scholarly journals Comparison of vitamin D, calcium and phosphorus values of essential hypertensive, preeclamptic and normotensive pregnant women

2021 ◽  
Vol 3 (1) ◽  
pp. 10-14
Author(s):  
Mehmet Emin Güneş ◽  
Ömür Keskin ◽  
Ayşe Rabia Şenkaya
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
The Other ◽  
Control Group ◽  
Positive Effects ◽  
Significant Difference ◽  
Low Phosphorus ◽  
25 Hydroxy Vitamin D ◽  
Calcium And Phosphorus ◽  
Phosphorus Levels

Abstract Objective: The aim of this study is; to examine the levels of 25 hydroxy vitamin D (25-OH D), calcium (Ca) and phosphorus (P) in preeclamptic, essential hypertensive and normotensive pregnant groups. Material and Method: A total of 120 pregnant women who came to our clinic for delivery between 35 and 40 weeks of gestation between April 2017 and November 2017 were included in the study. The study group consisted of 40 preeclamptic (n = 40) and 40 essential hypertensive (n = 40), and the control group consisted of 40 normotensive pregnant women (n = 40). The demographic, obstetric and laboratory results of the three groups were compared in terms of 25-OH D levels, calcium and phosphorus levels. Results: Maternal age, BMI and proteinuria were significantly lower in the preeclamptic and essential hypertensive group compared to the control group (p <0.05). Week of gestation was observed to be earlier in the preeclamptic group compared to the other two groups (p <0.05). The mean systolic and diastolic blood pressure of the preeclamptic and essential hypertensive groups were found to be statistically significantly higher than the control group (p <0.05). No statistically significant difference was found between the groups in terms of transaminase. It was found that creatinine in the control group was statistically lower than the average creatinine level in the other two groups (p <0.001). The Blood Urea Nitrogen (BUN) average of the control group was statistically significantly lower than the average of the other two groups (p = 0.001). Phosphorus levels were significantly higher in preeclamptic and essential hypertensive pregnant women compared to normotensive pregnant women (p<0.05). However, no statistically significant difference was found between calcium and 25-OH D levels in all three groups. Conclusion: Low phosphorus level is likely to play a role in the etiology of essential hypertension and preeclampsia. The effects of maternal vitamin D and calcium level on the development of preeclampsia are uncertain, but more extensive research is required on potential positive effects.

scholarly journals A Study of Vitamin D and Calcium Level in Beta Thalassemia Major in Duhok Province

2019 ◽  
Vol 7 (11) ◽  
pp. 1924
Author(s):  
Ghorbat Saleh Ali ◽  
Malika Kassem Najeeb ◽  
Amad M. Saleh Jubrail ◽  
Zeliha Selamoğlu
Keyword(s):  
Vitamin D ◽  
Blood Transfusion ◽  
Vitamin D Deficiency ◽  
Serum Calcium ◽  
Colorimetric Method ◽  
Thalassemia Major ◽  
Total Serum ◽  
Control Group ◽  
Significant Difference ◽  
25 Hydroxy Vitamin D

β-thalassemia major is severe hemolytic anemia which requires repeated blood transfusion and for survival, which leading to iron overload. Serious complications due to iron over load are recognized in the thalassemia patients. objectives Vitamin D and calcium are important factors for homeostasis of calcium in this study. This study was conducted for a period of two year including from patients with β- thalassemia major from Duhok Thalassemia Centre between 2014 -2015. Thirty eighth β- thalassemia major patients and thirty eighth persons with age- matched as control group were enrolled in the study. Serum concentration of 25- hydroxy vitamin D and calcium were estimated by enzyme linked fluorescent assay and colorimetric method, respectively. In patients, the level of serum 25- hydroxy vitamin D was significantly lower 11.11±4.36 ng/mL compared with control group (14.03±5.96ng/mL). Vitamin D deficiency is observed about 94.73% in patients. The mean level of serum calcium in patients group is 7.9±0.47mg/dL and 8.98±0.77 mg/dL in control group. There was a statistically significant difference in serum calcium value between patients and control group. 44.73% of patients have hypocalcaemia. This study demonstrated a high prevalence of Vitamin D deficiency and low total serum calcium levels in thalassemia patients with a significantly lower than healthy group. Hypocalcemia and vitamin D deficiency may be results from the negative effect of the repeated blood transfusion and malnourishment.

