scholarly journals Acylation-stimulating protein is a surrogate biomarker for acute myocardial infarction: Role of statins

2017 ◽  
Vol 9 (03) ◽  
pp. 163-169 ◽  
Author(s):  
Hayder M. Al-Kuraishy ◽  
Ali I. Al-Gareeb
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Troponin I ◽  
Treated Group ◽  
Anthropometric Parameters ◽  
Atorvastatin Group ◽  
Significant Difference ◽  
Acylation Stimulating Protein ◽  
Acute Mi ◽  
Group B

Abstract BACKGROUND: Acylation-stimulating protein (ASP) is an adipokine synthesized within adipocytes environment due to adipocyte differentiation. AIM: The aim of this study was to assess changes in ASP levels in patients with acute myocardial infarction (MI) and to correlate these variations with disease variables. SUBJECTS AND METHODS: A total number of 111 patients previously and currently treated with rosuvastatin or atorvastatin presented with acute MI in a Coronary Care Unit, were divided into three groups, Group A: Thirty-nine patients treated with atorvastatin, Group B: Thirty patients treated with rosuvastatin, compared to 42 patients presented with MI not previously treated with statins were enrolled in this study. ASP and troponin-I levels and lipid profile were estimated in each group. RESULTS: The effects of atorvastatin and rosuvastatin compared to nonstatins-treated group on the anthropometric and biochemical variables in patients with acute MI showed significant difference in all biochemical and anthropometric parameters P < 0.05. Serum ASP (nmol/l) levels were higher in control patients 57.25 ± 9.15 compared to atorvastatin-treated patients 48.43 ± 7.42 and rosuvastatin-treated patients 49.33 ± 6.52 P = 0.0124. CONCLUSION: ASP levels are elevated in patients with acute MI and regarded as surrogate biomarker for acute MI also; therapy with statins leads to significant reduction in ASP levels compared to nonstatins-treated patients that presented with acute MI.

Kinetics of high-sensitivity cardiac troponin T or troponin I compared to creatine kinase in patients with revascularized acute myocardial infarction

2015 ◽  
Vol 53 (5) ◽  
Author(s):  
Kamila Solecki ◽  
Anne Marie Dupuy ◽  
Nils Kuster ◽  
Florence Leclercq ◽  
Richard Gervasoni ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Significant Difference ◽  
Kinetics Of

AbstractCardiac biomarkers are the cornerstone of the biological definition of acute myocardial infarction (AMI). The key role of troponins in diagnosis of AMI is well established. Moreover, kinetics of troponin I (cTnI) and creatine kinase (CK) after AMI are correlated to the prognosis. New technical assessment like high-sensitivity cardiac troponin T (hs-cTnT) raises concerns because of its unclear kinetic following the peak. This study aims to compare kinetics of cTnI and hs-cTnT to CK in patients with large AMI successfully treated by percutaneous coronary intervention (PCI).We prospectively studied 62 patients with anterior AMI successfully reperfused with primary angioplasty. We evaluated two consecutive groups: the first one regularly assessed by both CK and cTnI methods and the second group by CK and hs-cTnT. Modeling of kinetics was realized using mixed effects with cubic splines.Kinetics of markers showed a peak at 7.9 h for CK, at 10.9 h (6.9–12.75) for cTnI and at 12 h for hs-cTnT. This peak was followed by a nearly log linear decrease for cTnI and CK by contrast to hs-cTnT which appeared with a biphasic shape curve marked by a second peak at 82 h. There was no significant difference between the decrease of cTnI and CK (p=0.63). CK fell by 79.5% (76.1–99.9) vs. cTnI by 86.8% (76.6–92.7). In the hs-cTnT group there was a significant difference in the decrease by 26.5% (9–42.9) when compared with CK that fell by 79.5% (64.3–90.7).Kinetic of hs-cTnT and not cTnI differs from CK. The role of hs-cTnT in prognosis has to be investigated.

scholarly journals New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Hayder M. Alkuraishy ◽  
Ali I. Al-Gareeb
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Disease ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cross Sectional Study ◽  
Type Ii ◽  
Sectional Study ◽  
Cross Sectional ◽  
Acute Mi

