scholarly journals Traveling Waves Induced by Sweeping Flows on Solidification Interfaces

2018 ◽  
Vol 941 ◽  
pp. 1546-1551
Author(s):  
Alain Pocheau ◽  
Tania Jiang ◽  
Marc Georgelin
Keyword(s):  
Directional Solidification ◽  
Traveling Waves ◽  
Thermal Gradient ◽  
Large Scale ◽  
Solid Phase ◽  
Travelling Waves ◽  
Thermosolutal Convection ◽  
Solidification Interface

Solidification of alloys in a thermal gradient usually involves the generation of flows by thermal or thermosolutal convection. We experimentally study their effects on the dynamics of a solidification interface by inducing a controlled sweeping flow in a directional solidification device. Flow is induced in the sample from an external thermosiphon. Downstream inclination of microstructures and downstream sidebranch development are observed. However, the major outcome is the evidence of large scale travelling waves on the solidification interface. They are induced by the coupling between solidification and flow and yield repetitive striations of the solid phase. Two waves are observed and characterized.

Cooling Process for Directional Solidification in Directed Energy Deposition

2018 ◽  
Author(s):  
Keiya Ishiyama ◽  
Ryo Koike ◽  
Yasuhiro Kakinuma ◽  
Tetsuya Suzuki ◽  
Takanori Mori
Keyword(s):  
Directional Solidification ◽  
Thermal Gradient ◽  
Large Scale ◽  
Energy Deposition ◽  
Production Efficiency ◽  
Production Costs ◽  
Special Structure ◽  
Mechanical Stiffness ◽  
Directed Energy Deposition ◽  
Directed Energy

Additive manufacturing (AM) for metals has attracted attention from industry because of its great potential to enhance production efficiency and reduce production costs. Directed energy deposition (DED) is a metal AM process suitable to produce large-scale freeform metal products. DED entails irradiating the baseplate with a laser beam and launching the metal powder onto the molten spot to produce a metal part on the baseplate. Because the process enables powder from different materials to be used, DED is widely applicable to valuable production work such as for a dissimilar material joint, a graded material, or a part with a special structure. With regard to parts with a special structure, directional solidification can prospectively be used in the power plant and aerospace industries because it can enhance the stiffness in a specific direction via only a simple process. However, conventional approaches for directional solidification require a special mold in order to realize a long-lasting thermal gradient in the part. On the other hand, from the viewpoint of thermal distribution in a produced part, DED is able to control the gradient by controlling the position of the molten pool, i.e., the position of the laser spot. Moreover, unlike casting, the thermal gradient can be precisely oriented in the expected direction, because the laser supplies heat energy on the regulated spot. In this study, the applicability of DED to directional solidification in Inconel® 625 is theoretically and experimentally evaluated through metal structure observation and Vickers hardness measurements. Furthermore, the effect of two different cooling processes on directional solidification is also considered with the aim of improving the mechanical stiffness of a part produced by DED. The observations and experimental results show that both the cooling methods (baseplate cooling and intermittent treatment with coolant) are able to enhance the hardness while retaining the anisotropy.

scholarly journals A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Ksenia Lisova ◽  
Jia Wang ◽  
Philip H. Chao ◽  
R. Michael van Dam
Keyword(s):  
Large Scale ◽  
Solid Phase ◽  
Acetonitrile Solution ◽  
Synthesis Methods ◽  
Pet Tracers ◽  
Molar Activity ◽  
Alternative Approaches ◽  
High Yields ◽  
Sufficient Concentration

Abstract Background Current automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot be economically produced on a conventional synthesizer. Alternative approaches are desired to produce small to moderate batches to reduce cost and the amount of reagents and radioisotope needed to produce PET tracers with high molar activity. In this work we describe the first reported microvolume method for production of [18F]Florbetaben for use in imaging of Alzheimer’s disease. Procedures The microscale synthesis of [18F]Florbetaben was adapted from conventional-scale synthesis methods. Aqueous [18F]fluoride was azeotropically dried with K2CO3/K222 (275/383 nmol) complex prior to radiofluorination of the Boc-protected precursor (80 nmol) in 10 μL DMSO at 130 °C for 5 min. The resulting intermediate was deprotected with HCl at 90 °C for 3 min and recovered from the chip in aqueous acetonitrile solution. The crude product was purified via analytical scale HPLC and the collected fraction reformulated via solid-phase extraction using a miniature C18 cartridge. Results Starting with 270 ± 100 MBq (n = 3) of [18F]Fluoride, the method affords formulated product with 49 ± 3% (decay-corrected) yield,> 98% radiochemical purity and a molar activity of 338 ± 55 GBq/μmol. The miniature C18 cartridge enables efficient elution with only 150 μL of ethanol which is diluted to a final volume of 1.0 mL, thus providing a sufficient concentration for in vivo imaging. The whole procedure can be completed in 55 min. Conclusions This work describes an efficient and reliable procedure to produce [18F]Florbetaben in quantities sufficient for large-scale preclinical applications. This method provides very high yields and molar activities compared to reported literature methods. This method can be applied to higher starting activities with special consideration given to automation and radiolysis prevention.

