Preparation of Bioactive Poly(Lactic-Co-Glycolic)Acid and Silica Gel Fibers Mixed Non-Woven Fabric

2007 ◽  
Vol 361-363 ◽  
pp. 519-522 ◽  
Author(s):  
Yang Jo Seol ◽  
In Ae Kim ◽  
Yong Keun Lee ◽  
Bum Soon Lim ◽  
Sang Hoon Rhee
Keyword(s):  
Electric Field ◽  
Acid Solution ◽  
Silica Gel ◽  
Bone Grafting ◽  
Glycolic Acid ◽  
Salt Water ◽  
High Surface ◽  
Volume Ratio ◽  
Woven Fabric ◽  
High Porosity

Poly(lactic-co-glycolic)acid and silica gel fibers mixed non-woven fabric was made by electro-spinning method for the potential application as a bone grafting material. The silica gel, the source material for electro-spinning, was prepared by the hydrolysis of tetraethyl orthosilicate in the presence of calcium salt, water, hydrochloric acid and ethanol. Poly(lactic-co-glycolic)acid solution was prepared by dissolving it in the hexafluoroisopropanol. Then, they were transferred to two separate syringes which were connected to the high voltage supply generating a high electric field between the spinneret and the ground collecting drum. The silica gel containing calcium and poly(lactic-co-glycolic)acid solution were spun together under the electric field of 2 ㎸/㎝. The FE-SEM observations showed that the silica gel and poly(lactic-co-glycolic)acid fibers were mixed together completely and its handling property was much improved compared to that of the non-woven silica gel fabric. After soaking in the SBF for 1 week, low crystalline apatite crystals were also observed to occur on the silica fiber surfaces first and then they were also observed to occur on the poly(lactic-co-glycolic)acid fiber surfaces. From the results, it can be concluded that the poly(lactic-co-glycolic)acid and silica gel fibers mixed non-woven fabric made by electro-spinning method has a bioactivity. It means it has a potential to be used as a bone grafting material because of its apatite-forming ability, high surface area to volume ratio and high porosity.

Apatite Forming Ability of a Non-Woven Silica Fabric Containing Calcium

2007 ◽  
Vol 330-332 ◽  
pp. 699-702 ◽  
Author(s):  
Sang Hoon Rhee ◽  
Il Yong Chung ◽  
Yong Keun Lee ◽  
Bum Soon Lim ◽  
Yang Jo Seol
Keyword(s):  
Electric Field ◽  
Bone Grafting ◽  
Salt Water ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
High Porosity ◽  
Heat Treated ◽  
High Voltage Supply ◽  
Low Crystalline

Non-woven silica fabric was made by electro-spinning method for the potential application as a bone grafting material. The silica gel, the source material for electro-spinning, was prepared by the hydrolysis of tetraethyl orthosilicate in the presence of calcium salt, water, hydrochloric acid and ethanol. It was transferred to a syringe, which was connected to the high voltage supply generating a high electric field between the spinneret and the ground collecting drum. The silica fibers containing calcium were spun under the electric field of 2 KV/cm. Their diameters were in the range from about 0.3 μm to 8 μm. It was heat-treated at 300 oC for 3 hours. After soaking in the SBF for 1 week, low crystalline apatite crystals were observed to occur on their surfaces. From the results, it can be concluded that the non-woven silica fabric containing calcium made by electro-spinning method and then heat-treated has a bioactivity. It means it has a potential to be used as a bone grafting material because of its apatite-forming ability, high surface area to volume ratio and high porosity.

Bioactive Non-Woven Silica Fabric Made Through Electro-Spinning Method

2006 ◽  
Vol 309-311 ◽  
pp. 465-468 ◽  
Author(s):  
Hanna Yoon ◽  
Yong Keun Lee ◽  
Bum Soon Lim ◽  
Sang Hoon Rhee
Keyword(s):  
Electric Field ◽  
Bone Grafting ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
High Porosity ◽  
Silica Fibers ◽  
High Voltage Supply ◽  
Low Crystalline ◽  
Hydrolysis Of

Non-woven silica fabric was made by electro-spinning method for the application as a bone grafting material. The silica gel, the source material for electro-spinning, was prepared by the hydrolysis of tetraethyl orthosilicate in the presence of water, hydrochloric acid and ethanol. It was transferred to a syringe (spinneret), which was connected to the high voltage supply generating a high electric field between the spinneret and the ground collecting drum. The silica fibers were spun under the electric field of 2 KV/cm. Their diameters were in the range from about 100 nm to 5 µm. After soaking in the SBF for 4 week, low crystalline apatite crystals were observed to occur partly on their surfaces. From the results, it can be concluded that the non-woven silica fabric made by electro-spinning method has the apatite forming ability in the SBF and it means it has a potential to be used as a bone grafting material because of its apatite-forming ability, high surface area to volume ratio and high porosity.

