Nghiên cứu tương quan của chiều dài bàn chân với chỉ số nhân trắc và tuổi thai theo Ballard mới ở trẻ sơ sinh

2021 ◽  
Author(s):  
Phuong Nguyen Le Binh
Keyword(s):  
Gestational Age ◽  
Medical Condition ◽  
High Sensitivity ◽  
University Hospital ◽  
Roc Curve Analysis ◽  
Anthropometric Parameters ◽  
Anthropometric Indices ◽  
Foot Length ◽  
Preterm Babies ◽  
The Difference

TÓM TẮT Đặt vấn đề: Thời kỳ sơ sinh là thời kỳ dễ tổn thương nhất trong cuộc đời. Đối với những trẻ sơ sinh sinh ra với một tình trạng bệnh lý nặng hoặc cần chăm sóc đặc biệt ngay thì việc xác định các yếu tố trưởng thành về thể chất và thần kinh để đánh giá tuổi thai hay các chỉ số nhân trắc học là khá khó khăn. Nghiên cứu nhằm mô tả chiều dài bàn chân, các chỉ số nhân trắc học và tìm hiểu mối tương quan giữa chiều dài bàn chân với các chỉ số nhân trắc và tuổi thai theo Ballard mới ở trẻ sơ sinh. Phương pháp: 240 trẻ sơ sinh được nhập viện và sống trong vòng 24 giờ đầu sau sinh tại Trung tâm Nhi khoa Bệnh viện Trung ương Huế và Bệnh viện Trường Đại học Y Dược Huế, thời gian nghiên cứu từ tháng 4/2019 đến tháng 1/2021. Thiết kế nghiên cứu mô tả cắt ngang. Kết quả: Giá trị trung bình và độ lệch chuẩn của chiều dài bàn chân là 76,4 ± 7,7 mm. Có mối tương quan thuận mức độ rất chặt giữa chiều dài bàn chân với tuổi thai (r = 0,927), cân nặng (r = 0,898), chiều dài (r = 0,891), vòng đầu (r = 0,851) và vòng ngực (r = 0,793). Điểm cắt chiều dài bàn chân ≤ 77,2 mm có độ nhạy (88,4%) và độ đặc hiệu (96,1%) để tiên đoán trẻ sơ sinh non tháng. Điểm cắt chiều dài bàn chân ≤ 73,1 mm có độ nhạy (95,4%) và độ đặc hiệu (90,9%) để tiên đoán trẻ sơ sinh cân nặng thấp. Kết luận: Chiều dài bàn chân có tương quan thuận rất chặt với tuổi thai, cân nặng, chiều dài, vòng đầu, vòng ngực. Đồng thời chiều dài bàn chân có độ nhạy và độ đặc hiệu cao trong tiên đoán trẻ sơ sinh non tháng hoặc có cân nặng thấp, đây là một chỉ số đáng tin cậy ở những nơi còn thiếu nhân lực và trang thiết bị như cân nặng, siêu âm. ABSTRACT CORRELATION OF FOOT LENGTH AND ANTHROPOMETRIC PARAMETERS AND GESTATIONAL AGE OF NEWBORN BY NEW BALLARD SCORE Background: Neonatal period is the most vulnerable period of life. For neonates born with a serious medical condition or who need immediate intensive care, determining physical and neurological maturation factors to assess gestational age or anthropometric indices is quite difficult. Therefore, determining the correlation of foot length with anthropometric indices and gestational age according to Ballard score, is a priority in the research. This study describes the foot length, some anthropometric parameters; and study the correlation between foot length and some anthropometric parameters and gestational age of newborn by new Ballard score. Methods: A survey was conducted with 240 neonatal in the first 24 hours at The Pediatric Center in Hue Central Hospital and Hue University Hospital of Medicine and Pharmacy from 4/2019 to 1/2021. Results: The Mean ± SD at birth for Foot Length (FL) was 76.4 ± 7.7 mm. The difference in FL between males and females was not statistically significant. We observed a significant correlation between FL and other anthropometric variables namely GA (r = 0.927), BW (r = 0.898), HC (r = 0.851), CC (r = 0.793) and length (r = 0.891). Using Receiver Operative Characteristic (ROC) curve analysis, we found that FL ≤ 73.1 mm had 95.4% sensitivity and 90.9% specificity in identifying LBW babies. FL ≤ 77.2 mm had 88.4% sensitivity and 96.1% specificity for identifying preterm babies. Conclusions: We observed a significant correlation between foot length and other variables, namely birth weight, gestational age, head circumference, chest circumference, and length. Foot length had a high sensitivity and specificity in identifying LBW and Preterm babies, making it a reliable variable in the rural setup where weighing facilities, ultrasound, and trained personnel are not available.