Background. Serum omentin-1 level was low in the most types of ischemic heart disease compared to normal subjects; it also dependently correlated with coronary heart disease; thus, omentin-1 is regarded as a novel biomarker in IHD.Objective. The aim of the present study was to establish the links between omentin-1 and acute myocardial infarction in metformin patients.Subjects and Methods. A cross-sectional study was performed on eighty-five patients with type II DM and acute MI. They are divided as follows: Group I, 62 patients with type II DM who received metformin prior to onset of acute MI; Group II, 23 patients with type II DM who did not receive metformin prior to onset of acute MI; and Group III, 30 normal healthy controls. Venous blood was drawn from each participant for determination of lipid profile, plasma omentin-1, cardiac troponin-I (cTn-I) and other routine tests.Results. Patients that presented with acute MI that received metformin show a significant difference in all biochemical parameters (p<0.001); metformin increases serum omentin-1 level and decreases serum cardiac troponin-I level compared with control subjects and nonmetformin treated patients.Conclusion. Metformin pharmacotherapy increases omentin-1 serum levels and may be regarded as a potential agent in the prevention of the occurrences of acute MI in diabetic patients.

scholarly journals Diagnostic Performance of High Sensitivity Compared with Contemporary Cardiac Troponin I for the Diagnosis of Acute Myocardial Infarction

2017 ◽  
Vol 63 (10) ◽  
pp. 1594-1604 ◽  
Author(s):  
Yader Sandoval ◽  
Stephen W Smith ◽  
Sarah E Thordsen ◽  
Charles A Bruen ◽  
Michelle D Carlson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Troponin ◽  
Diagnostic Performance ◽  
Troponin I ◽  
High Sensitivity ◽  
Cardiac Troponin I ◽  
Serial Testing ◽  
Safety Outcomes ◽  
Acute Mi

Abstract BACKGROUND We examined the diagnostic performance of high-sensitivity cardiac troponin I (hs-cTnI) vs contemporary cTnI with use of the 99th percentile alone and with a normal electrocardiogram (ECG) to rule out acute myocardial infarction (MI) and serial changes (deltas) to rule in MI. METHODS We included consecutive patients presenting to a US emergency department with serial cTnI onclinical indication. Diagnostic performance for acute MI, including MI subtypes, and 30-day outcomes were examined. RESULTS Among 1631 patients, MI was diagnosed in 12.9% using the contemporary cTnI assay and in 10.4% using the hs-cTnI assay. For ruling out MI, contemporary cTnI ≤99th percentile at 0, 3, and 6 h and a normal ECG had a negative predictive value (NPV) of 99.5% (95% CI, 98.6–100) and a sensitivity of 99.1% (95% CI, 97.4–100) for diagnostic and safety outcomes. Serial hs-cTnI measurements ≤99th percentile at 0 and 3 h and a normal ECG had an NPV and sensitivity of 100% (95% CI, 100–100) for diagnostic and safety outcomes. For ruling in MI, contemporary cTnI measurements had specificities of 84.4% (95% CI, 82.5–86.3) at presentation and 78.7% (95% CI, 75.4–82.0) with serial testing at 0, 3, and 6 h, improving to 89.2% (95% CI, 87.1–91.3) by using serial cTnI changes (delta, 0 and 6 h) &gt;150%. hs-cTnI had specificities of 86.9% (95% CI, 85.1–88.6) at presentation and 85.7% (95% CI, 83.5–87.9) with serial testing at 0 and 3 h, improving to 89.3% (95% CI, 87.3–91.2) using a delta hs-cTnI (0 and 3 h) &gt;5 ng/L. CONCLUSIONS hs-cTnI and contemporary cTnI assays are excellent in ruling out MI following recommendations predicated on serial testing and the 99th percentile with a normal ECG. For ruling in MI, deltas improve the specificity. ClinicalTrials.gov Identifier: NCT02060760

scholarly journals Number of Implanted Stents May Predict Posttraumatic Stress Disorder in Patients With Acute Myocardial Infarction

2020 ◽  
Author(s):  
Guo-An Zhang ◽  
Chun-Hui He ◽  
Zhong-Wei Liu ◽  
Shuo Pan ◽  
Ting He ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Troponin I ◽  
Stress Disorder ◽  
Density Lipoprotein ◽  
Confounding Factors ◽  
Chinese Han ◽  
Acute Mi