scholarly journals The relationship of serum vitamin D, calcium, and phosphorus levels of mothers with growth indices of their newborns in pregnant women admitted to Hajar hospital of Shahrekord in 2016

2019 ◽  
Vol 21 (5) ◽  
pp. 237-243
Author(s):  
Sheida Shabanian ◽  
Neda Neyazi ◽  
Abolfazl Khoshdel ◽  
Soleyman Kheiri ◽  
Mohammad Saleh Ghafari
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Analytical Study ◽  
Phosphorus Deficiency ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Calcium And Phosphorus ◽  
Relationship Of ◽  
The Relationship ◽  
Phosphorus Levels

Background and aims: Vitamin D deficiency is a known pandemic problem which has thousands of bad health outcomes. The aim of the current study was to investigate the effect of maternal vitamin D, Ca, and PO4 levels on growth indexes of newborns at birth and 1 month and 3 months after delivery in pregnant women admitted to Hajar hospital of Shahrekord, Iran in 2016. Materials and Methods: This descriptive-analytical study was conducted on 196 pregnant women admitted to the hospital. During pregnancy, 5 mL of mother’s blood and 5 mL of umbilical cord blood were taken. Serum calcium and phosphorus levels were determined immediately after sampling and then centrifuged. After collecting the samples, 25-OHD levels were measured by ELISA method. Neonatal growth indexes such as weight, height, and head circumference atbirth,1 month, and 3 months were measured. Data were analyzed using independent samples t test, ANOVA, and correlation coefficient by SPSS version 16.0. Results: Deficiency of vitamin D, phosphorus, and calcium was observed in 76%, 1%, and 25% of women, respectively. Moreover, deficiency of vitamin D, phosphorus, and calcium was reportedin56.1%, 15.8%, and 9.2% of newborns, respectively. There was a significant relationship between calcium level in newborns and their weight and height at birth, one month, and three months of age ( P<0.05). Levels of vitamin D, calcium and phosphorus of mother and newborns were significantly correlated ( P<0.05). Conclusion: More than two-thirds of mothers and more than half of the newborns were deficient in vitamin D. There was also a lack of calcium in one third of mothers and 9.2% of newborns, and phosphorus deficiency was observed only in 1% of mothers and 15.8% of newborns. Due to the low intake of these materials through nutrition, the supplementation of these substances, especially vitamin D and calcium, is required during pregnancy.

scholarly journals Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Xue Zhou ◽  
Ben Li ◽  
Chao Wang ◽  
Zhihong Li
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Subclinical Hypothyroidism ◽  
First Trimester ◽  
Control Group ◽  
Study Group ◽  
Significant Difference ◽  
Hs Crp ◽  
The Impact

Objective: To investigate the effect of vitamin D deficiency on the levels of thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPO-Ab), interleukin-1 (IL-1) and high-sensitivity C-reactive protein (hs-CRP) in pregnant women with early pregnancy complicated by subclinical hypothyroidism. Methods: A total of 172 pregnant women with subclinical hypothyroidism in the first trimester diagnosed and treated in a given hospital from August 2014 to May 2018 were selected, and their levels of vitamin D were determined. Depending on the abnormality of their vitamin D levels, the study participants were divided into two groups: the study group (vitamin D≤20 ng/L) and the control group (vitamin D>20 ng/L). The levels of TSH, TPO-Ab, IL-1 and hsCRP in the two groups were measured. Results: The levels of TSH, hsCRP and TPO-Ab in the study group were significantly higher than those in the control group (P < 0.05). The comparison between the two groups in terms of IL-1 showed no statistically significant difference. Conclusion: Vitamin D deficiency in the first trimester is associated with in an increased level of TSH in the first trimester, thereby aggravating subclinical hypothyroidism. The mechanism may be associated with the impact of vitamin D deficiency on hs-CRP and other body inflammation indicators, as well as on thyroid autoantibodies and other immune indicators, but has no effect on IL-1 levels. doi: https://doi.org/10.12669/pjms.36.6.1982 How to cite this:Zhou X, Li B, Wang C, Li Z. Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.1982 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals The Association Between Vitamin D Values and Psoriasis: A Literature Review

