Phomopsins: an overview of phytopathological and chemical aspects, toxicity, analysis and occurrence

2011 ◽  
Vol 4 (4) ◽  
pp. 345-359 ◽  
Author(s):  
P. Battilani ◽  
A. Gualla ◽  
C. Dall'Asta ◽  
C. Pellacani ◽  
G. Galaverna ◽  
...  
Keyword(s):  
Scientific Data ◽  
General Interest ◽  
Chromatographic Separations ◽  
Chemical Structures ◽  
Lupin Seed ◽  
Phomopsis Leptostromiformis ◽  
Lupin Seeds ◽  
Toxicity Analysis ◽  
Available Information ◽  
Specific Project

Phomopsis leptostromiformis, and its teleomorph Diaporthe toxica, is a lupin pathogen that causes stem blight in young lupins and, as a saprophyte, has been detected on dead lupine material. Under favourable conditions, the fungus produces phomopsins (PHOs), a family of macrocyclic hexapeptide mycotoxins capable of binding tubulin through the tripeptide side chain. The toxic effects appear largely confined to the liver. In particular, the ingestion of PHO contaminated lupin stubble has been linked to lupinosis, a debilitating disease of sheep (the most sensitive animal) characterised by disorientation, blindness, lethargy, and eventually death. The chemical structures of PHO A, B and D have been identified. Analytical methods to determine PHOs are mainly enzyme-linked immunosorbent assays or chromatographic separations, in combination with ultraviolet and mass spectrometric detection. The data about the PHOs occurrence are limited to Australia, restricted to lupin seed. Only one survey has been carried out on lupin seeds and flours from the Swiss market. Not many strategies have been developed to limit lupin seed contamination. Efforts devoted to control lupinosis in Australia focused on the development of cultivars resistant to Phomopsis infection. There are few examples in literature of decontamination or detoxification of PHOs; moreover, they have been shown to be resistant to extensive processing, including cooking. Australia and New Zealand are the only countries that included PHOs in their mycotoxin regulations, with a limit of 5 µg/kg in lupin seeds and derived products. Phomopsins are poorly studied mycotoxins and risk assessment on PHOs has not been done at the European level. The collection of all available scientific data was requested by EFSA in a specific project and partners involved considered it of general interest preparing this review to highlight the limited available information, which indicate that the assessment of potential risk related to PHOs is currently not feasible.

Pharmacological Uses of the Plants Belonging to the Genus Commiphora

2020 ◽  
Vol 18 ◽  
Author(s):  
Subbiah Latha ◽  
Palanisamy Selvamani ◽  
Thangavelu Prabha
Keyword(s):  
Secondary Metabolites ◽  
Plant Species ◽  
Dna Cleavage ◽  
Structural Information ◽  
Chemical Constituents ◽  
Future Research ◽  
Pharmacological Properties ◽  
Chemical Structures ◽  
Indigenous Uses ◽  
Available Information

: Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. To collect the various published literatures on Commiphora in various journals; to study and classify the available information on the pharmacological uses and chemical constituents; and to present the gathered information as a precise review to serve as a potential reference for future research. Pharmacological and phytochemical data on Commiphora plant species were collected from various journals, books, reference materials, websites including scientific databases, etc for compilation. This review article describes the various pharmacological properties of plants of Commiphora species viz., Anti-arthritic and anti-inflammatory, Anti-atherogenic, Antibacterial, Anti-coagulant, Anti-dicrocoeliasis, Anti-epileptic, Anti-fascioliasis, Anti-fungal, Anti-heterophyidiasis, Anti-hyper cholesterolemic, Anti-hyperlipidemic, Anti-hypothyroidism, Anti-obesity, Anti-osteoarthritic, Anti-osteoclastogenesis, Anti-oxidant, Anti-parasitic, Anti-pyretic, Anti-schistosomiasis, Anti-septic, Anti-thrombotic, Anti-ulcer, Cardioprotective, COX enzyme inhibitory, Cytotoxic /Anti-carcinogenic/Anti-cancer, DNA cleavage, Hypotensive, Inhibits lipid peroxidation, Inhibits NO and NO synthase production, Insecticidal, Local anesthetic, Molluscicidal, Smooth muscle relaxant, Tick repellent activities along with toxicity studies. Furthermore, the review also included various secondary metabolites isolated from various species of Commiphora genus along with their chemical structures serve as a ready resource for researchers. We conclude that the plant species belonging to the genus Commiphora possesses abundant pharmacological properties with a huge treasure of diverse secondary metabolites within themselves. This review indicates the necessity of further in-depth research, pre-clinical and clinical studies with Commiphora genus which may help to detect the unidentified potential of the Commiphora plant species.

