scholarly journals Kikuchi Fujimoto Disease

2012 ◽  
Vol 5 ◽  
pp. CMAMD.S9895 ◽  
Author(s):  
Al-Bishri Jamal
Keyword(s):  
Lymph Nodes ◽  
English Language ◽  
Cervical Lymphadenopathy ◽  
Low Grade ◽  
Research Papers ◽  
Benign Condition ◽  
Medicine Research ◽  
Night Sweats ◽  
Limiting Condition ◽  
First Time

In order to determine the clinical significance of Kikuchi Fujimoto Disease (histiocytic necrotizing lymhadenitis) and to review the literature available on this condition, we selected the Medicine research papers in English language published between the years 1972 to 2011. Kikuchi Fujimoto Disease (KFD) is an uncommon, cosmopolitan, benign and self-limiting condition with higher Japanese and Asian prevalence. Most of the sufferers of KFD are young people who seek treatment because of having acute tender cervical lymphadenopathy, low grade fever and night sweats. Coagulative necrosis with ample karyorrhetic debris in paracortical areas of the involved lymph nodes is the characteristic histologic feature of KFD. Diagnosing KFD is crucial as it can be mistaken for malignant lymphoma and SLE. KFD was put forth first time in 1972 by Dr. Masahiro Kikuchi and by Funimoto as lymphadenitis with reticular proliferation, histiocytes and abundant nuclear debris. It is a rare benign condition of lymph nodes and most of the clinicians and pathologists are unfamiliar with it. KFD is self-limiting disease (within 1 to 4 months), however, patients should be followed up regularly as it may crop up again or progress to SLE. Analgesics and antipyretics help to ameliorate the symptoms.

scholarly journals Cervical lymphadenopathies: a diagnostic crisis

2017 ◽  
Vol 4 (5) ◽  
pp. 1490
Author(s):  
Priya Joy ◽  
G. Gayathri ◽  
V. Gangadharan
Keyword(s):  
Lymph Nodes ◽  
Elevated Serum ◽  
Cervical Lymphadenopathy ◽  
Kimura’S Disease ◽  
Cervical Lymph Nodes ◽  
Benign Condition ◽  
Serum Ige ◽  
Kikuchi’S Disease ◽  
First Case ◽  
Kikuchi's Disease

Cervical lymphadenopathy refers to lymphadenopathy of the cervical lymph nodes. The causes are varied, and may be inflammatory, degenerative, infective or neoplastic. The first case presented here is of a 29-year old male presented with h/o recurrent progressive right sided painless swelling in the infraparotid region with cervical lymphadenopathy for past one year. Swelling was 6×6cm, nontender, firm mass. Cervical lymph nodes were palpable. He had raised eosinophil counts and elevated serum IgE levels. Biopsy showed abundant eosinophilic infiltration with microabscess suggestive of Kimura’s disease. Second case reported here is of a 17-year old female patient presented with fever for 3 weeks with cervical lymphadenopathy. The lymph node was 3×2cm, tender and firm. Routine blood investigations showed anemia. Biopsy showed lymph nodes composed of sheets of macrophages with crescent shaped nuclei with areas of necrosis and karyhorrhexis suggestive of Kikuchi’s disease. Kimura’s disease is a relatively uncommon chronic inflammatory benign condition mostly affecting the lymph nodes, subcutaneous tissue and salivary glands of head and neck region. It is seen in males in their second decade of lives. Peripheral eosinophilia, regional lymphadenopathy and elevated serum IgE levels are characteristics of Kimura’s disease. Kikuchi-Fujimoto disease is a benign, idiopathic and self-limited disease. Affects young females between 20-35 years of age. Usually there will be localized painful lymphadenopathy, fever and leukopenia. Kikuchi disease runs a benign course and resolves in several weeks to months. The two cases are presented to make clinicians aware of Kimura’s disease and Kikuchi’s disease as a differential diagnosis of cervical lymphadenopathy and to avoid the diagnostic dilemma both clinically and histopathologically.

scholarly journals Internal Jugular Vein Thrombosis in Isolated Tuberculous Cervical Lymphadenopathy

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Sanjay Khaladkar ◽  
Avadhesh Chauhan ◽  
Arijit Ghosh ◽  
Kunaal Jain ◽  
Surbhi Chauhan
Keyword(s):  
Lymph Nodes ◽  
Internal Jugular Vein ◽  
Jugular Vein ◽  
Cervical Lymphadenopathy ◽  
Response To Treatment ◽  
Public Health Issue ◽  
Low Grade ◽  
Cervical Lymph Nodes ◽  
Vein Thrombosis ◽  
Lower Neck

