scholarly journals Reflections of an Earliest Established Screening and Testing Facility for COVID-19 in the Largest Metropolis, Pakistan

As the world struggles to deal with the COVID-19 pandemic, this article talks about the experience and findings of the first COVID-19 screening facility in a tertiary care hospital in Karachi, Pakistan. Department of Family Medicine at Aga Khan University (AKU) took initiative where COVID-19 screening of stable patients first began in a dedicated area. Since testing kits were limited and community spread had not started, nurses would screen every walk-in patient based on the presence of fever, cough, travel history and exposure to COVID-19 positive patient in the last 14 days, and advise swab testing if indicated. Out of 742-screened patients, approximately 66% were males and 34% were females. 38% of patients reported fever and 54% of patients reported cough. 8% (65) patients checked all three screening criteria of cough, fever and international travel exposure whereas 35% were asymptomatic. The majority had clinical exposure (38.3%) followed by public exposure (33.4%) and international travel exposure (19.8%).

Author(s):  
Suchita Sachin Palve ◽  
Pallavi Sachin Chaudhari

Background: The COVID-19 pandemic has put global health at stake by creating havoc all over the world, due to which the world, as well as health agencies, are experiencing the greatest challenges. This disease is a health emergency due to its high level of infectiousness and the non-availability of any specific treatment [1]. Objectives: To determine and compare the significance of physiological and haematological parameters in the diagnosis of COVID 19 infection and compare the association of physiological and haematological parameters among mild and severe COVID-19 patients. Methodology: The present comparative, observational study was carried out in a designated tertiary care hospital, where admission of COVID19 patients in Pune district, India. Various parameters like age, height, weight, BMI, various physiological variables, haematological parameters, and CRP levels were assessed among 202 Mild and 50 severe COVID 19 diagnosed patients on day one of the hospital's stays. Results: Pearson’s correlation coefficient showed a significant correlation among physiological and haematological variables compared to both groups, especially physiological parameters like SBP and DBP. The results showed that TLC, CRP, NLR, PLR, among COVID 19 patients cans work as important biomarkers to understand the disease prognosis. Conclusion: Study of physiological and haematological parameters and their interrelation will help in understanding the impact of COVID 19 infection on the reactive inflammatory responses and help in understanding the prognosis of the disease among mild and severe patients.


2020 ◽  
Vol 42 (3) ◽  
pp. 97-101
Author(s):  
Anish Mudvari ◽  
Dipendra Yadav ◽  
Rakesh Ghimire ◽  
Pravin Prasad

Introduction Adverse drug reaction (ADR) is a leading cause of morbidity and mortality around the world. Causality assessment is done to establish relation of drug exposure with undesired clinical events. This study conducted in tertiary care hospital was undertaken to evaluate the patterns of ADR and causality assessment using Naranjo causality algorithm. MethodsData on suspected ADR cases were collected retrospectively from Medicine and Dermatology wards of Tribhuvan University Teaching Hospital, Kathmandu from April 2018 to April 2019. Naranjo causality assessment was performed. Statistical analysis was done using SPSS version 18. ResultsOf 34 suspected ADR, occurrence of ADR was more in females (18) as compared to males (16). Skin and integumentary system was the most common organ affected (35.29%). Pyrazinamide induced hepatitis was found to be the most common suspected ADR. Causality assessment was performed and ADRs were categorized as possible 17 (50%), probable 16 (47.06%) and definite 1 (2.94%). ConclusionThe patients are commonly admitted at the hospital due to suspected ADRs. Pyrazinamide induced hepatitis was the most common suspected ADR.


2008 ◽  
Vol 47 (169) ◽  
Author(s):  
Srijana Adhikari ◽  
B P Badhu ◽  
N K Bhatta ◽  
R S Rajbhandari ◽  
B K Kalakheti