2019 ◽  
Vol 25 (4) ◽  
pp. 193-199
Author(s):  
Zamfirescu Mihaela ◽  
Ghiță Nicolae-Alexandru ◽  
Chirilă Sergiu ◽  
Gurgaș Leonard ◽  
Hangan Tony
Keyword(s):  
Vitamin D ◽  
Web Of Science ◽  
The Other ◽  
Control Group ◽  
Healthy Controls ◽  
Significant Difference ◽  
Cellular Immune System ◽  
D Values ◽  
Cellular Immune ◽  
25 Hydroxycholecalciferol

Abstract The Vitamin D deficiency could be involved in the development of psoriasis, Vitamin D defficiency being considerd to be involved in the development of disorders related to cellular immune system. The aim of this study is to review the literature in order to find if there is an association between the Vitamin D level in the serum and psoriasis. A search for relevant articles was performed using PubMed, Web of Science and Springer databases. A total of 19 articles fulfilled the criteria for inclusion in this review. 14 studies revealed statistically significant lower levels of Vitamin D in psoriatic patients when compared to healthy controls. The other 5 studies did not found a statistically significant difference between 25-hydroxycholecalciferol levels in psoriasis group and in control group.

A study of Vitamin D supplementation to patients with chronic diseases admitted to Ain Shams University Hospital

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Raef Malak Botros ◽  
Ahmed Mohamed Bahaa El Din ◽  
Hany Khairy Mansour ◽  
Mariam Michel Ayad Grace
Keyword(s):  
Vitamin D ◽  
Single Dose ◽  
Chronic Diseases ◽  
Intervention Group ◽  
Vitamin D Supplementation ◽  
The Other ◽  
University Hospital ◽  
Control Group ◽  
P Value ◽  
Significant Difference

Abstract Background Vitamin D deficiency and insufficiency have become a common problem worldwide. Vitamin D has been associated with all causes of mortality in chronic diseases and associated with a longer hospital stay and poor outcome. Aim of the Study to evaluate the role of vitamin D supplementation on the outcome of hospitalization for patients with CLD or CHF admitted to Ain Shams University Hospitals (ASUH) with acute deterioration of their illness. Subjects and methods We conducted prospective case control on 80 patients collected from inpatient ward of endocrinology, divided into 2 groups; 40 patients with chronic liver diseases and 40 patients with heart failure. Serum 25OH-vitamin D and calcium, phosphate and PTH were measured to all participants before intervention. 20 patients of each group (Intervention group) received single dose of vitamin D within 3 days of admission and the other 20 patients of each group (control group) did not receive vitamin D vitamin D. Results no significant difference between patients who received vitamin D supplementation and who did not receive vitamin D supplementation as regards outcome and survival with P value 1.000 in patients with CLD and 0.823 in patients with CHF. On the other hand, we found baseline vitamin D level was an independent predictor of mortality (P value .018). Conclusion We found that a beneficial effect of vitamin D supplementation can't be achieved with single dose vitamin D (200,000 IU) on CHF or CLD hospitalized patients’ mortality. We recommend that vitamin D supplementation should be considered in CLD and CHF outpatients, with exception of hypercalcemic and hyperphosphatemic patients, as baseline vitamin D status affects the disease course and mortality prior to disease deterioration and hospitalization.

scholarly journals Serum Vitamine D3 Level in Women with Gestational Diabetes Mellitus

