ESTRUS AND PREGNANCY IN PRIMIPAROUS SOWS TREATED WITH PREGNANT MARE’S SERUM GONADOTROPIN OR ESTRADIOL-17β AND PROGESTERONE

1976 ◽  
Vol 56 (4) ◽  
pp. 693-698 ◽  
Author(s):  
G. W. DYCK
Keyword(s):  
Pregnancy Rates ◽  
History Of ◽  
Serum Gonadotropin ◽  
The Mean ◽  
And Control ◽  
Mean Time ◽  
Estradiol 17Β ◽  
Stimulation Of

Over a 3-yr period, the effectiveness of pregnant mare’s serum gonadotropin (PMSG-1,500 IU) or estradiol-17β (1 mg) plus progesterone (2 mg) for the stimulation of post-weaning estrus and conception in primiparous sows from a herd with a history of post-weaning anestrus was evaluated. On the day after weaning, an intramuscular (i.m.) injection of PMSG or steroids was given to 49 and 51 sows, respectively. Fifty untreated sows served as controls. Treated sows in estrus by day 8 and control sows in estrus by day 40 were bred on the 2nd day of estrus. Serviced sows were killed at day 25 of pregnancy or on the day after return to estrus. The remaining sows were killed when in estrus or between days 41 and 45 after weaning. By day 8, more (P < 0.01) PMSG-treated (98.0%) sows were in estrus than either the steroid-treated (64.7%) or control (66.0%) sows. By day 14, fewer (P < 0.05) steroid-treated than control sows were in estrus (64.7 vs. 82.0%). The mean interval between weaning and estrus for sows in estrus by day 8 was less for the PMSG (P < 0.01) - and steroid (P < 0.05) - treated sows than for the control sows (3.83 ± 0.11 and 4.36 ± 0.28 vs. 5.12 ± 0.23 days). For the steroid-treated and control sows in estrus after day 8, the mean time to estrus was 34.6 ± 3.5 and 21.2 ± 2.8 days, respectively (P < 0.01). Pregnancy rates were similar for the PMSG and steroid treatments (57.1 and 47.0%), and lower than for the control sows (84.0%). The PMSG-treated animals had larger litters (16.4 ± 1.0 embryos) than either the steroid-treated (12.8 ± 1.1 embryos) or control (11.3 ± 0.8 embryos) animals.

CHROMATOGRAPHY OF THE 17-KETOGENIC STEROIDS IN THE DIAGNOSIS AND CONTROL OF CONGENITAL ADRENAL HYPERPLASIA

1960 ◽  
Vol XXXIII (II) ◽  
pp. 230-250 ◽  
Author(s):  
Eileen E. Hill
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
List Type ◽  
Adrenal Hyperplasia ◽  
Normal Children ◽  
Paediatric Practice ◽  
The Mean ◽  
Cortisone Therapy ◽  
And Control ◽  
Clinical Problems ◽  
Stimulation Of

ABSTRACT A method for the fractionation of the urinary 17-ketogenic steroids with no oxygen grouping at C11 and those oxygenated at C11, is applied to the clinical problems of congenital adrenal hyperplasia. In normal children the mean ratio of the non-oxygenated to oxygenated steroids is 0.24. In childrern with congenital adrenal hyperplasia the ratio is 2.3. The reason for this difference in ratio is discussed. The changes in ratio found under stimulation of the adrenal gland with exogenous or endogenous corticotrophin and the suppression with cortisone therapy are studied. This test can be applied to isolated samples of urine, a major advantage in paediatric practice, and can be carried out in routine laboratories. It is found to be reliable in the diagnosis and sensitive in the control of congenital adrenal hyperplasia.

scholarly journals Human Milk output among mothers previously treated for severe acute malnutrition in childhood in Democratic Republic of Congo

BMC Nutrition ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Christine Chimanuka Murhima’Alika ◽  
Ghislain Maheshe Balemba ◽  
Pacifique Mwene-Batu Lyabayungu ◽  
Guy Mulinganya Mulume’oderhwa ◽  
Grace Munthali ◽  
...  
Keyword(s):  
Body Composition ◽  
Human Milk ◽  
Democratic Republic Of Congo ◽  
Severe Acute Malnutrition ◽  
Acute Malnutrition ◽  
Control Groups ◽  
Milk Output ◽  
History Of ◽  
The Mean ◽  
And Control

