scholarly journals The Effectiveness of Ondansetron in Preventing Hypotension and Bradicardia in Spinal Anestesia

Author(s):  
Albert; Akhyar Hamonangan Nasution ◽  
Qadri Fauzi Tanjung

Spinal anesthesia was typically used for elective surgery and was associated with the incidence of hypotension and bradycardia due to sympathetic block. Bezold-Jarisch reflex (BJR) is a reflex that contributes to cause hypotension and bradycardia mediated by serotonin receptors (5-HT3). Ondansetron, a 5-HT3 receptor antagonist, is assumed to inhibit the effect of serotonin and BJR. To assess the effectiveness of ondansetron in preventing hypotension and bradycardia after spinal anesthesia. This study was an experimental study with a "posttest with control group" design conducted at Haji Adam Malik General Hospital and USU Hospital in February 2020 to June 2020. Seventy study subjects who underwent lower abdominal, gynecology, lower extremities under spinal anesthesia were selected by consecutive sampling and were divided into 2 groups. Group 1 received 4 mg ondansetron, while group 2 received 2 cc normal saline, both interventions were given 30 minutes before spinal anesthesia Baseline and minimum mean arterial pressure were higher in the ondansetron group at 97.07 ± 5.09 mmHg and 85.20 ± 6.48 mmHg compared to the control group (p-value <0.05). Hypotension was more common in the control group (51.43%) than in ondansetron group (20%) (p-value <0.05). The mean baseline and minimum heart rate were higher in the ondansetron group at 81,09 ± 9,62 bpm and 79.7 ± 8.75 bpm compared to the control group (p<0.05). The incidence of bradycardia was more common in the control group (17.1%) compared to the ondansetron group (2.9%) (pvalue <0.05). Ondansetron 4 mg, given intravenously, is effective in lowering the incidence of hypotension and bradycardia under spinal anesthesia

2018 ◽  
Vol 4 (2) ◽  
pp. 161-167
Author(s):  
Syaukia Adini ◽  
Bedjo Santoso ◽  
Sarkum Sarkum ◽  
Sudirman Sudirman

Background: Ventilator Associated Pneumonia (VAP) is one of the causes of infection in the hospital and the main cause of death due to nosocomial infection. The strategy to prevent VAP is by oral hygiene. Honey may be a good solution for oral hygiene.Objective: This study aims to compare the effect of the use of 20% honey solution and 0.2% chlorhexidine as oral hygiene on VAP prevention in patients on mechanical ventilation.Methods: This was a quasi-experimental study with posttest only control group design in an incentive care unit of a general hospital in Indonesia. Thirty respondents were selected using consecutive sampling, which 15 respondents assigned in a 20% honey group and 0.2% chlorhexidine group. Clinical Pulmonary Infection Score (CPIS) was used to measure Ventilator Associated Pneumonia. Data were analyzed using Independent t-test.Results: The mean of CPIS in the honey group was 3.33 and the chlorhexidine group was 3.53. Independent t-test showed p-value 0.618 (>0.05), which indicated that there was no significant difference of the effect of honey and chlorhexidine on VAP event.Conclusions: The 20% honey solution has the same effect with 0.2% chlorhexidine in preventing VAP events in patients on mechanical ventilation.


2021 ◽  
Vol 2 (1) ◽  
pp. 10-15
Author(s):  
I Putu Astrawan ◽  
I Putu Prisa Jaya

Background: Footwork training is important in coaching basic movements in badminton. This research aims to learn about the influence of footwork training on improving leg muscles strength. Methods: The study used a randomized pretest-posttest control group design. The participants consisted of 42 male badminton players of Universitas Pendidikan Ganesha, Bali, Indonesia, who split into two groups of footwork training (ten repetitions two sets (group 1) and five repetitions with four sets (group 2)). The coach gave the footwork exercise three times per week for 6 weeks to each group and measured the leg muscle strength using the dynamometer test. Results: The result of the within-group paired T-test before and after the training shows group 1 and group 2 (p<0.05). For group 1, the mean of leg muscle strength was 114.19±33.13 kg before the training and 183.19±33.56 kg after the training, with an increase of 60% (69 kg). On the other hand, for group 2, the mean score of leg muscle strength before the training was 113.05±31.30 kg and after the training was 141.10±34.91, with an increase of 25% (28 kg). The leg muscle strength difference between the groups before and after the training was tested using the independent T-test with a significant α=0.05. Comparing the differences of leg muscle strength for both the groups before the training was p= 0.90, and after the training was p=0.00. Conclusion: The conclusion is training badminton footwork ten repetition two sets better than five repetitions four sets to improve leg muscle strength.


