Histological Evaluation of Percutaneous Device with Different Materials

2006 ◽  
Vol 309-311 ◽  
pp. 423-426
Author(s):  
L. Zheng ◽  
T. Yuan ◽  
Y.M. Jiang ◽  
J.M. Luo ◽  
Xing Dong Zhang
Keyword(s):  
Soft Tissue ◽  
Titanium Implant ◽  
Tissue Reaction ◽  
Histological Evaluation ◽  
Successful Development ◽  
New Device ◽  
Percutaneous Device ◽  
Key Factor ◽  
Implant Integration

Biological sealing is a key factor for successful development of percutaneous device (PD). A new device with arc-perforated flange as subcutaneous part and groove-shaped percutaneous part, was intended to improve integration of soft tissue and implant. Material and surface properties are known to have great impact on tissue-implant integration. To understand how a material and its surface property can influence tissue reaction, and to find the appropriate material for PD fabrication, five different kinds of materials were prepared for in vivo animal tests with corresponding histological evaluation. Results revealed that a more stable junction was formed between the soft tissue and HA coated titanium implant than other combinations.

scholarly journals Experimental Biointegration of a Titanium Implant in Delayed Mandibular Reconstruction

2020 ◽  
Vol 10 (1) ◽  
pp. 6 ◽  
Author(s):  
Alexander Dolgolev ◽  
Igor Reshetov ◽  
Dmitry Svyatoslavov ◽  
Mikhail Sinelnikov ◽  
Konstantin Kudrin ◽  
...  
Keyword(s):  
Bone Matrix ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Mandibular Reconstruction ◽  
Histological Evaluation ◽  
Plastic Plate ◽  
Extensive Resection ◽  
Bone Integration ◽  
Variable Integration

Background: Mandibular reconstruction, after extensive resection of the mandible for the treatment of oral cancer, is a well-known procedure, however, relatively little is known about bone integration into the titanium implant after reconstruction with a temporary plastic implant. The main goal of this experimental study was to study the process of osseous integration into the titanium implant in an in vivo experiment following prior mandibular reconstruction with a temporary plastic implant. Materials and Methods: Four ewes initially underwent a partial one-sided resection of the mandible, with the formation of an approximately 3 × 1 cm defect. All of the subjects received reconstruction with an implantation of a plastic plate (3 cm). The plastic plate was removed and replaced by a titanium implant at 1, 3, 6, and 12 months, accordingly. Both plastic and titanium implants were made via 3D-printing technology and personalized modeling. A total of 6 months after titanium implantation, a histological evaluation of biointegration was performed. Results: All surgeries were uncomplicated. The integration of osseous tissue into the titanium implant was seen in all cases. Histologically, each case showed variable integration of dense fibrotic tissue with fibroblasts and non-mature bone tissue with a definitive layer of bone matrix with many osteoblasts on the periphery. The prior implantation of the plastic plate did not interfere with bone integration into the titanium implant. Conclusion: Preliminary results demonstrated that a temporary plastic implant for mandibular reconstruction does not interfere with the consequent osseous biointegration of a permanent titanium implant. This shows that temporary reconstruction is a safe solution when delayed mandibular reconstruction is required due to disease severity.

scholarly journals Integration of a Three-Dimensional-Printed Titanium Implant in Human Tissues: Case Study

2020 ◽  
Vol 10 (2) ◽  
pp. 553 ◽  
Author(s):  
Jong Woong Park ◽  
Chae Ahn Song ◽  
Hyun Guy Kang ◽  
June Hyuk Kim ◽  
Kwun Mook Lim ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Soft Tissue ◽  
Three Dimensional ◽  
Titanium Implant ◽  
Histological Evaluation ◽  
Limb Salvage Surgery ◽  
Mesh Structure ◽  
Bone Surgery ◽  
Tissue Integration ◽  
3D Printed

A titanium alloy implant of appropriate pore size can potentially enhance osseointegration and soft tissue integration. However, the human clinical application of such implants has not been reported. Here, we present a case of limb salvage surgery for a bone tumor using customized three-dimensional (3D)-printed Ti6Al4V radius and ulna implants. The patient presented with local recurrence at the proximal junction of the ulna and underwent a re-wide excision. Single forearm bone surgery was performed using another 3D-printed implant after resection of the recurrent tumor with an ulnar implant. Host osseointegration and soft tissue integration of the retrieved implant were quantified through histological evaluation. The total tissue integration rates of the implant at the proximal and distal bone junctions were 45.96% and 15.03%, respectively. The mesh structure enhanced bone integration by up to 10.81% in the proximal and by up to 8.91% in the distal bone junction. Furthermore, the soft tissue adhesion rates of the implant shaft were 59.50% and 50.26% in the axial and longitudinal cuts, respectively. No area was left unoccupied throughout the shaft of the implant. Overall, these results indicate that the 3D-printed Ti6Al4V titanium alloy implant with a rough surface has considerable tissue integration ability.