Abstract Background: This study is intended to explore the confounding factors associated with posttraumatic stress disorder (PTSD) in Chinese Han population with acute myocardial infarction (MI).Methods: 300 acute MI patients were enrolled in this study, the demographic data, complicating diseases, medication, and perioperative procedures were documented. The PTSD was evaluated using the PTSD checklist-civilian version (PCL-C) scale one month after the occurrence of MI. Results: 97 (32.3%) patients were diagnosed as PTSD after finishing the PCL-C scale. The intra-aortic balloon pump (IABP) implantation and use of diuretic in PTSD patients with acute MI were significantly higher than those in non-PTSD patients with acute MI. The age, body mass index (BMI), heart rate, number of stents, urea nitrogen, white blood cells counts, creatine kinase-MB, myoglobin, troponin I, brain natriuretic peptide (BNP), total cholesterol, triglyceride, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, apolipoprotein A and apolipoprotein B were significantly and positively correlated with PTSD score (all P < 0.05). After the adjustment of the confounding factors, the number of stents was significantly associated with PTSD in acute MI patients (OR = 4.131, P = 0.003), meanwhile we also documented the troponin I and BNP were also significantly associated with PTSD in acute MI patients (OR = 1.066, P = 0.046; OR = 1.002, P = 0.019; respectively). The PTSD scores were 39.72 ± 11.12, 44.85 ± 13.46, 47.69 ± 9.39 and 49.33 ± 18.14 in acute MI patients with 1, 2, 3 and 4 stents respectively (P = 0.008).Conclusion: The study found that the number of implanted stents may predict PTSD in Chinese Han patients with acute MI.

scholarly journals Difficulties of diagnostics of acute myocardial infarction in elderly and senile patients and their influence on management in the acute period of disease

2019 ◽  
Vol 24 (3) ◽  
pp. 17-23
Author(s):  
O. V. Tukish ◽  
A. A. Garganeeva
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Troponin I ◽  
Age Groups ◽  
Statistical Processing ◽  
Acute Period ◽  
Prehospital Phase ◽  
Creatine Kinase Mb ◽  
Atypical Manifestations ◽  
Acute Mi

Aim. To study the features of disease progress and approaches to the diagnostics of acute myocardial infarction (MI) among elderly and senile patients and their influence on the management in the acute period of disease.Materials and methods. The study was performed using the WHO program “Register of acute myocardial infarction” (Tomsk). The study included 410 patients (60 years and older), who had acute MI. The study group is represented by a comparable number of men (n=212) and women (n=198). The mean age of patients was 71 (66; 77) years (women are 5 years older than men (p<0,001)). Statistical processing was performed using the program Statistica V10.0.Results. Most of the patients had history comorbid pathology. In one in five patients (17,8%), the disease had an atypical manifestations, which in 41% of cases was represented by the asymptomatic form. Atypical manifestation of MI lengthened the prehospital phase of medical care due to a longer time before the first medical contact (p=0,005), as well as a late help-seeking (120 [49; 311,5] minutes). In 28% of patients, the level of creatine kinase-MB remained normal, and the indicator of troponin I exceeded the maximum values only in half of the cases. One fifth of the patients underwent acute MI treatment in non-core hospitals, which resulted in a low frequency of intervention (38%) and increasing by 2 times the chance of death within 5 years. The level of hospital mortality from acute MI in elderly patients in noncore hospitals was 3 times higher than in specialized departments (p<0,001).Conclusion. Difficulties in diagnostics of MI in patients of older age groups is caused by the prevalence of comorbid pathology, an atypical manifestations of the disease and low information content of biochemical markers of myocardial necrosis. It leads to an increase in time delays at the prehospital phase and frequent hospitalization of patients in non-core hospitals, making it impossible for them to receive timely, preferred therapy.

P3604Gender difference in Low-BMI patients with acute myocardial infarction makes an impact on mid-term outcomes

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
G Yoshioka ◽  
Y Shibata ◽  
K Node ◽  
N Kuriyama ◽  
N Watanabe ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Death ◽  
Event Rate ◽  
Rank Test ◽  
Differential Impact ◽  
Term Outcome ◽  
Significant Difference ◽  
Acute Mi ◽  
Low Bmi

Abstract Background/Introduction There are some reports about impact of low body-mass-index (BMI) on patients with acute myocardial infarction (MI), suggesting an obesity paradox. However, the differential impact of gender between low-BMI and mid-term outcome remains unclear. Purpose To evaluate the differential impact of gender between low-BMI patients with acute MI and mid-term outcome. Methods We evaluated 3038 consecutive patients with acute MI in Miyazaki medical association hospital. Patients were stratified low-BMI group (BMI≤20) from other-BMI group (BMI>20), and compared. BMI was measured at admission of acute MI. Primary outcome was cardiac death. We also analyzed each gender, using Kaplan-meier curve with long-rank test. Result Among all patients, low-BMI patient was 8.6%. Median follow-up was 1085 days, and cardiac death was significantly higher rate in low-BMI group (14.5% vs 7.7%, p<0.001). Male patient with low-BMI was significantly higher event rate, compared with other-BMI group (11.0% vs 5.5%, p<0.001). However, female patient group had no significant difference of outcomes between low-BMI and other-BMI (12.6% vs 10.3%, p=0.315). Event rate is shown in the Figure. Gender Conclusions Low BMI was associated with mid-term outcomes in acute MI patients. Impact of low-BMI on mid-term outcome seems to be gender dependent in acute MI patients.