Preparation of Electrospun PLA Nanofiber Scaffold and the Evaluation In Vitro

2005 ◽  
Vol 288-289 ◽  
pp. 139-142 ◽  
Author(s):  
Xian Tao Wen ◽  
Hong Song Fan ◽  
Yan Fei Tan ◽  
H.D. Cao ◽  
H. Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
High Surface ◽  
Volume Ratio ◽  
Electrospinning Process ◽  
High Porosity ◽  
Electrospun Scaffold ◽  
Nanofiber Scaffold ◽  
Soft Tissue Engineering

A electrospinning process to prepare soft tissue engineering scaffold was introduced in this study. This kind of scaffold was composed with ultrathin fiber and characterized with high porosity, well-interconnected pores and high surface-to-volume ratio. Biodegradable polylaticacid (PLA) was used to spin the scaffold and the scaffold was evaluated in vitro by analysis the microscopic structure, porosity, mechanical property, especially cytocompatibility. The results indicated that the electrospun PLA scaffold showed good cytocompatibility and the tensile property of electrospun scaffold was similar to human’s soft tissue. It could be expected that the electrospun scaffold would be potential in soft tissue engineering or soft tissue repair.

Preparation of Bioactive Poly(Lactic-Co-Glycolic)Acid and Silica Gel Fibers Mixed Non-Woven Fabric

2007 ◽  
pp. 519-522
Author(s):  
Yang Jo Seol ◽  
In Ae Kim ◽  
Yong Keun Lee ◽  
Bum Soon Lim ◽  
Sang Hoon Rhee
Keyword(s):  
Silica Gel ◽  
Glycolic Acid ◽  
Woven Fabric

scholarly journals Perspective on Nanofiber Electrochemical Sensors: Design of Relative Selectivity Experiments

Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3706
Author(s):  
Stanley G. Feeney ◽  
Joelle M. J. LaFreniere ◽  
Jeffrey Mark Halpern
Keyword(s):  
Electrochemical Sensors ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrochemical Sensing ◽  
High Porosity ◽  
Specific Recognition ◽  
Materials Used ◽  
New Applications ◽  
Speed And Accuracy

The use of nanofibers creates the ability for non-enzymatic sensing in various applications and greatly improves the sensitivity, speed, and accuracy of electrochemical sensors for a wide variety of analytes. The high surface area to volume ratio of the fibers as well as their high porosity, even when compared to other common nanostructures, allows for enhanced electrocatalytic, adsorptive, and analyte-specific recognition mechanisms. Nanofibers have the potential to rival and replace materials used in electrochemical sensing. As more types of nanofibers are developed and tested for new applications, more consistent and refined selectivity experiments are needed. We applied this idea in a review of interferant control experiments and real sample analyses. The goal of this review is to provide guidelines for acceptable nanofiber sensor selectivity experiments with considerations for electrocatalytic, adsorptive, and analyte-specific recognition mechanisms. The intended presented review and guidelines will be of particular use to junior researchers designing their first control experiments, but could be used as a reference for anyone designing selectivity experiments for non-enzymatic sensors including nanofibers. We indicate the importance of testing both interferants in complex media and mechanistic interferants in the selectivity analysis of newly developed nanofiber sensor surfaces.

scholarly journals Development and Characterization of Eudragit®-Based Electrospun Nanofibrous Mats and Their Formulation into Nanofiber Tablets for the Modified Release of Furosemide

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 480 ◽  
Author(s):  
Marilena Vlachou ◽  
Stefanos Kikionis ◽  
Angeliki Siamidi ◽  
Sotiria Kyriakou ◽  
Andrew Tsotinis ◽  
...  
Keyword(s):  
Drug Loading ◽  
High Surface ◽  
Volume Ratio ◽  
Aqueous Solubility ◽  
Matrix Tablets ◽  
High Porosity ◽  
Promising Alternative ◽  
Emergency Situations ◽  
Acidic Nature ◽  
Absorption Window

Furosemide, a chloride channel blocker ordinarily used as a high-ceiling or loop diuretic, is practically insoluble in water and dilute acids. Due to its acidic nature, furosemide is mostly absorbed in the stomach and in the upper small intestine. Efforts have focused on the development of sustained release systems of furosemide in order to improve the effectiveness of the drug, which exhibits poor aqueous solubility and poor permeability. Recently, electrospun nanofibrous drug delivery systems have emerged as promising alternative solid-dosage forms due to their advantages of high porosity, high surface to volume ratio, and high drug-loading efficacy. Herein, a number of nanofibrous mats composed of different types of Eudragit® polymers in various concentrations and combinations loaded with furosemide were designed, successfully electrospun, and characterized using SEM, FTIR, DSC, and TGA analyses. The nanofibrous nonwovens were formulated in nanofiber tablets and the release profile of furosemide from them was evaluated at pH 1.2 and 6.8 and compared to that of physical mixture matrix tablets of analogous composition as well as to that of a commercial formulation. It was found that the release of furosemide was compatible with the gastroretentive and slower intestinal release requirements with a well-defined absorption window, while some nanofiber formulations could act as furosemide carriers in emergency situations where a relatively fast onset of its action is required, as in the case of critically ill post-traumatic patients.