scholarly journals Characterization of Pharmaceutical Tablets Using UV Hyperspectral Imaging as a Rapid Line to Line Analysis Tool

Sensors ◽  
2021 ◽  
Vol 21 (13) ◽  
pp. 4436
Author(s):  
Mohammad Al Ktash ◽  
Mona Stefanakis ◽  
Barbara Boldrini ◽  
Edwin Ostertag ◽  
Marc Brecht
Keyword(s):  
Hyperspectral Imaging ◽  
Large Scale ◽  
Solid Phase ◽  
Ultra Violet ◽  
Principal Component ◽  
Ccd Camera ◽  
Conveyor Belt ◽  
Hyperspectral Data ◽  
Analysis Tool ◽  
Sample Set

A laboratory prototype for hyperspectral imaging in ultra-violet (UV) region from 225 to 400 nm was developed and used to rapidly characterize active pharmaceutical ingredients (API) in tablets. The APIs are ibuprofen (IBU), acetylsalicylic acid (ASA) and paracetamol (PAR). Two sample sets were used for a comparison purpose. Sample set one comprises tablets of 100% API and sample set two consists of commercially available painkiller tablets. Reference measurements were performed on the pure APIs in liquid solutions (transmission) and in solid phase (reflection) using a commercial UV spectrometer. The spectroscopic part of the prototype is based on a pushbroom imager that contains a spectrograph and charge-coupled device (CCD) camera. The tablets were scanned on a conveyor belt that is positioned inside a tunnel made of polytetrafluoroethylene (PTFE) in order to increase the homogeneity of illumination at the sample position. Principal component analysis (PCA) was used to differentiate the hyperspectral data of the drug samples. The first two PCs are sufficient to completely separate all samples. The rugged design of the prototype opens new possibilities for further development of this technique towards real large-scale application.

Application of projection-based model reduction to finite-element plate models for two-dimensional traveling waves

2016 ◽  
Vol 28 (14) ◽  
pp. 1886-1904 ◽  
Author(s):  
Vijaya VN Sriram Malladi ◽  
Mohammad I Albakri ◽  
Serkan Gugercin ◽  
Pablo A Tarazaga
Keyword(s):  
Finite Element ◽  
Model Reduction ◽  
Traveling Waves ◽  
Large Scale ◽  
Fe Model ◽  
Plate Model ◽  
Reduction Techniques ◽  
State Frequency ◽  
Scale Down ◽  
The Stability

A finite element (FE) model simulates an unconstrained aluminum thin plate to which four macro-fiber composites are bonded. This plate model is experimentally validated for single and multiple inputs. While a single input excitation results in the frequency response functions and operational deflection shapes, two input excitations under prescribed conditions result in tailored traveling waves. The emphasis of this article is the application of projection-based model reduction techniques to scale-down the large-scale FE plate model. Four model reduction techniques are applied and their performances are studied. This article also discusses the stability issues associated with the rigid-body modes. Furthermore, the reduced-order models are utilized to simulate the steady-state frequency and time response of the plate. The results are in agreement with the experimental and the full-scale FE model results.

A numerical study of the nucleation, growth and settling of crystals from a turbulent convecting fluid

2021 ◽  
Author(s):  
Vojtech Patocka ◽  
Nicola Tosi ◽  
Enrico Calzavarini
Keyword(s):  
Magma Chamber ◽  
Solid Fraction ◽  
Large Scale ◽  
Solid Phase ◽  
Numerical Study ◽  
Equilibrium Concentration ◽  
Solid Particles ◽  
Settling Rate ◽  
Carrier Fluid ◽  
Nucleation Growth

<p>We evaluate the equilibrium concentration of a thermally convecting suspension that is cooled from above and in which<br>solid crystals are self-consistently generated in the thermal boundary layer near the top. In a previous study (Patočka et<br>al., 2020), we investigated the settling rate of solid particles suspended in a highly vigorous (Ra = 10<sup>8</sup> , 10<sup>10</sup>, and 10<sup>12</sup> ),<br>finite Prandtl number (Pr = 10, 50) convection. In this follow-up study we additionally employ the model of crystal<br>generation and growth of Jarvis and Woods (1994), instead of using particles with a predefined size and density that are<br>uniformly injected into the carrier fluid.</p><p>We perform a series of numerical experiments of particle-laden thermal convection in 2D and 3D Cartesian geometry<br>using the freely available code CH4 (Calzavarini, 2019). Starting from a purely liquid phase, the solid fraction gradually<br>grows until an equilibrium is reached in which the generation of the solid phase balances the loss of crystals due to<br>sedimentation at the bottom of the fluid. For a range of predefined density contrasts of the solid phase with respect to<br>the density of the fluid (ρ<sub>p</sub> /ρ<sub>f</sub> = [0, 2]), we measure the time it takes to reach such equilibrium. Both this time and<br>the equilibrium concentration depend on the average settling rate of the particles and are thus non-trival to compute for<br>particle types that interact with the large-scale circulation of the fluid (see Patočka et al., 2020).</p><p>We apply our results to the cooling of a large volume of magma, spanning from a large magma chamber up to a<br>global magma ocean. Preliminary results indicate that, as long as particle re-entrainment is not a dominant process, the<br>separation of crystals from the fluid is an efficient process. Fractional crystallization is thus expected and the suspended<br>solid fraction is typically small, prohibiting phenomena in which the feedback of crystals on the fluid begins to govern the<br>physics of the system (e.g. Sparks et al, 1993).</p><p>References<br>Patočka V., Calzavarini E., and Tosi N.(2020). Settling of inertial particles in turbulent Rayleigh-Bénard convection.<br>Physical Review Fluids, 26(4) 883-889.</p><p>Jarvis, R. A. and Woods, A. W.(1994). The nucleation, growth and settling of crystals from a turbulently convecting<br>fluid. J. Fluid. Mech, 273 83-107.</p><p>Sparks, R., Huppert, H., Koyaguchi, T. et al (1993). Origin of modal and rhythmic igneous layering by sedimentation in<br>a convecting magma chamber. Nature, 361, 246-249.</p><p>Calzavarini, E (2019). Eulerian–Lagrangian fluid dynamics platform: The ch4-project. Software Impacts, 1, 100002.</p>