Potential Antiulcer Agents From Plants: A Comprehensive Review

2019 ◽  
Vol 5 (3) ◽  
pp. 170-231
Author(s):  
Minky Mukhija ◽  
Bhuwan Chandra Joshi
Keyword(s):  
Medicinal Plants ◽  
Developed Countries ◽  
Scientific Data ◽  
Antiulcer Activity ◽  
Peptic Ulcers ◽  
Comprehensive Review ◽  
Chemical Structures ◽  
Mucosal Thickness

Background: Peptic ulcer is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Nowadays, several plants and compounds derived from it have been screened for their antiulcer activity. In the last few years, there has been an exponential growth in the field of herbal medicine. This field has gained popularity in both developing and developed countries because of their natural origin and less side effects. Objective: This review aims to provide a comprehensive summary of currently available knowledge of medicinal plants and phytoconstituents reported for their anti-ulcer properties. Methods: The worldwide accepted database like SCOPUS, PUBMED, SCIELO, NISCAIR, ScienceDirect, Springerlink, Web of Science, Wiley, SciFinder and Google Scholar were used to retrieve available published literature. Results: A comprehensive review of the present paper is an attempt to list the plants with antiulcer activity. The review narrates the dire need to explore potential chemical moieties that exert an antiulcer effect, from unexploited traditional plants. Furthermore, the present study reveals the intense requirement to exploit the exact mechanism through which either the plant extracts or their active constituents exhibit their antiulcer properties. Conclusion: This article is the compilation of the plants and its constituents reported for the treatment of peptic ulcers. The Comprehensive data will surely attract the number of investigators to initiate further research that might lead to the drugs for the treatment of ulcers. As sufficient scientific data is not available on plants, most of the herbals cannot be recommended for the treatment of diseases. This can be achieved by research on pure chemical structures derived from plants or to prepare new lead compounds with proven beneficial preclinical in vitro and in vivo effects. However, a lot remains to be done in further investigations for the better status of medicinal plants.

Bioassay of the contamination of lupin seed by the mycotoxin phomopsin

1985 ◽  
Vol 25 (2) ◽  
pp. 434 ◽  
Author(s):  
DS Petterson ◽  
JE Peterson ◽  
LW Smith ◽  
PM Wood ◽  
CCJ Culvenor
Keyword(s):  
Causative Agent ◽  
Western Australia ◽  
Infection Level ◽  
Lupin Seed ◽  
Low Concentrations ◽  
Phomopsis Leptostromiformis ◽  
Good Agreement

Samples of seed from commercial crops of Lupinus spp. in three States were tested for the presence of phomopsin, the causative agent of lupinosis. Each of 43 samples was tested in one of two laboratories using a nursling rat bioassay, and 12 of these were tested in both. Factors that could affect reproducibility of the assay were examined. There was good agreement in assessments of toxicity between laboratories. The efficiency of extraction was found to vary from about 15% at low concentrations of phomopsin to no more than 60%. Phomopsin was detected in 17 of the 43 samples, at levels ranging from < 6 �g/kg to 360 �g/kg. Phomopsis leptostromiformis infection was detected in 25 of 31 samples of seed from Western Australia, the highest infection level being 18%. The highest levels of phomopsin were found in samples with more than 8% infection.

scholarly journals Chemical constituents of the Rhizomes of Curcuma zedoaria

2021 ◽  
Vol 5 (2) ◽  
pp. first
Author(s):  
Truong Nhat Van Do ◽  
Hai Xuan Le ◽  
Tho Huu Le ◽  
Mai Thanh Thi Nguyen
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Preparative Thin Layer Chromatography ◽  
Chemical Constituent ◽  
Scientific Data ◽  
Curcuma Zedoaria ◽  
Etoac Extract ◽  
Chemical Structures ◽  
Pure Compounds