Foot length of newborn and its correlation with gestational age and various anthropometric parameters

2019 ◽  
Vol 12 (3) ◽  
pp. 79-82
Author(s):  
Suresh Nana Waydande ◽  
◽  
Madhavi Chintaman Sahastrabudhe ◽  
Keyword(s):  
Gestational Age ◽  
Anthropometric Parameters ◽  
Foot Length

scholarly journals Diagnostic accuracy of intrathecal kappa free light chains compared with OCBs in MS

2020 ◽  
Vol 7 (4) ◽  
pp. e775 ◽  
Author(s):  
Frida Duell ◽  
Björn Evertsson ◽  
Faiez Al Nimer ◽  
Åsa Sandin ◽  
Daniel Olsson ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Neurological Diseases ◽  
High Sensitivity ◽  
University Hospital ◽  
Oligoclonal Bands ◽  
Youden Index ◽  
Control Group ◽  
Healthy Controls ◽  
Class Iii ◽  
Roc Curve Analysis

ObjectiveTo determine what kappa free light chain (KFLC) metric has the highest capacity to separate healthy patients from patients with MS, we evaluated the sensitivity, specificity, and the overall diagnostic accuracy of 4 different KFLC metrics. To assess the usefulness of KFLC in the diagnostics of MS, we compared the different KFLC metrics with oligoclonal bands (OCBs), the current gold standard biochemical method to demonstrate intrathecal antibody production.MethodsCSF and plasma were collected from patients with confirmed or suspected MS, other neurological diseases, as well as symptomatic and healthy controls between May 2017 and May 2018 (n = 335) at the Department of Neurology, Karolinska University Hospital, as part of routine diagnostic workup. KFLC analysis and isoelectric focusing for the detection of oligoclonal bands (OCB) were determined and correlated with diagnosis. Receiver operating characteristic (ROC) curve analysis was used to determine accuracy.ResultsOCBs yielded a sensitivity of 87% and a specificity of 100%. All KFLC metrics showed a high sensitivity (89%–95%) and specificity (95%–100%). Using the optimal cutoff according to the Youden Index resulted for the KFLC intrathecal fraction in a cutoff of −0.41 with a sensitivity of 95% and a specificity of 97% and for CSF KFLC/CSF albumin with a cutoff of 1.93 × 10−3 with a sensitivity of 94% and specificity of 100%.ConclusionAll evaluated KFLC metrics have excellent accuracy, and both KFLC intrathecal fraction and CSF KFLC/CSF albumin are at least as good as OCB in separating patients with MS from a control group.Classification of evidenceThis study provides Class III evidence that CSF KFLC accurately distinguishes patients with MS from healthy controls.

scholarly journals Foot length as a surrogate maker to identify birth weight

2021 ◽  
Vol 8 (12) ◽  
pp. 1926
Author(s):  
Nitesh Upadhyay ◽  
Minhajuddin Ahmed
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Study Group ◽  
Medical College ◽  
Foot Length ◽  
Low Birth Weight Babies ◽  
Positive Linear Correlation ◽  
Preterm Babies ◽  
Higher Sensitivity

Background: Gestational age and birth weight is an important predicator for morbidity and mortality in neonates. Aim was to determine the correlation of foot length with birth weight and gestational age in neonates.Methods: This was a prospective observational study done in the neonatal unit department of pediatrics in Chirayu medical college and hospital, Bhopal. There were 1739 deliveries included during the study period from January 2016 to December 2020. Study group comprised of all live born babies delivered in within 24 hours of birth who fulfilled the inclusion criteria.Results: The study comprised of 1739 newborn babies, out of which 896 (51.51%) were males and 843 (48.49%) were females. Male:female ratio 1.06:1. In our study group, 337 (15.6%) babies were preterm and 1385 (84.39%) were of term gestation. We found a positive linear correlation of foot length with all birth weight groups in a newborn with a correlation coefficient (r=0.78) and p<0.001 was found. Similarly, a positive correlation of foot length and gestational age of newborn in both term and preterm babies with (r=0.83) with p<0.01. Foot length has 87.4% sensitivity and 91.7% specificity among low-birth-weight babies with respect to cut off foot length of 75.5 mm. Foot length has 78.7% sensitivity and 63.7% specificity among preterm babies.Conclusions: Foot length can be used as a screening tool to identify low birth weight (LBW) and preterm babies as it had a higher sensitivity and specificity.