Soft tissue response to zirconia and titanium implant abutments: an in vivo within-subject comparison

2012 ◽  
Vol 39 (10) ◽  
pp. 995-1001 ◽  
Author(s):  
Ralph van Brakel ◽  
Gert J. Meijer ◽  
Jan Willem Verhoeven ◽  
John Jansen ◽  
Cornelis de Putter ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Titanium Implant ◽  
Tissue Response ◽  
Implant Abutments ◽  
Soft Tissue Response ◽  
Subject Comparison

scholarly journals Histological Evaluation of the Local Soft Tissue Reaction After Implanting Resorbable and Non-resorbable Monofilament Fibers

2017 ◽  
Vol 46 (2) ◽  
pp. 135-143
Author(s):  
Bogusława Żywicka ◽  
Maria Szymonowicz ◽  
Danuta Bryła ◽  
Zbigniew Rybak
Keyword(s):  
Soft Tissue ◽  
Tissue Reaction ◽  
Histological Evaluation ◽  
Soft Tissue Reaction

An In vivo Experimental Study on Investigation of the Osseointegration of Zeolites A and Silicalite in Rats

2021 ◽  
Author(s):  
Taşkın Ceyhan ◽  
Ahmet Gülçubuk ◽  
Melkon Tatlıer ◽  
Damla Haktanır ◽  
Hümeyra Kocaelli
Keyword(s):  
Bone Repair ◽  
Glass Ceramics ◽  
Repair Process ◽  
Tissue Reaction ◽  
Histological Evaluation ◽  
Polycrystalline Materials ◽  
Time Intervals ◽  
Naturally Occurring ◽  
Medical Materials

Background: Zeolites are naturally occurring and can be artificially synthesized hydrated microporous crystallized aluminosilicates. Thus far, medical materials have comprised polycrystalline materials, glass, glass-ceramics and ceramic-filled composites for bone repair. The study aimed to investigate the potential in vivo osseointegration of two types of zeolites (A and silicalite) in rats by histologically presenting the repair process. Methods: Bone cavities of 1 mm3 were formed in rats and filled either with zeolite A or silicalite to investigate the possibility of using zeolites to repair bone defects. A comparative histological evaluation was performed regarding the interaction of zeolites with bone tissue and their osseointegration capacity for 15, 30 and 45-day intervals. Result: According to the results obtained, the growth of both fibrous and bone tissues took place around the zeolites placed in the live organism. It was observed that the zeolites used in this study did not give rise to necrosis, local tissue reaction, allergic or and any other harmful response. In conclusion, histopathology revealed that zeolites A and silicalite were biocompatible with the bone and could integrate with it at certain time intervals.

Attachment of oral bacteria to titanium surfaces: An SEM study

1994 ◽  
Vol 52 ◽  
pp. 468-469
Author(s):  
J. E. Laffoon ◽  
R. L. Anderson ◽  
J. C. Keller ◽  
C. D. Wu-Yuan
Keyword(s):  
Technical Problem ◽  
Titanium Implant ◽  
Oral Bacteria ◽  
Bacterial Cells ◽  
Thin Sections ◽  
Surface Ultrastructure ◽  
Sem Study ◽  
Key Factor ◽  
Titanium Surfaces

Titanium (Ti) dental implants have been used widely for many years. Long term implant failures are related, in part, to the development of peri-implantitis frequently associated with bacteria. Bacterial adherence and colonization have been considered a key factor in the pathogenesis of many biomaterial based infections. Without the initial attachment of oral bacteria to Ti-implant surfaces, subsequent polymicrobial accumulation and colonization leading to peri-implant disease cannot occur. The overall goal of this study is to examine the implant-oral bacterial interfaces and gain a greater understanding of their attachment characteristics and mechanisms. Since the detailed cell surface ultrastructure involved in attachment is only discernible at the electron microscopy level, the study is complicated by the technical problem of obtaining titanium implant and attached bacterial cells in the same ultra-thin sections. In this study, a technique was developed to facilitate the study of Ti implant-bacteria interface.Discs of polymerized Spurr’s resin (12 mm x 5 mm) were formed to a thickness of approximately 3 mm using an EM block holder (Fig. 1). Titanium was then deposited by vacuum deposition to a film thickness of 300Å (Fig. 2).

