scholarly journals Anticancer effect of Psidium guajava (Guava) leaf extracts against colorectal cancer through inhibition of angiogenesis

2020 ◽  
Vol 10 (7) ◽  
pp. 293
Author(s):  
AMSAbdul Majid ◽  
Bronwyn Lok ◽  
Doblin Sandai ◽  
HusseinM Baharetha ◽  
VMansoureh Nazari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Psidium Guajava ◽  
Anticancer Effect ◽  
Leaf Extracts ◽  
Inhibition Of Angiogenesis ◽  
Guava Leaf

scholarly journals Antibacterial activity of GUAVA, Psidium guajava Linnaeus, leaf extracts on diarrhea-causing enteric bacteria isolated from Seabob shrimp, Xiphopenaeus kroyeri (Heller)

2008 ◽  
Vol 50 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Flávia A. Gonçalves ◽  
Manoel Andrade Neto ◽  
José N. S. Bezerra ◽  
Andrew Macrae ◽  
Oscarina Viana de Sousa ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Essential Oil ◽  
Antimicrobial Effect ◽  
Enteric Bacteria ◽  
Psidium Guajava ◽  
Salmonella Spp ◽  
Leaf Extracts ◽  
Xiphopenaeus Kroyeri ◽  
Guava Leaves ◽  
Guava Leaf

Guava leaf tea of Psidium guajava Linnaeus is commonly used as a medicine against gastroenteritis and child diarrhea by those who cannot afford or do not have access to antibiotics. This study screened the antimicrobial effect of essential oils and methanol, hexane, ethyl acetate extracts from guava leaves. The extracts were tested against diarrhea-causing bacteria: Staphylococcus aureus, Salmonella spp. and Escherichia coli. Strains that were screened included isolates from seabob shrimp, Xiphopenaeus kroyeri (Heller) and laboratory-type strains. Of the bacteria tested, Staphylococcus aureus strains were most inhibited by the extracts. The methanol extract showed greatest bacterial inhibition. No statistically significant differences were observed between the tested extract concentrations and their effect. The essential oil extract showed inhibitory activity against S. aureus and Salmonella spp. The strains isolated from the shrimp showed some resistance to commercially available antibiotics. These data support the use of guava leaf-made medicines in diarrhea cases where access to commercial antibiotics is restricted. In conclusion, guava leaf extracts and essential oil are very active against S. aureus, thus making up important potential sources of new antimicrobial compounds.

scholarly journals Antimicrobial activity of Guava tree (Psidium Guajava) leaf extract and selected Commercial Antibiotics on Bacterial isolates from Kisubi Hospital

2020 ◽  
Author(s):  
◽  
David Serunjogi ◽  
Kizito Muwonge
Keyword(s):  
Antimicrobial Activity ◽  
Psidium Guajava ◽  
Diffusion Method ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Leaf Extracts ◽  
Drug Resistant Bacteria ◽  
The World ◽  
Guava Leaf ◽  
Tree Leaf

Background: Plant species such as the guava have been used in Uganda and elsewhere in the world to treat some of the medical conditions associated with bacteria, this is due to the increased number of drug resistant bacteria in the world. In this study, the antimicrobial activity of guava leaf extracts against some of the disease causing bacteria isolated from Kisubi hospital in Uganda is discussed. Methods: The guava leafs were collected from a plantation near Zika forest in Uganda (0°7′27″N 32°31′32″E / 0.12417°N 32.52556°E / 0.12417; 32.52556) and samples were put in a bag and transferred to the university laboratory where they were identified. The extracts were obtained by maceration using distilled water, 30%, 50% and 70 % methanol as the extraction solvents. Antimicrobial susceptibility testing was conducted using the disc diffusion method. Results: Gram-negative Escherichia coli was sensitive to the plant extract and synthetic commercial drugs such as trimethoprim-sulfamethozole, ciprofloxacin, and Gentamicin. Pseudomonas aeruginosa was resistant to all drugs. Streptococcus pneumonia and Staphylococcus aureus were all sensitive to the plant extracts with measurable inhibition zones. Conclusion: The Guava tree leaf crude extracts have antimicrobial activity against drug-resistant bacteria. More studies should be carried out to know the potency and the concentration of different plant origin extracts.