Tuberculosis is a common infectious disease with a high prevalence in developing countries and presents a major public health issue. Internal jugular vein (IJV) thrombosis is a rare complication in tuberculous cervical lymphadenopathy. We report a case of 26-year male patient with a history of low-grade evening rise in fever, dry cough, loss of appetite, and loss of weight with swelling in lower neck on right side. Ultrasonography (USG) neck showed well-defined hypoechoic lymph nodes posterior to right IJV and common carotid artery in the lower neck at level IV and in the right supraclavicular region showing central necrotic areas with adjoining IJV thrombosis. The association between tuberculosis and deep vein thrombosis is rare. Awareness of IJV thrombosis in isolated cervical lymphadenopathy needs high diagnostic suspicion and prompt treatment to avoid fatal complication. Our case is rare as there was isolated tuberculous cervical lymphadenopathy with adjoining IJV thrombosis. Both USG and computed tomography (CT) are accurate and reliable radiological investigations for detecting IJV thrombosis along with cervical lymph nodes. They are useful in assessing surrounding soft tissue and fat planes and knowing the size and extent of cervical lymphadenopathy. USG is inexpensive and readily available for monitoring response to treatment.

scholarly journals Kikuchi-Fujimoto Disease Associated with Myasthenia Gravis: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-3
Author(s):  
Olukayode Onasanya ◽  
David Nochlin ◽  
Victor Casas ◽  
Leema Reddy Peddareddygari ◽  
Raji P. Grewal
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Myasthenia Gravis ◽  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Lymph Gland ◽  
Unknown Etiology ◽  
Systemic Lupus ◽  
Benign Condition ◽  
Night Sweats ◽  
Sjögren’S Disease

Kikuchi-Fujimoto disease is a self-limited benign condition of unknown etiology characterized by cervical lymphadenopathy, fever, and leucopenia. An autoimmune hypothesis has been suggested and an association with systemic lupus erythematosus, Sjogren's disease, and antiphospholipid syndrome has been noted. We report a 27-year-old male who presented for evaluation of weakness and he was diagnosed with seropositive generalized myasthenia gravis and underwent a thymectomy. He was stable until five months post-thymectomy, when he developed a high fever associated with nontender cervical lymphadenopathy, chills, and night sweats. Histopathology of a cervical lymph gland biopsy was compatible with Kikuchi-Fujimoto lymphadenitis. He improved spontaneously and was asymptomatic at the followup six months later. Our case expands the association of Kikuchi-Fujimoto disease with autoimmune disorders to include myasthenia gravis.

More Christian Apocrypha

2012 ◽  
Vol 41 (3) ◽  
pp. 16-21
Author(s):  
Tony Burke
Keyword(s):  
New Testament ◽  
Old Testament ◽  
North American ◽  
English Language ◽  
Primary Sources ◽  
University Of Edinburgh ◽  
The University ◽  
First Time ◽  
Medieval Christianity

Scholars interested in the Christian Apocrypha (CA) typically appeal to CA collections when in need of primary sources. But many of these collections limit themselves to material believed to have been written within the first to fourth centuries CE. As a result a large amount of non-canonical Christian texts important for the study of ancient and medieval Christianity have been neglected. The More Christian Apocrypha Project will address this neglect by providing a collection of new editions (some for the first time) of these texts for English readers. The project is inspired by the More Old Testament Pseudepigrapha Project headed by Richard Bauckham and Jim Davila from the University of Edinburgh. Like the MOTP, the MCAP is envisioned as a supplement to an earlier collection of texts—in this case J. K. Elliott’s The Apocryphal New Testament (Oxford 1991), the most recent English-language CA collection (but now almost two decades old). The texts to be included are either absent in Elliott or require significant revision. Many of the texts have scarcely been examined in over a century and are in dire need of new examination. One of the goals of the project is to spotlight the abilities and achievements of English (i.e., British and North American) scholars of the CA, so that English readers have access to material that has achieved some exposure in French, German, and Italian collections.

scholarly journals A meta-ethnographic study of fathers’ experiences of caring for a child with a life-limiting illness