2021 ◽  
pp. 90-98
Author(s):  
Riham M. Enab ◽  
Amal A. El Sokary ◽  
Heba A. Mourad ◽  
Amal E. Mahfouz
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Control Group ◽  
Study Group ◽  
Significant Difference

Background: Vitamin D3 is synthesized in skin and sequentially metabolized in liver and kidney in humans. It is well known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. The primary objective of this study was to evaluate vitamin D3 level in pregnant women who were suffering from gestational diabetes mellitus and comparing it with the control groups. Materials and Methods: This case control study was conducted on 100 pregnant women who were attending the inpatient and outpatient clinics of Obstetrics department, Tanta University Hospital, who were divided into two equal groups.Group A (control group): Fifty apparently healthy pregnant women at 24th-28th weeks of gestation. Group B (study group): Fifty pregnant women had gestational diabetes. Results: There is significant increase between the two studied groups according to HbA1c, also there is decrease between the two groups as regards VIT D. Mean HbA1c % was statistically significant higher in the study group versus control group. There was statistical significant difference noted between mean serum level of vitamin D among the two studied groups. A statistically significant negative correlation was observed between serum 25 OH vitamin D and HbA1c among our cases (r=- 0.745) (p ≤ 0.001). Mean serum vitamin D was significantly lower in cases with complications than those with normal outcome. Conclusion: Vitamin D deficiency may have a positive relationship with gestational diabetes mellitus.

scholarly journals Association between Preeclampsia and vitamin D Deficiency

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A S Elhoussieny ◽  
M E Ibrahim ◽  
H F Gad ◽  
E H Mahdi
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Maternity Hospital ◽  
Control Group ◽  
Major Health Problem ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

Abstract Background Preeclampsia is a pregnancy-specific disorder that affects 3–5% of pregnant women worldwide and is one of the most frequently encountered medical complications of pregnancy. Recent research has pointed towards some role of vitamin D deficiency in pathogenesis of preeclampsia. Vitamin D deficiency in pregnant women and their children is a major health problem, with potential adverse consequences for overall health. Aim of the Study The aim of this study is to investigate the serum vitamin D levels in preeclampsia and healthy normotensive pregnant women. Patients and Methods This case control study was conducted at Ain Shams University Maternity Hospital from November 2017. The study included pregnant women 20-35years this study will be carried out on pregnant women recruited at pre labour room (preeclamptic group) and (non preeclamptic group) at Ain Shams University Maternity Hospital, 50 women in each group. Results All samples were screened by DRG® 25-OH Vitamin D (total) ELISA (EIA-5396) and it was found that mean 25 hydroxy vitamin D levels were lower in preeclamptic group than normotensive control group. Mean level of 25 hydroxy vitamin D between preeclamptic cases was 13.98 ±4.98 ng/ml and between normotensive controls was15.62± 3.51 ng/ml. Conclusion This study has shown no association between vitamin D deficiency and pre-eclampsia, supporting no role for vitamin D as a preventative agent against preeclampsia.

Vitamin D receptor polymorphisms and related biochemical parameters in various cancer species

2017 ◽  
Vol 42 (2) ◽  
Author(s):  
Hülya Çiçek ◽  
Nesli Güleken ◽  
Serdar Öztuzcu ◽  
Alper Sevinç
Keyword(s):  
Lung Cancer ◽  
Pancreatic Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Genetic Polymorphisms ◽  
Vitamin D Receptor ◽  
Control Group ◽  
Significant Difference ◽  
And Control ◽  
Phosphorus Levels