scholarly journals Viable Extreme Preterm Birth and Some Neonatal Outcomes in Double Cerclage versus Traditional Cerclage: A Randomized Clinical Trial

2011 ◽  
Vol 11 ◽  
pp. 1660-1666 ◽  
Author(s):  
Farzaneh Broumand ◽  
Fatemeh Bahadori ◽  
Tahereh Behrouzilak ◽  
Zahra Yekta ◽  
Farkhondeh Ashrafi
Keyword(s):  
Clinical Trial ◽  
Preterm Birth ◽  
Randomized Clinical Trial ◽  
Gestational Age ◽  
Preterm Labor ◽  
Absolute Risk ◽  
Absolute Risk Reduction ◽  
University Hospital ◽  
Control Group ◽  
The Difference

The pregnant women at higher risk of preterm labor, referred to the perinatal clinic of Kosar University Hospital in Urmia district of Iran, were enrolled into a parallel randomized clinical trial. In the investigational arm of the clinical trial, a double cervical cerclage procedure was performed addition to McDonald cerclage. In the control group however, only McDonald cerclage was performed. Extreme preterm labor (GA < 33 weeks) was the primary endpoint of this clinical trial. Age, gestational age at cerclage time, and gravidity were not found to be statistically different between the groups. Means of gestational age were 37.4 and 36.2 weeks, respectively, for the investigational and control groups. The gestational age was 1.2 weeks longer for double cerclage group but the difference was not found to be statistically significant. Preterm birth before 33 weeks of gestation was not experienced by any of the patients who received double cerclage, but five women in control group developed such an extreme preterm labor (). The absolute risk reduction in using double cerclage over traditional method was 18 percent (95% confidence interval, 4%–32%). Double cerclage appeared to have higher efficacy than traditional cerclage in preventing preterm labor <33 weeks of gestation.

scholarly journals A Formal Analysis of Anthropometric Parameters for Effective Forecasting of Dyslipidemia in Healthy Young Adults

2021 ◽  
pp. 308-319
Author(s):  
Srinidhi Rai ◽  
Tirthal Rai ◽  
. Sindhu ◽  
B. Shamantha Rai ◽  
P. Rithesh Pakkala ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Young Adults ◽  
Formal Analysis ◽  
Anthropometric Measurement ◽  
Healthy Individuals ◽  
Roc Curve Analysis ◽  
Anthropometric Parameters ◽  
Anthropometric Indices ◽  
Cross Sectional ◽  
Apparently Healthy

Background: Obesity in the younger age groups predisposes an individual for a high risk for developing dyslipidemia and cardiovascular disease. Distribution of the abdominal adipose tissue cannot be accurately described by the traditional anthropometric indices.Newer anthropometric indices are better predictors of obesity. Objective: To compare the ability of different anthropometric indices in predicting dyslipidemia in healthy young adults. Materials and Methods: The cross-sectional study was performed on 100 subjects (48 males and 52 females) at K S Hegde Medical Academy from 2017 to 2018 (power of study: 80%).  Apparently healthy individuals attending the executive health checkup plan and individuals from hospital staff aged 18-35 years were selected for the study. The Kolmogorov Smirnov test was used to determine the data's normality. Pearson's correlation test was used to measure the relationship between lipid parameters and various anthropometric indices. The predictive capacity of various anthropometric indices for distinguishing between dyslipidemic and healthy individuals was investigated using ROC curve analysis. Results: Newer anthropometric measurement approaches such as ABSI, BRI, CI, AVI, VAI, and LAP have been suggested as better instruments for predicting dyslipidemia. The present study found that VAI had the highest predictive efficiency in identifying dyslipidemia among apparently healthy adults using ROC analysis.  This discovery may lead to the use of a simple anthropometric index as a screening tool for cardiovascular disease prediction. Conclusion: The current study has shown that the VAI has emerged as a valuable instrument for dyslipidemia assessment in healthy young adults. Using regular laboratory tests and basic anthropometric measurements, VAI can be easily measured and can therefore be used as relevant dyslipidemia evaluation methods in clinical practice.

scholarly journals Postnatal foot length of newborn: its correlation with gestational maturity

