scholarly journals The composition of microorganisms in the skin lesions focus in patients with seborrheic dermatitis

2019 ◽  
pp. 38-41
Author(s):  
Инна Одинцова ◽  
Анатолий Дюдюн
Keyword(s):  
Microscopic Examination ◽  
Blood Test ◽  
Inflammatory Process ◽  
Pathological Condition ◽  
Seborrheic Dermatitis ◽  
Skin Lesions ◽  
Pathogenic Microorganisms ◽  
Degree Of Contamination ◽  
Acinetobacter Spp ◽  
Malassezia Spp

The purpose of the work is monitoring the microbial landscape of the skin of patients with seborrheic dermatitis. Materials and research methods. We observed 67 patients with seborrheic dermatitis aged 18 to 57 years. The average age of the patients was 27.5 years. All patients with seborrheic dermatitis were examined using the following methods: skin examination; microscopic, bacteriological methods; a general and biochemical blood test; a general urinalysis; consideration of the patient's subjective sensations. Results and its discussion. Among patients with seborrheic dermatitis, fatty seborrhea was found in 39 (58 %), a mixed form of seborrheic dermatitis was found in 20 (30 %) patients. While bacteriological and microscopic examination of the sampling material from the affected areas of the skin of patients with seborrheic dermatitis is carried out, it is noteworthy to consider that in 59 (88.1%) patients Malassezia spp. is detected, which indicates a certain its value in the occurrence and course of the pathological condition. Among other microorganisms the examinations revealed: St. capitis - at 54 (80.1 %), St. epidermidis - at 36 (53.7 %), Micrococcus spp. - at 20 (29.9 %), Acinetobacter spp. - at 10 (14.9 %). With a lesser degree of contamination, St. aureus, St. capitis, St. hominis, St. cohnii, St. xylosus have been found. Conclusions. It is necessary to consider the presence of fungi Malassezia spp. in association with pathogenic and conditionally pathogenic microorganisms that support the inflammatory process and affect the development and course of the disease while planning the treatment of patients with seborrheic dermatitis.

scholarly journals Lipogranulomas of the mammary glands: diagnosis and treatment

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Natalia Cara ◽  
◽  
Veronica Svet ◽  
Ion Mereuta ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Mammary Gland ◽  
Inflammatory Process ◽  
Pathological Condition ◽  
Scar Tissue ◽  
Mammary Glands ◽  
Diagnosis And Treatment ◽  
Breast Lesions ◽  
Fat Necrosis

Steatonecrosis of the mammary gland is necrosis of its adipose tissue, followed by replacement with scar tissue. Lipogranuloma is known as a benign inflammatory process, necrosis of breast fat occurs due to iatrogenic breast trauma. Most often, fatty necrosis is seen in women with large breasts – in women with small breasts, it develops much less often. It is important to diagnose lipogranulomas because it can often mimic breast cancer. Fat necrosis of the breast is a common pathological condition, with a wide variety of presentations on mammography, ultrasound and MRI. The incidence of fatty necrosis of the breast is estimated at 0.6%, representing 2.75% of all breast lesions.

scholarly journals Fungi of the genus Malassezia as opportunists of humans and animals

2018 ◽  
Vol 72 ◽  
pp. 359-375 ◽  
Author(s):  
Urszula Czyżewska ◽  
Magdalena Siemieniuk ◽  
Marek Bartoszewicz ◽  
Adam Tylicki
Keyword(s):  
Extracellular Enzymes ◽  
Cell Structure ◽  
Seborrheic Dermatitis ◽  
Epidemiological Data ◽  
Protein Profiling ◽  
Specific Cell ◽  
Malassezia Pachydermatis ◽  
Malassezia Folliculitis ◽  
Malassezia Spp

