño profesional de las enfermeras integrantes de las Fuerzas Armadas, actuando en diferentes situaciones y contextos, posibilitando reafirmar las prácticas de enfermería en la atención a la salud indígena, en un momento de desafío extremo que vive la población mundial.Descriptores: Enfermería Militar, Infecciones por Coronavirus, Salud de Poblaciones Indígenas, Grupos Poblacionales.

scholarly journals The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease

2019 ◽  
Vol 12 ◽  
pp. 175628481882225 ◽  
Author(s):  
Jonathan P. Segal ◽  
Benjamin H. Mullish ◽  
Mohammed Nabil Quraishi ◽  
Animesh Acharjee ◽  
Horace R. T. Williams ◽  
...  
Keyword(s):  
Systems Biology ◽  
Gut Microbiota ◽  
Potential Role ◽  
Intestinal Inflammation ◽  
Clinical Care ◽  
Complex Interaction ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Compositional Changes

The aetiopathogenesis of inflammatory bowel diseases (IBD) involves the complex interaction between a patient’s genetic predisposition, environment, gut microbiota and immune system. Currently, however, it is not known if the distinctive perturbations of the gut microbiota that appear to accompany both Crohn’s disease and ulcerative colitis are the cause of, or the result of, the intestinal inflammation that characterizes IBD. With the utilization of novel systems biology technologies, we can now begin to understand not only details about compositional changes in the gut microbiota in IBD, but increasingly also the alterations in microbiota function that accompany these. Technologies such as metagenomics, metataxomics, metatranscriptomics, metaproteomics and metabonomics are therefore allowing us a deeper understanding of the role of the microbiota in IBD. Furthermore, the integration of these systems biology technologies through advancing computational and statistical techniques are beginning to understand the microbiome interactions that both contribute to health and diseased states in IBD. This review aims to explore how such systems biology technologies are advancing our understanding of the gut microbiota, and their potential role in delineating the aetiology, development and clinical care of IBD.

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