2020 ◽  
Vol 7 (7) ◽  
pp. 1614
Author(s):  
Srinivasa S. ◽  
Anjum Aara C. A. ◽  
Pavan Kumar Kalla
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Newborn Infants ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Neonatal Deaths ◽  
Foot Length ◽  
Preterm Babies ◽  
R Value ◽  
Preterm Newborns

Background: Neonatal death is one of the major contributors (50%) of Under-five child mortality and 70% of the infant mortality. The main causes of neonatal deaths are prematurity and low birth weight (LBW). This study was undertaken to assess newborn foot length and determine its usefulness in identifying LBW/Preterm Babies.Methods: This is a cross sectional hospital based study of 173 newborn babies, done in KIMS Hospital, Bengaluru. All live newborn infants were included in the study. Newborn babies with lower limb congenital anomalies were excluded from the study.Results: Out of 173 newborn, 99 babies were male (57%) and 74 were female (43%). 122 (70.5%) were term and 51(29.5%) were preterm. 48 (38%) were SGA, 120 (69%) were AGA and 5 (3%) were LGA. Their gestational age ranged from 28 to 40 weeks. In this study positive Correlation between foot length and gestational age was found with the “r” value of 0.823. The study also showed a positive correlation between foot length and weight with the “r” value of 0.831.Conclusions: This study has a good correlation of Foot length with gestational maturity and birth weight. Foot length of 7.45cm can be used as a cut- off point for differentiating between term and preterm babies. Derived equation from this study can be used by ASHAs and Anganwadi workers for the estimation of gestational age in resource poor situations and refer the preterm newborns to higher centres for further management as early as possible to prevent long and short term complications of prematurity.

scholarly journals A study on new-born foot length measurement to identify high risk neonate

2018 ◽  
Vol 5 (3) ◽  
pp. 1078
Author(s):  
P. Sampathkumar ◽  
S. Amudha Devi
Keyword(s):  
Birth Weight ◽  
Standard Deviation ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Chest Circumference ◽  
Anthropometric Measurement ◽  
Study Group ◽  
Foot Length ◽  
Preterm Babies ◽  
The Mean

Background: In India, most of the neonatal mortality is due to low birth weight and prematurity. Since the majority of deliveries were conducted at the peripheral level, logistic constraints make it difficult for early and reliable identification of low birth weight babies who require extra care. There are so many studies have been conducted to find out an alternative anthropometric measurement for birth weight and Gestational age. One such innovation is the Foot length measurement. Various studies have been conducted on foot length reliability as a proxy measurement. The aim of the present study is to study the correlation between foot length and other variables like birth weight, gestational age, chest circumference and head circumference among small for gestational age, appropriate for gestational age and large for gestational age and to determine utility of using foot length as a screening tool to identify small babies (LBW/premature) in need of extra care.Methods: It is a cross-sectional descriptive study of 2000 neonate conducted in Government Mohan Kumaramangalam Medical College Hospital, Salem. Babies with lower limb anomaly were excluded from the study. The foot length, head & chest circumference, birth weight and gestational age of the study population were collected by using standard methods. The study group was categorized based on their sex, maturity and gestational age.Results: The study group included 53.7% of male and 46.3% female babies. There were 81.4% term and 18.6% preterm babies. In this study group, there were 85.1%, 14.3% and 0.6% of AGA, SGA and LGA babies respectively. The mean foot length for term babies observed in this study is 6.91 cm with the standard deviation of 0.44. The mean foot length for preterm babies is 5.94 cm with a standard deviation of 0.43. Statistically, by performing Scheffe’s multiple comparisons tests the foot length was found to be significantly different in AGA, SGA and LGA babies.Conclusions: Foot length is a simple and more reliable anthropometric measurement to assess the birth weight and gestational age in newborn babies. Foot length can emerge as an important anthropometric measurement in neonates and can be used to screen prematurity and SGA babies in need of care.

Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?

