scholarly journals MEDICAL AND SOCIAL ISSUES OF CARDIOVASCULAR DISEASES AND THEIR SOLUTION BASED ON THE EXPERIMENTAL STUDY OF MYOCARDIAL FIBROSIS

2019 ◽  
Vol 72 (1) ◽  
pp. 35-39
Author(s):  
Hanna Saturska ◽  
Аrkadii Shulhai ◽  
Rostyslav Levchuk ◽  
Nataliya Potikha ◽  
Ruslan Usynskyi
Keyword(s):  
Body Weight ◽  
Cardiovascular Diseases ◽  
Connective Tissue ◽  
Myocardial Fibrosis ◽  
Histological Examination ◽  
Calcium Gluconate ◽  
Experimental Modeling ◽  
Control Group ◽  
Resistance To Hypoxia ◽  
Group 2

Introduction: The prevalence and incidence of cardiovascular diseases have been attracting considerable attention in recent decades. This is partly due to the fact that myocardial fibrosis is the major consequence of the most nosological units of cardiovascular diseases. We believe that early pathogenic therapy of myocardial fibrosis should be taken into consideration as a solution to this issue. The change of the connective tissue metabolism in myocardium is the central chain in pathogenesis of diffuse ischemic necrotic cardiosclerosis (DINC) occurs after repeated epinephrine injury of myocardial tissues. The aim: The present study establishes that use of metabolic therapy by trimetazidine (TM) has a protective effect on myocardium repeatedly damaged by epinephrine in hight concentration during the development of DINC in rats with different resistance to hypoxia. Materials and methods: Using the method of hypobaric hypoxia, male albino rats were divided into three groups due to their different resistance to hypoxia. Each group was divided into four equal subgroups: control group, DINC group (2 times repeated injections of epinephrine hydrotartrate (0,5 mg/kg body weight) and calcium gluconate (5 mg/ kg body weight), control group introdused with trimetazidine dihydrochloride (10 mg/kg body weight), DINC treated with TM group (2 times repeated injections of epinephrine hydrotartrate (0,5 mg/kg body weight) and calcium gluconate (5 mg/kg body weight) group introduced with TM (10 mg/kg body weight) for all period of observation. The concentration of protein-bound oxyproline in homogenate of myocardium was determined at 7, 14 and 30 days after the modelling pathology and the histological examination of Masson trichrome staining of myocardium was performed. Results: Experimental modeling of DINC increased the concentration of protein-bound oxyproline in homogenate of myocardium at 7, 14 and 30 days after the modelling pathology, as well as accompanied by metabolic imbalances in diffuse connective tissue elements, which are rich in collagens. Experimental modeling of DINC+TM increased the concentration of protein-bound oxyproline in blood serum significantly less intensive. Conclusions: The intensity of metabolic imbalances in diffuse connective tissue elements of myocardium is the highest in the low resistant animals to hypoxia. Those results are confirmed by histological examination of the myocardium of rats with different resistance to hypoxia. Fibrotic regions in myocardium are rich in collagens. It has been revealed that the most pronounced therapeutic effect of TM is observed in animals with low resistance to hypoxia, slightly less – in animals with medium resistance to hypoxia, and the lowest – in animals with high resistance to hypoxia.

scholarly journals INFLUENCE OF TRIMETAZIDINE METABOLIC THERAPY ON CONNECTIVE TISSUE METABOLISM IN EXPERIMENTAL DIFFUSE ISCHEMIC NECROTIC CARDIOSCLEROSIS IN RATS WITH DIFFERENT RATES OF HYPOXIA RESISTANCE

2016 ◽  
Author(s):  
H. S. Saturska ◽  
Yu. I. Bondarenko ◽  
U. V. Saturska
Keyword(s):  
Body Weight ◽  
Connective Tissue ◽  
Histological Examination ◽  
Control Group ◽  
Resistance To Hypoxia ◽  
Metabolic Therapy ◽  
White Rats ◽  
Medium Resistance ◽  
Group A ◽  
Trimetazidine Dihydrochloride