2018 ◽  
Vol 23 (3) ◽  
pp. 112
Author(s):  
Ketut Agus Adrianta ◽  
I Made Agus Sunadi Putra

In daily life, Artocarpus heterophylla Lamk., the leaves are rarely used even just as animal feed. In the bark of Artocarpus heterophylla Lamk there are new flavonoid compounds namely morusin, artokarpin, artonin E, cycloartobilosantone, and artonol B. This research is an experimental design with randomized posttest only with control group design. A total of 21 mice were divided into 3 groups, each consisting of 7 mice, group 1: negative control given oral placebo and exposed to UV-B rays, group 2:giving Vitamin C cream 4% mg and exposed to UV-B rays, group 3: giving cream of Artocarpus heterophylla Lamk leaf extract 4% and exposed to UV-B rays. The total of UV radiation dose of 600 mJ / cm² for 3 weeks, then performed a biopsy for examination of the amount of dermis collagen. The average number of collagen in the three groups after treatment was given significantly different (p <0.05). Mean and Significant level of collagen density of group 1 : 51,42 ± 5,16; group P2 ± 91,18 ± 1,13; and P3 group: 88,77 ± 1,10. Conclusion : Cream of 4% Artocarpus heterophylla Lamk leaf extract can increase the amount of collagen density in mice exposed to UV-B rays.


2020 ◽  
Vol 13 (4) ◽  
pp. 365-372
Author(s):  
Andoko Andoko ◽  
Ermawati Ermawati

The effects of guided imagery on fatigue in patients with chronic kidney disease undergoing hemodialysisBackground: Kidney and urinary tract diseases contribute 850,000 mortality rates placing them as the disease burden in the world. One of the general nursing problems suffered from chronic kidney disease patients who undergo hemodialysis is fatigue. The intervention that can be given to overcome the fatigue on the clients is a relaxation therapy strategy. A well-recommended therapy to relieve the fatigue is known as guided imagery.Purpose: Knowing the effect of guided imagery on fatigue in patients with chronic kidney disease undergoing hemodialysis.Methods: A quantitative with a quasi experiment technique and nonequivalent control group design. The population of this study included 67 patients registered with chronic kidney disease undergoing hemodialysis at the hospital. The purposive sampling technique took 32 people. The samples were distributed into two groups; 16 people in each group. The analysis was a thorough T-Test.Result: Finding that the mean of the fatigue levels of experiment and control groups were different. The mean score before the intervention was 0.352, while the score after the intervention was 2.000 (p-value 0.025).Conclusion: There was the effect of guided imagery on fatigue in patients with chronic kidney disease undergoing hemodialysis. Chronic kidney disease patients who undergo hemodialysis should independently and regularly do relaxation therapy because this therapy is easy to apply and proven effective to reduce fatigue.Keywords: Guided Imagery; Fatigue; Chronic Kidney Disease; HemodialysisPendahuluan: Penyakit ginjal dan saluran perkemihan berkontribusi menjadi beban penyakit di dunia dengan sekitar 850.000 kematian setiap tahun. Masalah keperawatan yang banyak dihadapi pasien gagal ginjal kronik yang menjalani hemodialisa umumnya adalah fatigue (kelemahan). Intervensi keperawatan untuk membantu klien dalam mengatasi masalah kelemahan diantaranya melalui strategi pemberian terapi relaksasi. Salah terapi relaksasi yang dipercaya dapat membantu mengatasi fatigue adalah guided imagery.Tujuan: Diketahuinya pengaruh guided imagery terhadap tingkat fatigue pasien gagal ginjal kronik yang menjalani hemodialisis.Metode: Penelitian kuantitatif, desain quasi eksperiment dengan rancangan nonequivalent control group design. Populasi pasien gagal ginjal kronik yang menjalani hemodialisa yang berjumlah 67 orang, besar sampel yang diambil sebanyak 32 orang yang terbagi dalam 2 kelompok, masing-masing kelompok sebanyak 16 orang, teknik pengambilan sampel menggunakan purposive sampling. Analisis menggunakan uji t-test.Hasil: Didapatkan selisih rata-rata tingkat fatigue antara kelompok intervensi dengan kelompok kontrol sebelum perlakuan adalah 0,352 dan setelah perlakuan 2,000 (p-value 0,025).Simpulan: Ada pengaruh guided imagery terhadap tingkat fatigue pasien gagal ginjal kronik yang menjalani hemodialisis. Bagi pasien gagal ginjal kronik yang menjalani hemodialisa hendaknya dapat mempergunakan terapi relaksasi secara mandiri dan teratur karena selain mudah dilakukan, terapi ini telah terbukti efektif dalam menurunkan tingkat kelelahan.