2020 ◽  
pp. 026921632097915
Author(s):  
Gianina-Ioana Postavaru ◽  
Helen Swaby ◽  
Rabbi Swaby
Keyword(s):  
English Language ◽  
Psychosocial Interventions ◽  
Healthcare Services ◽  
Ethnographic Study ◽  
Qualitative Studies ◽  
Future Research ◽  
Care Experience ◽  
Care Giving ◽  
Critical Appraisal Skills ◽  
Limiting Condition

Background: There is a growing body of qualitative studies examining parents’ experiences of caring for a child with a life-limiting condition, coinciding with recent evidence that indicates an increasing incidence of paediatric life-limiting conditions. However, research focusing on fathers’ needs remains sparse and is often diluted among a predominant ‘mother’s voice’, raising questions about whether practices in clinical settings meet fathers’ needs. Aim: To provide an in-depth assembly of the current state of knowledge around fathers’ experiences of caring for their children diagnosed with life-limiting conditions and understand the implications for healthcare services and policies. Design: A meta-ethnography was conducted to synthesise findings from existing qualitative studies exploring fathers’ experiences of caring. Data sources: Four electronic databases (PubMed, PsycINFO, CINAHL and Science Direct) were searched up until April 2020. Qualitative studies exploring fathers’ care experience and published in English language were included. The Critical Appraisal Skills Programme (CASP) checklist was employed for study quality appraisal. No temporal limits were used. Results: Sixty-three studies met the inclusion criteria. Thirty life-limiting conditions were included. Based on responses from 496 fathers, a conceptual model was developed which translates key experiences within the fathers’ caregiving journeys. The overarching concepts identified were: the paradox of support, challenges in the caring process, ‘nobody thinks of men’, impact on family life and the fall of the curtain: an irrevocably altered world. These and associated sub-concepts are discussed, with recommendations for future research and practice provided. Conclusion: The findings indicate the value of a family-oriented approach to develop psychosocial interventions and support channels for fathers, thus empowering them whilst reducing the care-giving burden on the family unit.

scholarly journals The Remarkable Antioxidant and Anti-Inflammatory Potential of the Extracts of the Brown Alga Cystoseira amentacea var. stricta

Marine Drugs ◽  
2020 ◽  
Vol 19 (1) ◽  
pp. 2
Author(s):  
Gina De La Fuente ◽  
Marco Fontana ◽  
Valentina Asnaghi ◽  
Mariachiara Chiantore ◽  
Serena Mirata ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
No Production ◽  
Low Grade ◽  
Raw 264.7 ◽  
Ros Scavenging ◽  
Ligurian Sea ◽  
Raw 264.7 Macrophages ◽  
Pharmaceutical Industries ◽  
Anti Inflammatory ◽  
First Time

Inflammation and oxidative stress are part of the complex biological responses of body tissues to harmful stimuli. In recent years, due to the increased understanding that oxidative stress is implicated in several diseases, pharmaceutical industries have invested in the research and development of new antioxidant compounds, especially from marine environment sources. Marine seaweeds have shown the presence of many bioactive secondary metabolites, with great potentialities from both the nutraceutical and the biomedical point of view. In this study, 50%-ethanolic and DMSO extracts from the species C. amentacea var. stricta were obtained for the first time from seaweeds collected in the Ligurian Sea (north-western Mediterranean). The bioactive properties of these extracts were then investigated, in terms of quantification of specific antioxidant activities by relevant ROS scavenging spectrophotometric tests, and of anti-inflammatory properties in LPS-stimulated macrophages by evaluation of inhibition of inflammatory cytokines and mediators. The data obtained in this study demonstrate a strong anti-inflammatory effect of both C. amentacea extracts (DMSO and ethanolic). The extracts showed a very low grade of toxicity on RAW 264.7 macrophages and L929 fibroblasts and a plethora of antioxidant and anti-inflammatory effects that were for the first time thoroughly investigated. The two extracts were able to scavenge OH and NO radicals (OH EC50 between 392 and 454 μg/mL; NO EC50 between 546 and 1293 μg/mL), to partially rescue H2O2-induced RAW 264.7 macrophages cell death, to abate intracellular ROS production in H2O2-stimulated macrophages and fibroblasts and to strongly inhibit LPS-induced inflammatory mediators, such as NO production and IL-1α, IL-6, cyclooxygenase-2 and inducible NO synthase gene expression in RAW 264.7 macrophages. These results pave the way, for the future use of C. amentacea metabolites, as an example, as antioxidant food additives in antiaging formulations as well as in cosmetic lenitive lotions for inflamed and/or damaged skin.

