Microfluidic Applications in Vascular Bioengineering

Author(s):  
Anand Srinivasan ◽  
José L. López-Ribot ◽  
Anand K. Ramasubramanian

Microfluidics is the manipulation and control of fluids in small scale, and has heralded a new age in science as evidenced by the rapid increase in the amount and quality of academic and industrial research output in this area in the recent times. Microfluidics has shown tremendous promise in both fundamental and applied research in the field of vascular bioengineering. In this review, we outline the basic principles of microfluidic flow and fabrication techniques, and describe the recent advances in the applications of microfluidic devices in diagnostic and prognostic vascular bioengineering. The field is still in its infancy and has a great potential for research and development as it matures to deliver commercially viable products. This review, focusing on the current status of microfluidic applications to diagnose and treat blood-related disorders, should be a valuable and opportune addition to the literature of interest to both academia and industry.

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Adele Brunetti ◽  
Francesca Macedonio ◽  
Giuseppe Barbieri ◽  
Enrico Drioli

Abstract The recent roadmap of SPIRE initiative includes the development of “new separation, extraction and pre-treatment technologies” as one of the “key actions” for boosting sustainability, enhancing the availability and quality of existing resources. Membrane condenser is an innovative technology that was recently investigated for the recovery of water vapor for waste gaseous streams, such as flue gas, biogas, cooling tower plumes, etc. Recently, it has been also proposed as pre-treatment unit for the reduction and control of contaminants in waste gaseous streams (SOx and NOx, VOCs, H2S, NH3, siloxanes, halides, particulates, organic pollutants). This perspective article reports recent progresses in the applications of the membrane condenser in the treatment of various gaseous streams for water recovery and contaminant control. After an overview of the operating principle, the membranes used, and the main results achieved, the work also proposes the role of this technology as pre-treatment stage to other separation technologies. The potentialities of the technology are also discussed aspiring to pave the way towards the development of an innovative technology where membrane condenser can cover a key role in redesigning the whole upgrading process.


2020 ◽  
Vol 14 (1) ◽  
pp. 32-39
Author(s):  
B. G. Isayeva ◽  
M. M. Saparbayeva ◽  
S. M. Isayeva ◽  
M. M. Kulshymanova ◽  
Sh. M. Kaiyrgali ◽  
...  

Objective: to analyze the provision of medical, including rheumatology, care in Kazakhstan, to study the incidence of systemic lupus erythematosus (SLE), and to develop a registry of patients with this condition.Material and methods. The investigators analyzed the guidelines for the organization of medical, including rheumatology, care in the republic and the official statistical materials of the Ministry of Health of the Republic of Kazakhstan in the period 2012 to 2017. Articles were searched to select activity indices, organ damages and to assess the quality of life and treatment programs in order to create a registry of patients with SLE.Results and discussion. The paper presents the basic principles of providing medical, including rheumatology, care in the republic. It gives data on the issues of providing SLE patients with medicines in outpatient and inpatient settings. It also analyzes trends in the incidence of SLE in the population of Kazakhstan in 2012 to 2017. There were 4,448 SLE patients, including 3,986 women; a comparative analysis of indicators demonstrated a 62.8% increase in the incidence of SLE from 2012 to 2017. The purpose and objectives of the registry of patients with SLE were substantiated.Conclusion. An analysis of morbidity rates suggests that SLE remains to be significant in the republic. The incidence of SLE has been noted to increase in the period from 2012 to 2017; there is a female preponderance (89.6%). The application of the SLE registry in clinical practice will be able to improve the diagnosis of the disease in the early stage and to prevent possible complications. 