2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Corazon H. Dumaria ◽  
A AGP Wiraguna ◽  
Wimpie Pangkahila

Abstract: This study was aimed to prove that administration of 10% redfruit extract cream could prevent the increase of skin melanin in guinea pig exposed to UVB and to compare this effect with 4% hydroquinone cream. This was a true experimental study using post test only control group design. Subjects were devided into three groups; each of 10 guinea pigs. Group 1, the control group, was exposed to UVB and applied with basic cream. Group 2 was exposed to UVB and applied with 4% hydroquinone cream. Group 3 was exposed to UVB and applied with 10% redfruit extract cream. The total dose of UVB was 390 mJ/cm2 given for 2 weeks. The amount of melanin was calculated using the percentage of the pixel area of melanin and was compared with the pixel areas of all epidermal tissues. The results showed that the highest percentage of melanin area was in group 1 (19.78%±3.79%). The percentage of melanin area in group 3 was 1.25%±0.76% meanwhile in group 2 was 0.85%±0.37%. There were signi-ficant differences in melanin percentage between the control group and group 2 as well as group 3 (P <0.05). There was no significant difference in melanin percentage between group 2 and group 3 (P >0.05). Conclusion: The 10% redfruit extract cream could prevent the increase of skin melanin in guinea pig exposed to UVB as effectively as the 4% hydroquinone cream.Keywords: redfruit extract cream, melanin, UVBAbstrak: Penelitian ini bertujuan untuk membuktikan efek pemberian krim ekstrak buah merah 10% dalam mencegah peningkatan jumlah melanin kulit marmut yang dipapar sinar UVB dan perbandingannya dengan krim hidrokuinon 4%. Jenis penelitian ialah eksperimental murni dengan post test only control group design. Sampel terdiri dari tiga kelompok dengan jumlah sampel 10 ekor marmut jantan tiap kelompok. Kelompok 1 yaitu kelompok kontrol, diberi paparan sinar UVB dan diolesi krim dasar. Kelompok 2 diberi paparan sinar UVB dan diolesi krim hidrokuinon 4%. Kelompok 3 diberi paparan sinar UVB dan diolesi krim ekstrak buah merah 10%. Dosis total UVB yaitu 390 mJ/cm2 diberikan selama 2 minggu. Jumlah melanin dihitung dengan persentase pixel luas area melanin dibandingkan dengan pixel seluruh jaringan epidermis. Hasil penelitian menunjukkan jumlah melanin tertinggi pada kelompok 1 (19,78± 3,79%) dan terendah pada kelompok 2 (0,85±0,37%), sedangkan jumlah melanin pada kelompok 3 di antara keduanya (1,25±0,76%). Terdapat perbedaan bermakna antara kelompok 1 dengan kelompok 2 dan 3 (P <0,05). Tidak terdapat perbedaan bermakna antara kelompok 2 dan 3 dalam mencegah peningkatan jumlah melanin (P >0,05 ). Simpulan: Krim ekstrak buah merah 10% dapat mencegah peningkatan jumlah melanin kulit marmut yang dipapar sinar UVB sama efektif dengan krim hidrokuinon 4%.Kata kunci: krim ekstrak buah merah, melanin, UVB