scholarly journals Assessment of Multiple Cardiac Biomarkers in Acute STEMI Patients without Clinical Manifestation of Heart Failure in NICVD

2016 ◽  
Vol 4 (2) ◽  
pp. 55-60
Author(s):  
Syeda Shahina Subhan ◽  
Nasir Uddin Mithu ◽  
Md Rezwanur Rahman ◽  
Sharifun Nahar ◽  
Muhsina Abdullah ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Troponin I ◽  
Clinical Symptoms ◽  
Normal Serum ◽  
Cardiac Biomarkers ◽  
Age Group ◽  
Acute Stemi ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Group B

Background: In patients with acute coronary syndrome (ACS), Cardiac Troponin I (cTnI) elevation is indicative of myocardial damage. After acute myocardial infarction (AMI), level of Pro-BNP rises rapidly during the first 24 hours and tends to stabilize thereafter.Objective: The present study tried to explore the pattern of multiple cardiac biomarkers (cTnI, CK-MB, Pro-BNP, SGOT and LDH) in newly diagnosed acute ST-elevation myocardial infarction (STEMI) patients without clinical symptoms of heart failure.Materials and method: This was a prospective study. Total 82 acute STEMI patients were recruited purposively from National Institute of Cardiovascular Disease (NICVD), Dhaka, Bangladesh, within 24 hours of symptoms having normal serum creatinine level. cTnI and pro-BNP elevation were defined >1mg/mL and >125 pg/mL respectively. The study population was sub grouped according to age: group A (<40 years), group B (40-50 years), group C (>51-60 years) and group D (>60 years).Results: The mean±SD age of patients was 53.3±11.6 years and 42.70% population belonged to relatively younger age group (group B). Smoking was found on the top of the list (73.20%) as a risk factor. There was no difference among the groups regarding atherosclerotic marker and no other cardiac markers except pro-BNP. Only Pro-BNP (pg/mL) showed gradual and progressive increment with increasing age. No significant difference was observed between CRP positive and negative groups in different age groups (cut off value <6mg/dL). Group B (40-50 years) seems to be the most vulnerable as the anterior and the extensive anterior myocardial infarctions (worst prognosis) were highest in this group.Conclusion: Worst prognosis is associated with increased age and raised pro-BNP level.Delta Med Col J. Jul 2016 4(2): 55-60

Tetranectin Levels in Patients with Acute Myocardial Infarction and Their Alterations during Thrombolytic Treatment

1998 ◽  
Vol 35 (3) ◽  
pp. 400-407 ◽  
Author(s):  
E F Kamper ◽  
L Kopeikina ◽  
A Mantas ◽  
C Stefanadis ◽  
P Toutouzas ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Healthy Subjects ◽  
Positive Association ◽  
Treated Group ◽  
Fibrin Clot ◽  
Thrombolytic Treatment ◽  
Group A ◽  
Group B ◽  
Plasmin Inhibitor

Tetranectin (TN), a new regulator of fibrinolysis, was studied in the plasma of 60 patients with acute myocardial infarction (AMI) and 30 healthy subjects (HS), in relation to D-dimer (DD) and α2-plasmin inhibitor (α2-PI), to investigate its possible involvement in the pathophysiology of AMI. Thirty patients underwent thrombolytic treatment with fibrin-specific plasminogen activator (rt-PA) (group A); the other 30 patients, according to the exclusion criteria, were conventionally treated (group B). Twenty of the thrombolysized patients established early recanalization (subgroup A1), while 10 failed to respond to thrombolytic treatment (subgroup A2). Median (interquartile range), baseline plasma TN levels were lower in AMI patients compared to HS [8·27 (2·75) mg/L versus 12·1 (0·55) mg/L, P <10−6]. In subgroup A1, TN increased at the end of rt-PA infusion and returned to the baseline levels 12 h later. A positive association between DD and TN release (3 h level minus baseline level) was found ( rs = 0·48, P = 0·03) in subgroup A1. No significant alterations of TN levels were observed during therapy in subgroup A2 and group B. TN, DD and α2-PI concentrations in group B remained relatively constant during the study period. This study provides evidence of a significant decrease of TN levels in AMI patients compared to healthy subjects and of a remarkable difference in the evolution of TN levels during thrombolytic treatment with rt-PA between recanalized and non-recanalized AMI patients. Thus, an involvement of TN in the formation and dissolution of fibrin clot in AMI patients is worthy of further investigation.