Abstract Background Malnutrition is a public health problem, as wasting affects 7.5% of children worldwide. The harmful effects of severe acute malnutrition (SAM) can last a lifetime, but how SAM in childhood affects later breastfeeding ability is not clear. In the present study, we assessed the human milk output and body composition among mothers with a history of childhood SAM. Methods This retrospective cohort study was carried out in Miti-Murhesa Health Zone (Democratic Republic of Congo) from January 15 to March 17, 2020. We selected lactating mothers with breastfed infants aged 2–12 months. Two categories of mothers were included: those who had been treated for SAM during their childhood (years 1988–2003; n = 39) and a community control with no history of SAM (n = 40). The weight, height, and mid-upper arm circumference were measured and body mass index (BMI) calculated as weight/height2. Body composition and human milk output were assessed using standard deuterium dilution methods. Student t and chi2 tests ware applied to compare two groups. Results The mean age ± standard deviation of the mothers was 24.4 ± 5.1 and 26.0 ± 6.1 years for the SAM and control groups, respectively (p = 0.186). The age of their infants was 5.4 ± 2.3 months in both groups (p = 0.962). In the SAM and control groups, the mean maternal BMI was 23.8 ± 2.3 and 23.6 ± 3.7 kg/m2 (p = 0.849), mean Fat Mass 27.1% ± 5.0 and 27.1% ± 5.8% (p = 0.708), and the mean Fat Free mass 72.9% ± 5.0 and 72.9% ± 5.8% (p = 0.998), respectively. Human milk output was 833.7 ± 152.1 g/d in SAM group and 827.4 ± 171.4 g/d in the control group (p = 0.864). Conclusions We found no significant difference in human milk output and body composition in mothers treated for SAM during childhood compared to community controls.

scholarly journals The influence of adding estradiol to semen on reproductive performance of sows

1991 ◽  
Vol 71 (2) ◽  
pp. 589-591 ◽  
Author(s):  
R. N. Kirkwood ◽  
P. A. Thacker
Keyword(s):  
Key Words ◽  
Litter Size ◽  
Reproductive Performance ◽  
Artificial Insemination ◽  
Pregnancy Rates ◽  
And Control ◽  
Estradiol 17Β

One hundred gilts and one hundred mixed-parity sows of Yorkshire and Landrace breeding were inseminated with semen with or without an additional 10 μg estradiol-17β. Pregnancy rates of gilts receiving estradiol-supplemented and control semen were 90 and 79%, respectively (P < 0.09). The estradiol supplementation of semen did not improve the pregnancy rates or litter size in sows. Key words: Swine, artificial insemination, estradiol

scholarly journals Epidemiological and clinical characteristics of 671 COVID-19 patients in Henan Province, China

2020 ◽  
Vol 49 (4) ◽  
pp. 1085-1095
Author(s):  
Yifei Nie ◽  
Jitian Li ◽  
Xueyong Huang ◽  
Wanshen Guo ◽  
Xiaobai Zhang ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Case Series ◽  
Henan Province ◽  
X Rays ◽  
Illness Onset ◽  
Medical Disorders ◽  
History Of ◽  
The Mean ◽  
Wet Market ◽  
Mean Time

