Laccase Catalysis

2018 ◽  
pp. 178-212 ◽  
Author(s):  
Helina Patel ◽  
Akshaya Gupte
Keyword(s):  
Green Chemistry ◽  
Molecular Oxygen ◽  
Organic Synthesis ◽  
Bioactive Compounds ◽  
Cost Effective ◽  
Biochemical Properties ◽  
Physico Chemical ◽  
Grafting Reactions ◽  
Increasing Demand ◽  
Made In

The search for cost-effective and environmental benign practices for the production of bioactive compounds has gained considerable attention since last decade, due to increasing demand of eco-friendly processes. Many industries have started adopting routes for the development of green chemistry by employing enzymatic approaches to overcome the limitations of physico-chemical methods and environmental concerns. Laccase is one such enzyme which has gained considerable attention in recent years as a biocatalyst in organic synthesis. Laccases possess versatile biochemical properties and the reactions catalyzed by laccase require only molecular oxygen with concomitant release of water as a byproduct. They have been widely used for reactions such as dimerization, polymerization, coupling, and grafting reactions and for antibiotic modifications. This chapter summarizes the advances that have been made in developing technologies based on laccase mediated reactions in the field of medicine, agriculture, food, and pharmaceuticals.

Laccase Catalysis

Biotechnology ◽  
2019 ◽  
pp. 2054-2089
Author(s):  
Helina Patel ◽  
Akshaya Gupte
Keyword(s):  
Green Chemistry ◽  
Molecular Oxygen ◽  
Organic Synthesis ◽  
Bioactive Compounds ◽  
Cost Effective ◽  
Biochemical Properties ◽  
Physico Chemical ◽  
Grafting Reactions ◽  
Increasing Demand ◽  
Made In

The search for cost-effective and environmental benign practices for the production of bioactive compounds has gained considerable attention since last decade, due to increasing demand of eco-friendly processes. Many industries have started adopting routes for the development of green chemistry by employing enzymatic approaches to overcome the limitations of physico-chemical methods and environmental concerns. Laccase is one such enzyme which has gained considerable attention in recent years as a biocatalyst in organic synthesis. Laccases possess versatile biochemical properties and the reactions catalyzed by laccase require only molecular oxygen with concomitant release of water as a byproduct. They have been widely used for reactions such as dimerization, polymerization, coupling, and grafting reactions and for antibiotic modifications. This chapter summarizes the advances that have been made in developing technologies based on laccase mediated reactions in the field of medicine, agriculture, food, and pharmaceuticals.

Chlorine-free copper-catalyzed oxidative synthesis of 1,3,4-oxadiazoles with molecular oxygen as the sole oxidant

2011 ◽  
Vol 84 (3) ◽  
pp. 553-559 ◽  
Author(s):  
Huanfeng Jiang ◽  
Xianwei Li ◽  
Xiaoyan Pan ◽  
Peng Zhou
Keyword(s):  
Green Chemistry ◽  
Molecular Oxygen ◽  
Functional Groups ◽  
Organic Synthesis ◽  
Chemical Processes ◽  
The Past ◽  
New Concepts

Chlorine-free is not only one of the new concepts of green chemistry, but also a problematical task for chemical processes in industrial utility. During the past several decades, we devoted ourselves to the study of chlorine-free organic synthesis. Herein, we describe an efficient chlorine-free copper-catalyzed oxidative approach providing 1,3,4-oxadiazoles in good yields from readily available starting materials. This transformation requires only a green and inexpensive reagent to afford the structurally useful motifs, and has a broad functional groups tolerance.

scholarly journals Obtaining a Spreadable Cheese Sort with Additives of Bioactive Compounds

2017 ◽  
Vol 74 (2) ◽  
pp. 191
Author(s):  
Mihaela Adriana TIŢA
Keyword(s):  
Sodium Bicarbonate ◽  
Bioactive Compounds ◽  
Sensory Properties ◽  
Technological Scheme ◽  
Market Survey ◽  
Physico Chemical ◽  
Emulsifying Salts ◽  
Made In

