Screening and Follow-up for Retinopathy of Prematurity

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0063 ◽

2018 ◽

pp. 29-33

Keyword(s):

Preterm Birth ◽

Retinopathy Of Prematurity ◽

Vascular Diseases ◽

Effective Screening ◽

Screening Programs ◽

Premature Babies

Retinopathy of prematurity (ROP) that occurs in premature babies and can result in blindness is one of the vascular diseases of the retina. Currently, increased preterm birth and the survival of very small babies cause an increase in ROP incidence. Through effective screening programs, ROP can be detected and treated timely. The aim of this study is to review the most current global screening programs and the latest situation in our country.

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Incidence of retinopathy of prematurity among premature babies born at a tertiary care hospital - a longitudinal study with a short follow up

MedPulse International Journal of Ophthalmology ◽

10.26611/10092012 ◽

2021 ◽

Vol 20 (1) ◽

pp. 05-12

Author(s):

Alok B S ◽

Keyword(s):

Longitudinal Study ◽

Retinopathy Of Prematurity ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Premature Babies

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Study of retinopathy of prematurity in high risk infants

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20184301 ◽

2018 ◽

Vol 5 (6) ◽

pp. 2304

Author(s):

Yogesh N. Parikh ◽

Priya M. Patel ◽

Palak T. Hapani

Keyword(s):

Mechanical Ventilation ◽

Birth Weight ◽

High Risk ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Blood Products ◽

Premature Babies ◽

Tertiary Teaching ◽

A Prospective Study

Background: Retinopathy of prematurity is a vaso-proliferative disorder of retina in premature babies. The objective of this study was to study retinopathy of prematurity in premature babies and to study associated risk factors.Methods: Study was a prospective study was conducted among infants in high risk follow up clinic of our department KT Children Hospital, tertiary teaching hospital attached to Government medical college, Rajkot. Sample size of study was conducted on 100 high risk neonates who were brought to high risk follow up clinic at K T children hospital, Rajkot.Results: Out of studied 100 infant, 40% developed ROP, 12% developed stage 1 ROP, 13% developed stage 2 ROP,15% developed stage 3 ROP. Out of 100 cases 40% were ROP positive.15% occurred between 28-30 weeks of gestation. In 31-33 weeks of gestation 82.5%. In 34-36 weeks of gestation 2.5%. 15% of cases between 740-1000 gm of birth weight developed ROP.67.5% between 1000-1500 gm of birth weight developed ROP.15% between 1500-2000 gm of birth weight developed ROP.2.5% between 1500-2000 gm of birth weight developed ROP. 70 newborns received oxygen, 95% of newborns developed ROP. 5% newborns who have not received oxygen developed ROP. In present study there is association of ROP with oxygen therapy. 40 cases had apnea. Out of 40 cases 55% had ROP. Association between apnea and ROP. 21 received blood products.57% of them had ROP. Association between blood transfusion and ROP. 20 received ventilation. 75% of them had ROP. Association between ventilation and ROP. Out of 40 positive newborns there 17 were male and 23 were female. No difference in distribution of ROP in male and female sex. Significant relationship between gestational age, O2 therapy, mechanical ventilation, apnea and blood products. Insignificant relationship between sexes.Conclusions: This study has identified ROP is found to be associated with gestational age, o2 therapy, mechanical ventilation, apnea and blood products.

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Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity

Case Reports in Ophthalmology ◽

10.1159/000513181 ◽

2021 ◽

pp. 306-310

Author(s):

Ruba Saleh Alghofaili ◽

Saleh A. Almesfer

Keyword(s):

In Vitro Fertilization ◽

Early Diagnosis ◽

Retinopathy Of Prematurity ◽

Genetic Disease ◽

Advanced Stage ◽

Vitro Fertilization ◽

Premature Babies ◽

Bilateral Retinoblastoma

Retinopathy of prematurity (ROP) and retinoblastoma (RB) are well-described entities in premature babies. Although their pathogeneses are different, with ROP representing a disorder of interrupted development and RB a genetic disease, a few co-occurring cases have been reported, raising the possibility that the 2 conditions. Here, we report the sixth such case of co-occurring ROP and RB in an 8-month-old infant conceived by in vitro fertilization (IVF) who developed bilateral retinoblastoma a few months after treatment for advanced-stage ROP. While the ROP was initially adequately managed, bilateral RB necessitated bilateral enucleation. This case raises a number of important questions about whether IVF, ROP, and RB are causally related. Although the associations between IVF, ROP, and RB are likely to be coincidental, this case nevertheless highlights that ROP patients require regular follow-up for early diagnosis and treatment of ocular sequelae including RB.