2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Risnawati A. Haris ◽  
Lydia Tendean ◽  
Grace Turalaki

Abstract: The coffee beans composed of the compound caffeine, palmitic acid, linoleic acid and acid stearic. The content of caffeine in coffee can improve spermatozoa motility that are not motile by inhibiting cyclic nucleotide phosphodiesterase and affects the intracellular levels of cyclic AMP. Spermatozoa quality can be affected by various factors such as stress. In nocturnal animals, dark periode becomes a signal to do activity by suprachiasmatic nucleus. The change in activity of the nocturnal animals from initial condition in the dark then exposed to light can leads to stress. This study was aimed to determine the effect of coffee on the spermatozoa quality of wistar rats which had been exposed to stress. This was an experimental analytical study with a post-test only control group design. The study was conducted for 50 days from September to November 2016. The sample consisted of 9 rats divided into three groups: a control group (P0) is given only exposure to stress in the form of light, the treatment group 1 (P1) is given exposure to stress in the light form and liquid coffee 1 ml / kg and the treatment group 2 (P2) is given exposure to stress in the light form and coffee extracts. The results showed that there were significant differences in the concentration and motility treatment group 1 (P1) to the control group (P0) which is p <0.05 and significant differences in sperm motility treatment group 2 (P2) to the control group (P0) which is p <0.05. Conclusion: Coffee administration could improve the quality of spermatozoa of wistar rats exposed to stress.Keywords: stress, coffee, quality of spermatozoa. Abstrak: Biji kopi tersusun dari senyawa kafein, asam palmatik, asam linoleat dan asam stearik. Kandungan kafein yang terdapat didalam kopi mampu meningkatkan motilitas spermatozoa yang tidak motil dengan cara menghambat siklus nukleotida fosfodiesterase dan mempengaruhi level intraseluler dari siklus AMP. Kualitas spermatozoa juga dapat dipengaruhi oleh berbagai faktor lain seperti stres. Pada hewan nokturnal periode gelap menjadi sinyal untuk beraktiftas dilakukan oleh suprachiasmatic nucleus. Perubahan aktivitas pada hewan nokturnal dari kondisi awalnya ditempat yang gelap lalu diberikan paparan cahaya dapat menyebabkan terjadinya stres. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kopi terhadap kualitas spermatozoa tikus wistar yang terpapar stres. Jenis penelitian ialah eksperimental analitik dengan post-test only control group design. Penelitian dilakukan selama 50 hari dari bulan September – November 2016. Sampel sebanyak 9 ekor tikus dibagi menjadi tiga kelompok yaitu : kelompok kontrol (P0) hanya diberikan paparan stres berupa cahaya, kelompok perlakuan 1 (P1) diberikan paparan stres berupa cahaya dan cairan kopi 1 mL/KgBb dan kelompok perlakuan 2 (P2) diberikan paparan stres berupa cahaya dan ekstrak kopi. Hasil penelitian menunjukkan adanya perbedaan yang signifikan pada konsentrasi dan motilitas spermatozoa kelompok perlakuan 1 (P1) terhadap kelompok kontrol (P0) yaitu p<0,05 dan perbedaan yang signifikan pada motilitas spermatozoa kelompok perlakuan 2 (P2) terhadap kelompok kontrol (P0) yaitu p<0,05. Simpulan: Pemberian kopi meningkatkan kualitas spermatozoa yang terpapar stres. Kata kunci: stres, kopi, kualitas spermatozoa


2020 ◽  
Vol 1 (1) ◽  
pp. 101-109
Author(s):  
Riza Indra Dwijaya ◽  
Galih Dwi Pradipta ◽  
Setiyawan Setiyawan