<p>Background. The change in metabolism of the connective tissue elements of heart is the central chain in<br />pathogenesis of diffuse ischemic necrotic cardiosclerosis (DINC), which occurs after repeated epinephrine injury<br />of myocardial tissues.<br />Objective. This study proves that trimetazidine (TM) metabolic therapy has a protective effect on the<br />development of DINC in rats with different rates of hypoxia resistance.<br />Methods. Male white rats were divided into three groups due to the different rates of hypoxia resistance by<br />means of the method of hypobaric hypoxia: rats with low, middle and high rates of hypoxia resistance. Each<br />group was divided into equal subgroups: a control group, a DINC group (injections of epinephrine hydrotartrate<br />(0,5 mg/kg of body weight) and calcium gluconate (5 mg/kg of body weight) two times), a control group administrated<br />with trimetazidine dihydrochloride (10 mg/kg of body weight), a DINC group treated with TM every day<br />(10 mg/kg of body weight) for all period of observation. Concentration of protein-bound oxyproline in blood<br />serum was evaluated on the 7th, 14th and 30th days after the pathology simulation. Histological examination of<br />Masson trichrome staining of myocardium was performed on the 30th days after the pathology simulation.<br />Results. DINC increased the concentration of protein-bound oxyproline in blood serum on the 7th, 14th and<br />30th days after the pathology simulation, and followed by metabolic imbalances in diffuse connective tissue elements,<br />which are rich in collagens. DINC+TM increased the concentration of protein-bound oxyproline in blood<br />serum less intensively.<br />Conclusions. The intensity of metabolic imbalances in diffuse connective tissue elements is the highest in<br />the low resistant animals to hypoxia. Those results are confirmed by histological examination of the myocardium<br />of rats with different resistance to hypoxia. Fibrotic regions in myocardium are rich in collagens. It has been<br />revealed that the most pronounced therapeutic effect of TM is observed in animals with low resistance to hypoxia,<br />slight – in animals with medium resistance to hypoxia, and the lowest – in animals with high resistance to<br />hypoxia.<br />KEY WORDS: hypoxia, heart, diffuse cardiosclerosis, trimetazidine, oxyproline.</p>

Effects of sodium selenite and amiloride on calvarial calcification in closing small cranial defects

2011 ◽  
Vol 114 (2) ◽  
pp. 478-484 ◽  
Author(s):  
Derviş Mansuri Yιlmaz ◽  
Ersin Hacιyakupoğlu ◽  
Sebahattin Hacιyakupoğlu ◽  
Sait Polat ◽  
Hülya Özgür ◽  
...  
Keyword(s):  
Body Weight ◽  
Connective Tissue ◽  
Autogenous Bone ◽  
Control Group ◽  
Tissue Samples ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Osteoplastic Material ◽  
The Right

Object Fresh autogenous bone graft is the most preferred osteoplastic material, whether the purpose is cosmetic, psychological, or for the protection of the brain. These grafts are not rejected and do not react immunologically. The aim of this study was to evaluate the efficacy of autogenous fat rolled with bone dust derived from the bur hole in closing small cranial defects. Additionally, the authors examined the morphological and biochemical effects of Na selenite and amiloride on calvarial calcification. Methods The study group consisted of 20 domestic pigs. These animals were randomly divided into 4 groups. A bur hole with a diameter of 10 mm was made at the right parietal region in all animals, and then the periosteum around the bur hole was cauterized following exposure of the dura mater. The dura was coagulated with bipolar cautery. Group 1 (controls): only a bur hole was opened, and it was then closed with a mixture of the bone dust that had been created during the opening of the bur hole and fat tissue that was taken from the animal's neck. Group 2 (amiloride): 1 nmol/g body weight of amiloride was applied subcutaneously within 15 minutes after closure of the bur hole with bone dust and fat, and then amiloride was applied once a day for 4 weeks. Group 3 (Na selenite): 30 nmol/g body weight of Na selenite was applied subcutaneously within 30 minutes after closure of the bur hole with bone dust and fat, and then Na selenite was applied once a day for 4 weeks. Group 4 (amiloride and Na selenite): 1 nmol/g body weight of amiloride was applied subcutaneously at 15 minutes, and 30 nmol/g body weight of Na selenite was applied subcutaneously at 30 minutes after closure of the bur hole with bone dust and fat, and these 2 injections were repeated once a day for 4 weeks. At the end of 4 weeks, the animals were anesthetized to evaluate the closure of the bur hole. Tissue samples were obtained for ultrastructural and biochemical examination. Results The defect was covered with diffuse connective tissue in the control group. Although multiple capillary vessels were present, the authors did not observe osteogenic differentiation. Histological examination of the second group revealed osteogenic changes. Although new matrix was formed, calcification was not detected. The authors observed fibroblast, collagen fibers, and dense connective tissue filled with capillary in the third group of pigs, which had undergone Na selenite application. Calcification was not detected in this group. Both connective and osteogenic tissue were observed in specimens obtained in the fourth group, which had undergone amiloride and Na selenite application. Conclusions The authors experimentally evaluated the supplementary osteogenic effects of Na selenite and amiloride by using them separately and together. The findings seem promising as a lead-in to new studies in restoring cranial defects.

