scholarly journals COVID-19 and Cardiovascular Complications: An Updated Review

2021 ◽  
Vol 9 (F) ◽  
pp. 712-719
Author(s):  
Januar Wibawa Martha
Keyword(s):  
Myocardial Injury ◽  
Treatment Strategies ◽  
Cardiovascular Complications ◽  
Cytokine Release ◽  
Interval Prolongation ◽  
Coronary Syndrome ◽  
Qt Interval Prolongation ◽  
Coagulation Abnormalities ◽  
Global Pandemic ◽  
Plaque Destabilization

COVID-19 has become a global pandemic. Patients with pre-existing comorbidities such as hypertension, diabetes, and cardiovascular disease (CVD) are associated with greater severity and higher mortality. COVID-19 can cause cardiovascular complications, including myocardial injury, myocarditis, heart failure, acute coronary syndrome, and coagulation abnormalities. Possible pathophysiology and molecular pathways driving these disease processes are cytokine release syndrome, RAAS system dysregulation, plaque destabilization and coagulation disorders  Myocarditis is one concern among persons who received mRNA-Based COVID-19 vaccines. There are several cardiovascular complications that are possibly caused by COVID-19 treatments, such as QT interval prolongation, arrhythmia, and hypotension. Due to increasingly recognized CVD damage in COVID-19, we need to understand about COVID-19 related to cardiovascular complications and treatment strategies.

Extreme QT Interval Prolongation and Helicoid Ventricular Tachycardia (Torsade de Pointes) in Non-ST-Elevation Acute Coronary Syndrome

2012 ◽  
Vol 65 (3) ◽  
pp. 294-296
Author(s):  
Montse Vilaseca-Corbera ◽  
Gabriel Vázquez-Oliva ◽  
Cristina Campoamor-Cela ◽  
Alberto Zamora-Cervantes ◽  
Joan Bassanyanes-Vilarrasa ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Ventricular Tachycardia ◽  
Qt Interval ◽  
Torsade De Pointes ◽  
Interval Prolongation ◽  
Coronary Syndrome ◽  
Qt Interval Prolongation ◽  
St Elevation ◽  
Elevation Acute Coronary Syndrome

scholarly journals Adverse Cardiovascular Effects of Anti-COVID-19 Drugs

2021 ◽  
Vol 12 ◽  
Author(s):  
Dongling Liu ◽  
Xiang Zeng ◽  
Zufeng Ding ◽  
Fenghua Lv ◽  
Jawahar L. Mehta ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adverse Effects ◽  
Myocardial Injury ◽  
Cardiovascular Effects ◽  
Cardiovascular Complications ◽  
Therapeutic Interventions ◽  
Risk Of Death ◽  
Cardiovascular Comorbidities ◽  
Global Pandemic ◽  
Acute Myocardial Injury

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 infection is the cause of the ongoing global pandemic. Mortality from COVID-19 infection is particularly high in patients with cardiovascular diseases. In addition, COVID-19 patients with preexisting cardiovascular comorbidities have a higher risk of death. Main cardiovascular complications of COVID-19 are myocardial infarction, myocarditis, acute myocardial injury, arrhythmias, heart failure, stroke, and venous thromboembolism. Therapeutic interventions in terms of drugs for COVID-19 have many cardiac adverse effects. Here, we review the relative therapeutic efficacy and adverse effects of anti-COVID-19 drugs.

scholarly journals Saudi Heart Rhythm Society Task Force on Management of Potential Arrhythmogenicity Associated with Pharmacotherapy for COVID-19

2020 ◽  
Vol 40 (5) ◽  
pp. 365-372
Author(s):  
Naeem A. AlShoaibi ◽  
Khadijah Maghrabi ◽  
Haitham Alanazi ◽  
Mousa Al Harbi ◽  
Saleh Alghamdi
Keyword(s):  
Ventricular Arrhythmias ◽  
Myocardial Injury ◽  
Task Force ◽  
Heart Rhythm ◽  
Cardiovascular Complications ◽  
Qt Prolongation ◽  
Drug Induced ◽  
Global Pandemic ◽  
Risk Patients ◽  
Antiviral Medications

