Repairing the Dog's Femoral Defect with the Autologous Osteoblast Integrated the Nano-Calcium Phosphate/Zirconia Scaffold

2007 ◽  
Vol 336-338 ◽  
pp. 1662-1665
Author(s):  
Guo Hua Xu ◽  
Xiao Jian Ye ◽  
Wen Yuan ◽  
Shu Cai ◽  
Jian Gang Shi ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Calcium Phosphates ◽  
Strength Test ◽  
Control Group ◽  
Haversian Canal ◽  
Artificial Bone ◽  
Simple Material ◽  
Femoral Defect ◽  
Significant Difference ◽  
Defect Repair

In this paper, we study the effect of repairing the dog's femoral defects with the artificial bone integrating the nano-calcium phosphates/zirconia porous artificial bone scaffold with the autologous osteoblasts. We transplanted the artificial bone to the femoral defect of the dog, and at the same time, simple scaffold and the autologous cancellous bone were implanted as the control group. 3 months after the transplantation, the specimen was taken out with complete integration with the bone in these 3 groups and the bone defect got the complete bone union. The mechanics strength test showed that the group of the artificial bone was the strongest, followed by the cancellous bone group, and the simple material group was lower, but the strength was stronger than that before the transplantation. In the sixth month, the complete femoral defect repair was found in each group and the complete formation of the Haversian canal can be found on the histology examination. According to the mechanics strength test, there was no significant difference (P<0.05).

scholarly journals The influence of plastic techniques in surgery of primary skin melanoma on patient survival

2020 ◽  
Vol 25 (1) ◽  
pp. 27-36
Author(s):  
S. A. Yargunin ◽  
Y. N. Shoyhet ◽  
A. F. Lazarev
Keyword(s):  
Plastic Surgery ◽  
Distant Metastasis ◽  
Comparison Group ◽  
Progression Free Survival ◽  
Control Group ◽  
Skin Melanoma ◽  
Early Stages ◽  
Significant Difference ◽  
Comparison Groups ◽  
Defect Repair

Objective. To analyze the feasibility of performing plastic surgery in patients with primary skin melanoma (SM). Material and methods. We studied patients with primary MK treated in our institution in 2013 (n = 333), who were randomized to a group of 2 blind selection methods to the main one (n = 168), in which the tumor removal operation in patients ended with a tissue defect repair and a comparison group ( n = 165) (after removal of the tumor, simple linear suturing of the wound was performed). A statistically significant difference was found in the comparison groups in the occurrence of negative dynamics (ND), progression-free survival (PFS) and overall survival (OS) in patients with MK 0-IIA st during the follow-up period up to 36 months. Results. It was found that patients with 0-IIA st who underwent plastic surgery to close the defect when removing primary SM have a statistically proven advantage in ND, PFS, and OS compared with patients without plastic surgery for up to 36 months. In general, the use of plastics has a statistical tendency towards the dynamics of an increase in PFS and OS in the early stages of SM. Discussion. In the early stages (0-IIA) up to 36 months, cases of negative dynamics (4.2%) were observed 2.3 times less frequently than in the comparison group (9.7%) (p = 0.048), and fatal outcomes in the main group (1.8%) were observed 3.7 times less than in the comparison group (6.7%) (p = 0.028). The analysis also shows that in patients who underwent surgery using plastic surgery statistically significantly reduces the risk of distant metastasis by 3 times (p = 0.05), but significantly more often (in every third patient) (p = 0.022) than in the control group (without plastic surgery) met transient metastases. The appearance of ND, as well as an increase in PFS, OS depended on the plastic replacement of the defect after excision of the primary SM in patients with SM 0-IIA st during the observation period up to 36 months. Conclusion. The use of plastic methods for closing a wound defect reduces the risk of distant metastasis by 3 times compared with linear suturing, provides a reduction in mortality in patients with SM 0 IIA st for 60 months, prolongs the patients life by an average of 10 months and is the operation of choice in this category.

scholarly journals Effect of Silver Nanoparticles on Some Physical& Biological Properties of Fluid Denture Base Material

2020 ◽  
Vol 04 (1) ◽  
pp. 27-40
Author(s):  
Jaymin Taher ◽  
Salem Salem
Keyword(s):  
Silver Nanoparticles ◽  
Impact Strength ◽  
Color Change ◽  
Base Material ◽  
Color Stability ◽  
Biological Properties ◽  
Strength Test ◽  
Control Group ◽  
Transverse Strength ◽  
Significant Difference