Abstract Background Despite many reports on the characteristics of coronavirus disease 2019 (COVID-19) in Wuhan, China, relatively little is known about the transmission features of COVID-19 outside Wuhan, especially at the provincial level. Methods We collected epidemiological, demographic, clinical, laboratory, radiological and occupation information, along with contact history, of 671 patients with laboratory-confirmed COVID-19 reported from January 23 to February 5, 2020, in Henan province, China. We described characteristics of these cases, compared the diagnostic accuracy and features of blood testing, computed tomography (CT) scans and X-rays, and analysed SARS-CoV-2 transmission sources and patients’ occupations in Henan province. Results The mean age of patients in this case series was 43 years, 56.2% were male and 22.4% had coexisting medical disorders. The death rate was 0.3%. Fourteen patients did not show any symptoms. Lymphocyte percentage was associated with disease severity (χ2 = 6.71, P = 0.035) but had a large variation in each sample group. The mean time from illness onset to diagnosis was 5.6 days. A total of 330 patients had ever lived in or visited Wuhan, 150 had contact with confirmed cases, 323 had been to a hospital and 119 had been to a wet market. There were 33 patients who did not have a traceable transmission source, with 21.2% of these being farmers and 15.2% being workmen. Conclusions Lymphocyte percentage was a sign of severe COVID-19 in general but was not a good diagnostic index. Longer time from illness onset to diagnosis was associated with higher COVID-19 severity, older age, higher likelihood of having coexisting cardiovascular diseases including hypertension, and being male. Farming was found to be a high-risk occupation in Henan province, China.

POSTWEANING PLASMA CONCENTRATIONS OF LUTEINIZING HORMONE AND ESTROGENS IN SOWS: EFFECT OF TREATMENT WITH PREGNANT MARE’S SERUM GONADOTROPIN OR ESTRADIOL-17β PLUS PROGESTERONE

1979 ◽  
Vol 59 (1) ◽  
pp. 159-166 ◽  
Author(s):  
G. W. DYCK ◽  
W. M. PALMER ◽  
S. SIMARAKS
Keyword(s):  
Luteinizing Hormone ◽  
Plasma Concentrations ◽  
Treated Group ◽  
Linear Increase ◽  
Control Group ◽  
History Of ◽  
Serum Gonadotropin ◽  
Effect Of Treatment ◽  
Secretory Pattern ◽  
Estradiol 17Β

The plasma concentrations of luteinizing hormone (LH) and estrogens (E) were determined for 12 sows, from a herd with a history of postweaning anestrus, from the day of weaning to 32 days after weaning (trial I). A linear increase in plasma LH and E was observed in six sows which remained in anestrus (LH, 0.32–0.47 ng/ml; E, 16.1–24.7 pg/ml). These concentrations were similar to those observed in cycling sows during diestrus. In the remaining sows concurrent peaks of LH and E were observed during proestrus and estrus. In a second trial, two groups each of five sows were treated with a single injection of pregnant mare’s serum gonadotropin (PMSG, 1500 IU) or steroids (estradiol-17β, 1 mg plus progesterone, 2 mg) on the day after weaning. The plasma concentrations of LH and E for 10–12 days after weaning were compared with those of five untreated control sows. In the PMSG-treated group, concurrent peaks of LH (4.7 ± 0.5 ng/ml) and E (121 ± 41 pg/ml) were observed at estrus. The control group produced a lower LH peak at estrus (1.5 ± 0.4 ng/ml) which was not accompanied by a rise in plasma E. No consistent secretory pattern for plasma LH and E was observed in the steroid treatment group.

Clinical and pathological significance of sibling Graves' disease

1980 ◽  
Vol 94 (4) ◽  
pp. 498-502 ◽  
Author(s):  
Toshio Tanaka ◽  
Shoichi Katayama ◽  
Kanji Kuma ◽  
Hajime Tamai ◽  
Fumio Matsuzuka ◽  
...  
Keyword(s):  
Subtotal Thyroidectomy ◽  
Graves Disease ◽  
Lymphoid Follicles ◽  
Mean Values ◽  
Significant Difference ◽  
Thyroid Glands ◽  
History Of ◽  
The Mean ◽  
And Control ◽  
Age And Sex