Author(s):  
Bagus Haryono

AbstractThis aims of this research is to explore the Social Capital, the level of understanding of citizens about Disaster Mitigation in their area and readiness in dealing with it. This research is designed to apply qualitative strategies which are explorative, descriptive and explanative. Data collected by observation, literature study, interview or experiment. It is interesting to note that residents have often watched coverage of various disasters that occur in Indonesia through television, even understanding the great potential of disasters in their region. But based on their low level of Social Capital, it turns out they still lack adequate understanding of Disaster Mitigation in their region. Based on this data, it can be assumed that they only have a low level of preparedness in dealing with it, if a disaster does occur, they will become victims of such a large impact. Even in the event of a small-scale catastrophic event, it turns out that their understanding of Disaster Mitigation is still lacking, starting from the level of disasters, causes, anticipations, or even the consequences that will result. Therefore, a literature study is needed, strengthening a comprehensive understanding of Disaster Mitigation, raising critical awareness, and needing actions that directly involve citizens are urgently needed. The research output is designed in the form of national or international proceedings; national or international speaker certificate; with scale achievements following the stages: literature study, discovery of basic principles that have been formulated, experiments, towards a scientifically feasible model.   Penelitian ini bertujuan untuk mengeksplorasi Modal Sosial, tingkat pemahaman warga tentang Mitigasi Bencana di wilayahnya dan kesiapan dalam menghadapinya. Penelitian ini dirancang menerapkan strategi kualitatif yang berjenis eksploratif, deskriptif, dan eksplanatif. Data dikumpulkan dengan observasi, studi pustaka, wawancara atau eksperimen. Menarik untuk diteliti bahwa warga telah sering menonton liputan tentang berbagai bencana yang terjadi di Indonesia melalui tayangan televisi, bahkan memahami potensi besar bencana di wilayahnya. Namun dengan Modal Sosial yang dimilikinya, ternyata mereka masih kurang memiliki pemahaman yang memadai tentang Mitigasi Bencana di wilayahnya. Berdasarkan gambaran tersebut dapat diduga mereka hanya memiliki tingkat kesiapan yang rendah dalam menghadapinya, apabila bencana benar-benar terjadi, mereka akan menjadi korban terdampak yang begitu besar. Bahkan pada saat terjadi kejadian bencana yang berskala kecil sekalipun, ternyata masih kurang pemahaman mereka mengenai Mitigasi Bencana yang jelas mulai dari tataran perihal bencana, faktor penyebab, antisipasi, atau bahkan akibat yang akan ditimbulkannya. Oleh karena itu, diperlukan studi pustaka, penguatan pemahaman Mitigasi Bencana yang komprehensif, peningkatan kesadaran kritis, serta perlu langkah aksi yang langsung melibatkan warga sangat diperlukan. Luaran penelitian ini dirancangkan berupa publikasi prosiding nasional atau internasional; sertifikat pemakalah nasional atau internasional; dengan capaian skala mengikuti tahapan: studi pustaka, penemuan prinsip dasar yang telah diformulasikan, eksperimen, menuju model yang layak secara ilmiah.


2009 ◽  
Vol 6 (4) ◽  
pp. 250-264
Author(s):  
Nadja Adamovic ◽  
Ioanna Giouroudi ◽  
Jovan Matovic ◽  
Zoran Djinovic ◽  
Ulrich Schmid

Much effort in microfluidics research has been aimed at designing microscale pumps, valves, switches, dispensers, mixers, filters, separators, and so on, which have a major role in the development of innovative systems like chemical process control, bioanalytical devices, medical drug delivery systems, environmental control, and others. Most of these microfluidic devices have one thing in common: the need for precise manipulation and control of small amounts of fluids. MEMS/NEMS research is continuously opening up new knowledge on modeling approaches, novel materials, and MEMS/NEMS processing technologies that stimulate and accelerate the development of new actuation principles and novel actuator configurations. This review paper presents research work on different actuation techniques that are used for the whole range of microfluidic applications. It covers thermomechanical and electrochemical actuation principles, as well as actuation induced with external electric or magnetic fields. It presents a brief explanation of the operating principle of each type of actuator, actuator configuration, its main characteristics, like power consumption, operational voltage, frequency range, and working fluids, and a discussion of comparisons among different actuation schemes. This study compiles and provides some basic guidelines for selection of the actuation schemes that are currently implemented in microfluidic devices.