Tale and Parable: Theorizing Fictions in the Old English Boethius

PMLA ◽  
2021 ◽  
Vol 136 (3) ◽  
pp. 340-355
Author(s):  
Jennifer A. Lorden
Keyword(s):  
Old English ◽  
English Language ◽  
Ninth Century ◽  
Sixth Century ◽  
English Writing ◽  
Classical Myth ◽  
History Of ◽  
Consolation Of Philosophy ◽  
First Time ◽  
Fictional Story

AbstractScholarship has often considered the concept of fiction a modern phenomenon. But the Old English Boethius teaches us that medieval people could certainly tell that a fictional story was a lie, although it was hard for them to explain why it was all right that it was a lie—this is the problem the Old English Boethius addresses for the first time in the history of the English language. In translating Boethius's sixth-century Consolation of Philosophy, the ninth-century Old English Boethius offers explanatory comments on its source's narrative exempla drawn from classical myth. While some of these comments explain stories unfamiliar to early medieval English audiences, others consider how such “false stories” may be read and experienced by those properly prepared to encounter them. In so doing, the Old English Boethius must adopt and adapt a terminology for fiction that is unique in the extant corpus of Old English writing.

Histologic Grade Remains a Prognostic Factor for Breast Cancer Regardless of the Number of Positive Lymph Nodes and Tumor Size: A Study of 161 708 Cases of Breast Cancer From the SEER Program

2014 ◽  
Vol 138 (8) ◽  
pp. 1048-1052 ◽  
Author(s):  
Arnold M. Schwartz ◽  
Donald Earl Henson ◽  
Dechang Chen ◽  
Sivasankari Rajamarthandan
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Tumor Size ◽  
Nodal Status ◽  
Histologic Grade ◽  
Axillary Lymph Nodes ◽  
Low Grade ◽  
Axillary Lymph ◽  
Data Set

Context.—The appropriate staging of breast cancers includes an evaluation of tumor size and nodal status. Histologic grade in breast cancer, though important and assessed for all tumors, is not integrated within tumor staging. Objective.—To determine whether the histologic grade remains a prognostic factor for breast cancer regardless of tumor size and the number of involved axillary lymph nodes. Design.—By using a new clustering algorithm, the 10-year survival for every combination of T, N, and the histologic grade was determined for cases of breast cancer obtained from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. There were 36 combinations of TN, defined according to the American Joint Committee on Cancer, and grade. Results.—For each combination of T and N, a categorical increase in the histologic grade was associated with a progressive decrease in 10-year survival regardless of the number of involved axillary lymph nodes or size of the primary tumor. Absolute survival differences between high and low grade persisted despite larger tumor sizes and greater nodal involvement, though trends were apparent with increasing breast cancer stage. Statistical significance depended on the number of cases for each combination. Conclusions.—Histologic grade continues to be of prognostic importance for overall survival despite tumor size and nodal status. Furthermore, these results seem to indicate that the assignment of the histologic grade has been consistent among pathologists when evaluated in a large data set of patients with breast cancer. The incorporation of histologic grade in TNM staging for breast cancer provides important prognostic information.

scholarly journals Left Supraclavicular Lymphadenopathy as the Only Clinical Presentation of Prostate Cancer: A Case Report

2017 ◽  
Vol 17 (2) ◽  
pp. 41-44 ◽  
Author(s):  
Mohanad Abusultan ◽  
Pavel Hanzel ◽  
D. Durcansky ◽  
A. Hajtman
Keyword(s):  
Prostate Cancer ◽  
Lymph Nodes ◽  
Clinical Presentation ◽  
Cervical Lymphadenopathy ◽  
Cervical Lymph Node Metastasis ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Regional Lymph Nodes ◽  
Node Metastasis ◽  
Male Patients

AbstractProstate cancer usually metastasis to the regional lymph nodes and can rarely metastases to nonregional supradiaphragmatic lymph nodes. Cervical lymph node metastasis of prostate cancer is extremely rare. However, it should be considered in the differential diagnosis of cervical lymphadenopathy in male patients with adenocarcinoma of unknown primary site. In this report we present a rare case of metastatic prostate adenocarcinoma with left supraclavicular lymphadenopathy as the only clinical presentation with no other evidence of metastasis to the regional lymph nodes or bone metastasis.

Sign in / Sign up

Export Citation Format

Share Document