Relationship between dietary factors and risk of Preeclampsia: A Systematic review

Preeclampsia is characterized by development of high blood pressure (hypertension) and proteinuria after 20 weeks of gestation. It is found in 3â€ 10% of pregnancies and remains a major cause of maternal and fetal morbidity and mortality worldwide. The etiology of preeclampsia is unknown. Preeaclamptic pregnancies are characterized by endothelial dysfunction, disturbed placentation, oxidative stress, and an exaggerated inflammatory response to pregnancy. A possible modification of these pathophysiological events by lipids, nutrients, and antioxidant supplementation has been hypothesized in previous reports, suggesting that the dietary factors may play a role in Preeclampsia. This review was undertaken to show the relationship between the dietary factors and risk of developing preeclampsia. The review finally suggests women to have a diet containing plant food (vegetables, fruits and vegetable oils) rich in calcium, vitamin D and antioxidants.

Download Full-text

The importance and significance of gene polymorphisms in preeclampsia

HEALTH OF WOMAN ◽

10.15574/hw.2016.114.45 ◽

2016 ◽

pp. 45-49

Author(s):

P.N. Veropotvelyan ◽

◽

I.S. Tsehmistrenko ◽

N.P. Veropotvelyan ◽

N.S. Rusak ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Early Diagnosis ◽

Gene Polymorphisms ◽

Individual Risk ◽

Extended Study ◽

Stress Genes ◽

Detoxification System ◽

The Individual ◽

The Relationship

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.

Download Full-text

The effects of vitamin D supplementation on mental health, and biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2019.109651 ◽

2019 ◽

Vol 94 ◽

pp. 109651 ◽

Cited By ~ 14

Author(s):

Hamidreza Jamilian ◽

Elaheh Amirani ◽

Alireza Milajerdi ◽

Fariba Kolahdooz ◽

Hamed Mirzaei ◽

...

Keyword(s):

Oxidative Stress ◽

Mental Health ◽

Systematic Review ◽

Vitamin D ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Controlled Trials ◽

Randomized Controlled ◽

And Oxidative Stress

Download Full-text

Role of Purinergic Signalling in Endothelial Dysfunction and Thrombo-Inflammation in Ischaemic Stroke and Cerebral Small Vessel Disease

Biomolecules ◽

10.3390/biom11070994 ◽

2021 ◽

Vol 11 (7) ◽

pp. 994

Author(s):

Natasha Ting Lee ◽

Lin Kooi Ong ◽

Prajwal Gyawali ◽

Che Mohd Nasril Che Mohd Nassir ◽

Muzaimi Mustapha ◽

...

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Inflammatory Response ◽

Small Vessel Disease ◽

Ischemia Reperfusion ◽

Cerebral Small Vessel Disease ◽

Small Vessel ◽

Purinergic Signalling ◽

Vessel Disease ◽

The Brain

The cerebral endothelium is an active interface between blood and the central nervous system. In addition to being a physical barrier between the blood and the brain, the endothelium also actively regulates metabolic homeostasis, vascular tone and permeability, coagulation, and movement of immune cells. Being part of the blood–brain barrier, endothelial cells of the brain have specialized morphology, physiology, and phenotypes due to their unique microenvironment. Known cardiovascular risk factors facilitate cerebral endothelial dysfunction, leading to impaired vasodilation, an aggravated inflammatory response, as well as increased oxidative stress and vascular proliferation. This culminates in the thrombo-inflammatory response, an underlying cause of ischemic stroke and cerebral small vessel disease (CSVD). These events are further exacerbated when blood flow is returned to the brain after a period of ischemia, a phenomenon termed ischemia-reperfusion injury. Purinergic signaling is an endogenous molecular pathway in which the enzymes CD39 and CD73 catabolize extracellular adenosine triphosphate (eATP) to adenosine. After ischemia and CSVD, eATP is released from dying neurons as a damage molecule, triggering thrombosis and inflammation. In contrast, adenosine is anti-thrombotic, protects against oxidative stress, and suppresses the immune response. Evidently, therapies that promote adenosine generation or boost CD39 activity at the site of endothelial injury have promising benefits in the context of atherothrombotic stroke and can be extended to current CSVD known pathomechanisms. Here, we have reviewed the rationale and benefits of CD39 and CD39 therapies to treat endothelial dysfunction in the brain.