Evaluation of 99mTc-Label led Vitamin K4 as an Agent for Testicular Imaging

1991 ◽  
Vol 30 (01) ◽  
pp. 35-39 ◽  
Author(s):  
H. S. Durak ◽  
M. Kitapgi ◽  
B. E. Caner ◽  
R. Senekowitsch ◽  
M. T. Ercan
Keyword(s):  
Soft Tissue ◽  
Room Temperature ◽  
Normal Subjects ◽  
Left Testis ◽  
Wide Range ◽  
Activity Ratios ◽  
The Right ◽  
Radioactivity Levels

Vitamin K4 was labelled with 99mTc with an efficiency higher than 97%. The compound was stable up to 24 h at room temperature, and its biodistribution in NMRI mice indicated its in vivo stability. Blood radioactivity levels were high over a wide range. 10% of the injected activity remained in blood after 24 h. Excretion was mostly via kidneys. Only the liver and kidneys concentrated appreciable amounts of radioactivity. Testis/soft tissue ratios were 1.4 and 1.57 at 6 and 24 h, respectively. Testis/blood ratios were lower than 1. In vitro studies with mouse blood indicated that 33.9 ±9.6% of the radioactivity was associated with RBCs; it was washed out almost completely with saline. Protein binding was 28.7 ±6.3% as determined by TCA precipitation. Blood clearance of 99mTc-l<4 in normal subjects showed a slow decrease of radioactivity, reaching a plateau after 16 h at 20% of the injected activity. In scintigraphic images in men the testes could be well visualized. The right/left testis ratio was 1.08 ±0.13. Testis/soft tissue and testis/blood activity ratios were highest at 3 h. These ratios were higher than those obtained with pertechnetate at 20 min post injection.99mTc-l<4 appears to be a promising radiopharmaceutical for the scintigraphic visualization of testes.

Nanodrugs as a new approach in therapy of cardiovascular diseases and cancer with tumor-associated angiogenesis

2020 ◽  
Vol 28 ◽  
Author(s):  
Justyna Hajtuch ◽  
Karolina Niska ◽  
Iwona Inkielewicz-Stepniak
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Controlled Drug Release ◽  
Biological Properties ◽  
Comprehensive Information ◽  
Conventional Drug ◽  
Key Factor ◽  
Functionalized Materials

Background: Cancer along with cardiovascular diseases are globally defined as leading causes of death. Importantly, some risk factors are common to these diseases. The process of angiogenesis and platelets aggregation are observed in cancer development and progression. In recent years, studies have been conducted on nanodrugs in these diseases that have provided important information on the biological and physicochemical properties of nanoparticles. Their attractive features are that they are made of biocompatible, well-characterized and easily functionalized materials. Unlike conventional drug delivery, sustained and controlled drug release can be obtained by using nanomaterials. Methods: In this article, we review the latest research to provide comprehensive information on nanoparticle-based drugs for the treatment of cancer, cardiovascular disease associated with abnormal haemostasis, and the inhibition of tumorassociated angiogenesis. Results: The results of the analysis of data based on nanoparticles with drugs confirm their improved pharmaceutical and biological properties, which gives promising antiplatelet, anticoagulant and antiangiogenic effects. Moreover, the review included in vitro, in vivo research and presented nanodrugs with chemotherapeutics approved by Food and Drug Administration. Conclusion: By the optimization of nanoparticles size and surface properties, nanotechnology are able to deliver drugs with enhanced bioavailability in treatment of cardiovascular disease, cancer and inhibition of cancer-related angiogenesis. Thus, nanotechnology can improve the therapeutic efficacy of the drug, but there is a need for a better understanding of the nanodrugs interaction in the human body, because this is a key factor in the success of potential nanotherapeutics.

scholarly journals Non-invasive diagnostics in fossils - Magnetic Resonance Imaging of pathological belemnites

2005 ◽  
Vol 2 (2) ◽  
pp. 133-140 ◽  
Author(s):  
D. Mietchen ◽  
H. Keupp ◽  
B. Manz ◽  
F. Volke
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Clinical Diagnostics ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Physiological Processes ◽  
Magnetic Resonance Imaging Mri ◽  
Invasive Diagnostics

Abstract. For more than a decade, Magnetic Resonance Imaging (MRI) has been routinely employed in clinical diagnostics because it allows non-invasive studies of anatomical structures and physiological processes in vivo and to differentiate between healthy and pathological states, particularly of soft tissue. Here, we demonstrate that MRI can likewise be applied to fossilized biological samples and help in elucidating paleopathological and paleoecological questions: Five anomalous guards of Jurassic and Cretaceous belemnites are presented along with putative paleopathological diagnoses directly derived from 3D MR images with microscopic resolution. Syn vivo deformities of both the mineralized internal rostrum and the surrounding former soft tissue can be traced back in part to traumatic events of predator-prey-interactions, and partly to parasitism. Besides, evidence is presented that the frequently observed anomalous apical collar might be indicative of an inflammatory disease. These findings highlight the potential of Magnetic Resonance techniques for further paleontological applications.

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