An Instructional Design “Use Case”

2011 ◽  
pp. 168-183
Author(s):  
Shalin Hai-Jew
Keyword(s):  
Instructional Design ◽  
Instructional Technology ◽  
Instructional Designer ◽  
Use Case ◽  
Multiple Use ◽  
Design Work ◽  
Content Development ◽  
Communication And Coordination ◽  
The Many

The work of an instructional designer is highly dependent on an instructional technology substrate, at every phase of the instructional design work: research, planning, communication and coordination, prototyping, design, content searches, content development, branding, alpha and beta testing, revisions, the delivery of course contents, and the archival in learning object repositories. Technologies in this substrate are built to a variety of standards. There are standards for interoperability, for machines to communicate with each other, for information to be held securely (information assurance), for from-life information to be captured and recorded (whether light, detail, sound, or motion), for communications to be exchanged among people, and for digital artifacts to be labeled and protected and delivered to users. The instructional designer “use case” then refers to the on-ground realities of instructional design work and the critical reliance on instructional technologies, and what this in vivo perspective shows about the need for (in part) user-based insights for instructional technology research, design, and development. Every technology has multiple use cases, or theoretical situations in which users use that technology. An instructional designer use case shows the many uses of technologies by an instructional designer, to shed light on how the software technologies may be better tailored to the needs of instructional designers and other digital content developer stakeholders.

scholarly journals Development, implementation, and initial evaluation of a foundational open interoperability standard for oncology treatment planning and summarization

2015 ◽  
Vol 22 (3) ◽  
pp. 577-586 ◽  
Author(s):  
Jeremy L Warner ◽  
Suzanne E Maddux ◽  
Kevin S Hughes ◽  
John C Krauss ◽  
Peter Paul Yu ◽  
...  
Keyword(s):  
Early Stage ◽  
Treatment Plan ◽  
Lessons Learned ◽  
Use Case ◽  
Cancer Subtypes ◽  
Clinical Document ◽  
Oncology Treatment ◽  
Communication And Coordination ◽  
The Many ◽  
Data Elements

Abstract Objective Develop and evaluate a foundational oncology-specific standard for the communication and coordination of care throughout the cancer journey, with early-stage breast cancer as the use case. Materials and Methods Owing to broad uptake of the Health Level Seven (HL7) Consolidated Clinical Document Architecture (C-CDA) by health information exchanges and large provider organizations, we developed an implementation guide in congruence with C-CDA. The resultant product was balloted through the HL7 process and subsequently implemented by two groups: the Health Story Project (Health Story) and the Athena Breast Health Network (Athena). Results The HL7 Implementation Guide for CDA, Release 2: Clinical Oncology Treatment Plan and Summary, DSTU Release 1 (eCOTPS) was successfully balloted and published as a Draft Standard for Trial Use (DSTU) in October 2013. Health Story successfully implemented the eCOTPS the 2014 meeting of the Healthcare Information and Management Systems Society (HIMSS) in a clinical vignette. During the evaluation and implementation of eCOPS, Athena identified two practical concerns: (1) the need for additional CDA templates specific to their use case; (2) the many-to-many mapping of Athena-defined data elements to eCOTPS. Discussion Early implementation of eCOTPS has demonstrated successful vendor-agnostic transmission of oncology-specific data. The modularity enabled by the C-CDA framework ensures the relatively straightforward expansion of the eCOTPS to include other cancer subtypes. Lessons learned during the process will strengthen future versions of the standard. Conclusion eCOTPS is the first oncology-specific CDA standard to achieve HL7 DSTU status. Oncology standards will improve care throughout the cancer journey by allowing the efficient transmission of reliable, meaningful, and current clinical data between the many involved stakeholders.

scholarly journals Spanning the gap: unraveling RSC dynamics in vivo

2021 ◽  
Author(s):  
Heinz Neumann ◽  
Bryan J. Wilkins
Keyword(s):  
Cell Cycle ◽  
Posttranslational Modifications ◽  
Transcriptional Activation ◽  
Binding Mode ◽  
Binding Modes ◽  
Binding Domains ◽  
Binding Interface ◽  
The Many ◽  
And Function