Download Full-text

Effect of Anthocyanin-Rich Extract of Sour Cherry for Hyperglycemia-Induced Inflammatory Response and Impaired Endothelium-Dependent Vasodilation

Nutrients ◽

10.3390/nu12113373 ◽

2020 ◽

Vol 12 (11) ◽

pp. 3373

Author(s):

Arnold Markovics ◽

Attila Biró ◽

Andrea Kun-Nemes ◽

Mónika Éva Fazekas ◽

Anna Anita Rácz ◽

...

Keyword(s):

Oxidative Stress ◽

Gene Expression ◽

Diabetes Mellitus ◽

Endothelial Dysfunction ◽

Inflammatory Response ◽

Proinflammatory Cytokines ◽

Sour Cherry ◽

The Elderly ◽

Human Umbilical Cord ◽

Dependent Manner

Diabetes mellitus (DM)-related morbidity and mortality are steadily rising worldwide, affecting about half a billion people worldwide. A significant proportion of diabetic cases are in the elderly, which is concerning given the increasing aging population. Proper nutrition is an important component in the effective management of diabetes in the elderly. A plethora of active substances of plant origin exhibit potency to target the pathogenesis of diabetes mellitus. The nutraceutical and pharmaceutical effects of anthocyanins have been extensively studied. In this study, the effect of Hungarian sour cherry, which is rich in anthocyanins, on hyperglycemia-induced endothelial dysfunction was tested using human umbilical cord vein endothelial cells (HUVECs). HUVECs were maintained under both normoglycemic (5 mM) and hyperglycemic (30 mM) conditions with or without two concentrations (1.50 ng/µL) of anthocyanin-rich sour cherry extract. Hyperglycemia-induced oxidative stress and inflammatory response and damaged vasorelaxation processes were investigated by evaluating the level of reactive oxygen species (ROS) and gene expression of four proinflammatory cytokines, namely, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1α (IL-1α), as well as the gene expression of nitric oxide synthase (NOS) endothelin-1 (ET-1) and endothelin-converting enzyme-1 (ECE-1). It was found that hyperglycemia-induced oxidative stress was significantly suppressed by anthocyanin-rich sour cherry extract in a concentration-dependent manner. The gene expression of the tested proinflammatory cytokines increased under hyperglycemic conditions but was significantly reduced by both 1 and 50 ng/µL anthocyanin-rich sour cherry extract. Further, although increased ET-1 and ECE-1 expression due to hyperglycemia was reduced by anthocyanin-rich sour cherry extract, NOS expression was increased by the extract. Collectively, these data suggest that anthocyanin-rich sour cherry extract could alleviate hyperglycemia-induced endothelial dysfunction due to its antioxidant, anti-inflammatory, and vasorelaxant effects.

Download Full-text

The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index

Journal of Cellular Biochemistry ◽

10.1002/jcb.27934 ◽

2018 ◽

Vol 120 (4) ◽

pp. 6441-6448 ◽

Cited By ~ 7

Author(s):

Negin Rezavand ◽

Saba Tabarok ◽

Ziba Rahimi ◽

Asad Vaisi‐Raygani ◽

Ehsan Mohammadi ◽

...