THE APPLICATION OF GUAJAVA LEAF EXTRACT (Psidium guajava Linnaeus) AS IMMUNOSTIMULANT OF COMMON CARP (Cyprinus carpio Linnaeus) INFECTED BY MOTILE AEROMONAS SEPTICEMIA

2021 ◽  
Vol 6 (2) ◽  
pp. 48-59
Author(s):  
Rissa Amelia ◽  
Esti Harpeni ◽  
Hilma Putri Fidyandini
Keyword(s):  
Common Carp ◽  
Cyprinus Carpio ◽  
Aeromonas Hydrophila ◽  
Leaf Extract ◽  
Psidium Guajava ◽  
Phagocytic Index ◽  
Leaf Extracts ◽  
Common Carp Cyprinus Carpio ◽  
Carp Cyprinus Carpio ◽  
Guava Leaf

This study aims to analyze the effect of the various concentration of guava leaf extract (Psidium guajava Linnaeus) on the prevention of Motile Aeromonas Septicemia disease in common carp (Cyprinus carpio Linnaeus). In a total of 150 common carp, length 9-11 cm with a density of 10 carps/aquarium. This study used a completely randomized design through 5 treatments, each treatment has 3 replications, namely (K+) consists of without guava Psidium guajava leaf extracts and without bacteria-infection Aeromonas hydrophila, (K-) consists of without guava Psidium guajava leaf extracts with bacteria-infection Aeromonas hydrophila, (A) the application of 125 ppm guava Psidium guajava leaf extracts, (B) the application of 250 ppm guava leaf extracts, (C) the application of 500 ppm guava Psidium guajava leaf extracts for 23 days. The parameters observed total of leukocytes, differensial leukocytes, hematocrit levels, erythrocyte, hemoglobin, phagocytic activity (AF), phagocytic index (IF), relative percent survival (RPS), survival rate (SR) and water quality. Data were analyzed with Anova 95% confidence interval and continued with Duncan test. The parameter also showed a significant result (P<0,05) with the application of guava Psidium guajava leaf extracts to the total leukocytes, differensial leukocytes, erythrocyte, hemoglobin, phagocytic activity, phagocytic index and relative percent survival. The results of this research indicate the concentration of 250 ppm guava Psidium guajava leaf extracts is the optimum application to increase common carp non-spesific immune responses.

Green and Sustainable Encapsulation of Guava Leaf Extracts (Psidium guajava L.) into Alginate/Starch Microcapsules for Multifunctional Finish over Cotton Gauze

2019 ◽  
Vol 7 (22) ◽  
pp. 18612-18623 ◽  
Author(s):  
Mohamed Rehan ◽  
Omar A. Ahmed-Farid ◽  
Shaimaa R. Ibrahim ◽  
Aliaa Ali Hassan ◽  
Areeg M. Abdelrazek ◽  
...  
Keyword(s):  
Psidium Guajava ◽  
Leaf Extracts ◽  
Cotton Gauze ◽  
Guava Leaf

scholarly journals Antimicrobial activity of Guava tree (Psidium Guajava) leaf extract and selected Commercial Antibiotics on Bacterial isolates from Kisubi Hospital

2020 ◽  
Author(s):  
◽  
David Serunjogi
Keyword(s):  
Antimicrobial Activity ◽  
Psidium Guajava ◽  
Diffusion Method ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Leaf Extracts ◽  
Drug Resistant Bacteria ◽  
The World ◽  
Guava Leaf ◽  
Tree Leaf

Abstract Background: Plant species such as the guava have been used in Uganda and elsewhere in the world to treat some of the medical conditions associated with bacteria, this is due to the increased number of drug resistant bacteria in the world. In this study, the antimicrobial activity of guava leaf extracts against some of the disease causing bacteria isolated from Kisubi hospital in Uganda is discussed. Methods: The guava leafs were collected from a plantation near Zika forest in Uganda (0°7′27″N 32°31′32″E / 0.12417°N 32.52556°E / 0.12417; 32.52556) and samples were put in a bag and transferred to the university laboratory where they were identified. The extracts were obtained by maceration using distilled water, 30%, 50% and 70 % methanol as the extraction solvents. Antimicrobial susceptibility testing was conducted using the disc diffusion method. Results: Gram-negative Escherichia coli was sensitive to the plant extract and synthetic commercial drugs such as trimethoprim-sulfamethozole, ciprofloxacin, and Gentamicin. Pseudomonas aeruginosa was resistant to all drugs. Streptococcus pneumonia and Staphylococcus aureus were all sensitive to the plant extracts with measurable inhibition zones. Conclusion: The Guava tree leaf crude extracts have antimicrobial activity against drug-resistant bacteria. More studies should be carried out to know the potency and the concentration of different plant origin extracts.

