scholarly journals A CONCEPTUAL STUDY ON YASHTIMADHU (GLYCYRRHIZA GLABRA) – A REVIEW ARTICLE

2021 ◽  
Vol p5 (6) ◽  
pp. 3130-3134
Author(s):  
Rekha Karveti ◽  
Shiromani Mishra

Yashtimadhu (Glycyrrhiza glabra), a powerful medicinal plant listed in Ayurveda, heals a wide range of ailments, from simple coughs to more serious illnesses including hepatitis and cancer. Glycyrrhizin, glycyrrhetine acid, glycyrrheic acid, asparagine, liquirtin, glabrine, A & B, and flavonoids have all been identified as significant phy- toconstituents. Anti-tussive, anti-inflammatory, anti-ulcer, antioxidant, antispasmodic, spasmodic, antibiotic, and antiviral medications are all available through the organisation. The important pharmacological actions are sum- marised in this article, with a focus on the role of flavonoids and isoflavonoids in pain relief. This might aid with future medical outcomes identification and development. Keywords: Yashtimadhu, glycyrrhizin, Glycyrrhiza glabra etc.


Vestnik ◽  
2021 ◽  
pp. 252-255
Author(s):  
Д.К. Айдарбаев ◽  
А.Ж. Жарқынбек

В статье рассматриваются биологические и экологические особенности цистанхе, а также предусматривается этноботанические исследования, рекомендации по рациональному использованию. Выявлены некоторые значения Cistanchе, которое произрастает в Казахстане. Определена область использования в народной медицине цистанхе из семейства Orobanchaceae. В исследовании показана роль цистанхе, как растения с широким спектром фармакологических свойств. Проведен анализ маршрутно-рекогносцировочных исследований популяции цистанхе, определены распределение, запасы и объемы ежегодных заготовок по основным расположенным флористическим районам. Проведен расчет среднего суммарного объема заготовок сырья, собранных в Прибалхашье Алматинской области. В настоящее время в результате глобального потепления климатические условия меняются, и многие виды растений вымирают. Поэтому защита и эффективное использование растений является одной из самых актуальных проблем. Также важно изучить цистанхе, используемый в народной медицине как лекарственное растение. The article discusses the biological and ecological features of cistanche, as well as provides for ethnobotanical research, recommendations for rational use. Some values of Cistanche, which grows in Kazakhstan, are revealed. The scope of use in folk medicine of cistanha from the family Orobanchaceae is determined. The study shows the role of cistanche as a plant with a wide range of pharmacological properties. Conducted analysis of route-reconnaissance studies of cisterna populations, determined the distribution, stock and volumes of annual preparations for the main floristic areas. Calculated the average total volume of raw materials collected in the Balkhash region of Almaty region. As a result of global warming, climatic conditions are changing and many plant species are dying. Therefore, the protection and efficient use of plants is one of the most pressing problems. It is also important to study the tanks used in folk medicine as a medicinal plant.





2014 ◽  
Vol 17 (5) ◽  
pp. 521-539 ◽  
Author(s):  
Elizabeth D. E. Papathanassoglou ◽  
Panagiota Miltiadous ◽  
Maria N. Karanikola

Introduction: Exercise attenuates inflammation and enhances levels of brain-derived neurotrophic factor (BDNF). Exercise also enhances parasympathetic tone, although its role in activating the cholinergic anti-inflammatory pathway is unclear. The physiological pathways of exercise’s effect on inflammation are obscure. Aims: To critically review the evidence on the role of BDNF in the anti-inflammatory effects of exercise and its potential involvement in the cholinergic anti-inflammatory pathway. Methods: Critical literature review of studies published in MEDLINE, PubMed, CINAHL, Embase, and Cochrane databases. Results: BDNF is critically involved in the bidirectional signaling between immune and neurosensory cells and in the regulation of parasympathetic system responses. BDNF is also intricately involved in the inflammatory response: inflammation induces BDNF production, and, in turn, BDNF exerts pro- and/or anti-inflammatory effects. Although exercise modulates BDNF and its receptors in lymphocytes, data on BDNF’s immunoregulatory/anti-inflammatory effects in relation to exercise are scarce. Moreover, BDNF increases cholinergic activity and is modulated by parasympathetic system activation. However, its involvement in the cholinergic anti-inflammatory pathway has not been investigated. Conclusion: Converging lines of evidence implicate BDNF in exercise-mediated regulation of inflammation; however, data are insufficient to draw concrete conclusions. We suggest that there is a need to investigate BDNF as a potential modulator/mediator of the anti-inflammatory effects of exercise and of the cholinergic anti-inflammatory pathway during exercise. Such research would have implications for a wide range of inflammatory diseases and for planning targeted exercise protocols.



2020 ◽  
Vol 1 (337) ◽  
pp. 33-40
Author(s):  
Yedilova A.K. ◽  
Inelova Z.A.