This research is based on the lack of ability to roll the backhand of badminton extracurricular students at SMK Negeri 3 Jepara because the backhand style is still difficult and they are not used to the variation of punch training and have never been given special training by the coach. The purpose of this study was to determine all the effects of training exercises on the accuracy of the back strokes of badminton extracurricular students at SMK Negeri 3 Jepara. This research was conducted with a quantitative approach. The design of this study is a Quasi Experiment with the method of The Untreated Control Group Design with Pretest and Posttest with data retrieval using tests. The population in this study was 30 students and the sample was taken by purposive sampling or with certain provisions as many as 16 students and divided into 2 groups, namely group 1 as treatment recipient and group 2 without treatment. The data technique uses the treatment of the drill training method. The data analysis technique used in this study was the prerequisite test, including the normality test, homogeneous test, and hypothesis testing. The results of the study indicate that the training method affects the accuracy of rolling backhand badminton extracurricular students of SMK Negeri 3 Jepara from group 1 with an average of 22.5 and a value of 10.828> t table 2.145 and a significance value of 0.000 <0.05, with a percentage increase of 13, 47%, while for group 2 without treatment with an average of 19,625 which is only 8.47% with an average difference of 3,875 posttest. The anatomical results of the training method also have an effect on increasing the students' body movements, because the body stimulates the body with fast movements so that the student's body becomes accustomed to doing backhand clear strokes. It can be rejected that the hypothesis h1 is accepted there is an effect of the drill training method on the accuracy of rolling backhand clear at SMK Negeri 3 Jepara is accepted.   Keywords: Keywords: backhand clear, drill practice, accuracy Abstrak Penelitian ini di latar belakangi oleh kurangnya kemampuan pukulan backhand clear siswa ekstrakurikuler bulutangkis SMK Negeri 3 Jepara dikarenakan pukulan backhand dianggap masih sulit dan belum terbiasa juga kurangnya variasi latihan pukulan dan belum pernah diberikan latihan secara khusus oleh pelatih. Tujuan penelitian ini untuk mengetahui seberapa besar pengaruh latihan drill untuk ketepatan pukulan backhand clear siswa ekstrakuriler bulutangkis SMK Negeri 3 Jepara. Penelitian ini dilakukan dengan pendekatan kuantitatif. Desain penelitian ini adalah Quasi Experimen dengan metode The Untreated Control Group Design with Pretest and Posttest dengan pengambilan data menggunakan tes. Populasi dalam penelitian ini adalah 30 siswa dan diambil sampel dengan purposive sampling atau dengan ketentuan tertentu sebanyak 16 siswa dan dibagi menjadi 2 kelompok yaitu kelompok 1 sebagai penerima treatment dan kelompok 2 tanpa treatment. Teknik pengumpulan data menggunakan treatment metode latihan drill. Teknik analisis data dalam penelitian menggunakan uji prasyarat antara lain uji normalitas, uji homogeny, dan uji hipotesis. Hasil dari penelitian menunjukan bahwa metode latihan drill berpengaruh terhadap ketepatan pukulan backhand clear siswa ekstrakurikuler bulutangkis SMK Negeri 3 Jepara dari kelompok 1 dengan rata-rata 22,5 dan nilai thitung 10,828 > ttabel 2,145 dan nilai signifikansi 0,000 < 0,05, dengan peningkatan presentase 13,47%, sedangkan untuk kelompok 2 tanpa perlakuan dengan rata-rata 19,625 yang hanya sebesar 8,47% dengan selisih rata-rata posttest 3,875. Hasil secara anatomi metode latihan drill juga berpengaruh dalam peningkatan pergerakan tubuh siswa, karena rangsangan tubuh dengan gerakan cepat sehingga gerak tubuh siswa menjadi terbiasa dalam melakukan pukulan backhand clear.Dapat disimpulkan bahwa hipotesis h1 diterima yaitu ada pengaruh metode latihan drill terhadap ketepatan pukulan backhand clear SMK Negeri 3 Jepara diterima... Kata kunci: backhand clear, latihan drill, ketepatan


Author(s):  
Ni Luh Putu Gita Karunia Saraswati ◽  
I Dewa Putu Sutjana ◽  
Wahyuddin ◽  
Ni Wayan Tianing ◽  
Luh Made Indah Sri Handari Adiputra ◽  
...  