Biocontrol of Food Spoilage Microorganisms using Leaf extracts from Magnifera indica (Mango) and Psidium guajava (Guava).

2020 ◽  
Vol 45 (4) ◽  
Author(s):  
F.O. Oseghale ◽  
K.A. Fasina ◽  
A. Ohifueme ◽  
J. Omoruyi
Keyword(s):  
Psidium Guajava ◽  
Penicillium Oxalicum ◽  
Potassium Sorbate ◽  
Food Spoilage ◽  
Leaf Extracts ◽  
Benin City ◽  
Microbiological Techniques ◽  
Guava Leaves ◽  
Guava Leaf ◽  
Spoilage Microorganisms

The shelf life of processed food is greatly reduced by spoilage microorganisms, which has resulted in great losses to food processors, wholesalers, retailers and even consumers. This study was aimed at controlling food spoilage microorganisms using leaf extracts from mango and guava. Fried meat (beef, chicken, grass-cutter, and goat meat), fried fish and fresh bread were purchased from Benin City, and left to spoil, after which spoilage organisms were isolated, identified and characterized using standard microbiological techniques. Mango and guava leaf extracts (ethanolic and aqueous), with Potassium sorbate and sodium nitrite was used. Significant highest (<0.05) (15.67±0.88 mg/ml) antibacterial activity of Mango leaf extract was recorded against Escherichia coli, and significant highest (<0.05) antifungal activity (19.67±0.33) was recorded against Penicillium oxalicum. Ethanolic leaf extracts of mango had better MICs (6.25 mg/ml) against E. coli tested than guava (25 mg/ml). In addition, ethanolic leaf extracts from Mango did not have any effect on Bacillus polymyxa. This study suggests that extracts from Mango and Guava leaves can be explored for controlling spoilage organisms; however, ethanolic extracts are more potent than aqueous extracts.

scholarly journals Elucidation of Bioactive Potential of Two Commonly Grown North Indian Psidium guajava viz., Lalit and Shweta against Pathogenic Foodborne and MDR Bacteria

2021 ◽  
Vol 11 (6) ◽  
pp. 14090-14102
Keyword(s):  
Micrococcus Luteus ◽  
Psidium Guajava ◽  
Shigella Dysenteriae ◽  
Bacterial Strains ◽  
Leaf Extracts ◽  
Inhibition Of Growth ◽  
Food Borne ◽  
Phytochemical Profile ◽  
Guava Leaf ◽  
Bioactive Potential

Food-borne diseases (FBD) can cause serious health hazards. Day by day, these pathogens are becoming resistant to various antibiotics. Consequently, severe outbreaks of (multidrug resistance food-borne diseases) MDR-FBD are possible. About this, there is an urgent requirement to explore new antimicrobial compounds. As Psidium guajava L. has been in folkloric use to treat many diseases, in this study, the phytochemical profile of two North- Indian cultivars (c.v) Lalit (Pink) and Shweta (White) was elucidated, and their bioactive potential was evaluated against antibiotic-resistant FBD. Phytochemical profile relating to good antioxidant activity was exhibited by Leaf (methane, hexane, dichloromethane, and aqueous) extracts containing a good amount of flavonoid/phenolics. Putatively, they are responsible for the antibacterial potential of the extracts. As these extracts showed inhibition of growth in all the ten bacterial strains (including Staphylococcus aureus (MDR), Bacillus pumilus, Micrococcus luteus, Enterobacter epidermidis, Bacillus subtilis, Listeria monocytogens, Escherichia coli (MDR), Salmonella abony, Klebsiella pnemoneae, and Shigella dysenteriae) guava leaf extracts can be formulated as a functional food for combating MDR-FBD.