ABSTRACT Evidence of cardiovascular complications associated with the COVID-19 global pandemic continues to evolve. These include direct and indirect myocardial injury with subsequent acute myocardial ischemia, and cardiac arrhythmia. Some results from a limited number of trials of antiviral medications, along with chloroquine/hydroxychloroquine and azithromycin, have been beneficial. However, these pharmacotherapies may cause drug-induced QT prolongation leading to ventricular arrhythmias and sudden cardiac death. Mitigation of the potential risk in these susceptible patients may prove exceptionally challenging. The Saudi Heart Rhythm Society established a task force to perform a review of this subject based on has recently published reports, and studies and recommendations from major medical organizations. The objective of this review is to identify high-risk patients, and to set clear guidelines for management of patients receiving these pharmacotherapies.

scholarly journals Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System

2021 ◽  
Author(s):  
Kyle Ernzen ◽  
Aaron J. Trask ◽  
Mark E. Peeples ◽  
Vidu Garg ◽  
Ming-Tao Zhao
Keyword(s):  
Cardiovascular System ◽  
Myocardial Injury ◽  
Clinical Manifestations ◽  
Angiotensin Converting Enzyme 2 ◽  
Coronary Syndrome ◽  
Differentiated Cells ◽  
Global Pandemic ◽  
Bidirectional Relationship ◽  
Stem Cell Models ◽  
Pro Inflammatory Cytokines

AbstractThe virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 190 million people to date, causing a global pandemic. SARS-CoV-2 relies on binding of its spike glycoprotein to angiotensin-converting enzyme 2 (ACE2) for infection. In addition to fever, cough, and shortness of breath, severe cases of SARS-CoV-2 infection may result in the rapid overproduction of pro-inflammatory cytokines. This overactive immune response is known as a cytokine storm, which leads to several serious clinical manifestations such as acute respiratory distress syndrome and myocardial injury. Cardiovascular disorders such as acute coronary syndrome (ACS) and heart failure not only enhance disease progression at the onset of infection, but also arise in hospitalized patients with COVID-19. Tissue-specific differentiated cells and organoids derived from human pluripotent stem cells (hPSCs) serve as an excellent model to address how SARS-CoV-2 damages the lungs and the heart. In this review, we summarize the molecular basis of SARS-CoV-2 infection and the current clinical perspectives of the bidirectional relationship between the cardiovascular system and viral progression. Furthermore, we also address the utility of hPSCs as a dynamic model for SARS-CoV-2 research and clinical translation. Graphical abstract

scholarly journals Myocardial injury in coronavirus infection combined with lung, skin and kidney lesions: clinical case and literature review

2021 ◽  
pp. 5-12
Author(s):  
E.Yu, Jebzeeva ◽  
◽  
E.V. Mironova ◽  
I.F. Krotkova ◽  
V.A. De ◽  
...  
Keyword(s):  
Heart Failure ◽  
Myocardial Injury ◽  
Clinical Case ◽  
Skin Lesions ◽  
Cardiovascular Complications ◽  
Coronary Syndrome ◽  
Wide Range ◽  
Systemic Manifestations ◽  
Coronavirus Infection ◽  
Kidney Lesions

Th e most common clinical manifestation of new coronavirus infection is bilateral pneumonia. At the same time, COVID-19 has a wide range of cardiovascular complications, with the development of acute heart failure, arrhythmias, acute coronary syndrome, and myocarditis. Myocardial injury is relatively common in COVID-19, accounting 7-23 % of cases. Th e presented clinical case describes a 56-year-old patient with a confi rmed coronavirus infection. Th e peculiarity of this clinical case is that it is the first report on COVID-19 with systemic manifestations: lungs, heart, kidneys and skin lesions. It should be noted that despite viral pneumonia typical for COVID-19, clinical picture and severity of the patient’s condition were determined by the developed myocardial injury. Th e presented clinical case is specifi c due to skin lesions

scholarly journals A study of cardiac changes in asymptomatic diabetic patients in comparison with normal population

