scholarly journals Alteration of Plasma Lipid Profiles and Atherogenic Indices by Stachytarpheta jamaicensis L. (Vahl)

Biokemistri ◽  
2010 ◽  
Vol 21 (2) ◽  
Author(s):  
CJ Ikewuch ◽  
CC Ikewuchi
Keyword(s):  
Plasma Lipid ◽  
Lipid Profiles ◽  
Atherogenic Indices

Cardioprotective Effects of Diet with Different Grains on Lipid Profiles and Antioxidative System in Obesity-Induced Rats

2012 ◽  
Vol 82 (2) ◽  
pp. 85-93 ◽  
Author(s):  
Y. Kim ◽  
H. Shin ◽  
S. Lee
Keyword(s):  
Aortic Wall ◽  
Plasma Lipids ◽  
Antioxidant Activities ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Thiobarbituric Acid ◽  
Lipid Profiles ◽  
Dietary Lipids ◽  
Male Rats

In the present study, the nutritional quality of four grains including adlay (AD), buckwheat (BW), glutinous barley (GB), and white rice (WR) were evaluated in terms of plasma lipid parameters, gut transit time, and thickness of the aortic wall in rats. The rats were then raised for 4 weeks on the high-fat diet based on the American Institute of Nutrition-93 (AIN-93 G) diets containing 1 % cholesterol and 20 % dietary lipids. Forty male rats were divided into 4 groups and raised for 4 weeks with a diet containing one of the following grains: WR, AD, BW, or WB. The level of thiobarbituric acid-reactive substances (TBARS) in liver was shown to be higher in rats by the order of those fed WR, AD, GB, and BW. This indicates that other grains decreased oxidative stress in vivo more than WR. The superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase levels in the AD, BW, and GB groups were significantly higher than those in the WR group (p < 0.05). Plasma lipid profiles differed significantly according to grain combination, and decreased aortic wall thickness was consistent with the finding of decreased plasma low-density lipoprotein cholesterol (LDL-C) (p < 0.05) and increased high-density lipoprotein (HDL-C) in rats fed AD, BW, and GB (p < 0.001). The antioxidant and hypolipidemic capacities of grains are quite high, especially those of adlay, buckwheat, and glutinous barley. In conclusion, this study has demonstrated that the whole grains had a cardioprotective effect. This effect was related to several mechanisms that corresponded to lowering plasma lipids, decreasing TBARS, and increasing antioxidant activities.

scholarly journals Profiling of Cerebrospinal Fluid Lipids and Their Relationship with Plasma Lipids in Healthy Humans

Metabolites ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 268
Author(s):  
Kosuke Saito ◽  
Kotaro Hattori ◽  
Shinsuke Hidese ◽  
Daimei Sasayama ◽  
Tomoko Miyakawa ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Total Protein ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Lipid Profiles ◽  
Brain Diseases ◽  
Lipid Homeostasis ◽  
Total Protein Content ◽  
Lipid Profiling ◽  
Healthy Humans

Lipidomics provides an overview of lipid profiles in biological systems. Although blood is commonly used for lipid profiling, cerebrospinal fluid (CSF) is more suitable for exploring lipid homeostasis in brain diseases. However, whether an individual’s background affects the CSF lipid profile remains unclear, and the association between CSF and plasma lipid profiles in heathy individuals has not yet been defined. Herein, lipidomics approaches were employed to analyze CSF and plasma samples obtained from 114 healthy Japanese subjects. Results showed that the global lipid profiles differed significantly between CSF and plasma, with only 13 of 114 lipids found to be significantly correlated between the two matrices. Additionally, the CSF total protein content was the primary factor associated with CSF lipids. In the CSF, the levels of major lipids, namely, phosphatidylcholines, sphingomyelins, and cholesterolesters, correlated with CSF total protein levels. These findings indicate that CSF lipidomics can be applied to explore changes in lipid homeostasis in patients with brain diseases.

scholarly journals Association Between 3'APOB-VNTR Polymorphism and Plasma Lipid Profiles in Type 2 Diabetes Patients

2020 ◽  
Author(s):  
Jamshid Mehrzad ◽  
Elahe Kargozar ◽  
Mohammadreza Erfanian-Khorasani ◽  
Mahdieh Mohammaditabar
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Plasma Lipid ◽  
Lipid Profiles ◽  
Control Group ◽  
Cholesterol Accumulation ◽  
Vntr Polymorphism ◽  
Vntr Polymorphisms ◽  
Control Study

Objective: Apolipoprotein B (APOB) plays an important role in the metabolism of cholesterol and impairment in its function can lead to cholesterol accumulation in the pancreatic islets. It can then reduce insulin secretion and lead to Type 2 diabetes (T2DM). The purpose of this study was to investigate the association of 3chr('39')APOB-VNTR polymorphism with plasma lipid profiles in T2DM individuals in Khorasan Razavi province, Iran. Materials and Methods: In this case-control study, 204 patients with T2DM and 207 non-diabetic volunteers were examined as a control group. All samples were analyzed for plasma lipid profiles. Genotypes were determined by PCR and electrophoresis. Differences in lipid variables between genotypes were assessed using one-way analysis of variance (ANOVA) with SPSS 20.0. Results: We found 18 different alleles of the APOB gene 3chr('39')VNTR comprising from 26 to 45 hypervariable elements (HVEs) in the control groups and 21 alleles ranging from 30 to 51 repeats in the T2DM patients. Short alleles (26 to 29 HVEs) were only in controls and large alleles (46 to 51 HVEs) were only in T2DM patients. Our results showed that in people with long HVE polymorphism, HDL-C levels decreased, but LDL-C increased. Therefore, longer alleles for T2DM are considered risk factors. It was also observed that the TC / HDL-C ratio was significantly lower in shorter genotypes than the longer genotypes in T2DM patients. Conclusion: It is concluded that 3chr('39')APOB-VNTR polymorphisms, especially longer alleles, affect plasma lipid levels in individuals with T2DM and are risk factors for this disease.