scholarly journals Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction

2016 ◽  
Vol 23 (8) ◽  
pp. 1052-1059 ◽  
Author(s):  
Alok Ravindra Amraotkar ◽  
David Day Song ◽  
Diana Otero ◽  
Patrick James Trainor ◽  
Imtiaz Ismail ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Count ◽  
Acute Phase ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Quiescent Phase ◽  
Significant Difference ◽  
Acute Mi ◽  
Stable Cad

Platelet count has been shown to be lower and mean platelet volume (MPV) to be higher in acute myocardial infarction (MI). However, it is not known whether these changes persist post-MI or if these measures are able to distinguish between acute thrombotic and non-thrombotic MI. Platelet count and MPV were measured in 80 subjects with acute MI (thrombotic and non-thrombotic) and stable coronary artery disease (CAD) at cardiac catheterization (acute phase) and at >3-month follow-up (quiescent phase). Subjects were stratified using stringent clinical, biochemical, histological, and angiographic criteria. Outcome measures were compared between groups by analysis of variance. Forty-seven subjects met criteria for acute MI with clearly defined thrombotic (n = 22) and non-thrombotic (n = 12) subsets. Fourteen subjects met criteria for stable CAD. No significant difference was observed in platelet count between subjects with acute MI and stable CAD at the acute or quiescent phase. MPV was higher in acute MI (9.18 ± 1.21) compared to stable CAD (8.13 ± 0.66; P = 0.003) at the acute phase but not at the quiescent phase (8.48 ± 0.58 vs 8.94 ± 1.42; P = 0.19). No difference in platelet count or MPV was detected between thrombotic and non-thrombotic subsets at acute or quiescent phases. The power to detect differences in these measures between thrombotic and non-thrombotic subsets was 58%. Higher MPV at the time of acute MI is not observed by 3 months post-MI (quiescent phase). Platelet count and MPV do not differ in subjects with thrombotic versus non-thrombotic MI. Further investigation is warranted to evaluate the utility of these measures in the diagnosis of acute MI.

scholarly journals Serum uric acid levels in patients of acute myocardial infarction

2019 ◽  
Vol 7 (1) ◽  
pp. 51
Author(s):  
Hardeep Singh Deep ◽  
Jasmine Kaur ◽  
Gaurav Chopra ◽  
Jaskiran Kaur ◽  
Jasleen Kaur ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Congestive Heart Failure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Control Group ◽  
Significant Difference ◽  
Group A ◽  
Group B

Background: Following Myocardial Infarction some proteins and enzymes, CPK-MB/ Troponin-I, T, are released into the blood from the necrotic heart muscle. Serum Uric Acid (SUA) may be a risk factor and negative prognostic marker for cardiovascular diseases. Aim of the study was to study serum uric acid levels in patients of acute Myocardial infarction with congestive heart failure, its relation with stages of congestive heart failure as per Killip classification and the role of serum uric acid levels as a marker of mortality.Methods: The case control study was conducted on 120 patients divided into two groups. Group A included 60 patients of acute Myocardial infarction. Group A was further divided into two categories. One includes 30 patients of with congestive heart failure and another includes 30 patients without congestive heart failure. Group B consists of 60 control patients. Serum uric acid levels were measured in Group A on 1st, 3rd and 7th day of hospital admission and in Group B on 1st day.Results: The study showed females have higher degree of hyperuricemia than males. SUA was significantly higher in patients of acute myocardial infarction than control group patients. SUA were also higher in patients with history of IHD, in patients with BNP >100 and it correlates with Killip class and mortality rates. Patients of acute myocardial infarction with diabetes mellitus had higher degree of hyperuricemia than nondiabetic and control group. No significant difference in SUA levels were observed with regard to age, alcohol intake, lipid profile, ejection fraction and hypertension.Conclusions: In acute myocardial infarction, patients with hyperuricemia had higher mortality and may be considered as poor prognostic biomarker.

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