scholarly journals Fate of Contaminants of Emerging Concern in a Sinkhole Lake, Florida, USA

2020 ◽  
Vol 49 (2-3) ◽  
Author(s):  
Van Beynen Philip ◽  
Ethan Upton ◽  
Ela Bialkowska-Jelinska ◽  
Laurent Calcul
Keyword(s):  
Sampling Site ◽  
Individual Compound ◽  
Contaminants Of Emerging Concern ◽  
Main Question ◽  
Sample Type ◽  
Carbonate Platforms ◽  
Wet Season ◽  
Liquid Chromatograph ◽  
The Individual ◽  
Sinkhole Lake

Highly karstified carbonate platforms such as Florida are characterized by rapid infiltration rates, highly permeable bedrock and the direct connection to the below aquifer through the high density of sinkholes. This combination of physical features makes the groundwater and aquifers highly vulnerable to contamination from synthetic chemicals commonly referred to as contaminants of emerging concern (CECs). The use of septic tanks, otherwise referred to as onsite water treatment systems (OWTS), promotes the introduction of CECs into the environment. In order to study the impacts of CECs from OWTS on a karst landscape, water, sediment, and vegetation samples were collected in a sinkhole lake surrounded by residential housing using this waste disposal method. The main question of this research project is what is the fate of CECs from OWTSs effluent within the catchment of a sinkhole lake? Liquid chromatograph mass spectrometry was used to analyze the samples for the presence of CECs. It was found that the relative quantity of CECs in the individual constituents is dependent upon 1) the hydrophobicity and polarity of the individual compound, 2) the specific sampling site, 3) the topography gradient, and 4) for vegetation, the connectedness of the sample type to the sediment. Hydrogeological studies have found that the sinkholes of the area are all connected to the below aquifer. Consequently, these CECs pose a risk of the contamination of the groundwater. This study is a temporal snapshot, that being the dry season of Florida which is most likely the time of lowest CEC contamination. It is imperative that sampling extend into the wet season when flushing of CECs from the OWTS may increase their concentrations in both the lake but also the aquifers especially since residents use well water as their source of potable water. While this study is based in Florida, we strongly suspect that our findings and recommendations are applicable more generally as OWTS are used throughout the many karst regions of the world.

scholarly journals Seasonal evolution of aerosol stratigraphy in Ürümqi glacier No. 1 percolation zone, eastern Tien Shan, China

2006 ◽  
Vol 43 ◽  
pp. 245-249 ◽  
Author(s):  
Feiteng Wang ◽  
Zhongqin Li ◽  
Xiaoni You ◽  
Chuanjin Li ◽  
Huilin Li ◽  
...  
Keyword(s):  
Wind Erosion ◽  
Sampling Site ◽  
Chemical Species ◽  
Early Summer ◽  
Tien Shan ◽  
Wet Season ◽  
Surface Layers ◽  
Different Depths ◽  
Physical And Chemical ◽  
Percolation Zone

AbstractThe processes involved in the evolution of vertical profiles of Mg2+, Ca2+ and microparticle concentrations, as well as their seasonal variation in surface snow, were studied by weekly sampling from September 2003 to September 2004 of a snow pit on Ürümqi glacier No. 1, eastern Tien Shan, China. The development of the microparticle and Mg2+ and Ca2+ stratigraphy in the snow pit is closely related to the physical development of the snow–firn pack. The sampling site is located at 4130 ma.s.l. in the percolation zone of the glacier, and in addition to the effects of sublimation and wind erosion, melting plays a crucial role in both the physical and chemical evolution processes. During the winter, soluble aerosol concentrations in the surface layers are altered slightly by sublimation and wind erosion, and the concentrations are further modified as the wet season begins in late April. In contrast, soluble aerosol stratigraphy in the deeper layers remains relatively unchanged through the winter. In early summer, as melting occurs in the upper part of the snow–firn pack, meltwater carries chemical species to different depths in the underlying snow–firn layers, such that at the end of the ablation season, all of the surface cations might be leached out from the upper layers. In addition, the possible source of calcium and magnesium is discussed in this paper.