The article provides an overview of the structural features of the natural populations of Humulus lupulus L. in the world and in Kazakhstan. Currently, the use in medicine of natural products, medicines and biologically active substances of plant origin is increasing. Significant parts of the medicinal raw materials are wild plants. The need for medicinal plant raw materials (medicinal plants) is not decreasing; the technology of its procurement and reproduction in natural conditions wants significant perfection. It is known that they have a milder, more complex effect on the human body and are used in the treatment of many chronic diseases. The growing anthropogenic impact on populations of valuable medicinal plants is decreasing their stocks of raw materials. In this regard, the study of biological characteristics and the development of scientifically based agricultural techniques for the cultivation of many medicinal plants are becoming relevant. Humulus lupulus L. (common hop) is a valuable medicinal plant. They are used as painkillers, sedatives, hypnotics for increased nervous irritability, sleep distur-bances, neuralgia, vegetovascular dystonia, mild coronary spasms, tachycardia, and in the early stages of hyper-tension. According to the classification of medicinal plant resources, Humulus lupulus L. is a plant with a wide range, but with a limited supply of raw materials. In places of growth of Humulus lupulus L. does not form large thickets [1]. Recently, a comprehensive approach has been applied in the study of natural plant populations, including ontomorphological and population-ecological studies. This makes it possible to objectively assess the state of the species in the cenosis and predict its future behavior. In this regard, a comprehensive study of the natural populations of Humulus lupulus L. is of great relevance. Hops (Humulus lupulus L.) is an important crop worldwide, known as the main flavor ingredient in beer. A diversified brewing industry requires a variety of flavors, superior technological properties and sustainable agro-nomy, which are the center of advanced molecular breeding efforts in hops. Hop breeders have been limited in their ability to create strains with desirable traits, however, due to unusual and unpredictable inheritance patterns and the associated non-Mendelian segregation of genetic markers [2]. The use of hops has recently been undergoing a new change, driven by a growing international preference for more intensely flavored beer, supported by the craft-brewing sector. This movement led to the introduction of much more hops at various stages of beer production and to an ever-growing search for new flavors. Some hop varieties have thus received particular attention, including several older typical hops mostly used to date, although an intensive search for new varieties dubbed "Green Gold" has also taken place. A large number of new exquisite varieties have been described and are increasingly appreciated in the market. Global hop growing areas have increased over the past 5 years, although total world beer production has declined over the same period, confirming the trend of using more hops per liter of beer. In addition, a wide range of pharmacological properties have been described for hops and its derivatives, namely antioxidant, anti-inflammatory and antitumor properties, which are of great importance for the pharmaceutical industry. The bioactivity of beer can depend on the use of hops, which can become an important tool for brewers aiming to develop functional products. Taken together, the compounds isolated from Humulus lupulus L. have a wide range of biological activity, such as anti-inflammatory action, antimicrobial action, antioxidant action, antiproliferative effects, cytochrome P450 effects, glucose metabolism effects, hormonal effects, lipid effects and sedative / hypnotic effects. Therefore, the purpose of this Chapter is to describe the importance of hops in this new direction of beer production, market overview of hops, varieties, forms and methods of use, composition, value in bioactivity of beer and new discoveries in research hops [3].



Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Atish K. Maldhure

Abstract:: Nanotechnology is multidisciplinary science which deals with physics, chemistry, materials science, and engineering sciences. The applications of Nanotechnology cover almost all the branches of science and technology. In late 2019, SARS-CoV-2 virus becomes caused to infection of coronavirus infectious disease (COVID-19). The outbreak of 2019 coronavirus disease (COVID-19) becomes challenge to Hospitals and laboratories, due to the large number samples comes for testing the presence of the causative pathogen. Many Scientist and researchers are devotedly working on to find out rapid immunodiagnostic methods to find positive cases. Nano based drugs offer a new therapeutic scheme against the wide range of bacterial pathogens. In this review article, I try to focus on the role of nanomaterial fighting against COVID-19.



2020 ◽  
Vol 11 (1) ◽  
pp. 657-662
Author(s):  
Vasanth M P ◽  
Purushotham KG ◽  
Sathish M ◽  
Vimal Raj D ◽  
Venkatesh M