To conduct this study, a market survey was conducted in the form of a questionnaire to see what assortment of cheese and what ingredients bioactive compounds people want to consume. In order to find out what assortment of cheese and what ingredients with bioactive compounds people want to consume, a market survey was made in the form of a questionnaire. Taking into account the results of the survey,to process a melted cheese mix with the addition of dried tomatoes and basil. A technological scheme was developed for this cheese and sodium bicarbonate was used instead of melting and emulsifying salts to try to obtain a healthier product. The obtained product was analyzed for a period of 30 days from a sensory and physico-chemical. Physico-chemical and sensory properties of the obtained product were analyzed for a period of 30 days.

Flavones and Their Analogues as Bioactive Compounds – An Overview

2019 ◽  
Vol 16 (4) ◽  
pp. 377-391 ◽  
Author(s):  
B.S. Jayashree ◽  
H. Venkatachalam ◽  
Sanchari Basu Mallik
Keyword(s):  
Biological Activity ◽  
Free Radical ◽  
Bioactive Compounds ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Cost Effective ◽  
Free Radical Scavenging ◽  
Polyphenolic Compounds ◽  
Pharmacological Activities ◽  
Poor Solubility

Flavonoids constitute a large group of polyphenolic compounds that are known to have antioxidant properties, through their free radical scavenging abilities. They possess a chromone (γ- benzopyrone) moiety, responsible for eliciting many pharmacological activities. Even though, natural flavonoids are highly potent, owing to their poor solubility, they are less used. Therefore, attempts have been made to improve their stability, solubility, efficacy and kinetics by introducing various substituents on the flavone ring. For nearly the last two decades, flavones were synthesized in our laboratory by simple, convenient and cost-effective methods, with the knowledge of both synthetic and semi-synthetic chemistry. In this direction, it was considered worthwhile to present an overview on the synthesized flavonoids. This review creates a platform for highlighting various modifications done on the flavone system along with their biological activity.

scholarly journals Physico-chemical aspects of grape juices produced in the region of Campanha Gaucha, RS, Brazil (Southern Brazil)

2019 ◽  
Vol 12 ◽  
pp. 01018
Author(s):  
V.B. Costa ◽  
S.B. de Andrade ◽  
P.L.P.K. Lemos ◽  
A. Bender ◽  
C. Goulart ◽  
...  
Keyword(s):  
Grape Juice ◽  
Soluble Solids ◽  
Soluble Solids Content ◽  
Southern Brazil ◽  
Color Intensity ◽  
Volatile Acidity ◽  
Physico Chemical ◽  
Increasing Demand ◽  
Solids Content ◽  
Grape Juices

The Campanha Gaucha region, southern Brazil, has received significant investments in Viticulture during the last decades, especially for the production of quality wines. However, implementing the production of American and hybrid grapes in this region constitutes and opportunity to supply the increasing demand of the grape juice market in Brazil. Juices of two varieties, “Bordô” and “Concord”, from two locations, Dom Pedrito and Santana do Livramento, were analysed in terms of the following physico-chemical aspects: total city, volatile acidity, density, pH, soluble solids content, color intensity, and hue. “Bordô” juices presented higher total acidity and did not differ in relation to location. Higher volatile acidity was found in “Concord” juice from Santana do Livramento. Higher pH was found in the variety “Concord” and in the location Dom Pedrito. For this same location, the “Concord” grape juices showed higher soluble solids values. Color intensity was higher in Santana do Livramento. Color hue was higher in Dom Pedrito. Both variety and location impacted significantly on physico-chemical aspects of grape juices, although all the grapes were produced within the Campanha Gaucha region.

scholarly journals Bi2O3 nano-flakes as a cost-effective antibacterial agent

2021 ◽  
Author(s):  
Luke D Geoffrion ◽  
David Medina Cruz ◽  
Matthew Kusper ◽  
Sakr Elsaidi ◽  
Fumiya Watanabe ◽  
...  
Keyword(s):  
Bismuth Oxide ◽  
Antibacterial Agent ◽  
Chemical Properties ◽  
Cost Effective ◽  
Bismuth Compound ◽  
Photo Catalysis ◽  
Physico Chemical

Bismuth oxide is an important bismuth compound having applications in electronics, photo-catalysis and medicine. At the nanoscale, bismuth oxide experiences a variety of new physico-chemical properties because of its increased...