Evaluation of the sensitivity of faecal sampling for detection of monophasic Salmonella Typhimurium and other Salmonella in cattle and pigs

2014 ◽  
Vol 143 (8) ◽  
pp. 1681-1691 ◽  
Author(s):  
M. E. ARNOLD ◽  
R. J. GOSLING ◽  
F. MARTELLI ◽  
D. MUELLER-DOBLIES ◽  
R. H. DAVIES
Keyword(s):  
Faecal Sample ◽  
Management Practices ◽  
Age Groups ◽  
Farm Animals ◽  
Infection Prevalence ◽  
Sample Type ◽  
Sample Data ◽  
Using Data ◽  
The Individual ◽  
Positive Groups

SUMMARYThere has been a rapid rise in the prevalence of cases of monophasic Salmonella Typhimurium (mST) in both humans and farm animals, and it has been found in pigs, cattle and poultry. It is therefore vital to have a good understanding of how to efficiently detect infected farms. The objective of this project was to determine sample type sensitivity in the detection of Salmonella to detect infected groups of animals on both pig (breeder, grower and finisher sites) and cattle (beef and dairy) farms, using data collected from a study investigating farms that were positive for mST, and to explore any variation between different age groups and management practices. A Bayesian approach in the absence of a gold standard was adopted to analyse the individual and pooled faecal sample data collected from each epidemiological group on each of the farms. The sensitivity of pooled sampling depended on the prevalence of infection in the group being sampled, with a higher prevalence leading to higher sensitivity. Pooled sampling was found to be more efficient at detecting positive groups of animals than individual sampling, with the probability of a random sample from a group of animals with 5% prevalence testing positive being equal to 15·5% for immature pigs (3·6% for an individual faecal sample, taking into account the sensitivity and infection prevalence), 7·1% for adult pigs (1·2% for individual sampling), 30% for outdoor cattle (2% for individual sampling) and 34% for indoor cattle (1% for individual sampling). The mean prevalence of each epidemiological group was higher in outdoor farms than indoor for both pigs and cattle (mean within-farm prevalence of 29·4% and 38·7% for outdoor pigs and cattle, respectively, compared to 19·8% and 22·1% for indoor pigs and cattle)

scholarly journals Territoriality Beyond the State: The EU’s Territorial Claims and the Search for Their Legitimacy

2021 ◽  
Vol 22 (4) ◽  
pp. 650-672
Author(s):  
Josef Weinzierl
Keyword(s):  
The State ◽  
Political Community ◽  
The Other ◽  
Main Question ◽  
Eu Law ◽  
European Level ◽  
Territorial Claims ◽  
The One ◽  
The Individual ◽  
The Eu

AbstractQuite a few recent ECJ judgments touch on various elements of territorial rule. Thereby, they raise the profile of the main question this Article asks: Which territorial claims does the EU make? To provide an answer, the present Article discusses and categorizes the individual elements of territoriality in the EU’s architecture. The influence of EU law on national territorial rule on the one hand and the emergence of territorial governance elements at the European level on the other provide the main pillars of the inquiry. Once combined, these features not only help to improve our understanding of the EU’s distinctly supranational conception of territoriality. What is more, the discussion raises several important legitimacy questions. As a consequence, the Article calls for the development of a theoretical model to evaluate and justify territoriality in a political community beyond the state.

scholarly journals Educational reform in Morocco in the light of TIMSS evaluation

2013 ◽  
Vol 4 (5) ◽  
Author(s):  
Ahmed AGHBAL
Keyword(s):  
Academic Performance ◽  
Educational Reform ◽  
Educational Resources ◽  
Family Context ◽  
Main Question ◽  
Contextual Variables ◽  
Cultural Variables ◽  
The Family ◽  
The Individual