Abstract. The clinical picture and serum antithyroid antibodies in 16 pairs of siblings with Graves' disease were compared with an age and sex matched group of 32 patients with Graves' disease who did not have a family history of any thyroid disease (control patients). There was a significant difference in frequency and mean titres of antibodies to thyroglobulin between sibling patients. (positive 76.0%) and control patients (positive 40.0%), but not in microsomal antibodies (sibling; positive 92.0%, control; 92.0%). There were no significant differences in the mean values of 24 h 131I-thyroidal uptake, serum T3U, serum T4 and T3 concentrations before treatment between the two groups. Lymphoid follicles and degeneration of the epithelia were more often found in the thyroid glands of sibling patients than in those of the control patients, when 32 (16 sibling, 16 control) thyroid glands from the same groups in the clinical study, including antibody series, were examined pathologically after subtotal thyroidectomy for Graves' disease. Moreover, there was a strong tendency to increased lymphocyte and plasma cell infiltration in the thyroid glands of sibling patients with Graves' disease. The findings might indicate that Graves' disease is closely related to Hashimoto's thyroiditis, especially in sibling patients with Graves' disease.

XLIV. Observations on the Bayeux Tapestry, by Hudson Gurney, Esq. M.P. F.S.A. in a Letter to Henry Ellis, Esq. F.R.S. Secretary

Archaeologia ◽  
1817 ◽  
Vol 18 ◽  
pp. 359-370 ◽  
Author(s):  
Hudson Gurney
Keyword(s):  
Contemporary History ◽  
History Of ◽  
The Mean ◽  
Bayeux Tapestry ◽  
Mean Time

I am sorry to say in answer to your note, that I am unable to send you the Remarks, with which I had proposed to trouble the Society concerning the Bayeux Tapestry, in as perfect a form as I could have wished; but as I understand from our noble President, that we are to expect a fac simile of this document, so very curious as giving in picture a continuous, and nearly contemporary History of the Events represented, from that excellent and most accurate artist, Mr. Stothard, junr. I shall venture in the mean time, to commit them to you, just as they are.

SARS-CoV-2 Infection in a Spanish Cohort of CKD-5D Patients: Prevalence, Clinical Presentation, Outcomes, and De-Isolation Results

2020 ◽  
pp. 1-8
Author(s):  
José Jesús Broseta ◽  
Diana Rodríguez-Espinosa ◽  
Elena Cuadrado ◽  
Elena Guillén-Olmos ◽  
Evelyn Hermida ◽  
...  
Keyword(s):  
Health Resources ◽  
Maintenance Hemodialysis ◽  
Common Symptom ◽  
Time To Death ◽  
Reactive Protein ◽  
Increased Risk ◽  
Discharged Patients ◽  
History Of ◽  
The Mean ◽  
Mean Time

<b><i>Introduction:</i></b> COVID-19 is a highly contagious disease that has easily spread worldwide. Outpatient maintenance hemodialysis seems to entail an increased risk of contagion, and previous reports inform of increased mortality among this population. <b><i>Methods:</i></b> We retrospectively analyzed clinical and laboratory parameters, outcomes, and management once discharged of CKD-5D patients infected with SARS-CoV-2 from our health area. <b><i>Results:</i></b> Out of the 429 CKD-5D population, 36 were diagnosed with SARS-CoV-2 infection (8%): 34 on in-center hemodialysis and 2 on peritoneal dialysis. Five were asymptomatic. The most common symptom was fever (70%), followed by dyspnea and cough. History of cardiovascular disease and elevation of LDH and C-reactive protein during admission were associated with higher mortality. Thirteen patients died (36%), 8 patients were admitted to an ICU, and survival was low (38%) among the latter. The mean time to death was 12 days. Most discharged patients got negative rRT-PCR in nasopharyngeal swabs within 26 days of diagnosis. However, there is a portion of cured patients that continue to have positive results even more than 2 months after the initial presentation. <b><i>Conclusions:</i></b> Patients on dialysis have an increased mortality risk if infected with SARS-CoV-2. Preventive measures have proven useful. Thus, proper ones, such as universal screening of the population and isolation when required, need to be generalized. Better de-isolation criteria are necessary to ensure an appropriate use of public health resources.

scholarly journals 2526. Side Effects of Antiretroviral Therapy in Children with HIV in a Referral Center in Mexico