Yeasts from the genus Malassezia are common commensals and pathogens found in humans and animals, and are responsible for tinea cases. Due to their specific cell structure, they may be resistant to environmental stresses and difficult to eliminate by the host’s immune system. In spite of several virulence factors, the pathogenicity of Malassezia spp. and their interactions with hosts still arouse great interest. Genomes of particular isolates, representing the majority of species from the Malassezia genus, have been sequenced in recent years. Moreover, reconstruction of the phylogeny, by the usage of ITS and IGS sequences, has been attempted as well. Biochemical analyzes led to a better understanding of those fungi’s ecology and virulence. Lipid and protein profiling, the assessment of phospholipases and extracellular enzymes activities, brought new insight into the genesis and courses of diverse illnesses, including pityriasis versicolor, seborrheic dermatitis, atopic dermatitis, Malassezia folliculitis, psoriasis and systemic fungemia. Special attention should be paid to Malassezia pachydermatis, which is a potential model of zoophilic species with an increasing frequency of tinea cases caused in humans. Furthermore, in vitro experiments suggest its possible drug resistance. The members of Malassezia genus are a serious medical and therapeutic challenge. Because of difficulties in the assessment of their virulence, high genetic and biochemical diversity and, finally, complicated evolutionary traits, they require further research. Genomic and proteomic analyses, supported with biochemical profiling and epidemiological data, will contribute to a better understanding of the biology of the yeasts, especially the issue of opportunism among fungi.

scholarly journals Видовий склад фітопатогенної флори насіння сої

2015 ◽  
pp. 44-48
Author(s):  
Г. Д. Поспєлова
Keyword(s):  
Species Composition ◽  
Quality Indicators ◽  
Bacterial Flora ◽  
Soybean Seeds ◽  
Pathogenic Microorganisms ◽  
Degree Of Contamination

Викладено результати фітоекспертизи насіннясої. Визначено показники якості, ступінь інфікуваннята видовий склад патогенних мікроорганізмів. Іден-тифіковані представники грибної (роди Alternaria,Fusarium, Peronospora, Cladosporium, Botrytis, Aspergillus,Penicillium, Mucor) і бактеріальної флори (бак-терії роду Pseudomonas). Серед виявлених патогенівнайбільшу поширеність мали гриби родів Alternaria(26–35 %) і Mucor (22–47 %). Встановлено, що видо-вий склад патогенів є неоднаковим на різних сортахсої. Найбільш різноманітним він був у насінні сої сор-ту Київська 98. The results of photoexpress of soybean seeds are presented. The quality indicators, the degree of contamination and species composition of pathogenic microorganisms are defined. The representatives of mushrooms (genus Alternaria, Fusarium, Peronos-pora, Cladosporium, Botrytis, Aspergillus, Penicil-lium, Mucor) and bacterial flora (bacteria of the genus Pseudomonas) are identified. Among the pathogenic microorganisms was widely spread fungi of the genus Alternaria (26–35 %) and Mucor (22–47 %). The species composition of pathogens is varies on different soybean varieties. It was more diverse of soybean seed’s variety Kyivs’ka 98.

scholarly journals An Observational Cross-Sectional Study of the Proportion of Cutaneous Lesions Affecting External Ear, Presenting to Outpatient Clinic of a Tertiary Care Medical College in the Eastern Part of India

2021 ◽  
Vol 8 (19) ◽  
pp. 1414-1419
Author(s):  
Kanishka Chowdhury ◽  
Sabyasachi Banerjee
Keyword(s):  
Seborrheic Dermatitis ◽  
Tertiary Care ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Outpatient Department ◽  
Basic Knowledge ◽  
External Ear ◽  
Cutaneous Lesions ◽  
Cross Sectional ◽  
Medical College