Curcuma zedoaria (Berg.), belongs to the Zingiberaceae family, is one of the medicinal plants that is found in Southeast Asia. This plant is known as “Nghe tim” in Vietnam; and a decoction of its rhizomes has been used traditionally for the cure flatulence, fatigue, and hepatitis. Previously, some studies on the chemical constituent of the rhizomes of C. zedoaria have reported plenty of curcuminoids and sesquiterpenoids together with their derivatives, which have shown a lot of various bioactivities such as antiproliferative characteristic, anti-ulcer, antioxidant and antibacterial potential. By chromatography column method along with preparative thin layer chromatography on a normal phase silica gel on the EtOAc extract of the rhizomes of Curcuma zedoaria, we have isolated five pure compounds. Their chemical structures have been elucidated by NMR techniques and comparison with publishing data that have determined to be gajustulactone A (1), isozedoarondiol (2), neolitacumone (3), β-sitosterol (4), and β-stigmasterol (5). The results of this study have contributed to the scientific data system on the chemical composition of Vietnamese medicinal plants, especially the rhizomes of Curcuma zedoaria grown in Tinh Bien, An Giang. Therefore, there is more evidence to continue screening studies to detect interesting biological activities from this species.

scholarly journals Anticancer Activities of Chemical Constituents from Leaves and Twigs of Mitrephora winitii

2021 ◽  
Vol 21 (3) ◽  
pp. 699
Author(s):  
Sukee Sukdee ◽  
Puttinan Meepowpan ◽  
Narong Nantasaen ◽  
Siriporn Jungsuttiwong ◽  
Sarinya Hadsadee ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Chemical Constituents ◽  
Cancer Cell Line ◽  
2D Nmr ◽  
Anticancer Activities ◽  
Chromatographic Separations ◽  
Chemical Structures ◽  
Anti Cancer ◽  
First Time ◽  
Mcf 7

The genus Mitrephora has been investigated and its anti-inflammatory, anti-bacterial and anti-parasitical activities were examined along with its potential as an anti-cancer cell line and inhibitor for platelet aggregation. In this work, air-dried leaves and twigs of M. winitii were grounded and extracted with n-hexane, ethyl acetate and methanol, respectively. Chromatographic separations of these extracts led to the isolation of three known compounds and one new compound (compound 2). The chemical structures of these were identified using spectroscopic investigation of 1D- and 2D-NMR and the resulting data confirmed these as stigmasterol (1), (3,4-dimethoxyphenyl)(5-(3,4-dimethoxyphenyl)-4-(hydroxymethyl)tetrahydrofuran-3-yl)methanol (2), diayangambin (3), and methyl-L-inositol (4). The chemical constituents were reported the first time in M. winitii. Compound 2 showed anti-cancer cell lines with ED50 13.07 µg/mL against KB cells and then was tested for cytotoxicity against MCF-7 cells with ED50 11.77 µg/mL.

A standard technique for detecting seed transmitted Phomopsis leptostromiformis of lupins and for testing commercial seed in South Australia

1982 ◽  
Vol 22 (116) ◽  
pp. 190 ◽  
Author(s):  
SM Ali ◽  
J Paterson ◽  
J Crosby
Keyword(s):  
Confidence Intervals ◽  
Microscopic Examination ◽  
Agar Plate ◽  
South Australia ◽  
Standard Technique ◽  
Plate Method ◽  
Lupin Seed ◽  
Commercial Seed ◽  
Phomopsis Leptostromiformis ◽  
Agar Media

A standard agar plate method was tested for its ability to detect Phomopsis leptostromiformis on lupin seed. It proved to be reliable. The 95% confidence intervals of Phomopsis level of five seed samples were 13.2-1 5.8, 13.2-1 5.5, 15.4-1 7.9, 13.2-1 4.8 and 15.6-1 8.0. The characteristic colony produced by Phomopsis infected seeds on agar media was confirmed by microscopic examination for accuracy of detection and no exception was observed. The method is described in detail. The method was then used in a two year survey of 160 samples of commercial lupin seed from all parts of South Australia. The percentage of seed infected in these samples ranged from 0-20% and only 13% of the samples were free of P. leptostromiformis.