Chloroacetonitrile induces intrauterine growth restriction and musculoskeletal toxicity in fetal mouse

2008 ◽  
Vol 24 (8) ◽  
pp. 511-518 ◽  
Author(s):  
AE Ahmed ◽  
HM El-Mazar ◽  
AA Nagy ◽  
AB Abdel-Naim
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Connective Tissue ◽  
Musculoskeletal System ◽  
Axial Skeleton ◽  
Epidemiological Studies ◽  
Control Group ◽  
Intrauterine Exposure ◽  
Calcified Cartilage ◽  
High Doses

Chloroacetonitrile (CAN) is a by-product of chlorination of drinking water. Epidemiological studies indicate that it might present a hazard to human health. The present study was designed to investigate the potential adverse effects of intrauterine exposure to CAN on fetal body weight and development of the musculoskeletal system in mice. At gestation day 6, pregnant mice were given CAN (12.5, 25, or 50 mg/kg/day) till gestation day 18. Uteri were then examined and live fetuses were collected, weighed, and evaluated for any malformations. High doses of CAN (50 mg/kg) significantly elevated fetal anomalies and reduced fetal viability. Chloroacetonitrile at a dose of 25 mg/kg did not affect fetal viability and significantly reduced fetal body weight. Subsequent experimentation was performed using this dose level. Histological examination of fetal axial skeleton indicated that CAN resulted in delayed appearance of endochondral ossification centers, widening of the vertebrae, and destruction of the calcified zone. In addition, the skeletal muscle fibers were markedly distorted, were small in size, and were widely separated by connective tissue. Both connective tissue perimysium and endomysium were less cellular compared with control sections. The histological findings were further confirmed by assessing the morphometric changes. Ratios of calcified cartilage to non-calcified cartilage areas in both control and CAN-exposed groups were determined. Also, skeletal muscle fiber diameter of CAN-exposed fetuses was significantly decreased compared with control group. In conclusion, intrauterine exposure to low levels of CAN decreases fetal body weight and induces malformations in the musculoskeletal system in mice.

Berberis vulgaris L. effects on oxidative stress and liver injury in lead-intoxicated mice

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Jawhar Laamech ◽  
Jaouad El-Hilaly ◽  
Hamadi Fetoui ◽  
Yassine Chtourou ◽  
Hanane Gouitaa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Aqueous Extract ◽  
Lead Acetate ◽  
Protein Carbonyls ◽  
Control Group ◽  
Distilled Water ◽  
Once Daily ◽  
Group 2 ◽  
Mice Liver

AbstractBackgroundL. (BV), commonly known as “MethodsSixty IOPS mice were divided into six groups and were treated as follows: group 1 (normal control) received double distilled water; group 2 (toxic control) received lead acetate (5 mg/kg body weight/day) in double distilled water for 40 days; groups 3–6 received BV aqueous extract at doses of 25, 50, 100 and 150 mg/kg body weight , respectively, once daily for 30 days from 11 day after beginning of lead acetate exposure to the end of the experiment.ResultsToxic control group showed a significant alteration of serum alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), total cholesterol (TC), total bilirubin (TB), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH). Histological assessment of lead-intoxicated mice liver revealed alterations in hepatocytes and focal necrosis. BV treatment significantly prevented lead accumulation, increased ALT, AST, TC, and TB, inhibited lipid peroxidation and protein carbonyls(PCO) formation. Additionally, BV extract normalized the antioxidant enzymes (CAT, SOD and GPx), GSH and architecture of liver tissues.ConclusionsBV aqueous extract exerts significant hepatoprotective effects against lead-induced oxidative stress and liver dysfunction. The BV effect may be mediated through the enhancement of antioxidant status, lead-chelating abilities and free radicals quenching.