The purpose of this study is to analyze Moroccan TIMSS 2011 data using the multi-level approach in order to detect the entanglement of factors that influence the academic performance of students in the second year of college secondary education (grade eight ). The main question is, what is the influence of factors related to the individual characteristics and characteristics of the school attended on the performance of students in mathematics? This question can be answered in many ways: 1. Does student achievement in mathematics vary by school? 2. Is there a significant relationship between the socioeconomic and cultural characteristics of the students and their performance in mathematics? the main question is whether the effect of socio-cultural variables linked to the family context (in particular family educational resources) tends to worsen when they interact with the contextual variables of the school. This raises the question of both the efficiency of schools and the equitable distribution of performance in mathematics. The question can be formulated in the following way: Does the effect of socio-cultural variables at the individual level increase with contact with socioeconomic variables at school level? 3. To what extent do the contextual variables of the school (school climate, educational resources available to schools, etc.) have a moderating or amplifying effect on the relationship between the socio-cultural variables linked to the family context of students and academic performance in math? 4. And what are the determinants of the quality of academic performance defined according to TIMSS standards? Added to this is the question of what has been the impact of the educational reform on the dynamics of school organizations and on the quality of academic performance.

Liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites in serum.

1988 ◽  
Vol 34 (11) ◽  
pp. 2235-2238 ◽  
Author(s):  
L L Yung-Jato ◽  
P R Durie ◽  
S J Soldin
Keyword(s):  
High Performance ◽  
Internal Standard ◽  
High Performance Liquid Chromatographic ◽  
Peak Height ◽  
Individual Compound ◽  
Aminobenzoic Acid ◽  
Serum Samples ◽  
The Individual ◽  
A Minor ◽  
Liquid Chromatographic

Abstract This is a high-performance liquid-chromatographic method for measuring p-aminobenzoic acid (PABA) and its metabolites in plasma or serum. Samples are deproteinized, then extracted with organic solvents before chromatography. For quantification, the peak height of the individual compound is compared with that of the internal standard. Analytical recoveries ranged from 41% to 100%, depending on the compound studied. Comparison of patients' samples after oral administration of either N-benzoyl-L-tyrosyl-p-aminobenzoic acid or free PABA revealed that PABA is extensively metabolized and conjugated to either p-acetamidobenzoic acid, p-aminohippuric acid, or p-acetamidohippuric acid. PABA concentrations in serum as measured with the Bratton-Marshall ultraviolet spectrophotometric procedure would appear predominantly to reflect measurements of metabolites, with only a minor contribution from PABA itself.

scholarly journals Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice

2021 ◽  
Vol 22 (21) ◽  
pp. 11791
Author(s):  
Torsten Hoffmann ◽  
Jens-Ulrich Rahfeld ◽  
Mathias Schenk ◽  
Falk Ponath ◽  
Koki Makioka ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Transgenic Mice ◽  
Combination Index ◽  
Individual Compound ◽  
Additive Effects ◽  
Glutaminyl Cyclase ◽  
Independence Model ◽  
Mice Brain ◽  
The Individual ◽  
Bliss Independence

Compelling evidence suggests that pyroglutamate-modified Aβ (pGlu3-Aβ; AβN3pG) peptides play a pivotal role in the development and progression of Alzheimer’s disease (AD). Approaches targeting pGlu3-Aβ by glutaminyl cyclase (QC) inhibition (Varoglutamstat) or monoclonal antibodies (Donanemab) are currently in clinical development. Here, we aimed at an assessment of combination therapy of Varoglutamstat (PQ912) and a pGlu3-Aβ-specific antibody (m6) in transgenic mice. Whereas the single treatments at subtherapeutic doses show moderate (16–41%) but statistically insignificant reduction of Aβ42 and pGlu-Aβ42 in mice brain, the combination of both treatments resulted in significant reductions of Aβ by 45–65%. Evaluation of these data using the Bliss independence model revealed a combination index of ≈1, which is indicative for an additive effect of the compounds. The data are interpreted in terms of different pathways, in which the two drugs act. While PQ912 prevents the formation of pGlu3-Aβ in different compartments, the antibody is able to clear existing pGlu3-Aβ deposits. The results suggest that combination of the small molecule Varoglutamstat and a pE3Aβ-directed monoclonal antibody may allow a reduction of the individual compound doses while maintaining the therapeutic effect.