Poly methyl methacrylate (PMMA) is one of the most widely used materials in modern prosthodontics. It is widely known due to its simplicity in use and acceptable aesthetic. A new concept of polymerization fluid resin technique was instead of heat and gypsum material. Forty specimens were prepared from two brands of fluid acrylic resin. The samples were divided into two groups, the first one was the control while the other group was incorporated with silver nanoparticles(modified). The tests performed were impact strength, transverse strength, color stability and candida retention ability on the samples. 10 samples for each test were used. The results showed that modified group had significantly higher impact strength than the control group. There was non-significant difference between group of modified fluid acrylic and control group. Regarding color stability, there were highly significant color change after 10 days of immersion in the tea solution for the modified group the results of the biological test showed that the candida retention of the control group was significantly higher than modified group. Within the limitation of this study it can be concluded that addition of silver nanoparticles has resulted in significant difference between control and modified group for impact strength test. While non-significant difference was seen for transverse strength test. In regard to color stability, showed enhancement in color stability for both before and after placement in tea solution. Addition of silver nanoparticles also caused reduction in candida albicans retention in the added samples.

scholarly journals The Effect of Pilates Reformer Exercises to Tennis Skills on Tennis Players

2019 ◽  
Vol 7 (9) ◽  
pp. 48
Author(s):  
Mine Gül
Keyword(s):  
Strength Test ◽  
Control Group ◽  
Test Analysis ◽  
Significance Level ◽  
Tennis Players ◽  
Test Parameters ◽  
Significant Difference ◽  
Statistical Program ◽  
Tennis Skills ◽  
Experimental Group

The aim of this study is to determine the effect of reformer pilates trainings on ITN tennis test regarding the elite women aged 16-18 years. The research is done for voluntary participation of 14 elite female tennis players, whose age of training is 10,25 ± 1,72 years and average age 17,35 ± 0,77 years, All athletes were tested on the first day, then they were randomly divided into control (n=7) and experimental (n=7) groups. 90 minutes of pilates training sessions were performed for 3 days/week during eight weeks. The experimental group applied the pilates reformer studies and participated in the team trainings of the control group. After the 8-weeks training program, the last measurements of ITN Skills test were taken from experimental&control group athletes and the results were evaluated by SPSS 22.0 statistical program at 0.05 significance level. No significant difference was found for ITN depth&strength test, vole test, service test and stellar test when the last measurement test parameters of the experimental&control group athletes were compared (p>0.05). There was a significant difference between the two groups in the ITN sensitivity&strength test analysis (p<0.05). As a result, it can be said that 8-weeks duration pilates reformer trainings have an effect on the tennis players' ability to reach the ball on time in parallel and cross-strokes and an effect to have a recovery ability to be ready for the next shot.

scholarly journals Reconstruction of Medial Wall Blowout Fracture Defect with a Combination of Resorbable Meshed Plate and Cancellous Bone Allograft

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Jongweon Shin ◽  
Song I Park ◽  
Yunsup Hwang ◽  
Ho Kwon ◽  
Hyung-Sup Shim
Keyword(s):  
Cancellous Bone ◽  
Statistical Significance ◽  
Operation Time ◽  
Bone Allograft ◽  
Medial Wall ◽  
Control Group ◽  
Reconstruction Surgery ◽  
Blowout Fracture ◽  
Computed Tomography Images ◽  
Significant Difference

Background. Various materials are available for the reconstruction of bone defects in cases of medial wall blowout fracture. This study was conducted to assess the efficacy of the combination of a resorbable meshed plate and cancellous bone allograft. Methods. From March 2014 to March 2017, a total of 111 patients were evaluated. Sixty-three patients received reconstruction surgery with porous polyethylene plates (control group) and the other forty-eight patients underwent operation with a resorbable meshed plate plus allogenic cancellous bone (combined group). The results were assessed by exophthalmometric measurements, width, and volume discrepancies as compared with the unaffected orbit, and operation time. Results. The difference in exophthalmometric measurements between the affected and unaffected orbits were 0.94 ± 0.70 mm in the control group and 1.05 ± 0.73 mm in the combined group without statistical significance (p=0.425). In the analysis of computed tomography images, the width discrepancy was 1.55 ± 0.86 mm and 1.08 ± 0.69 mm, respectively (p=0.003); however, the volume discrepancy demonstrated no statistically significant difference (2.58 ± 1.40 cm3 versus 2.20 ± 1.80 cm3; p=0.209). Operation time was significantly shorter in the combined group as compared with the control group (43.0 ± 7.0 versus 38.3 ± 7.0 minutes; p=0.001). Conclusion. The combination material composed of resorbable meshed plate and cancellous bone allograft made reconstruction surgery of medial wall blowout fracture easier and quicker to perform with long-lasting results.

scholarly journals Influence of furnace type in the crystallization of lithium disilicate on bond strength and flexural strength