AbstractMultiple reports over the past 2 years have provided the first complete structural analyses for the essential yeast chromatin remodeler, RSC, providing elaborate molecular details for its engagement with the nucleosome. However, there still remain gaps in resolution, particularly within the many RSC subunits that harbor histone binding domains.Solving contacts at these interfaces is crucial because they are regulated by posttranslational modifications that control remodeler binding modes and function. Modifications are dynamic in nature often corresponding to transcriptional activation states and cell cycle stage, highlighting not only a need for enriched spatial resolution but also temporal understanding of remodeler engagement with the nucleosome. Our recent work sheds light on some of those gaps by exploring the binding interface between the RSC catalytic motor protein, Sth1, and the nucleosome, in the living nucleus. Using genetically encoded photo-activatable amino acids incorporated into histones of living yeast we are able to monitor the nucleosomal binding of RSC, emphasizing the regulatory roles of histone modifications in a spatiotemporal manner. We observe that RSC prefers to bind H2B SUMOylated nucleosomes in vivo and interacts with neighboring nucleosomes via H3K14ac. Additionally, we establish that RSC is constitutively bound to the nucleosome and is not ejected during mitotic chromatin compaction but alters its binding mode as it progresses through the cell cycle. Our data offer a renewed perspective on RSC mechanics under true physiological conditions.

scholarly journals Human Immunodeficiency Virus Inhibits Multilineage Hematopoiesis In Vivo

1998 ◽  
Vol 72 (6) ◽  
pp. 5121-5127 ◽  
Author(s):  
Prasad S. Koka ◽  
John K. Fraser ◽  
Yvonne Bryson ◽  
Gregory C. Bristol ◽  
Grace M. Aldrovandi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Progenitor Cells ◽  
Ex Vivo ◽  
Erythroid Differentiation ◽  
Inhibitory Effect ◽  
Immunodeficiency Virus ◽  
The Many ◽  
Hiv 1

ABSTRACT Human immunodeficiency virus type 1 (HIV-1)-infected individuals often exhibit multiple hematopoietic abnormalities reaching far beyond loss of CD4+ lymphocytes. We used the SCID-hu (Thy/Liv) mouse (severe combined immunodeficient mouse transplanted with human fetal thymus and liver tissues), which provides an in vivo system whereby human pluripotent hematopoietic progenitor cells can be maintained and undergo T-lymphoid differentiation and wherein HIV-1 infection causes severe depletion of CD4-bearing human thymocytes. Herein we show that HIV-1 infection rapidly and severely decreases the ex vivo recovery of human progenitor cells capable of differentiation into both erythroid and myeloid lineages. However, the total CD34+ cell population is not depleted. Combination antiretroviral therapy administered well after loss of multilineage progenitor activity reverses this inhibitory effect, establishing a causal role of viral replication. Taken together, our results suggest that pluripotent stem cells are not killed by HIV-1; rather, a later stage important in both myeloid and erythroid differentiation is affected. In addition, a primary virus isolated from a patient exhibiting multiple hematopoietic abnormalities preferentially depleted myeloid and erythroid colony-forming activity rather than CD4-bearing thymocytes in this system. Thus, HIV-1 infection perturbs multiple hematopoietic lineages in vivo, which may explain the many hematopoietic defects found in infected patients.

scholarly journals The legacy of building in the mountain. A report from the Grisons

ARCHALP ◽  
2021 ◽  
Author(s):  
Gordian Blumenthal ◽  
Ramun Capaul
Keyword(s):  
Cultural Landscape ◽  
Cultural Influences ◽  
Design Work ◽  
Space Planning ◽  
Human Needs ◽  
Cultural Aspects ◽  
Close Relationship ◽  
The Alps ◽  
The Many