Criteria for the economic large scale solid-phase synthesis of oligonucleotides

Tetrahedron ◽  
1994 ◽  
Vol 50 (8) ◽  
pp. 2617-2622 ◽  
Author(s):  
F.Xavier Montserrat ◽  
Anna Grandas ◽  
Ramon Eritja ◽  
Enrique Pedroso
Keyword(s):  
Large Scale ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

scholarly journals The GC/MS Analysis of Volatile Components Extracted by Different Methods fromExocarpium Citri Grandis

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Zhisheng Xie ◽  
Qundi Liu ◽  
Zhikun Liang ◽  
Mingqian Zhao ◽  
Xiaoxue Yu ◽  
...  
Keyword(s):  
Solid Phase Microextraction ◽  
Large Scale ◽  
Steam Distillation ◽  
Extraction Efficiency ◽  
Solid Phase ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Components ◽  
Germacrene D ◽  
Long Time ◽  
Sample Amount

Volatile components fromExocarpium Citri Grandis(ECG) were, respectively, extracted by three methods, that is, steam distillation (SD), headspace solid-phase microextraction (HS-SPME), and solvent extraction (SE). A total of 81 compounds were identified by gas chromatography-mass spectrometry including 77 (SD), 56 (HS-SPME), and 48 (SE) compounds, respectively. Despite of the extraction method, terpenes (39.98~57.81%) were the main volatile components of ECG, mainly germacrene-D, limonene, 2,6,8,10,14-hexadecapentaene, 2,6,11,15-tetramethyl-, (E,E,E)-, andtrans-caryophyllene. Comparison was made among the three methods in terms of extraction profile and property. SD relatively gave an entire profile of volatile in ECG by long-time extraction; SE enabled the analysis of low volatility and high molecular weight compounds but lost some volatiles components; HS-SPME generated satisfactory extraction efficiency and gave similar results to those of SD at analytical level when consuming less sample amount, shorter extraction time, and simpler procedure. Although SD and SE were treated as traditionally preparative extractive techniques for volatiles in both small batches and large scale, HS-SPME coupled with GC/MS could be useful and appropriative for the rapid extraction and qualitative analysis of volatile components from medicinal plants at analytical level.

scholarly journals Glassy Carbon: A Promising Material for Micro- and Nanomanufacturing

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 1857 ◽  
Author(s):  
Swati Sharma
Keyword(s):  
Glassy Carbon ◽  
Carbon Material ◽  
Large Scale ◽  
Solid Phase ◽  
Three Dimensional ◽  
Industrial Applications ◽  
Degradation Temperature ◽  
Pass Through ◽  
Semi Solid ◽  
Device Research

When certain polymers are heat-treated beyond their degradation temperature in the absence of oxygen, they pass through a semi-solid phase, followed by the loss of heteroatoms and the formation of a solid carbon material composed of a three-dimensional graphenic network, known as glassy (or glass-like) carbon. The thermochemical decomposition of polymers, or generally of any organic material, is defined as pyrolysis. Glassy carbon is used in various large-scale industrial applications and has proven its versatility in miniaturized devices. In this article, micro and nano-scale glassy carbon devices manufactured by (i) pyrolysis of specialized pre-patterned polymers and (ii) direct machining or etching of glassy carbon, with their respective applications, are reviewed. The prospects of the use of glassy carbon in the next-generation devices based on the material’s history and development, distinct features compared to other elemental carbon forms, and some large-scale processes that paved the way to the state-of-the-art, are evaluated. Selected support techniques such as the methods used for surface modification, and major characterization tools are briefly discussed. Barring historical aspects, this review mainly covers the advances in glassy carbon device research from the last five years (2013–2018). The goal is to provide a common platform to carbon material scientists, micro/nanomanufacturing experts, and microsystem engineers to stimulate glassy carbon device research.

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