scholarly journals Investigation of Chemical Constituents of Eranthis longistipitata (Ranunculaceae): Coumarins and Furochromones

2021 ◽  
Vol 23 (1) ◽  
pp. 406
Author(s):  
Andrey S. Erst ◽  
Alexander A. Chernonosov ◽  
Natalia V. Petrova ◽  
Maxim S. Kulikovskiy ◽  
Svetlana Yu. Maltseva ◽  
...  
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Chemical Constituents ◽  
Natural Populations ◽  
Individual Compound ◽  
Physiological Processes ◽  
Structural Formulas ◽  
Different Populations ◽  
Ethanol Extracts ◽  
The Individual ◽  
First Time

Aqueous-ethanol extracts (70%) from the leaves of Eranthis longistipitata Regel. (Ranunculaceae Juss.)—collected from natural populations of Kyrgyzstan—were studied by liquid chromatography with high-resolution mass spectrometry (LC-HRMS). There was no variation of the metabolic profiles among plants that were collected from different populations. More than 160 compounds were found in the leaves, of which 72 were identified to the class level and 58 to the individual-compound level. The class of flavonoids proved to be the most widely represented (19 compounds), including six aglycones [quercetin, kaempferol, aromadendrin, 6-methoxytaxifolin, phloretin, and (+)-catechin] and mono- and diglycosides (the other 13 compounds). In the analyzed samples of E. longistipitata, 14 fatty acid–related compounds were identified, but coumarins and furochromones that were found in E. longistipitata were the most interesting result; furochromones khelloside, khellin, visnagin, and cimifugin were found in E. longistipitata for the first time. Coumarins 5,7-dihydroxy-4-methylcoumarin, scoparone, fraxetin, and luvangetin and furochromones methoxsalen, 5-O-methylvisammioside, and visamminol-3′-O-glucoside were detected for the first time in the genus Eranthis Salisb. For all the above compounds, the structural formulas are given. Furthermore, detailed information (with structural formulas) is provided on the diversity of chromones and furochromones in other representatives of Eranthis. The presence of chromones in plants of the genus Eranthis confirms its closeness to the genus Actaea L. because chromones are synthesized by normal physiological processes only in these members of the Ranunculaceae family.

scholarly journals Increasing Trends of Legacy and Emerging Organic Contaminants in a Dated Sediment Core From East-Africa

2022 ◽  
Vol 9 ◽  
Author(s):  
Maja Nipen ◽  
Rolf David Vogt ◽  
Pernilla Bohlin-Nizzetto ◽  
Katrine Borgå ◽  
Eliezer Brown Mwakalapa ◽  
...  
Keyword(s):  
Sediment Core ◽  
Organic Contaminants ◽  
Urban Areas ◽  
Flame Retardants ◽  
Temporal Trends ◽  
Sub Saharan Africa ◽  
Individual Compound ◽  
Emerging Organic Contaminants ◽  
Sub Saharan ◽  
The Individual