“In the Alps, the cultural landscape changes with the way people live and act. Social structures and economic conditions shape human needs and define the appearance of the territory and landscape, contributing to the development of specific settlement and housing models, in close relationship with the place. The local typology and construction technologies, developed throughout the history, thus embody the responses to the particular local housing needs, characterizing the places according to different cultural influences. These conditions, together with the influences of the environmental and natural context, as well as the cultural aspects linked to the traditions of the local communities, today are still distinctive elements of the characterization of the villages and mountain valleys. The essay, starting from design experiences conducted personally by the architects in their region of origin – the Grisons – explores the many suggestions that the “legacy” of the different ways of building in the mountains offered for their design work. From space planning to materials, from construction solutions to typology, the architectural projects of Capaul & Blumenthal, both in the case of the recovery of the existing heritage and in the case of new buildings, seem to move from a clever re-interpretation of the complex heritage that combines savoir faire, knowledge, inspirations and materials, to seek careful answers to the current problems of the Alpine world.”

scholarly journals Are we teaching UML according to what IT companies need? A survey on the São Carlos-SP region

2021 ◽  
Author(s):  
João Choma Neto ◽  
Luiz Henrique Ten Caten Bento ◽  
Edson OliveiraJr ◽  
Simone Do Rocio Senger Souza
Keyword(s):  
Unified Modeling Language ◽  
Use Case ◽  
Modeling Languages ◽  
Software Modeling ◽  
Unified Modeling ◽  
Agile Processes ◽  
Universal Language ◽  
Specific Subset ◽  
Development Processes ◽  
The Many

The Unified Modeling Language (UML) arisen intending to unify the many modeling languages and become the universal language for software modeling. Since its creation, more than 25 years have passed. With the growing success of agile methodologies for software development, supported by less modeling and documentation manifest, the use of UML-driven software processes has decreased, thus a specific subset of diagrams has been adopted, such as use case, class, and sequence. On the other hand, in academia, UML is still being taught in Computing courses, most of the time without knowing whether what is taught is what the industry needs for practical use. This paper presents an overview of the UML adoption in IT companies of the region. We analyzed quantitative and qualitative data to support academia at focusing on the most used UML diagrams by practitioners. We constructed a survey composed of 21 questions, distributed to 10 region companies, and we received 24 answers. The results of our study show high usage of UML, including companies adopting agile methods. Certain diagrams are more intensively used, for instance, use case diagrams. The results provide directions to improve UML teaching, focusing on diagrams that best adhere to the development processes employed, in particular, agile processes.

scholarly journals In vivotissue-specific chromatin profiling inDrosophila melanogasterusing GFP-tagged nuclei

2021 ◽  
Author(s):  
Juan Jauregui-Lozano ◽  
Kimaya Bakhle ◽  
Vikki M. Weake
Keyword(s):  
Cell Types ◽  
Chromatin Accessibility ◽  
Chromatin State ◽  
Specific Cell ◽  
Histone Marks ◽  
The Many ◽  
Chromatin Profiling ◽  
Photoreceptor Neurons ◽  
Multicellular Organisms

AbstractThe chromatin landscape defines cellular identity in multicellular organisms with unique patterns of DNA accessibility and histone marks decorating the genome of each cell type. Thus, profiling the chromatin state of different cell types in an intact organism under disease or physiological conditions can provide insight into how chromatin regulates cell homeostasisin vivo. To overcome the many challenges associated with characterizing chromatin state in specific cell types, we developed an improved approach to isolateDrosophilanuclei tagged with GFP expressed under Gal4/UAS control. Using this protocol, we profiled chromatin accessibility using Omni-ATAC, and examined the distribution of histone marks using ChIP-seq and CUT&Tag in adult photoreceptor neurons. We show that the chromatin landscape of photoreceptors reflects the transcriptional state of these cells, demonstrating the quality and reproducibility of our approach for profiling the transcriptome and epigenome of specific cell types inDrosophila.

New insights in the interaction of FGF/FGFR and steroid receptor signaling in breast cancer

Endocrinology ◽  
2022 ◽  
Author(s):  
Cecilia Pérez Piñero ◽  
Sebastián Giulianelli ◽  
Caroline A Lamb ◽  
Claudia Lanari
Keyword(s):  
Breast Cancer ◽  
Hormone Receptors ◽  
Endocrine Resistance ◽  
Short Review ◽  
Experimental Models ◽  
Luminal Breast Cancer ◽  
Tumor Subtypes ◽  
Stromal Tissue ◽  
The Many