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Factors associated with preterm birth at Wachemo University Nigist Eleni Mohammed memorial hospital, southern Ethiopia: case-control study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03503-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Negeso Gebeyehu Gejo ◽

Melaku Tesfaye W/mariam ◽

Biruk Assefa Kebede ◽

Ritbano Ahmed Abdo ◽

Abebe Alemu Anshebo ◽

...

Keyword(s):

Preterm Birth ◽

Antenatal Care ◽

Medical Records ◽

Case Control Study ◽

Southern Ethiopia ◽

Preterm Neonates ◽

Factors Associated ◽

Induced Hypertension ◽

Control Study

Abstract Background Preterm birth is defined as the birth of a baby before 37 completed weeks of gestation. Worldwide, prematurity is the second foremost cause of death in children under the age of 5 years. Preterm birth also gives rise to short and long term complications. Therefore, the primary aim of this study was to identify the factors associated with preterm birth in Wachemo University Nigist Eleni Mohammed Memorial referral hospital, Hadiya Zone, Southern Ethiopia. Methods An institution-based unmatched case-control study was conducted from July 01, 2018 to June 30, 2019 among mothers who gave birth in Wachemo University Nigest Eleni Mohammed Memorial referral hospital. A retrospective one-year data was retrieved from medical records of mothers with their index neonates. Simple random sampling technique was employed to recruit study participants. SPSS version 20 software was used for data entry and computing statistical analysis. Both bivariable and multivariable logistic regression analyses were used to determine the association of each independent variable with the dependent variable. Odds ratio with their 95% confidence intervals was computed to identify the presence and strength of association, and statistical significance was affirmed if p < 0.05. Result The current study evaluated 213 medical records of mothers with index neonates (71 cases and 142 controls). Urban residency [AOR = 0.48; 95% Cl; 0.239, 0.962], antenatal care follow up [AOR = 0.08; 95 Cl; 0.008, 0.694], premature rupture of membranes [AOR = 3.78; 95% Cl; 1.467, 9.749], pregnancy induced hypertension [AOR = 3.77; 95% Cl; 1.408, 10.147] and multiple pregnancies [AOR = 5.53; 95% Cl; 2.467, 12.412] were the factors associated with preterm birth. More than one-third (36.6%) preterm neonates died in the present study. Conclusions The present study found that urban residency, antenatal care follow up, premature rupture of membranes, pregnancy induced hypertension and multiple pregnancies were factors associated with preterm birth. The mortality among preterm neonates is high. Enhancing antenatal care follow up and early detection and treatment of disorders among pregnant women during antenatal care and undertaking every effort to improve outcomes of preterm birth and reduce neonatal mortality associated with prematurity is decisive.

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Adrenoleukodystrophy Newborn Screening in California Since 2016: Programmatic Outcomes and Follow-Up

International Journal of Neonatal Screening ◽

10.3390/ijns7020022 ◽

2021 ◽

Vol 7 (2) ◽

pp. 22

Author(s):

Jamie Matteson ◽

Stanley Sciortino ◽

Lisa Feuchtbaum ◽

Tracey Bishop ◽

Richard S. Olney ◽

...

Keyword(s):

Newborn Screening ◽

Program Implementation ◽

Screening Program ◽

Birth Prevalence ◽

Variant Of Uncertain Significance ◽

Implementation Challenges ◽

Screening Programs ◽

Uncertain Significance ◽

Long Term Follow Up

X-linked adrenoleukodystrophy (ALD) is a recent addition to the Recommended Uniform Screening Panel, prompting many states to begin screening newborns for the disorder. We provide California’s experience with ALD newborn screening, highlighting the clinical and epidemiological outcomes observed as well as program implementation challenges. In this retrospective cohort study, we examine ALD newborn screening results and clinical outcomes for 1,854,631 newborns whose specimens were received by the California Genetic Disease Screening Program from 16 February 2016 through 15 February 2020. In the first four years of ALD newborn screening in California, 355 newborns screened positive for ALD, including 147 (41%) with an ABCD1 variant of uncertain significance (VUS) and 95 males diagnosed with ALD. After modifying cutoffs, we observed an ALD birth prevalence of 1 in 14,397 males. Long-term follow-up identified 14 males with signs of adrenal involvement. This study adds to a growing body of literature reporting on outcomes of newborn screening for ALD and offering a glimpse of what other large newborn screening programs can expect when adding ALD to their screening panel.