2019 ◽  
Vol 18 ◽  
pp. e191405
Author(s):  
Karla Zancope ◽  
Thácio de Castro ◽  
Lucas do Nascimento Tavares ◽  
Marcel Santana Prudente ◽  
Flávio Domingues das Neves
Keyword(s):  
Flexural Strength ◽  
Bond Strength ◽  
Storage Time ◽  
Lithium Disilicate ◽  
Strength Test ◽  
Resin Cement ◽  
Holding Time ◽  
Control Group ◽  
Representative Specimen ◽  
Significant Difference

Aim: The crystallization step is required for lithium disilicate ceramics to change color, improve the mechanical properties and yield material to support mouth loading. Several furnaces could complete the crystallization process. This study evaluated the flexural and bond strength of lithium disilicate ceramics crystallized by different furnaces with the presence or not of vacum and different holding time. Methods: Forty lithium disilicate samples were divided into two groups: Programat P300 - control group with vacuum and holding time 7 minutes (CG) and FVPlus- experimental group and without vacuum and holding time 25 minutes (EG) and submitted to 2 experimental tests: 3-point flexural strength test and micro shear bond strength test (µSBS). For this test, the surface of the samples was treated and 1mm² of resin cement was applied on the surface. The samples were stored in artificial saliva over 2 time periods (24 hours: T0; 1-month storage: T1). To analyze the morphologic crystals of the ceramics tested, one representative specimen from each group were analyzed by using Scanning Electron Microscopy (SEM). Results: There was no significant difference in 3-point flexural strength test between groups CG and EG (p= 0.984). The µSBS results showed no statistical difference between groups, considering different storage time. There was no difference in the 3-point flexural strength and μSBS for lithium disilicate samples regardless of heat treatment of furnace type. The storage time had no influence on the μSBS. No differences were noted in the shape and size of these crystals when comparing the furnace analyzed by SEM images. Conclusion: Different furnaces did not influence the flexural and bond strength of lithium disilicate ceramics.

Imaging Observation of Nano-Artificial Bone in the Repair of the Defect in Osteonecrosis of the Femoral Head

2020 ◽  
Vol 20 (12) ◽  
pp. 7775-7780
Author(s):  
Ziyan Li ◽  
Xiurong Yang ◽  
Shuang Liang ◽  
Hongyi Li ◽  
Linlin Hu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Femoral Head ◽  
Bone Defects ◽  
Control Group ◽  
Graft Material ◽  
Artificial Bone ◽  
Significant Difference ◽  
Marrow Mesenchymal Stem Cells

To observe the effect of nano-artificial bone and bone marrow mesenchymal stem cells (BMSCs) in the treatment of femoral head osteonecrosis. The bilateral femoral head internal bone defect model was established and divided into three groups. Group A was used to make the defect without filling any material as the control, group B was only filled with nano-artificial bone, and group C was filled with composite materials of nano-artificial bone and bone marrow mesenchymal stem cells. The femoral head was examined using radiography and high-resolution focused 48-slice computed tomography (CT) at 12 weeks after implantation. A significant difference was found between groups B and C in the aspect of repairing the defect in osteogenesis of the femoral head as compared with the control group. Nano-collagen-based bone has strong osteogenic and osteogenic effects and is a good graft material for repairing bone defects of the femoral head. The use of bone marrow mesenchymal stem cells can promote the repair of bone defects, which is of great value in the treatment of osteonecrosis of the femoral head.

scholarly journals Effectiveness of plyometric exercises to improve muscular strength and digital achievement for students in shot put

2019 ◽  
Vol 8 (2) ◽  
pp. 36-41
Author(s):  
Belaidouni Mustapha ◽  
Benzidane Houcine ◽  
Ahmed Benklaouz Touati ◽  
Mokrani Djamel
Keyword(s):  
Experimental Method ◽  
Muscular Strength ◽  
Control Sample ◽  
Achievement Test ◽  
Strength Test ◽  
Control Group ◽  
Experimental Sample ◽  
Significant Difference ◽  
Shot Put ◽  
Experimental Group

To identify the effectiveness of plyometric exercises to improve muscular strength and achievement in shot put event by students (20-22 years old). The researchers used an experimental method; the sample was formed by students belonging to the institute of physical education & sports, University of Mostaganem (Algeria). Thus it was the application of the experimental method was applied on a sample of third-year students (males) of 45 students divided into two groups, first control group of 22 students and an experimental group of 23 students. While the tests used were (strength test, achievement test). After the treatment of the results by statistical means, and through these results it have been reached several conclusions of them, plyometric Exercises to develop muscular strength and achievement in shot put [discussion significant difference (*p?0.05)]. And best improve of the experimental sample based on plyometric exercises compared to the control sample, which rely more on the technical side only in shot put event.