scholarly journals Nanofibres made from biocompatible and biodegradable polymers, with potential application as medical textiles

2018 ◽  
Vol 69 (01) ◽  
pp. 55-58 ◽  
Author(s):  
SUBTIRICA ADRIANA-IOANA ◽  
BANCIU CRISTINA ANTONELA ◽  
CHIVU ANDREEA ANA-MARIA ◽  
LAURENTIU CHRISTIAN DINCA
Keyword(s):  
Biodegradable Polymers ◽  
Textile Industry ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Electrospinning Process ◽  
High Porosity ◽  
Medical Textiles ◽  
Small Pore

An important and growing part of the textile industry is the medical and related healthcare and hygiene sector. Recently, ultrafine fiber webs made from biocompatible and biodegradable polymers have been obtained by the electrospinning process. Their unique properties such as high surface area-to-volume ratio, small pore sizes, high porosity, and the possibility of incorporation therapeutic compounds into the electrospun nanofibers has attracted the researcher’s attention lately. This paper presents the obtaining of PEO and PVA nanofibers.

Synthesis of chitosan/PEO/silica nanofiber coating for controlled release of cefepime from implants

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24418-24429 ◽  
Author(s):  
Azam Bagheri Pebdeni ◽  
Minoo Sadri ◽  
Sajjad Bagheri Pebdeni
Keyword(s):  
Controlled Release ◽  
High Surface ◽  
Volume Ratio ◽  
Medical Applications ◽  
High Porosity ◽  
Nanofiber Coating ◽  
Silica Nanofiber

Nanofibers, which have good properties such as high surface to volume ratio, high porosity, very small pores, and the ability to load drugs, can be considered for a variety of medical applications.

scholarly journals NANOFIBER MESHES FOR ABDOMINAL HERNIA REPAIR – CHALLENGES AND OPPORTUNITIES

2019 ◽  
Vol 2019 ◽  
pp. 183-186
Author(s):  
Gratiela GRADISTEANU PIRCALABIORU ◽  
Bianca TIHAUAN ◽  
Madalina AXINIE ◽  
Ana IVANOF ◽  
Stelian Sergiu MAIER
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
High Surface ◽  
Volume Ratio ◽  
Microbial Colonization ◽  
Abdominal Hernia ◽  
Prosthetic Material ◽  
Material Strength ◽  
High Porosity ◽  
Impaired Wound Healing

Implantation of any prosthetic material triggers a cascade of events that mark the initiation of the healing process. In the case of abdominal mesh implantation, the course of inflammation and wound healing are paramount. The biomaterials employed as a medical device are in close proximity with devitalized tissue parts which can promote microbial colonization resulting in infection and subsequently impaired wound healing. The advent of nanofiber based systems provides novel opportunities to develop hernia meshes with increased biocompatibility and good material strength. Electrospun nanofiber matrices exhibit morphological similarities to the natural extra-cellular matrix (ECM), with ultrafine continuous fibers, high porosity high surface-to-volume ratio, and variable pore-size distribution. This mini review summarizes the advantages and challenges associated to nanofiber systems.

scholarly journals Electrospinning Nanotechnology-A Robust Method for Preparation of Nanofibers for Medicinal and Pharmaceutical Application.

2020 ◽  
Vol 8 (3) ◽  
pp. 176-184
Author(s):  
Bhadarge Meghana ◽  
Dhas Umesh ◽  
Shirode Abhay ◽  
Kadam Vilasrao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Delivery Systems ◽  
Successful Implementation ◽  
Theoretical Principle ◽  
High Porosity ◽  
Pharmaceutical Application

Nanotechnology has evolved as a preferred choice in current research arena due to the advantages offered by it. The current research in pharmaceutical development is all about exploring and/or adopting different approaches for preparation of nanostructured drug delivery systems. Electrospinning nanotechnology has made its mark as a technology of choice for preparation of nanofibers for different applications. Electrospinning is a novel, robust and efficient fabrication process that is widely accepted and used to assemble nanofibers with distinct features such as length of several kilometers and diameter less than 300 nm. One of the most striking features of nanofibers is that they provide exceptionally high surface area-to-volume ratio and high porosity, making them a robust and attractive candidate for many advanced applications. Many researchers working on development of medicinal and pharmaceutical product design and development have reported their studies indicating successful implementation of electrospinning nanotechnology for preparation of nanofibers with distinct medicinal and pharmaceutical drug delivery applications. Authors of this article aims to provide a comprehensive review of electrospinning method for preparation of nanofibers with respect to theoretical principle, mechanics of electrospinning, critical process parameters, polymers and drug loaded nanofibers incorporated in different drug delivery systems for various pharmaceutical application.  

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