ABSTRACTBackground: Tailor work characteristics such as sitting static and bending can trigger complaints such as lower back area muscle tension which if left untreated can cause a decrease in lumbar flexibility. Purpose: to prove postural stability exercise is more to increase lumbar flexibility than static stretching exercise on tailors in Denpasar City. Method: This study was an experimental study with pre and post test control group design. The study sample consisted of 30 people divided into two groups. Group 1 given static stretching exercise, while Group 2 given postural stability exercise. Measurement of lumbar flexibility using a modified-modified Schoober test. Result: Paired Sample t-test in Group 1 and Group 2 showed p value p <0.05 which showed that there were significant changes after giving training to each group. Furthermore, a comparison test between Group 1 and Group 2 used independent sample t-test and obtained p <0.05. This result showed that there are significant differences between the two groups. Conclusion: postural stability exercise increases lumbar flexibility more than static stretching exercise for tailors in Denpasar City.Keywords: lumbar flexibility, static stretching exercise, postural stability exercise, tailor.


2014 ◽  
Vol 1 (2) ◽  
pp. 6
Author(s):  
Diyah Fatmasari ◽  
Setiadji Musthofa ◽  
Bedjo Santoso

Background: Bit fruit (Beta vulgaris) is plants as group of vegetables, has potencial as a source of natural dyes for food products. In dental health, a coloring agent which has contrast color with teeth is used for dental plaque identification. Disclosing solution is the most common used material for this purpose. Purpose of this study was to identify if bit fruit can substitute disclosing solution as coloring agent for plaque identification. Method: Research design was Quasi Eksperimental Research.with Posttest Only Control Group Design. Samples was 36 elementary students which divided into 2 groups. Group 1 was 18 students given disclosing solution while group 2 was given bit fruit solution. Independent t test was used to determine diferences between two groups. Result: Research results showed mean of plaque index after application of bit fruit and disclosing solution was 3,75 and 2,66 , with independent t-test resulten significancy 0,000 < 0,05. There was differences of plaque index after two group of application. Conclusion: the bit fruit was more effective to determine plaque compared to disclosing solution.


2021 ◽  
Vol 15 (8) ◽  
pp. 2006-2009
Author(s):  
Riffat Saeed ◽  
Nasir Ali ◽  
Syed Mehmood Ali ◽  
Iram Qamar ◽  
Amer Latef ◽  
...  

Background: Shivering in the post anesthesia care unit is a common and distressing complication for patients after receiving general or regional anesthesia. Perioperative hypothermia has been associated with an increase in morbidity and mortality. Both central and peripheral thermoregulation is impaired by regional anesthesia. Thermoregulatory system synchronizes with defense system to maintain body’s heat and coolness within the narrow range, thus improving the normal functioning. Objective: To compare the efficacy of intravenous tramadol versus normal saline in suppression of postoperative shivering in patients undergoing elective surgery. Design: It was a randomized control trial. Study Settings: Trial was conducted at Department of Anesthesiology and ICU, Sheikh Zayed Hospital, Lahore, for a period of one year w.e.f 7-11-2019 to 7-11-20. Patients and Methods: A total of 50 patients with age 18 years and above from both the genders undergoing elective surgery under general anesthesia were included in the study and divided into two equal groups randomly. Patients in tramadol group were given tramadol 0.5mg/kg I/V and patients of control group were given 0.9% normal saline 5ml I/V. Results: In tramadol groups the mean age of patients was 27.88±2.79 years while the mean age of the patients from placebo group was 27.84±4.23 years. In this study the efficacy was achieved in 37(74.0%) patients. In control group the efficacy was achieved in 15(60%) patients and in tramadol group the efficacy was achieved in 22(88.0%) patients (p-value<0.05). Conclusion: According to this study the intravenous tramadol is safe and effective drug in suppression of postoperative shivering in patients undergoing elective surgery under spinal anesthesia. Keywords: Intravenous Tramadol, Spinal Anesthesia, Shivering, Elective Surgery.


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