Levels of Prothrombin Fragment F1+2 in Patients with Hyperhomocysteinemia and a History of Venous Thromboembolism

1997 ◽  
Vol 78 (05) ◽  
pp. 1327-1331 ◽  
Author(s):  
Paul A Kyrle ◽  
Andreas Stümpflen ◽  
Mirko Hirschl ◽  
Christine Bialonczyk ◽  
Kurt Herkner ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Thrombin Generation ◽  
Oral Anticoagulant Therapy ◽  
Oral Anticoagulants ◽  
Control Group ◽  
Prothrombin Fragment ◽  
Hemostatic System ◽  
Significant Difference ◽  
System Activation ◽  
One Year

SummaryIncreased thrombin generation occurs in many individuals with inherited defects in the antithrombin or protein C anticoagulant pathways and is also seen in patients with thrombosis without a defined clotting abnormality. Hyperhomocysteinemia (H-HC) is an important risk factor of venous thromboembolism (VTE). We prospectively followed 48 patients with H-HC (median age 62 years, range 26-83; 18 males) and 183 patients (median age 50 years, range 18-85; 83 males) without H-HC for a period of up to one year. Prothrombin fragment Fl+2 (Fl+2) was determined in the patient’s plasma as a measure of thrombin generation during and at several time points after discontinuation of secondary thromboprophylaxis with oral anticoagulants. While on anticoagulants, patients with H-HC had significantly higher Fl+2 levels than patients without H-HC (mean 0.52 ± 0.49 nmol/1, median 0.4, range 0.2-2.8, versus 0.36 ± 0.2 nmol/1, median 0.3, range 0.1-2.1; p = 0.02). Three weeks and 3,6,9 and 12 months after discontinuation of oral anticoagulants, up to 20% of the patients with H-HC and 5 to 6% without H-HC had higher Fl+2 levels than a corresponding age- and sex-matched control group. 16% of the patients with H-HC and 4% of the patients without H-HC had either Fl+2 levels above the upper limit of normal controls at least at 2 occasions or (an) elevated Fl+2 level(s) followed by recurrent VTE. No statistical significant difference in the Fl+2 levels was seen between patients with and without H-HC. We conclude that a permanent hemostatic system activation is detectable in a proportion of patients with H-HC after discontinuation of oral anticoagulant therapy following VTE. Furthermore, secondary thromboprophylaxis with conventional doses of oral anticoagulants may not be sufficient to suppress hemostatic system activation in patients with H-HC.

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G Cella ◽  
H de Haas ◽  
M Rampling ◽  
V Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected with comparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 secs-lat 37°c using a Wells Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/l00ml in the control group ( < 0.05). Although whole blood viscosity was high in patients, when corrected to a common haematocrit, there was no significant difference between patients and controls. The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

Is perioperative antibiotic necessary in straightforward implant placement procedures?

2020 ◽  
Author(s):  
Elçin Bedeloğlu ◽  
Mustafa Yalçın ◽  
Cenker Zeki Koyuncuoğlu
Keyword(s):  
Clavulanic Acid ◽  
Dental Implant ◽  
Prophylactic Antibiotic ◽  
Antibiotic Use ◽  
Implant Failure ◽  
Control Group ◽  
Implant Placement ◽  
Significant Difference ◽  
Amoxicillin Clavulanic Acid ◽  
Experimental Group

The purpose of this non-random retrospective cohort study was to evaluate the impact of prophylactic antibiotic on early outcomes including postoperative pain, swelling, bleeding and cyanosis in patients undergoing dental implant placement before prosthetic loading. Seventy-five patients (45 males, 30 females) whose dental implant placement were completed, included to the study. Patients used prophylactic antibiotics were defined as the experimental group and those who did not, were defined as the control group. The experimental group received 2 g amoxicillin + clavulanic acid 1 h preoperatively and 1 g amoxicillin + clavulanic acid twice a day for 5 days postoperatively while the control group had received no prophylactic antibiotic therapy perioperatively. Data on pain, swelling, bleeding, cyanosis, flap dehiscence, suppuration and implant failure were analyzed on postoperative days 2, 7, and 14 and week 12. No statistically significant difference was detected between the two groups with regard to pain and swelling on postoperative days 2, 7, and 14 and week 12 ( p &gt;0.05), while the severity of pain and swelling were greater on day 2 compared to day 7 and 14 and week 12 in both groups ( p =0.001 and p &lt;0.05, respectively). Similarly, no significant difference was found between the two groups with regard to postoperative bleeding and cyanosis. Although flap dehiscence was more severe on day 7 in the experimental group, no significant difference was found between the two groups with regard to the percentage of flap dehiscence assessed at other time points. Within limitations of the study, it has been demonstrated that antibiotic use has no effect on implant failure rates in dental implant surgery with a limited number of implants. We conclude that perioperative antibiotic use may not be required in straightforward implant placement procedures. Further randomized control clinical studies with higher numbers of patients and implants are needed to substantiate our findings.

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