scholarly journals Experimental justification for prompt neutralization of traumatic action of thermal exo- and endogenous damage factors (morphological features)

2021 ◽  
Vol 26 (6) ◽  
pp. 3040-3046
Author(s):  
VASYL NAGAICHUK ◽  
ROMAN CHORNOPYSHCHUK ◽  
OLEKSANDR NAZARCHUK ◽  
LUDMILA SIDORENKO ◽  
MYKOLA ZHELIBA ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Histological Examination ◽  
Thermal Damage ◽  
Burn Injuries ◽  
Control Group ◽  
Experimental Conditions ◽  
Skin Appendages ◽  
Experimental Justification ◽  
Traumatic Effect ◽  
Burn Depth

Objective: morphological substantiation of efficiency of prompt neutralization of traumatic action of exogenous and endogenous damage factors in burn injuries in experimental conditions. After simulating the burns on 60 rats, the traumatic hyperthermic damage factors in the main group were immediately neutralized by a gauze napkin soaked in water. Depending on its duration, the animals were divided into subgroups. Such applications were not performed on the control group. The study involved histological examination of tissues. Animals of the main groups had the presence of histologically confirmed skin appendages with a formed scar of connective tissue without signs of inflammation. In animals of the control group there were no skin appendages, which indicates a deeper thermal damage to tissues and the impossibility of self-epithelialization of wounds. These results confirm the importance and necessity of prompt neutralization of the traumatic effect of damage factors as the main elements of burn depth formation.

Obesity and body weight deficiency as predictors of gestational hypertension and cardiovascular disease

2020 ◽  
Vol 21 (4) ◽  
pp. 112-126
Author(s):  
A. D. Popov ◽  
◽  
T. V. Zuevskaya ◽  
E. S. Chernaya ◽  
E. V. Sadrieva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Cardiovascular Diseases ◽  
Pregnant Women ◽  
Gestational Hypertension ◽  
Clinical State ◽  
Control Group ◽  
Clinical Group ◽  
Second Trimester ◽  
Microbiological Methods

Purpose of work. To reveal possible predictors of cardiovascular diseases on the basis of studying mechanisms of gestational adaptation, parameters of homeostasis in women with obesity and body weight deficiency. Material and methods. During pregnancy in 297 patients with changed body weight and 107 women of the comparison group carried out dynamic study of homeostasis parameters and adaptation mechanisms. The clinical state was assessed using morphological, electrophysiological, hormonal, biochemical and microbiological methods. Results. Analysis of anamnestic data revealed that parents of 87% of patients with obesity and weight deficit had arterial hypertension combined with atherosclerosis, obesity, diabetes mellitus, and depression. The upper distribution of subcutaneous tissue and gestational hypertension were found to be prevalent in women of the main clinical group: during the whole period, the average blood pressure was exceeded in obese women and in women with a deficit of body weight in the second trimester. General cholesterol level in the second trimester was increased due to atherogenic fractions in pregnant women of the first group up to 6.21 ± 0.13 mmol/l, in the second group – 5.95 ± 0.20 mmol/l, against the control group 4.96 ± 0.31 mmol/l. Transitor glucosuria (in case of excluded diabetes mellitus) occurred only in pregnant women with changed body weight in the 2nd trimester. Stress reactions prevailed in women with obesity and deficit of body weight on the eve of labor: 77% (1) and 88% (2), exceeding the parameters of the control group; there was also an increase in the level of norepinephrine and dioxyphenylalanine in daily excretion of urine by 4-6 times. Decrease in species landscape of intestinal and vaginal flora with increasing share of pathogenic microorganisms was registered in 91% of pregnant main groups and only in 33% of control group patients. Conclusion. In women with changed body weight, pregnancy is accompanied by excessive activation and disintegration of adaptation systems, the clinical equivalent of which is gestational hypertension, metabolic and microecology disorders. Gestational stress-test allows to estimate phylogenetic features of response systems of young women and probable ontogenetic risks of cardiovascular diseases.