BACKGROUND Cutaneous lesions of external ear are quite common in clinical practice. Patients often present with various cutaneous lesions of the external ear to various disciplines. They are often underdiagnosed as many lesions, though commonly diagnosed by our dermatologist colleague are missed by other clinicians. These lesions can be classified in various ways, according to the aetiology, and according to the anatomic sites. In the present study, we tried to assess the prevalence of different skin lesions affecting external ear presenting to an ENT and skin outpatient department of a tertiary care medical college in Eastern part of India. METHODS This is a descriptive observational study, cross sectional in design. 240 patients attended the outpatient department with cutaneous lesions affecting external ear from January 2019 to February 2020. The patients presenting in both ENT and skin outpatient department were chosen randomly. Cases were diagnosed based on history and clinical examination and appropriate investigation as required. All cases were categorised into 5 types (infective, inflammatory, autoimmune, neoplasm & naevi, and reactive & reparative) according to the aetiology. In each category, prevalence of various skin lesions was recorded. RESULTS A total number of 240 cases were detected during the study period. Among them, infective 43.33 %, inflammatory 30.83 %, autoimmune 9.17 %, neoplasm & naevi 4.17 % and reactive & reparative were 12.82 %. Taenia was the most common lesions encountered (20.51 %) followed by keloid (12.5 %). Impetigo and seborrheic dermatitis shared same number of cases (9.4 %). Neoplastic lesions were the least common. CONCLUSIONS With some awareness and basic knowledge, many of the cutaneous lesions of external ear can be diagnosed and treated whenever patients report to a clinician, thus saving valuable time, effort and money of the patient. KEYWORDS Cutaneous Lesions, Skin Lesions, External Ear

scholarly journals Dermatoses in parkinsonism: the importance of multidisciplinary follow-up

2019 ◽  
Vol 65 (6) ◽  
pp. 791-795 ◽  
Author(s):  
Isadora Antunes ◽  
Kátia Sheylla Malta Purim ◽  
Luara Leticia Grande ◽  
Nathália Cristina Alberton ◽  
Tatiana Francinne Regis Navarro ◽  
...  
Keyword(s):  
Actinic Keratosis ◽  
Seborrheic Dermatitis ◽  
Skin Lesions ◽  
Disease Diagnosis ◽  
Seborrheic Keratosis ◽  
Cross Sectional ◽  
Inflammatory Dermatoses ◽  
Malignant Skin ◽  
Pigmented Nevus

Summary Parkinsonism is characterized by bradykinesia with rigidity and/or resting tremor, in addition to non-motor symptoms, which include dermatological manifestations. The objective of this study is to evaluate the main dermatoses in patients with parkinsonism found at the Philanthropic Association of Curitiba - PR. A cross-sectional descriptive study was carried out with the application of a questionnaire and dermatological evaluation of the patients. The sample consisted of 386 patients and was composed mainly by men (55.4%), between 60-74 years old (51.6%), with complete primary education (45.3%), disease diagnosis time between 5-10 years (35%) and in use of medication (96.6%). The most prevalent dermatoses were pigmented nevus (36.3%), warts (25.1%), actinic keratosis (22%), seborrheic keratosis (21.5%), seborrheic dermatitis (20.5%), and rosacea (19.2%). Among the 13 cases (3.4%) of malignant cutaneous neoplasms confirmed by biopsy, 2 were melanomas. Regarding patients’ sex, there was a higher prevalence of inflammatory dermatoses (OR 1.64, 95% CI 1.08-2.51, p = 0.025) and benign cutaneous neoplasms (OR 1.77, 95% CI 1.16-2.69, p = 0.01) in men. As to age, patients aged between 60-74 years had more pre-malignant skin lesions (OR 2.60, 95% CI 1.05-6.44, p <0.001) and seborrheic keratosis (OR 2.52, 95% CI 1.02-6.25, p = 0.001) and, in those older than 75 years, actinic keratosis was more frequent (OR 5.43, 95% CI 2.17-13.6, p <0.001). The results of the study show that it is fundamental to dermatologically evaluate and monitor these patients, aiming at diagnosis and early treatment of lesions, especially of skin cancer.

scholarly journals Prevalence and Antibiogram Profiling of Rotten Fruits from Different Areas of Dhaka City, Bangladesh