AbstractObjective:Certain cancer types have been shown to be associated with vitamin D deficiency. The aim of this study was to appraise the relationship between the vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) of VDR Fok1 and Bsm1 with serum vitamin D, calcium and phosphorus levels among patients of lung, colon, breast and pancreatic cancer patients.Materials and methods:Groups; lung, colon, breast and pancreatic cancer patients (n=212) and 58 age-matched healthy controls. Serum levels of vitamin D were measured by immunochemiluminesence method and Fok1 and Bsm1 genotypes were assessed with Real-Time Polymerase Chain Reaction.Results:VDR Fok1 and Bsm1 genetic polymorphisms have a significant difference between lung cancer and control group subjects (p=0.042, p=0.040, respectively). VDR Bsm1 genetic polymorphism has a significant association between breast cancer and control group according to the logistic regression model (p=0.038). Vitamin D levels were found significantly lower in all cancer groups (p<0.01). Phosphorus levels of lung cancer and calcium levels of pancreatic cancer patients were statistically significantly lower than control group (p<0.02, p<0.01).Conclusion:This study indicates that VDR genetic polymorphisms, calcium, phosphorus and vitamin D status of individuals were associated with certain cancer species.

scholarly journals Serum 25-Hydroxy-Vitamin D and Vitamin B12 Levels in Childhood Alopesia Areata

2021 ◽  
Author(s):  
Selcen Kundak ◽  
Ayşe Kutlu
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Age Of Onset ◽  
Control Group ◽  
Control Groups ◽  
Dermatology Clinic ◽  
Family Medical History ◽  
Significant Difference ◽  
25 Hydroxy Vitamin D ◽  
And Control

Objective: Alopecia areata (AA); is a sudden onset, non-scaring hair loss. Twenty percent of cases are children.Although it is thought to be related to genetic predisposition, inflammation, immunological processes or psychological triggers, its pathophysiology is still not fully understood. This study was planned to investigate the levels of serum 25-hydroxy vitamin D, vitamin B12, thyroid-stimulating hormone (TSH) and free T4 FT4) in children with AA and compare the results with age-matched healthy individuals. Methods: A retrospective medical record review was carried out in an outpatient dermatology clinic in a tertiary medical center between January 1,2013 and December 31, 2017. The study included 520 patients (ages 0-18 years) who received a clinical diagnosis of AA.106 patients with AA met the inclusion criteria.Patients in the control group (n=106) were selected among children aged 0-18 years without any medical and/or psychiatric diagnosis. Both past medical and family medical history were also noted. Results of laboratory tests including vitamin D, vitamin B12, TSH, FT4, and thyroid auto-antibodies were noted. Results: There was no significant difference between the patient and control groups in terms of mean age.Mean age of onset was 8.0 years. The number of boys and girls in both the patient and control groups were 55 and 51. Serum levels of FT4 and TSH in patients with AA were significantly higher than the control group. Both vitamin D and vitamin B12 levels of the patients with AA were significantly lower than the control group. Conclusion: Although its role in etiopathogenesis is not understood, the importance of monitoring both vitamins and thyroid functions in childhood AA cases is obvious.

scholarly journals Vitamin D Status in Migraine Patients: A Case-Control Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Alireza Zandifar ◽  
Samaneh sadat Masjedi ◽  
Mahboobeh Banihashemi ◽  
Fatemeh Asgari ◽  
Navid Manouchehri ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Control Group ◽  
Vitamin D Status ◽  
Significant Difference ◽  
25 Hydroxy Vitamin D ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study

Background. There have been few studies on the relation between vitamin D and migraine. We investigated the prevalence of vitamin D deficiency in migraine patients and compared it with a control group. We also evaluated the relationship of vitamin D deficiency with severity of migraine.Methods. 105 newly diagnosed migraine patients and 110 controls, matched for age, sex, socioeconomic status, education, and sun exposure, were enrolled during the spring of 2011. 25-Hydroxy vitamin D [25(OH)D] plasma levels were measured by chemiluminescence immunoassay.Results. The mean ± SE concentration of 25(OH)D was13.55±0.91 ng/mL in cases and13.19±1.19 ng/mL in controls. There was no significant difference in 25(OH)D concentration between cases and controls. We found no relationship between severity of headache and 25(OH)D status.Conclusions. We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level. Further studies with larger sample sizes are required to confirm our results.

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