scholarly journals PROTECTIVE EFFECT OF CURCUMA LONGA ADMINISTRATION ON LUNG OF MICE EXPOSED TO CADMIUM

2018 ◽  
Vol 11 (10) ◽  
pp. 536
Author(s):  
Suman Sharma ◽  
Amrita Kumari
Keyword(s):  
Heavy Metal ◽  
Body Weight ◽  
Oral Dose ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Curcuma Longa ◽  
Protective Action ◽  
Control Group ◽  
Toxic Heavy Metal ◽  
Group 2

Objective: Cadmium (Cd) is a toxic heavy metal which is introduced into the environment by various anthropogenic and natural activities. It can cause various health problems even at low concentration by inducing oxidative damage in tissues of organisms. Nowadays, the focus has been raised toward the use of herbal treatment against the heavy metal toxicity. Hence, the present study was aimed to investigate the protective effect of curcumin (Cur) against Cd-induced toxicity in the lung of albino mice.Materials and Methods: Albino mice were divided into 4 groups and 5 mice were kept in each group. The experiment was carried out for 15 and 45 days. Group 1 mice were kept as control. Group 2 mice were given an oral dose of 1mg/kg body weight of Cd on alternate days. Group 3 mice were administered an oral dose of 1mg/kg body weight of Cd on alternate days and 100 mg/kg body weight of Cur daily. Group 4 mice were received an oral dose of 100 mg/kg body weight of Cur daily. Autopsies were done on 15 and 45 days post-treatment.Result: Biochemical observations showed an increased level of lipid peroxidation and decreased the activity of antioxidant enzymes, i.e., superoxide dismutase, catalase, and glutathione peroxidase. However, Cur administration improved the level of malondialdehyde and oxidative stress in lung tissue by its antioxidant activity. Furthermore, cotreatment of Cd and Cur ameliorated the antioxidant level.Conclusion: The results of the present experiment showed the protective action of Cur on the Cd-induced oxidative damage in the lung of mice.

scholarly journals Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice

2020 ◽  
Vol 80 (3) ◽  
pp. 484-496 ◽  
Author(s):  
S. Ali ◽  
M. Ejaz ◽  
K. K. Dar ◽  
S. Nasreen ◽  
N. Ashraf ◽  
...  
Keyword(s):  
Body Weight ◽  
Plant Extract ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Artemisia Vulgaris ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Glutamyl Transferase ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract The main objective of current study was to investigate the chemopreventive and chemotherapeutic activity of Artemisia vulgaris extract on diethylnitrosoamine induced hepatocarcinogenesis in Balb C mice. Diethylnitrosoamine (DEN: 0.9%) was prepared to induce hepatocarcinoma in Balb C mice. The extract Artemisia vulgaris (AV) was prepared by maceration technique. Mice were classified into four groups as follows: Group 1 a control group (N=7) received saline solution (3.5 μl/mg), group 2 (N=14) received diethylnitrosoamine (3.5 μl/mg) intraperitoneally once in a week for eight consecutive weeks, group 3 (N=7) received only plant extract (AV: 150 mg/kg (Body weight) once in a week, while group 4 (N=7) was given in combination of diethylnitrosoamine (3.5 μl/mg) and plant extract (AV: 150 mg/kg (body weight). After eight weeks of DEN administration, mice of group 2 were divided into two subgroups containing seven mice each; subgroup 1 was sacrificed while subgroup 2 was treated with plant extract only (150 mg/kg (body weight)) once in a week for eight consecutive weeks. The DEN injected mice significant decline in levels of albumin with concomitant significant elevations such as aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alpha feto protein, gamma glutamyl transferase, 5 nucleotidase, glucose-6-phosphate dehydrogenase and bilirubin. The administration of A. vulgaris significantly decreased the DEN induced hepatotoxicity. Present study revealed the potential anti-cancerous nature of Artemisia vulgaris, both in case of chemopreventive and post-treatment of A. vulgaris. Further studies are needed to explore the mechanism of prevention and therapy.