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Gestational Age ◽

Gene Polymorphisms ◽

Vdr Gene ◽

Vdr Gene Polymorphisms ◽

Risk Of Preeclampsia

Download Full-text

Vitamin D deficiency and depression in adults: systematic review and meta-analysis

The British Journal of Psychiatry ◽

10.1192/bjp.bp.111.106666 ◽

2013 ◽

Vol 202 (2) ◽

pp. 100-107 ◽

Cited By ~ 342

Author(s):

Rebecca E. S. Anglin ◽

Zainab Samaan ◽

Stephen D. Walter ◽

Sarah D. McDonald

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Randomised Controlled Trials ◽

Meta Analysis ◽

Controlled Trials ◽

Cross Sectional ◽

Cross Sectional Studies ◽

Randomised Controlled ◽

The Relationship

BackgroundThere is conflicting evidence about the relationship between vitamin D deficiency and depression, and a systematic assessment of the literature has not been available.AimsTo determine the relationship, if any, between vitamin D deficiency and depression.MethodA systematic review and meta-analysis of observational studies and randomised controlled trials was conducted.ResultsOne case-control study, ten cross-sectional studies and three cohort studies with a total of 31 424 participants were analysed. Lower vitamin D levels were found in people with depression compared with controls (SMD = 0.60,95% Cl 0.23–0.97) and there was an increased odds ratio of depression for the lowest v. highest vitamin D categories in the cross-sectional studies (OR = 1.31, 95% CI 1.0–1.71). The cohort studies showed a significantly increased hazard ratio of depression for the lowest v. highest vitamin D categories (HR=2.21, 95% CI 1.40–3.49).ConclusionsOur analyses are consistent with the hypothesis that low vitamin D concentration is associated with depression, and highlight the need for randomised controlled trials of vitamin D for the prevention and treatment of depression to determine whether this association is causal.

Download Full-text

Relationship Between Advanced Glycation End Products and Their Receptor, sRAGE and Cardiovascular Diseases Risk in Adults with T2D and Vitamin D Insufficiency/deficiency (FS12-08-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz049.fs12-08-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Justina Owusu ◽

Fatma Huffman ◽

Juan Liuzzi ◽

Tan Li ◽

Vijaya Narayanan

Keyword(s):

Blood Pressure ◽

Vitamin D ◽

Cardiovascular Diseases ◽

Advanced Glycation End Products ◽

Serum Levels ◽

Vitamin D Insufficiency ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products ◽

The Relationship

Abstract Objectives Advanced Glycation End Products, (AGEs) and their soluble receptor (sRAGE) have been implicated in the development of complications and mortality among individuals with type 2 diabetes (T2D). There is limited information on the relationship between AGEs and sRAGE and risk of cardiovascular diseases (CVD) in minority groups, who have a higher burden of T2D. The relationship between AGEs and sRAGE and CVD risks in adults with T2D and vitamin D insufficiency/deficiency was assessed in a minority population. Methods A cross sectional study of Hispanics and African Americans with T2D (n = 64, 41 women and 23 men, mean age = 54 ± 9) recruited from two clinics in Miami Dade. Systolic (SBP) and diastolic blood pressure (DBP), weight and height measurement and serum lipid profile were completed. ELISA kits were used to assess serum levels of AGEs (Biotang Inc/TSZ Elisa, Waltham, MA, USA) and sRAGE (Biotang Inc/TSZ Elisa, Waltham, MA, USA). Multiple linear regression was used to assess association between AGEs, sRAGE and CVD risks. Results A negative and significant association between AGEs and high-density lipoprotein cholesterol (HDL-C)(B = −0.551, P = 0.029) was found. The relationship between AGEs and HDL-C persisted after adjusting for covariates (P < 0.05). sRAGE was significantly associated with SBP (B = 0.015, P = 0.025) and diastolic blood pressure DBP (B = 0.0271, P = 0.037). Results loss significance when association between sRAGE and DBP and SBP were adjusted for covariates such as age, body mass index (BMI), smoking and alcohol intake. Conclusions Our results suggest that AGEs and sRAGE are related to markers of cardiovascular risk such as HDL-C, SBP and DBP in the study population of African Americans and Hispanics with T2D and vitamin D insufficiency/deficiency. Measures on reducing serum levels of AGEs and improving sRAGE and vitamin D are warranted in these populations for risk reduction of CVD. Funding Sources Partial funding for this research was provided through an NIH/NIDDK sponsored grant.

Download Full-text