2020 ◽  
pp. 1-9
Author(s):  
Mahmuda Akhter Akhi ◽  
Avijit Banik ◽  
Oshin Ghurnee ◽  
Nantu Chandra Das ◽  
Showmitro Nondi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Vibrio Parahaemolyticus ◽  
Pathogenic Microorganisms ◽  
Dhaka City ◽  
Salmonella Spp ◽  
Street Vendors ◽  
E Coli ◽  
Daily Diet ◽  
Acinetobacter Spp ◽  
Klebsiella Spp

Fruits are highly nutritious, sources of vitamins, minerals, fibers etc. and these are part of our daily diet. However, during cultivation, harvesting, transportation, handling fruits get contaminated with pathogenic microorganisms which leads to severe problems to community. Owning to this point, in current research, bacteriological analysis was performed on Sofeda, Pineapple, Grape, Banana, Apple, Orange, Guava, papaya, Jujube and Starfruit. Total 50 samples were randomly collected from market and street vendors of Dhaka city. Higher numbers of rotten fruits were present in wholesale markets. 35 strains were isolated which included Salmonella spp., Acinetobacter spp., Klebsiella spp., Vibrio cholerae, Vibrio parahaemolyticus, Staphylocoous aureus and E. coli. They were identified using biochemical test and antibiogram for selective isolates. In case of drug resistance of isolates, majority exhibited resistance against Erythromycin, Vancomycin and Amoxycillin and showing sensitivity against Ciprofloxacin and Ceftriaxone. It was observed in the current study that 100% isolates were resistant against Erythromycin, followed by Amoxycillin 90.63% and vancomycin 86.25%, where only 35.27% isolates were resistant against Ciprofloxacin. In case of sensitivity 64.73% isolates were sensitive against Ciprofloxacin followed by Ceftriaxone 66.25%. 

scholarly journals Efficacy of nilotinib in a patient in late chronic phase CML, intolerant to imatinib and resistant to dasatinib

2015 ◽  
Vol 5 (5S) ◽  
pp. 27-30
Author(s):  
Emilio Usala
Keyword(s):  
Cytogenetic Analysis ◽  
Blood Test ◽  
Chronic Phase ◽  
Bone Marrow Aspiration ◽  
Cytogenetic Response ◽  
Skin Lesions ◽  
2Nd Generation ◽  
Sokal Score ◽  
Level Reduction

We describe the case of a 60-year-old woman who was admitted to our hospital in 1999. A blood test performed for pain in the upper left side of the abdomen had showed leukocytosis. At the admission the patient was apyretic, with no systemic signs. An important splenomegaly was found at physical examination. The results of the bone marrow aspiration (hypercellularity) and the cytogenetic analysis (chromosoma Ph in all metaphasis) allowed us to diagnose CML. The patient’s Sokal score was high (1.252). The patient was treated with hydroxyurea until 2002, when imatinib became available. Then she started imatinib at the dosage of 400 mg/die. Tests performed during the follow up showed a fast haematological response but no cytogenetic response in two years. The patient received imatinib until February 2004, when a psoriasiform-lichenoid dermatosis appeared. Therefore we decided to interrupt the therapy and the skin lesions disappeared. After starting again imatinib, also dermatosis reappeared, so we decided to interrupt imatinib definitively. On July 2007 the patient started dasatinib, a 2nd generation TKI. No adverse events occurred and cytogenetic analysis performed periodically was always positive (no response). She continued on dasatinib until May 2010, when she switched to nilotinib. In seven months a complete cytogenetic response (CCyR) was documented with level reduction of Bcr Abl transcript from 13.0 to 2.0. Currently the patient is still receiving nilotinib, with persistent CCyR.

scholarly journals Seborrheic dermatitis and its relationship with Malassezia spp