The G.glabra is otherwise called liquorice is a medicinal plant is used for various diseases like cold, cough, hypokalemia and muscle weakness, etc. The liquorice family belongs to the Fabaceae family of the G.glabra. Hence this study tells about the anti-inflammatory and antioxidants.  The quantitative study of phytochemical analysis, antioxidant and Anti-inflammatory, cytotoxicity assay using a response from the root extract of G.glabra  The results are showed above preliminary activity phytochemicals were present Alkaloids, Flavonoids, Coumarin, Saponins, Terpenoids, Steroids, Cardiac Glycosides. The antioxidant activity of aqueous extract of G. glabra were evaluated with the 2,2-diphenyl-1-picryl hydrazyl (DPPH), nitric oxide radical (NO), superoxide radical (SO), hydrogen peroxide radical (H2O2), and hydroxyl radical (HO) scavenging activity. This study shows about the activity of Glycyrrhiza glabra herbal medicinal plant aqueous extract using antioxidant assays, Anti-inflammatory assays.  The in vitro MTT 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Cytotoxicity assay were studied GG(G.glabra)  extract using the macrophages  Raw 246.7 Cell line. The cell line assay were studied in two different activity. One is anti-inflammation studies, and another is cytotoxicty of GG aqueous extract. The anti-inflammation IC50 value is 143.65, and GG extract dry sample were against the IC50 value is 326.27. From above, the results were a potential activity of GG extract R-value 0f 0.991.



2019 ◽  
Vol 9 (1-s) ◽  
pp. 505-509 ◽  
Author(s):  
Shaheen Sulthana ◽  
P. Pandian

In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Indole, Benzothiazole and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Indole, Benzothiazole and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. Hence, their extensive structural modification has result in different analogues of Indole and Benzothiazole derivatives depicting wide range of biological and pharmacological activities such as antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer. This review article literature survey summarizes the synthesis and pharmacological activities of Indole, Benzothiazole and its derivatives. Keywords: Indole, Benzothiazole, antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer



2021 ◽  
Vol 11 (4) ◽  
pp. 141-148
Author(s):  
Noman Anwar ◽  
N. Zaheer Ahmed ◽  
Shehnaz Begum

The current pandemic caused by SARS-CoV-2 has led to a massive change in every aspect of our lives. It has grossly affected the healthcare system, business and world trade, disruption of movement and supply of essential goods and has crippled the global economy. Although few vaccines have been approved for the control of disease, targeted therapy options for this virulent disease still remain limited and elusive. Exhaustive search for potent therapeutic candidate is in progress, for which herbal armory are also being explored. Medicinal plants and their products play a vital role in alleviating various diseases and have been reported to exhibit a wide range of biological activities. Plant-based drugs with antiviral, anti-inflammatory and immunomodulotry activities were hypothetically considered as potential drugs to prevent and mitigate the prevailing situation caused by SARS-CoV-2. Arq Ajīb ‘a Unani formulation’ presents compelling approach in treating numerous diseases. The ingredients of Arq Ajīb and their phytocompounds have been reported for wide-ranging pharmaco-biological activities including antiviral, anti-inflammatory, immunomodulotry, anti-allergic, antitussive and bronchodilatory activities. Scientific data available on the formulation ingredients and their phytocompounds indicates that the formulation may have a significant role in augmenting the immune status of individual, protecting them from infection and providing symptomatic relief to patients affected with COVID-19. Hence, it may be considered as a potential drug for the development of novel therapeutic candidate for SARS-CoV-2 infection. This multi-faceted review highlights the therapeutic significance and pharmacological actions of Arq Ajīb and its ingredients to demonstrate the plausible role of the formulation in combating COVID-19. Keywords: Arq Ajīb, COVID-19, Pudina, Ajwain, Camphor, Unani formulation



Author(s):  
Sunny Jalhan

In this review article data is collected regarding the various derivatives of coumarin and oxadiazole as both these have wide range of biological activities and they can be further modified to synthesize more effective and potent drugs. Coumarin class of organic compounds consists of 1,2-benzopyrone ring system as a basic parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and gamma benzopyrones; with coumarin class of compounds belonging to alpha-benzopyrones. Since the last few years, coumarins were synthesized in many of their derivative forms. Their pharmacological, therapeutic and biochemical properties depend upon their pattern of substitution. Coumarins exhibit a wide range of pharmacological activities, which includes anti-diabetic, anti-viral, anti-microbial, anticancer, anti-oxidant, anti-parasitic, anti-helminthic, anti-proliferative, anti-convulsant, anti-inflammatory and antihypertensive activities. 1,3,4-Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-membered ring. It is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogens (-N=). There are three known isomers: 1,2,4-oxadiazole, 1,2,3-oxadiazole and 1,2,5- oxadiazole. Oxadiazole moiety shows antimicrobial, anticancer and anti-inflammatory activity and suitably substituted 1,3,4-oxadiazole having biological activities like antimicrobial, anticancer and other biological activities.



Author(s):  
Hari Naik ◽  
Vijay Jadhav

Jatamansi has antioxidant and anti-inflammatory properties that you can count on to fight various health problems. It promotes hair growth, aids sleep, protects your liver, and lowers high blood pressure. Jatamansi improves learning and memory and eases depression and stress. This review article is summary of the benefits and therapeutic uses of this medicinal plant as in literature.



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