World Health Organization’s Vision 2020 program has recognized Retinopathy of Prematurity(ROP) as an important cause of childhood blindness in industrialized and developing countries. Inthe last few years, it has been identifi ed in many under developed countries as well, as a result ofimproved neonatal intensive care. In Nepal, ROP screening is carried out in a few tertiary hospitalsbut there is no published data on this disease. The purpose of this study was to fi nd out the incidence,severity and risk factors of ROP among infants screened in a tertiary care hospital in the EasternRegion of Nepal.A prospective cohort study was carried out in neonates with gestational age of 34 weeks or less and,or birth weight of 1700 gm or less born over the period of one year. Dilated fundus examination ofall babies was done by indirect ophthalmoscopy between 2-4 weeks after birth and followed up tillthe retinal vascularization was complete. Classifi cation of ROP was done according to internationalclassifi cation (ICROP). Maternal and neonatal risk factors were also noted.A total of 55 babies fulfi lled the screening criteria. ROP was present in 25.45% (n=14) of the babies.Threshold disease was noted in 5.45% (n=3) of the babies screened. Low birth weight (p<0.01)and low gestational age (p<0.01) was signifi cantly associated with the incidence of ROP. Oxygensupplementation (p=<0.01) was an independent risk factor.ROP screening should be performed in all preterm low birth weight infants where there is availabilityof good neonatal intensive care units. The examination should be intensifi ed in those having riskfactors like oxygen. Further studies in the other tertiary care hospitals in Nepal would help toestablish the screening criteria for Nepalese infants.Key words: Retinopathy of prematurity, Eastern Nepal, screening


2012 ◽  
Vol 2 (1) ◽  
pp. 20-22 ◽  
Author(s):  
Sudarshan L Reddy ◽  
Sridhar D Reddy ◽  
AVVSL Prasad

ABSTRACT A prospective study conducted over a period of 2 years at a tertiary care hospital on all patients who underwent total laryngectomy to study the complications of the surgeries, their possible etiology. Laryngectomy is one of the most frequently done oncological surgeries in this part of the world, with high incidence of morbidity. Through improved techniques and preand postoperative protocols the incidence of complications have reduced, none the less they occur. Aim of the present study is to note the incidence of complications and their management in our setup. How to cite this article Reddy SL, Reddy SD, Prasad AVVSL. A Prospective Study of Total Laryngectomy and associated Complications. Int J Phonosurg Laryngol 2012;2(1):20-22.


Author(s):  
Jayshree Dawane ◽  
Kalyani Khade ◽  
Yamini Ingale ◽  
Vijaya Pandit

Objective: The objective of this study is to evaluate pain and to assess if analgesic prescriptions are according to the World Health Organization guidelines. Methods: The study was conducted in the Department of Surgery in a tertiary care hospital. Patients with age >18 years, of either sex, admitted to surgery ward were included in the study. Pain assessment was done using a visual analog scale and McGill questionnaire. Information obtained from case paper sheets was recorded, such as name of analgesics, the generic name of prescribed analgesics, dosage, route of administration, frequency, number of analgesics per prescription, and non-pharmacological techniques. Data generated from the questionnaire were entered into an Excel sheet, and percentages were calculated. Results: A total of eight different analgesics were prescribed in the study group. Paracetamol was the maximally prescribed drug (40%). In 48% of cases, antacids were given along with analgesics. A majority of analgesics were prescribed in generic names (52%). No drug was prescribed to almost 18% cases even though the pain intensity was of mild-to-moderate intensity. Conclusion: Commonly prescribed drugs were paracetamol + tramadol. Prescription pattern of analgesics is partially deviating from standard guidelines. Generic names were written in the majority of prescriptions, which is in accordance with standard prescription writing.


2020 ◽  
Vol 71 (11) ◽  
pp. 2976-2980 ◽  
Author(s):  
Wei Gu ◽  
Xianding Deng ◽  
Kevin Reyes ◽  
Elaine Hsu ◽  
Candace Wang ◽  
...  

Abstract In early-to-mid March 2020, 20 of 46 (43%) COVID-19 cases at a tertiary care hospital in San Francisco, California were travel related. Cases were significantly associated with travel to either Europe (odds ratio, 6.1) or New York (odds ratio, 32.9). Viral genomes recovered from 9 of 12 (75%) cases co-clustered with lineages circulating in Europe.


Author(s):  
Waseeqa Nigeen ◽  
Saima Salam ◽  
Samina Ashraf ◽  
Abdus Sami Bhat