Phytosomal Curcumin Elicits Anti-tumor Properties Through Suppression of Angiogenesis, Cell Proliferation and Induction of Oxidative Stress in Colorectal Cancer

2019 ◽  
Vol 24 (39) ◽  
pp. 4626-4638 ◽  
Author(s):  
Reyhaneh Moradi-Marjaneh ◽  
Seyed M. Hassanian ◽  
Farzad Rahmani ◽  
Seyed H. Aghaee-Bakhtiari ◽  
Amir Avan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Therapeutic Potential ◽  
Vegf Signaling ◽  
Anticancer Effects ◽  
Inhibition Of Angiogenesis ◽  
Underlying Mechanisms ◽  
Apoptotic Activity

Background: Colorectal cancer (CRC) is one of the most common causes of cancer-associated mortality in the world. Anti-tumor effect of curcumin has been shown in different cancers; however, the therapeutic potential of novel phytosomal curcumin, as well as the underlying molecular mechanism in CRC, has not yet been explored. Methods: The anti-proliferative, anti-migratory and apoptotic activity of phytosomal curcumin in CT26 cells was assessed by MTT assay, wound healing assay and Flow cytometry, respectively. Phytosomal curcumin was also tested for its in-vivo activity in a xenograft mouse model of CRC. In addition, oxidant/antioxidant activity was examined by DCFH-DA assay in vitro, measurement of malondialdehyde (MDA), Thiol and superoxidedismutase (SOD) and catalase (CAT) activity and also evaluation of expression levels of Nrf2 and GCLM by qRT-PCR in tumor tissues. In addition, the effect of phytosomal curcumin on angiogenesis was assessed by the measurement of VEGF-A and VEGFR-1 and VEGF signaling regulatory microRNAs (miRNAs) in tumor tissue. Results: Phytosomal curcumin exerts anti-proliferative, anti-migratory and apoptotic activity in-vitro. It also decreases tumor growth and augmented 5-fluorouracil (5-FU) anti-tumor effect in-vivo. In addition, our data showed that induction of oxidative stress and inhibition of angiogenesis through modulation of VEGF signaling regulatory miRNAs might be underlying mechanisms by which phytosomal curcumin exerted its antitumor effect. Conclusion: Our data confirmed this notion that phytosomal curcumin administrates anticancer effects and can be used as a complementary treatment in clinical settings.

Serum Starvation Sensitizes Anticancer Effect of Anemarrhena asphodeloides via p38/JNK-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells

2021 ◽  
pp. 1-16
Author(s):  
Kon-Young Ji ◽  
Ki Mo Kim ◽  
Yun Hee Kim ◽  
Ki-Shuk Shim ◽  
Joo Young Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Serum Starvation ◽  
Anticancer Effect ◽  
Cycle Arrest ◽  
Colorectal Cancer Cells ◽  
Anemarrhena Asphodeloides ◽  
Hct116 Cells

The molecular mechanism underlying the anticancer effects of Anemarrhena asphodeloides (A. asphodeloides) on colon cancer is unknown. This is the first study evaluating the anticancer effect of A. asphodeloides extract (AA-Ex) in serum-starved colorectal cancer cells. Changes in cell proliferation and morphology in serum-starved MC38 and HCT116 colorectal cancer cells were investigated using MTS assay. Cell cycle and apoptosis were investigated using flow cytometry, and cell cycle regulator expression was determined using qRT-PCR. Apoptosis regulator protein levels and mitogen-activated protein kinase (MAPK) phosphorylation were assessed using western blotting. AA-Ex sensitively suppressed proliferation of serum-starved colorectal cancer cells, with MC38 and HCT116 cells showing greater changes in proliferation after treatment with AA-Ex under serum starvation than HaCaT and RAW 264.7 cells. AA-Ex inhibited cell cycle progression in serum-starved MC38 and HCT116 cells and increased the expression of cell cycle inhibitors (p53, p21, and p27). Furthermore, AA-Ex induced apoptosis in serum-starved MC38 and HCT116 cells. Consistently, AA-Ex suppressed the expression of the anti-apoptotic molecule Bcl-2 and upregulated pro-apoptotic molecules (cytochrome c, cleaved caspase-9, cleaved caspase-3, and cleaved-PARP) in serum-starved cells. AA-Ex treatment under serum starvation decreased AKT and ERK1/2 phosphorylation in the cell survival signaling pathway but increased p38 and JNK phosphorylation. Furthermore, AA-Ex treatment with serum starvation increased the levels of the transcription factors of the p38 and JNK pathway. Serum starvation sensitizes colorectal cancer cells to the anticancer effect of A. asphodeloidesvia p38/JNK-induced cell cycle arrest and apoptosis. Hence, AA-Ex possesses therapeutic potential for colon cancer treatment.

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