Temporal trends of industrial organic contaminants can show how environmental burdens respond to changes in production, regulation, and other anthropogenic and environmental factors. Numerous studies have documented such trends from the Northern Hemisphere, while there is very limited data in the literature from sub-Saharan Africa. We hypothesized that the temporal trends of legacy and contemporary industrial contaminants in sub-Saharan Africa could greatly differ from the regions in which many of these chemicals were initially produced and more extensively used. For this purpose, a dated sediment core covering six decades from a floodplain system in urban Dar es Salaam, Tanzania, was analysed. The samples were analysed for selected legacy persistent organic pollutants (POPs) [polychlorinated biphenyls (PCBs) and polybrominated biphenyl ethers (PBDEs)] and chemicals of emerging concern (CECs) [alternative brominated flame retardants (aBFRs), chlorinated paraffins (CPs), and dechloranes]. All groups of chemicals showed a steep increase in concentrations towards the uppermost sediment layers reflecting the more recent years. Concentrations of the individual compound groups in surface sediment were found in the order CPs >> aBFRs ∼ ∑25PBDEs > dechloranes ∼ ∑32PCBs. Time trends for the individual compounds and compound groups differed, with ∑32PCBs showing presence in sediments since at least the early 1960s, while some CECs first occurred in sediments corresponding to the last decade. Investigations into potential drivers for the observed trends showed that socioeconomic factors related to growth in population, economy, and waste generation have contributed to increasing concentrations of PBDEs, aBFRs, CPs, and Dechlorane Plus. Further monitoring of temporal trends of industrial organic contaminants in urban areas in the Global South is recommended.

Aggregation of Information by Binary Voting Rules

2019 ◽  
pp. 126-144
Author(s):  
Shmuel Nitzan ◽  
Jacob Paroush
Keyword(s):  
Decision Making ◽  
Collective Decision ◽  
Aggregation Rule ◽  
Collective Decision Making ◽  
Main Question ◽  
Relevant Variables ◽  
Aggregation Of Information ◽  
Group Members ◽  
The Individual ◽  
The Relationship

A group of individuals faces the choice of an alternative out of a set of alternatives. Each member of the group holds an opinion regarding the most suitable (best) alternative for which he or she votes. In this setting, the individual votes are based on their decisional competencies, which hinge on the information to which they are exposed and on their ability to make use of that information. The main question is how to translate the group members’ voting profile to a single collective choice. This chapter studies different aspects of this question in the context of binary voting where the group faces only two alternatives. The selection of an appropriate aggregation rule is a central issue in the fields of social choice, public choice, voting theory, and collective decision making. Since the votes are based on the individual competencies, the applied aggregation rule should take into account not only the voting profile but also the competency profile. In fact, it should also take into consideration any other relevant environmental information such as the asymmetry between the feasible alternatives, the dependence between individual votes, decision-making costs, and the available past record of the voters’ decisions. The chapter focuses on the clarification of the relationship between the performance of binary aggregation rules and the relevant variables and parameters. This has direct normative implications regarding the desirable mode of collective decision making and, in particular, regarding the desirable aggregation rule and the size and the composition of the decision-making body.

scholarly journals Impact of microwave heating on hydroxymethylfurfural content in Czech honeys

2011 ◽  
Vol 29 (No. 4) ◽  
pp. 328-336 ◽  
Author(s):  
K. Bartáková ◽  
M. Dračková ◽  
I. Borkovcová ◽  
L. Vorlová
Keyword(s):  
Microwave Heating ◽  
Hplc Method ◽  
Conventional Heating ◽  
Liquid Chromatograph ◽  
The Czech Republic ◽  
Long Time ◽  
Time Periods ◽  
Temperature Levels ◽  
The Individual ◽  
Botanic Origin

As far as honey is concerned, microwave oven heating finds its use especially for crystallised honey reliquefying. We focused on monitoring the changes in hydroxymethylfurfural content which is an indicator of heat damage done to honey, among others. Microwave honey heating was carried out in four degrees of microwave power levels over seven variously long time periods. In total, 22 analysed honey samples came directly from bee-keepers from the Czech Republic from the 2004 and 2006 harvests. Hydroxymethylfurfural content was determined by HPLC method using a liquid chromatograph Alliance 2695 with a PDA detector 2996. We obtained relatively interesting results: despite the honey having reached relatively high temperature levels (80–90°C) at the highest power levels and the longest time periods, there was no gradual significant increase in hydroxymethylfurfural content which could be expected at conventional heating. On the other hand, hydroxymethylfurfural content varied in the course of heating of the individual samples, which is a very interesting result. A significant role was played also by the botanic origin of the honeys because the course of the changes in hydroxymethylfurfural content due to microwave heating was not the same in all honeys analysed.

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