Background: Obstetric ICUs have become an important part of any tertiary care obstetric hospital. There have been studies in different parts of the world including India to determine the clinical spectrum, management and outcome of the patients admitted to these units. There have been a few studies on the subject from our part of the country, so we tried to carry out the said study. Our objective was to study indications of admissions, the pattern of complications, interventions required, and the maternal and fetal /neonatal outcome of the patients admitted in an obstetric ICU of our hospital.Methods: A retrospective descriptive study carried out at Lalla Ded hospital Srinagar, a tertiary care hospital of north India, between January 2017 and June 2017.Results: Fifty patients among 4890 obstetric admissions required ICU care giving an admission rate of 1.02%. Most of the patients fell in the age group of 26-30years (52%) followed by 31-35 years (24%).The most frequent indication for admission to ICU was pregnancy induced hypertension related eclampsia and preeclampsia which constituted about 44% (n=22) of the admissions. Obstetric haemorrhage was a close second and accounted for 34% (n=17) of the admissions. Mean ICU stay was 2.5±1 days. Four patients died giving a maternal mortality rate of 8% in this ICU. There were eleven fetal and neonatal deaths excluding ectopic pregnancy giving a fetal /neonatal mortality rate of 22%.Conclusions: Obstetric ICUs have become an important part of any tertiary care obstetric hospital. Significant number of patients get admitted and treated in these ICUs. In our part of the world majority of ICU admissions are because of eclampsia/preeclampsia and obstetric haemorrhage. Although a large number of mothers and their neonates get benefitted by way of admission to ICUs, a significant proportion of these mothers and their neonates die. There is a lot of scope of improvement in maternal and perinatal mortality. In addition to the importance of setting up of state of the art obstetric ICUs, the need for supervision of pregnancies, institutional deliveries, early detection of complications and early referral cannot be overemphasized. 


Biomedicines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 4
Author(s):  
Anders Larsson ◽  
Miklós Lipcsey ◽  
Michael Hultström ◽  
Robert Frithiof ◽  
Mats Eriksson

COVID-19 has shaken the world and intensive care units (ICU) have been challenged by numerous patients suffering from a previously unknown disease. Leptin is a polypeptide pleiotropic hormone, mainly expressed by adipocytes. It acts as a proinflammatory cytokine and is associated with several conditions, known to increase the risk of severe COVID-19. Very little is known about leptin in severe viral disorders. Plasma leptin was analyzed in 222 out of 229 patients with severe COVID-19 on admission to an ICU at Uppsala University Hospital, a tertiary care hospital in Sweden, and compared to plasma leptin in 25 healthy blood donors. COVID-19 was confirmed by positive PCR. Leptin levels were significantly higher in patients with COVID-19 (18.3 ng × mL−1; IQR = 30.4), than in healthy controls (7.8 ng × mL−1; IQR = 6.4). Women had significantly higher leptin values (22.9 ng × mL−1; IQR = 29.8) than men (17.5 ng × mL−1; IQR = 29.9). Mortality at 30 days was 23% but was not associated with increased leptin levels. Neither median duration of COVID-19 before admission to ICU (10 days; IQR = 4) or median length of ICU stay (8 days; IQR = 11) correlated with the plasma leptin levels. Leptin levels in COVID-19 were higher in females than in males. Both treatment (e.g., use of corticosteroids) and prophylaxis (vaccines) have been improved since the start of the COVID-19 pandemic, which may contribute to some difficulties in deciphering relations between COVID-19 and leptin.


2020 ◽  
Author(s):  
Somen Kumar Pradhan ◽  
Dinesh Prasad Sahu ◽  
Durgesh Prasad Sahoo ◽  
Arvind Kumar Singh ◽  
Binod Kumar Patro ◽  
...  

AbstractIntroductionThe COVID-19 pandemic continuing to be a significant public health concern across the whole world, including India. In the absence of any specific treatment or vaccine against COVID-19., the role of efficient testing and reporting has been uncontested so far as the number of cases is rising daily. In order to strengthen the screening activities and to prevent nosocomial infection, facility-based screening centres have been designed and operated at various level of healthcare, including tertiary care institutions.MethodsThe present study has been planned with an objective to understand the patient profile and evaluate the functioning of COVID-19 screening OPD(CS-OPD) at a tertiary care hospital. In this hospital-based retrospective study, data from individuals visiting the COVID-19 screening OPD during the period from 17th March 2020 to 31st July 2020 were collected. We documented and analysed relevant demographic, epidemiological and clinical characteristics of the patients.ResultsA total of 10,735 patients visited the COVID-19 screening OPD during the defined study period out of which 3652 individuals were tested. Majority of the patients, i.e. 65.67% (7050) were male and in 15-59 years age group (84.68%). Most common symptoms among patients visiting CS-OPD was Cough (9.86%). Out of the total, 17.17% (1843) of patient reported to the CS-OPD with contact history of COVID-19 positive patient. On the other hand, 13.49% (1448) of patients were with either domestic or international travel history. The overall testing rate and positivity rate for CS-OPD during this period were found to be 34.02% and 7.94% respectively.ConclusionThe clinical, demographic and epidemiological characteristics of patients visiting CS-OPD varied across the study period depending upon the containment and testing strategy. The CS-OPD played a crucial role in preventing nosocomial infection and maintaining non-COVID care at the tertiary care hospital.


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