Infectio ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 120
Author(s):  
Manuel Alejandro Salamanca-Córdoba ◽  
Carolina Alexandra Zambrano-Pérez ◽  
Carlos Mejía-Arbeláez ◽  
Adriana Motta ◽  
Pedro Jiménez ◽  
...  
Keyword(s):  
Seborrheic Dermatitis ◽  
Malassezia Spp

scholarly journals Sorafenib-related generalized eruptive keratoacanthomas (Grzybowski syndrome): a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
M. Nazim Abbas ◽  
Wei Son Tan ◽  
Ganessan Kichenadasse
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tyrosine Kinases ◽  
Seborrheic Dermatitis ◽  
Excisional Biopsy ◽  
Skin Lesions ◽  
Multikinase Inhibitor ◽  
Skin Squamous Cell Carcinoma ◽  
Cutaneous Toxicities

Abstract Background Sorafenib is an oral multikinase inhibitor that targets Raf serine/threonine receptor tyrosine kinases and inhibits tumor cell growth and angiogenesis. Cutaneous toxicities of sorafenib are common, including cutaneous eruptions (such as truncal erythema and seborrheic-dermatitis-like changes) and hand–foot syndrome. Keratoacanthomas and squamous cell carcinomas have been reported previously; however, we report a case of multiple eruptive keratoacanthomas in the form of Grzybowski syndrome after initiation of sorafenib. Case presentation We report a 63-year-old Caucasian male who developed multiple cutaneous eruptive keratoacanthomas after starting sorafenib 400 mg twice daily. He had a known history of hepatitis-C-related cirrhosis and hepatocellular carcinoma, and previously had actinic keratosis and skin squamous cell carcinoma excision. Approximately two and a half months after starting sorafenib, the patient initially developed two lesions, one on each forearm, and after excision, these lesions demonstrated histological features of squamous cell carcinoma. One month later, the patient presented with approximately 48 new skin lesions of varying size on the back, bilateral upper limbs, and face requiring excisional biopsy of a large number of these lesions. Histopathology showed eruptive invasive keratoacanthomas (Grzybowski syndrome). Sorafenib was temporarily stopped and subsequently restarted at a lower dose. Acitretin 25 mg daily was commenced after few weeks, and no further keratoacanthomas developed during his treatment. Conclusions We report a unique case of sorafenib-associated Grzybowski syndrome. Temporary interruption and dose reduction of sorafenib and use of acitretin appeared to prevent further development of keratoacanthomas.

scholarly journals Occurrence of Malassezia Spp. on Healthy Human Skin

2019 ◽  
Vol 63 (4) ◽  
pp. 54-59
Author(s):  
Z. Malinovská ◽  
E. Čonková ◽  
P. Váczi ◽  
M. Harčárová ◽  
E. Böhmová
Keyword(s):  
Normal Skin ◽  
Seborrheic Dermatitis ◽  
The Elderly ◽  
Host Immune System ◽  
Healthy Human ◽  
Humoral Immune ◽  
Clinically Normal ◽  
Malassezia Spp ◽  
Animal Skin

Abstract The genus Malassezia currently includes seventeen species that have been isolated from healthy and diseased human and other animal skin. Malassezia are implicated in a range of cutaneous diseases in humans: pityriasis versicolor, atopic or seborrheic dermatitis, dandruff, folliculitis and psoriasis. The outbreak of the disease depends on the interaction between the host immune system and Malassezia species. Malassezia stimulates both the cellular and humoral immune response in humans. Although Malassezia species have been associated with various dermatological diseases in people, the detailed pathological role of Malassezia remains obscured. Malassezia yeasts require lipids for their growth and therefore to a greater extent they colonize the sites with more sebaceous glands. The ecosystem on skin is complex and its balance depends on several factors. The aim of this study was to determine the presence of Malassezia yeasts in clinically normal skin of 42 healthy, randomly selected individuals of different ages. In the group of people examined, up to 30 persons (71.4 %) represented by children, adults and the elderly were positive to Malassezia yeasts. It has been shown that the back is an area with a higher incidence (66.7 %) of observed yeast compared to the head (40.5 %).

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