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Outcomes of infants born to pregnant women with syphilis: a nationwide study in Korea

BMC Pediatrics ◽

10.1186/s12887-021-02502-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Joohee Lim ◽

So Jin Yoon ◽

Jeong Eun Shin ◽

Jung Ho Han ◽

Soon Min Lee ◽

...

Keyword(s):

Mental Retardation ◽

Renal Disease ◽

Hearing Impairment ◽

Congenital Syphilis ◽

Day Treatment ◽

National Level ◽

International Classification Of Diseases ◽

Nationwide Study ◽

Screening Programs

Abstract Background Despite the expansion of antenatal syphilis screening programs, congenital syphilis (CS) remains a concern. Purpose This study aimed to analyze the manifestation and progress of CS, including treatment and follow-up, based on a nationwide study. Methods From the Korean National Health Insurance Service database, a total of 548 infants were examined for CS during their first year of life from 2013 to 2018. Neurosyphilis and complications were investigated using the International Classification of Diseases-10 codes. Results The birth rate of infants from mothers with syphilis was 2.8 per 10,000 live births for 5 years, which is not indicative of a decreasing trend. Overall, 148 infants were proven or highly probable or possible of having CS with treatment for 10 days; 66 infants were possible or less likely of having CS with only 1-day treatment. Jaundice (56 %) was common, followed by hearing impairment (14 %), renal disease (8 %), and mental retardation (8 %). Fourteen cases of neurosyphilis occurred. Infants with complications, including mental retardation, eye involvement, hearing impairment, or renal disease, were significantly associated with neurosyphilis (OR 8.49, P < 0.0001). Of 250 patients who received treatment, 92.8 % were treated with one medication: benzathine penicillin was used in 73 % of patients. Only four patients were re-treated due to treatment failure. In addition to the treponemal test, fluorescent treponemal antibody-absorption was the most utilized tool for diagnosis and follow-up. Conclusions Establishing standardized guidelines for the evaluation of CS, as well as the establishment of treatment regimens and follow up-plans for the disease, at a national level would help improve maternal and neonatal care and facilitate the eradication of CS in Korea.

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The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives—State of the Art

Cancers ◽

10.3390/cancers13153711 ◽

2021 ◽

Vol 13 (15) ◽

pp. 3711

Author(s):

François Montagne ◽

Florian Guisier ◽

Nicolas Venissac ◽

Jean-Marc Baste

Keyword(s):

Lung Cancer ◽

Residual Disease ◽

State Of The Art ◽

Locally Advanced ◽

Small Cell Lung ◽

Lung Cancers ◽

Screening Programs ◽

Systemic Therapies

Non-small cell lung cancers (NSCLC) are different today, due to the increased use of screening programs and of innovative systemic therapies, leading to the diagnosis of earlier and pre-invasive tumors, and of more advanced and controlled metastatic tumors. Surgery for NSCLC remains the cornerstone treatment when it can be performed. The role of surgery and surgeons has also evolved because surgeons not only perform the initial curative lung cancer resection but they also accompany and follow-up patients from pre-operative rehabilitation, to treatment for recurrences. Surgery is personalized, according to cancer characteristics, including cancer extensions, from pre-invasive and local tumors to locally advanced, metastatic disease, or residual disease after medical treatment, anticipating recurrences, and patients’ characteristics. Surgical management is constantly evolving to offer the best oncologic resection adapted to each NSCLC stage. Today, NSCLC can be considered as a chronic disease and surgery is a valuable tool for the diagnosis and treatment of recurrences, and in palliative conditions to relieve dyspnea and improve patients’ comfort.

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