A survey of Phomopsis leptostromiformis infection of lupin seed in Western Australia: 1976-81

1985 ◽  
Vol 25 (1) ◽  
pp. 164 ◽  
Author(s):  
PM Wood ◽  
DS Petterson
Keyword(s):  
Western Australia ◽  
Animal Husbandry ◽  
Australian Journal ◽  
Infection Level ◽  
Lupin Seed ◽  
Phomopsis Leptostromiformis

Samples of seed from commercial crops of Lupinus spp. in Western Australia were tested over a 6-year period (1976-8 1) for levels of infection by Phomopsis leptostromiformis. Of the 584 samples tested, 49% were not infected and a further 43% had <4% infection. Overall the levels of infection were higher than those previously recorded in this State. There was a highly significant effect of rainfall zone (P<0.001) on infection level. After accounting for this, there was no significant effect of cultivar, year, or growing zone. The method used was compared with that of Ali et al. (Australian Journal of Experimental Agriculture and Animal Husbandry, 1982, 22, 190-3). No significant differences between the two methods in assessment of lupin seed were observed.

scholarly journals Safety Assessment of Stearyl Heptanoate and Related Stearyl Alkanoates as Used in Cosmetics

2012 ◽  
Vol 31 (5_suppl) ◽  
pp. 141S-146S ◽  
Author(s):  
Monice M. Fiume ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
General Class ◽  
Safety Assessment ◽  
Expert Panel ◽  
Stearyl Alcohol ◽  
Heptanoic Acid ◽  
Chemical Structures ◽  
Similar Chemical ◽  
Available Information

Stearyl heptanoate is an ester of stearyl alcohol and heptanoic acid that functions in cosmetics as a skin conditioning agent and is in the general class of chemicals called stearyl alkanoates. Stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are stearyl alkanoates with similar chemical structures, toxicokinetics, and functions in cosmetics. These water-insoluble stearyl alkanoates, when metabolized, yield stearyl alcohol and a corresponding fatty acid. The available information supports the safety of all of the related stearyl alkanoates. The Expert Panel concluded that stearyl heptanoate, stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are safe in the present practices of use and concentration.

scholarly journals Effect of the type of non-fibre carbohydrates in grass silage-based diets on in sacco ruminal degradability and protein value of lupin (Lupinus angustifolius L. cv. Sonet) seeds ground to different particle sizes

2011 ◽  
Vol 56 (No. 5) ◽  
pp. 231-241 ◽  
Author(s):  
B. Niwińska ◽  
M. Andrzejewski
Keyword(s):  
Particle Size ◽  
Small Intestine ◽  
Lupinus Angustifolius ◽  
Seed Particle ◽  
Particle Sizes ◽  
Experimental Conditions ◽  
Grass Silage ◽  
Lupin Seed ◽  
Lupin Seeds ◽  
In Sacco

The study was conducted to find out the effects of the type of non-fibre carbohydrates (NFC) included in grass silage-based diets on in sacco degradability of dry matter (DM), crude protein (CP) and neutral detergent fibre (NDF) of lupin (Lupinus angustifolius L. cv. Sonet) seeds ground to different particle sizes. Measurements of degradability were carried out as a 3 &times; 2 &times; 3 &times; 3 experimental design of treatments with carbohydrates included in diets as primary sources of NFC (starch vs. pectin vs. sugars), particle size of ground seeds (1.0 vs. 5.7 mm), period of the trial (1 vs. 2 vs. 3) and cannulated cow (1 vs. 2 vs. 3). The variables of in sacco kinetics were calculated according to the equations of &Oslash;rskov and McDonald (1979) for degradation data corrected for the particle loss. The protein value of lupin seeds for ruminants was expressed as the amount of protein digested in the small intestine, and it was estimated based on the obtained characteristics of degradability. Under our experimental conditions, the type of NFC included in the grass silage-based diets and the particle size of seeds affected the course and extent of rumen degradation of lupin seed nutrients. Higher values of DM and CP degradation were estimated after 8 and 16 h of incubation (P &lt; 0.05). The higher rate of degradation of insoluble but potentially degradable fractions (P &lt; 0.05) and higher effective degradability (P &lt; 0.05) were found out in the rumen of cows receiving diets containing sucrose compared with cows receiving diets containing starch. In comparison with starch and pectin, sucrose decreased the amount of protein digested in the small intestine (P &lt; 0.05). The results suggested that the type of NFC determined ruminal microbial activity. An enlargement of the lupin seed particle size from 1.0 to 5.7 mm decreased the rumen degradability of lupin seed nutrients (P &lt; 0.05) and increased the amount of protein digested in the small intestine (P &lt; 0.05). The results indicated that feeding standards should consider the influence of the grinding level of lupin seeds in order to assess their nutritional value.

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