2019 ◽  
Vol 6 (2) ◽  
pp. 291
Author(s):  
Mukhtarahmed Bendigeri ◽  
Rizwan P. Sadique ◽  
Asbin Abdul Aziz ◽  
Prakruthi Jaladhar
Keyword(s):  
Early Stage ◽  
Normal Population ◽  
Regional Wall Motion ◽  
Cardiovascular Complications ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Interval Prolongation ◽  
Ecg Changes ◽  
Non Invasive ◽  
Qt Interval Prolongation

Background: India is predicted to bear the greatest Coronary artery disease (CAD) burden, according to the estimates from the global burden of disease study. Majority of the time the patient of diabetes presents with complications like Myocardial infarction (MI), heart failure, being end stages of cardiovascular disease associated with other macro and micro-vascular complications.Methods: This study was done in view of screening the asymptomatic diabetic individuals presenting to our hospital for any evidence of early cardio-vascular manifestations. With the aid of non-invasive testing such as electrocardiography (ECG) and 2D echo the early changes were noted and compared with the normal population and the cardiac status thus evaluated. A total of 106 patients (53 were diabetic and 53 non-diabetic controls) were included in the study in order to compare the ECG and 2D echo findings among the population. The main aim of the present study was to observe the ECG manifestations in diabetic patients without overt symptoms of any cardiac disease and to evaluate the ECG changes along with 2D echocardiogram in asymptomatic diabetic patients and compare with normal population.Results: From the study, it was observed that majority among the diabetic population were found to have statistically significant changes in the ECG like PR interval prolongation, T wave inversions and QT interval prolongation. 2D ECHO studied showed the presence of Left ventricular diastolic dysfunction and Regional wall motion abnormalities to be evident among the diabetic population.Conclusions: It was concluded from the study that diabetic patients have a higher risk of cardiovascular morbidities compared to the general population and ECG changes are observed even when they are clinically asymptomatic. This observation has been confirmed by the 2D echo findings. It is essential to screen diabetic patients at an early stage to prevent cardiovascular complications. ECG being a relatively cheap and non-invasive investigation should be utilized to screen diabetics for the same.

scholarly journals Clinical features of arterial hypertension in men and women (according to the National Registry of Arterial Hypertension)

2019 ◽  
Vol 91 (1) ◽  
pp. 4-12
Author(s):  
I E Chazova ◽  
A V Aksenova ◽  
E V Oschepkova
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Arterial Hypertension ◽  
Treatment Strategies ◽  
Cardiovascular Complications ◽  
Cerebrovascular Diseases ◽  
National Registry ◽  
Diagnosis And Treatment ◽  
Men And Women ◽  
Coronary Syndrome

Modern clinical guidelines for the diagnosis and treatment of arterial hypertension (AH) do not provide different treatment strategies separately for men and women. The analysis of gender differences in cardiovascular complications and features of AH therapy contributes to the development of an individualized approach to diagnosis and treatment of hypertension. The purpose of this study is to study the effect of sex on the features of therapy of arterial hypertension and the development of cardiovascular complications. Materials and methods. Data from the register of AH from outpatient hospital and cardiology departments of hospitals of 22 regions of the Russian Federation were analyzed. Data of medical documents of 33 564 patients with AH [(36.2%) men and 21 423 (63.8%) women] were entered into the on-line computer program and were analyzed using the statistical software package STATISTICA 10. Results. Cardiovascular and cerebrovascular diseases are more often diagnosed in men: peripheral artery disease, coronary heart disease, acute coronary syndrome, congestive heart failure, ischemic stroke, dissecting aortic aneurysm. The beginning of development cardiovascular disease in men with elevated blood pressure is already observed at age of 25-44 years, which indicates the need for preventive measures already in adolescence and closer monitoring of treatment at a young age. Conclusion. The study confirmed the role of the male sex as a risk factor for the development of cardiovascular disease in hypertensive men and women with comparable figures of blood pressure in. Identified gender features must be considered when diagnosing patients with AH.

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