2017 ◽  
Vol 68 (5) ◽  
pp. 1070-1072
Author(s):  
Dan Navolan ◽  
Mirela Nicolov ◽  
Simona Vladareanu ◽  
Ioana Ciohat ◽  
Marius Craina ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Biochemical Markers ◽  
Biochemical Marker ◽  
Second Trimester ◽  
Established Method ◽  
Crown Rump Length ◽  
The Difference ◽  
Fetal Aneuploidies ◽  
Singleton Pregnancies

Screening of fetal aneuploidies in early pregnancy is a well-established method in the materno-fetal medicine. The aim of our study was to analyze if the medians recommended by the manufacturers are adequate to perform an accurate screening or if there is a need for own laboratory medians calculation in second trimester biochemical marker screening.Sera were collected between 14 wp and 22 wp from 3374 singleton pregnancies. We analyzed three second trimester biochemical markers (AFP, hCG and free Estriol) concentration in all pregnant women and in a subgroup of pregnant women in which gestational age was determined based on crown-rump length. Our results showed that for all biochemical markers the difference between the manufacturer and the own calculated median was lower than 10% excepting the hCG value in the group of pregnant women in which the gestational age was determined on basis of crown-rump-length. Our results show it is recommended to replace the values of the median for hCG measurement with the own laboratory calculated medians. This does not seem to be necessary in the case of AFP and free Estriol measurement.

Hepatitis A Seroprevalence Among Patients with Chronic Hepatitis B Infection: A Cross-Sectional Study in Iran During 2016-2017

2020 ◽  
Vol 20 (5) ◽  
pp. 748-751
Author(s):  
Seyed Ali Dehghan Manshadi ◽  
Neda Alijani ◽  
Mohammadreza Salehi ◽  
Omid Dadras ◽  
SeyedAhmad SeyedAlinaghi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis A ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Reasonable Approach ◽  
The Difference ◽  
Prevention Method

Introduction: The aim of this study was to determine the prevalence of exposure to hepatitis A by means of serologic markers in chronic hepatitis B patients, with the secondary aim of finding the best prevention method for hepatitis A infection in susceptible groups of our setting. Methods: During the period between 2016 and 2017, we recruited 403 hepatitis B patients aged more than 14 years and regularly attending the infectious diseases clinic at a referral university hospital, Tehran, Iran. A blood sample was collected from all the patients and tested for hepatitis A IgG. The data was analyzed by SPSS v.19. Results: Although none of the patients had previously received hepatitis A vaccine, the results for serologic level of hepatitis A IgG, demonstrated positive results in 379 (94%) cases. The mean age of patients with negative and positive IgG was 29.17 and 42.46 years, respectively; the difference was statistically significant (P≤0.001). The majority of seronegative patients were young adults aged < 25 years and 25 to 35 years (P <0.001). Conclusion: Seroprevalence of hepatitis A in chronic HBV patients in Iran is high. As HBV infected patients younger than 35 years could be seronagative for HAV infection, evaluation of these patients for HAV infection and vaccination of seronegative patients would be a reasonable approach.

Baseline apparent diffusion coefficients: Validation study of new predictor of survival in patients with unresectable hepatocellular carcinoma following chemoembolization

2021 ◽  
pp. 1-10
Author(s):  
Lichao Xu ◽  
Shiqin Wang ◽  
Shengping Wang ◽  
Ying Wang ◽  
Wentao Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Roc Curve ◽  
Cox Regression ◽  
Response To Treatment ◽  
Roc Curve Analysis ◽  
Adc Value ◽  
Apparent Diffusion Coefficients ◽  
Apparent Diffusion ◽  
Response Biomarker ◽  
The Difference

OBJECTIVES: To investigate whether the baseline apparent diffusion coefficient (ADC) can predict survival in the hepatocellular carcinoma (HCC) patients receiving chemoembolization. MATERIALS AND METHODS: Diffusion-weighted MR imaging of HCC patients is performed within 2 weeks before chemoembolization. The ADC of the largest index lesion is recorded. Responses are assessed by mRECIST after the start of the second course of chemoembolization. Receiver operating characteristic (ROC) curve analysis is performed to evaluate the diagnostic performance and determine optimal cut-off values. Cox regression and Kaplan–Meier survival analyses are used to explore the differences in overall survival (OS) between the responders and non-responders. RESULTS: The difference is statistically significant in the baseline ADC between the responders and non-responders (P <  0.001). ROC analyses indicate that the baseline ADC value is a good predictor of response to treatment with an area under the ROC curve (AUC) of 0.744 and the optimal cut-off value of 1.22×10–3 mm2/s. The Cox regression model shows that the baseline ADC is an independent predictor of OS, with a 57.2% reduction in risk. CONCLUSION: An optimal baseline ADC value is a functional imaging response biomarker that has higher discriminatory power to predict tumor response and prolonged survival following chemoembolization in HCC patients.

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