scholarly journals Influence of cadmium sulfate at different doses on the functional state of the liver of laying chicken

2019 ◽  
Vol 21 (94) ◽  
pp. 103-108 ◽  
Author(s):  
A. Y. Ostapyuk ◽  
B. V. Gutyj
Keyword(s):  
Body Weight ◽  
Blood Serum ◽  
Functional State ◽  
The Body ◽  
Control Group ◽  
Cadmium Sulfate ◽  
Group 4 ◽  
Group 2 ◽  
Destructive Processes ◽  
Different Doses

The article presents the results of studies on the influence of cadmium sulfate in different doses on the organism of poultry. Absorbed cadmium accumulates in the liver as a complex with metallothionein. The purpose of the work was to find out the effect of cadmium sulfate in doses of 2 and 4 mg / kg of body weight on the functional state of the liver of chicken. For research, three groups of birds were formed: control and two experimental. The control group of chickens were in the usual diet, they were fed with forage and were given water without introducing cadmium sulfate. To the drinking water of chickens of experimental groups for 30 days, added cadmium sulfate in doses: the first group – 2 mg/kg, the second group – 4 mg/kg body weight. The conditions for keeping chickens and the microclimate parameters in the room for all bird groups were similar. Blood from the chickens was taken from the subclavian vein in periods: before the dasg was given and on the first, seventh, fourteenth, twenty-first and thirtieth day of the experiment. It was determined that the presentation of cadmium sulfate in doses of 2 and 4 mg/kg of body weight of cows, which contributed to a violation of the functional state of the liver, as evidenced by the increased activity of aminotransferases in their blood serum. The activity of alanine and aspartate aminotransferase was higher in serum of blood of chickens in the second experimental group at 21st and 30th days of the experiment. The high activity of aminotransferases in the blood serum of chickens for cadmium loading indicates destructive processes in the liver that cause an increase in the release of aminotransaminases from cellular organelles in the blood of experimental poultry. Thus, the obtained results indicate an increase in destructive processes in the body of chickens for cadmium loading.

scholarly journals The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats

2018 ◽  
Vol 87 (4) ◽  
pp. 379-385 ◽  
Author(s):  
Mehtap Ozcelik ◽  
Mine Erişir ◽  
Osman Guler ◽  
Murat Baykara ◽  
Esra Kirman
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Body Weight ◽  
Glutathione Peroxidase ◽  
Control Group ◽  
Sod Activity ◽  
Irradiation Group ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The effect of irradiation on oxidants and antioxidants in selected tissues and a possible protective effect of curcumin on these indices were investigated. A total of 28 rats were divided into 3 groups; group 1 was control; group 2 was the irradiation group, saline was administered intraperiotenally (i.p.) for three days and then, 9 Gy gamma irradiation was applied; group 3 was the irradiation + curcumin group: curcumin was given i.p. for three days at 200 mg/kg body weight and then the same dose of irradiation was applied. A significant increase in malondialdehyde (MDA) was detected in the liver, kidney, and brain tissues of the rats as a result of irradiation (P< 0.01). Glutathione peroxidase (GSH-Px) activity in all the tissues (except for kidneys) decreased (P< 0.01), liver SOD (superoxide dismutase) activity decreased (P< 0.05), and GSH (glutathione) levels in kidney and ovary tissues (P< 0.001) significantly increased. While curcumin administration returned the increased MDA levels in the kidneys and brain in result of irradiation to normal (P< 0.01), it did not return the increased MDA levels in the liver tissue to normal (P< 0.001) despite significantly reducing them. While decreased GSH-Px and SOD activity in the liver in result of irradiation increased with the addition of curcumin (P< 0.05), increased GSH levels in the kidneys and ovaries returned to control levels (P< 0.001). When MDA values were examined, it was found that the addition of curcumin protected the liver, kidneys and brain from the oxidative damage caused by irradiation.

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