2019 ◽  
Vol 8 (3) ◽  
pp. 4721-4727

The proposed project is to design a commercial Programming Logic Controller based automation unit with SCADA and HMI for Demineralization Unit. In Demineralization, the raw water obtained from underground and Lake is treated to meet standard as per usage. Some of the closely monitored are pH, turbidity, etc. The automation tool designed uses DELTA PLC which is interfaced to local HMI which is in-turn connected to Wi–Fi using TP– Link thus supporting Remote Monitoring and Control. For centralized control unit SCADA is used by interfacing PLC with Computer. To match the communication protocol between PLC and SCADA, OPC software called KEPServer is used. Significant improvement in quantity and quality of demineralized water can be achieved. The proposed design is cost effective as it suit for small scale industry


1969 ◽  
Vol 14 (4) ◽  
pp. 10-19 ◽  
Author(s):  
M. C. Cheney

Presented is an introduction to the basic principles of the Advancing Blade Concept (ABC) rotor and a review of the related experimental and analytical research conducted in support of the Sikorsky ABC helicopter program. The ABC helicopter is comprised of two coaxial, counter‐rotating rotors having blades rigidly attached to the hub except for feathering freedom. The blades are significantly stiffer than conventional rotor Blades and are capable of supporting large moments without excessive tip deflections. Improved forward flight efficiency and the elimination of retreating blade stall results from the ability of the ABC rotor to utilize to a large extent the lifting potential of the advancing blades—a capability not present in conventional single rotors. Results of various small‐scale wind tunnel experiments are presented along with summaries of several analytical investigations which were conducted to provide information concerning rotor performance, blade dynamics, vibration, and stability and control


2021 ◽  
Vol 22 (7) ◽  
pp. 3594
Author(s):  
Eriko Toyoda ◽  
Miki Maehara ◽  
Masahiko Watanabe ◽  
Masato Sato

Osteoarthritis (OA) of the knee is a disease that significantly decreases the quality of life due to joint deformation and pain caused by degeneration of articular cartilage. Since the degeneration of cartilage is irreversible, intervention from an early stage and control throughout life is important for OA treatment. For the treatment of early OA, the development of a disease-modifying osteoarthritis drug (DMOAD) for intra-articular (IA) injection, which is attracting attention as a point-of-care therapy, is desired. In recent years, the molecular mechanisms involved in OA progression have been clarified while new types of drug development methods based on gene sequences have been established. In addition to conventional chemical compounds and protein therapeutics, the development of DMOAD from the new modalities such as gene therapy and oligonucleotide therapeutics is accelerating. In this review, we have summarized the current status and challenges of DMOAD for IA injection, especially for protein therapeutics, gene therapy, and oligonucleotide therapeutics.


2020 ◽  
Vol 3 (2) ◽  
pp. 31
Author(s):  
Wenwen He ◽  
Yingyi Bi ◽  
Hongjiao Xu ◽  
Liqian Gao ◽  
Xing Zhao

Concerned about the current situation of hemodialysis patients' awareness of the problems related to dialysis complicated with hyperphosphatemia, further analyze the existing problems and causes, give targeted and individualized health education, improve the compliance of diet, medication and self-management, strengthen nurse-patient communication, establish a good nurse-patient relationship, reduce and control the incidence of hyperphosphatemia, improve patients' quality of life, and improve prognosis.


Author(s):  
Russell L. Steere ◽  
Eric F. Erbe ◽  
J. Michael Moseley

We have designed and built an electronic device which compares the resistance of a defined area of vacuum evaporated material with a variable resistor. When the two resistances are matched, the device automatically disconnects the primary side of the substrate transformer and stops further evaporation.This approach to controlled evaporation in conjunction with the modified guns and evaporation source permits reliably reproducible multiple Pt shadow films from a single Pt wrapped carbon point source. The reproducibility from consecutive C point sources is also reliable. Furthermore, the device we have developed permits us to select a predetermined resistance so that low contrast high-resolution shadows, heavy high contrast shadows, or any grade in between can be selected at will. The reproducibility and quality of results are demonstrated in Figures 1-4 which represent evaporations at various settings of the variable resistor.


1989 ◽  
Author(s):  
Constantine Tsikos ◽  
Tom Chmielewski ◽  
Brian Frederick

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