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S878-S878 ◽  
Author(s):  
Luis Xochihua Diaz ◽  
Javier Ordoñez Ortega ◽  
Karen Alejandra Linares Lopez ◽  
Itzel Villanueva Garcia ◽  
Jose Luis Copado Gutierrez
Keyword(s):  
Antiretroviral Therapy ◽  
Side Effects ◽  
Adverse Effects ◽  
Pediatric Population ◽  
Common Effect ◽  
The Mean ◽  
And Control ◽  
Mean Time ◽  
Observational Descriptive Study ◽  
Complete Medical Record

Abstract Background Human Inmunodeficiency Virus infection (HIV) is still a challenge in many parts of the world, mainly in children. In Mexico the infection has been decreasing, however we still have cases, in 2018 we had 40 perinatal new cases reported. The antiretroviral therapy has shown to be effective to control the disease but it is not free of adverse effects, the children with vertical transmission are exposed to many years of the antiretroviral therapy. Methods Retrospective, observational descriptive study at Instituto Nacional de Pediatría during 2004–2019. We included every children under 18 years old who received treatment for HIV and had a complete medical record. Results We found 61 patients under 18 years that fulfill the data for the analysis. 37 (60%) were male, the mean age at diagnosis of HIV infection was 47 months, the antiretroviral therapy that received 57 patients (93.4%) of the study was zidovudine, lamivudine and lopinavir/ritonavir, only 4 received another therapy: 3 of them received abacavir, lamivudine, and lopinavir/ritonavir and the missing one received abacavir, lamivudine and raltegravir. 43% of the children of our study showed adverse effects after the antiretroviral therapy, the mean time of adverse effects presentation was 37 months after the beginning of the treatment. The most common effect was hypertriglyceridemia with 13 cases, in second place we found hypercholesterolemia in 7 cases, and both in 5 cases, other frequent effects were hepatotoxicity in 5 cases, diarrhea in 4 cases, anemia in 3 cases, vomit in 3 cases, abdominal pain and night terrors in 2 cases each one. It was necessary the change of the therapy because of adverse effects in 6 cases (9.8%). Conclusion Antiretroviral therapy is effective although it has many side effects. We observe that adverse effects are frequent, almost the half, in pediatric population, it depends on the antiretroviral selection, for children we had only a few options because of the little doses they need or the inability to swallow tablets. It′s important to monitor and control all the adverse effects because they increase morbidity and mortality, especially dyslipidemia, that has been associated with cardiovascular risk and it was the most common effect found in our study. Disclosures All authors: No reported disclosures.

scholarly journals Clinical experience of combination therapy of infliximab and total glucosides of paeony for severe psoriasis with liver disorder history

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Yu Hu ◽  
Lin Lin ◽  
Pangen Cui ◽  
Xu Yao ◽  
Chao Luan ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Combined Therapy ◽  
Liver Disorder ◽  
Severe Psoriasis ◽  
Hepatic Toxicity ◽  
Pasi Score ◽  
History Of ◽  
The Mean ◽  
Mean Time

Severe psoriasis patients are reported to have a higher risk of liver abnormalities. Treatment option for severe psoriasis patients with liver disorder history remains a great challenge. Hepatic toxicity and long-term safety are the major concerns. Hence it is necessary to look for safer and more effective treatment for those patients. This retrospective review evaluated safety and efficacy of combination therapy of infliximab and TGP in treating 13 severe psoriasis patients with liver disorder history.Thirteen patients with severe psoriasis, including 8 men and 5 women, with a mean age of 37.3 ± 12.3 were observed. The patients experienced a mean course of psoriasis of 11.2 ± 7.1 years. The mean PASI score was 29.3 ± 12.9. All patients have the history of liver disorder. In our study, these patients were treated with infliximab at a dose of 5mg/kg and TGP at a dose of 1.8g/day. No liver test abnormalities were seen during combination therapy. After treatment, 61.5% patients showed PASI 50 response at week 2, and 81.8% patients have PASI 75 response at week 6. The mean time for achieving PASI 75 and PASI 90 improvement was 4.2 week and 9.6 week, respectively. Conclusion: Our observation demonstrates that combined therapy of infliximab and TGP is effective and safe in the treatment of severe psoriasis, especially for the patients with liver disorder history.

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