Abstract Luminal breast cancer (BrCa) has a favorable prognosis compared to other tumor subtypes. However, with time tumors may evolve and lead to disease progression. Thus, there is a great interest in unraveling the mechanisms that drive tumor metastasis and endocrine resistance. In this review we focused in one of the many pathways that have been involved in tumor progression, the FGF/FGFR axis. We emphasized in data obtained from in vivo experimental models since we believe that in luminal BrCa, tumor growth relies in a crosstalk with the stromal tissue. We revisited the studies that illustrate the interaction between hormone receptors and FGFR. We also highlighted the most frequent alterations found in BrCa cell lines and we provide a short review on the trials that use FGFR inhibitors in combination with endocrine therapies. The analysis of this data suggests that there are many players involved in this pathway that might be also targeted to decrease FGF signaling in addition to specific FGFR inhibitors that may be exploited to increase their efficacy.

The Cultural Adaptation of E-Learning

2011 ◽  
pp. 308-325 ◽  
Author(s):  
Andrea L. Edmundson
Keyword(s):  
Instructional Design ◽  
Learning Styles ◽  
Learning Outcomes ◽  
Cultural Analysis ◽  
Instructional Designer ◽  
Course Content ◽  
Instructional Methodologies ◽  
Cultural Preferences ◽  
E Learning ◽  
Design Skills

Culturally appropriate instructional design requires the integration of instructional design skills with intercultural knowledge. In e-learning, as in classroom-based courses, courses that accommodate the learning styles and cultural preferences of the targeted learners will offer the best—and fastest—learning outcomes. In this chapter, the author illustrates how to modify an existing e-learning course—or design one ‘from scratch’—that aligns the course content, the instructional methodologies (including activities and assessments) and the technology to the needs and environment of learners in other countries. The ‘smart’ instructional designer conducts a cultural analysis and makes validated changes to e-learning courses, before they are sent for translation, localization, or final production.

Investigating Sociocultural Issues in Instructional Design Practice and Research

2011 ◽  
pp. 49-73 ◽  
Author(s):  
Katy Campbell ◽  
Richard A. Schwier ◽  
Heather Kanuka
Keyword(s):  
Instructional Design ◽  
Design Research ◽  
Research Question ◽  
Preliminary Investigation ◽  
Instructional Designer ◽  
Instructional Designers ◽  
Culturally Appropriate ◽  
Social Difference ◽  
Design Problems ◽  
Values And Beliefs

This chapter is a narrative account of the process involved to initiate a program of research to explore how instructional designers around the world use design to make a social difference locally and globally. The central research question was, “Are there social and political purposes for design that are culturally based?” A growing body of research is concerned with the design of culturally appropriate learning resources and environments, but the focus of this research is the instructional designer as the agent of the design. Colloquially put, if, as has been suggested, we tend to design for ourselves, we should understand the sociocultural influences on us and how they inform our practices. We should also develop respect for, and learn from, how various global cultures address similar design problems differently. The authors report the results of a preliminary investigation held with instructional designers from ten countries to examine culturally situated values and practices of instructional design, describe the research protocol developed to expand the investigation internationally, and share emerging issues for instructional design research with international colleagues. In this chapter, the authors link their earlier work on instructional designer agency with the growing research base on instructional design for multicultural and/or international learners. This research takes the shape of user-centred design and visual design; international curriculum development, particularly in online or distance learning; and emphasis on culturally appropriate interactions. We have suggested that instructional designers’ identity, including their values and beliefs about the purpose of design, are pivotal to the design problems they choose to work on, the contexts in which they choose to practice, and with whom. Our interest in the culture of design, then, is less process-based (how to do it) than interrogative (why we do it the way we do). And that has led us to ask, “Is there one culture of instructional design, or are there many, and how are these cultures embodied in instructional designers’ practice?” The idea of design culture is well established. Most notably, investigations of professional culture have attracted significant attention (Boling, 2006; Hill, J., et. al., 2005; Snelbecker, 1999). These investigations have concentrated on how different professions, such as architecture, drama, engineering and fine art approach design differently, with the goal of informing the practice of design in instructional design (ID). The decision-making processes of design professionals have also been illuminated by scholars like Donald Schon (1983) who described knowing-in-action and suggested the link between experience, (sociocultural) context, and intuition with design made visible through reflective practice.

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