Chiral imidazolidinones: A class of priviliged organocatalysts in stereoselective organic synthesis

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Laura Raimondi ◽  
Chiara Faverio ◽  
Monica Fiorenza Boselli
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry ◽  
Organic Synthesis ◽  
Catalytic Synthesis ◽  
Biological Chemistry ◽  
Chiral Molecules ◽  
Catalytic Systems ◽  
Drug Synthesis ◽  
Industry Needs

AbstractChiral molecules hold a mail position in Organic and Biological Chemistry, so pharmaceutical industry needs suitable strategies for drug synthesis. Moreover, Green Chemistry procedures are increasingly required in order to avoid environment deterioration. Catalytic synthesis, in particular organocatalysis, in thus a continuously expanding field. A survey of more recent researches involving chiral imidazolidinones is here presented, with a particular focus on immobilized catalytic systems.

scholarly journals NOD: a web server to predict New use of Old Drugs to facilitate drug repurposing

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tarun Jairaj Narwani ◽  
Narayanaswamy Srinivasan ◽  
Sohini Chakraborti
Keyword(s):  
Chemical Space ◽  
Web Server ◽  
Drug Repurposing ◽  
Cost Effective ◽  
Evolutionary Information ◽  
Cost Effective Alternative ◽  
Similarity Searches ◽  
Old Drugs ◽  
Control Study ◽  
Made In

AbstractComputational methods accelerate the drug repurposing pipelines that are a quicker and cost-effective alternative to discovering new molecules. However, there is a paucity of web servers to conduct fast, focussed, and customized investigations for identifying new uses of old drugs. We present the NOD web server, which has the mentioned characteristics. NOD uses a sensitive sequence-guided approach to identify close and distant homologs of a protein of interest. NOD then exploits this evolutionary information to suggest potential compounds from the DrugBank database that can be repurposed against the input protein. NOD also allows expansion of the chemical space of the potential candidates through similarity searches. We have validated the performance of NOD against available experimental and/or clinical reports. In 65.6% of the investigated cases in a control study, NOD is able to identify drugs more effectively than the searches made in DrugBank. NOD is freely-available at http://pauling.mbu.iisc.ac.in/NOD/NOD/.

scholarly journals Optimal Solutions for the Use of Sewage Sludge on Agricultural Lands

Water ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 585
Author(s):  
Catalina Iticescu ◽  
Puiu-Lucian Georgescu ◽  
Maxim Arseni ◽  
Adrian Rosu ◽  
Mihaela Timofti ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Sewage Sludge ◽  
Agricultural Production ◽  
Agricultural Land ◽  
Chemical Characteristics ◽  
Optimal Solutions ◽  
Physico Chemical ◽  
Agricultural Areas ◽  
The Impact ◽  
Made In

The use of sewage sludge in agriculture decreases the pressure on landfills. In Romania, massive investments have been made in wastewater treatment stations, which have resulted in the accumulation of important quantities of sewage sludge. The presence of these sewage sludges coincides with large areas of degraded agricultural land. The aim of the present article is to identify the best technological combinations meant to solve these problems simultaneously. Adapting the quality and parameters of the sludge to the specificity of the land solves the possible compatibility problems, thus reducing the impact on the environment. The physico-chemical characteristics of the fermented sludge were monitored and optimal solutions for their treatment were suggested so as to allow that the sludge could be used in agriculture according to the characteristics of the soils. The content of heavy metals in the sewage sludge was closely monitored because the use of sewage sludge as a fertilizer does not allow for any increases in the concentrations of these in soils. The article identifies those agricultural areas which are suitable for the use of sludge, as well as ways of correcting some parameters (e.g., pH), which allow the improvement of soil quality and obtained higher agricultural production.

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