Dietary Protein Source and Plasma Lipid Profiles of Infants

PEDIATRICS ◽  
1990 ◽  
Vol 85 (4) ◽  
pp. 548-552
Author(s):  
Emily Tseng ◽  
Susan M. Potter ◽  
Mary Frances Picciano
Keyword(s):  
Amino Acids ◽  
Human Milk ◽  
Dietary Protein ◽  
Plasma Cholesterol ◽  
Plasma Lipid ◽  
Lipid Profiles ◽  
Plasma Triglyceride ◽  
Term Infants ◽  
Cholesterol Levels ◽  
The Impact

Total cholesterol and triglyceride concentrations were measured in plasma samples taken at 4 and 8 weeks of age from 40 full-term infants who had been fed either human milk or one of three formulas containing casein-to-whey ratios of 82:18, 66:34, or 50:50 to investigate whether dietary protein influenced the development of plasma lipid profiles. Infants fed the formula with the casein-to-whey ratio of 82:18 had significantly higher plasma cholesterol levels at both 4 and 8 weeks of age compared with other groups of infants (P &lt; .05). Infants fed the high-casein formula also showed an increase in plasma cholesterol levels with time (P &lt; .001). Plasma triglyceride concentrations decreased as concentration of casein decreased (P &lt; .05) among the formula-fed groups and increased with time. Infants fed human milk had plasma triglyceride concentrations similar to those infants who had been fed the 82:18 formula at 4 weeks of age; however, triglyceride concentrations eventually fell and were similar to those concentrations in infants who had been fed the 50:50 formula at 8 weeks of age. Results indicate that constituent lipids of human milk or formulas were not determining factors for changes observed in plasma cholesterol levels and triglyceride concentrations among groups. Since formulas differed only in proteins and their constituent amino acids, further investigation of the impact of dietary protein (amino acids) on development of blood lipid profiles in infants is warranted.

Effects of simvastatin and omega 3-fatty acids on blood pressure, plasma lipid profiles, liver and renal function in type 2 diabetes

2016 ◽  
Vol 8 (3) ◽  
pp. 73
Author(s):  
MustafaYG Younis ◽  
RagabB Roaeid ◽  
FadyaAbdulraof Menesi ◽  
Safa Elbadri ◽  
Esam Denna ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Renal Function ◽  
Plasma Lipid ◽  
Lipid Profiles ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Pressure Plasma

scholarly journals Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease

2019 ◽  
Vol 10 (5) ◽  
pp. e00044 ◽  
Author(s):  
Partho Sen ◽  
Cecilia Carlsson ◽  
Suvi M. Virtanen ◽  
Satu Simell ◽  
Heikki Hyöty ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Plasma Lipid ◽  
Lipid Profiles

scholarly journals The Type of Fat Ingested at Breakfast Influences the Plasma Lipid Profile of Postmenopausal Women

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
J. M. Morillas-Ruiz ◽  
J. M. Delgado-Alarcon ◽  
J. M. Rubio-Perez ◽  
M. D. Albaladejo Oton
Keyword(s):  
At Risk ◽  
Lipid Profile ◽  
Olive Oil ◽  
Total Cholesterol ◽  
Postmenopausal Women ◽  
Plasma Lipid ◽  
Lipid Profiles ◽  
Sample Population ◽  
Plasma Lipid Profile ◽  
Arterial Blood

To assess whether the type of fat ingested at breakfast can modify the plasma lipid profile and other cardiovascular risk variables in postmenopausal women at risk of cardiovascular disease, a longitudinal, randomized, and crossover study was carried out with postmenopausal women at risk of CVD. They were randomly assigned to eat each type of breakfast during one month: 6 study periods (breakfast with the same composition plus butter/margarine/virgin olive oil) separated by two washout periods. On the first and last days of each study period, weight, arterial blood pressure, heart rate, and body mass index were recorded in fasting conditions and a blood sample was collected to measure plasma lipid profile. When comparing final values to baseline values, we only found out statistically significant differences on plasma lipid profiles. Butter-based breakfast increased total cholesterol and HDL, while margarine-based breakfast decreased total cholesterol and LDL and increased HDL. After the olive oil-based breakfast intake, a tendency towards a decrease of total cholesterol and LDL levels and an increase of HDL levels was observed. No statistically significant differences were observed in triglycerides levels, BMI, and arterial pressure in any breakfast type. The margarine-based breakfast was the only one which significantly increased the percentage of volunteers with optimal lipid profiles. The polyunsaturated fat at breakfast has improved the plasma lipid profile in the analyzed sample population, suggesting that PUFA-based breakfast can be advisable in women at risk of CVD.

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