scholarly journals A Randomised Clinical Control Study to Evaluate the Efficacy of Shodhita Kuchla Powder (Purified Strychnos Nux-Vomica L.) and Brahmi Extract (Bacopa Monnieri L. Pennell) on Klaibya (Dhwajbhang) w.s.r. to Erectile Dysfunction

AYUSHDHARA ◽  
2021 ◽  
pp. 3511-3523
Author(s):  
Deepak Verma ◽  
Ashwini Kumar Sharma ◽  
Megha Shukla
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Activity ◽  
Laboratory Tests ◽  
Bacopa Monnieri ◽  
Initial Evaluation ◽  
Classical Text ◽  
Clinical Control ◽  
Group A ◽  
Group B ◽  
Control Study

Klaibya is defined in Ayurveda as the inability to achieve and maintain sufficient rigidity in the penis, which is essential for his sexual urges or the needs of his female partner during sexual activity. Chakrapani limits the concept of Klaibya to merely erectile dysfunction. Dhwajbhang, according to Acharya Sushruta, is a form of Klaibya caused by excessive coitus. The standard initial evaluation of a man experiencing ED is conducted in person and involves sexual, medical, and psychosocial histories, as well as laboratory tests comprehensive enough to identify comorbid diseases that may predispose the patient to ED and may contraindicate particular treatments. Properties of Ayurvedic drug; Kuchla (Strychnos nux-vomica) in classical text Rasatarangani as therapeutic of Klaibya (ED) and Brahmi (Bacopa monnieri) is well known Medhya drug that works on neuro- psychological disorders. The current study evaluated the effects of Kuchla and Brahmi on 36 erectile dysfunction patients, having 30 of them completing the trial. The patients were categorized into two parts: Group A administered an ED 250 capsule (Hypothetical) once a day (250mg) with milk, and Group B received a placebo once a day with milk HS for 30 days, followed by another 30 days.

scholarly journals AN OPEN LABELLED CLINICAL CONTROL STUDY TO EVALUATE THE EFFICA-CY OF VIDANGADI ARKA NASYA IN THE MANAGEMENT OF ARDHAVABHEDA-KA (MIGRAINE WITHOUT AURA)

2020 ◽  
Vol 8 (10) ◽  
pp. 4742-4747
Author(s):  
Jeeva P ◽  
Veerayya R Hiremath ◽  
Shashikala K ◽  
Gururaj N
Keyword(s):  
Repeated Measures ◽  
Migraine Without Aura ◽  
Signs And Symptoms ◽  
Treatment Modalities ◽  
Current Line ◽  
Clinical Control ◽  
Group A ◽  
Bonferroni Test ◽  
Group B ◽  
Control Study

Background and Objective: Ardhavabhedaka (migraine without aura) is characterized by severe tearing, pricking and piercing pain in one half of the head and giddiness which develops suddenly after ten days or a fortnight. Based on signs and symptoms it may correlate with migraine characterized by half sided head-ache associated with nausea, vomiting, photophobia and phonophobia. The current line of management for migraine advocates the use of analgesics and antiemetics, vasoconstrictors, sumatriptan, topiramate, flunar-izine, Propranolol. Ayurveda emphasizes various treatment modalities of Ardhavabhedaka, includes both Shodhana and Shamana. Vidangadi avapeedana Nasya and Vidangadi arka (distillate) Nasya have been mentioned for ardhavabhedaka chikitsa. Arka is the essence of the drug; possesses laghu, ushna, kaphavatahara, increased potency, more shelf life, easy absorption and act fast. Materials and Methods: 20 patients of Group A were treated with Vidangadi Arka Nasya and Group B 20 patients were treated with Vidangadi Avapeedana Nasya (each nostril 6 drops for 7 days). Results: The data of both the groups were collected according to the objective and subjective Parameters and analyzed using repeated measures of ANOVA, Bonferroni test, and Mann- Whitney U Test. The efficacy was statistically highly significant with-in the group at P <0.001and statistically insignificant between the group at P >0.05 among all the parame-ters. Interpretation and Conclusion: Study can be concluded that patients treated with Vidangadi Arka and Avapeedana Nasya showed not much difference in the results statistically, clinically group A showed better results than group B.

scholarly journals Evaluation of penile cavernosal artery intima-media thickness in patients with erectile dysfunction. A new parameter in the diagnosis of vascular erectile dysfunction. Our experience on 59 cases

2014 ◽  
Vol 86 (1) ◽  
pp. 9 ◽  
Author(s):  
Domenico Prezioso ◽  
Fabrizio Iacono ◽  
Umberto Russo ◽  
Giuseppe Romeo ◽  
Antonio Ruffo ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Carotid Artery ◽  
Doppler Ultrasound ◽  
Erectile Function ◽  
Color Doppler ◽  
Peak Systolic Velocity ◽  
Cavernosal Artery ◽  
Vascular Origin ◽  
Group A ◽  
Group B

Objective: A precise characterization of erectile dysfunction (ED) of vascular origin has not yet been achieved, although cavernous peak systolic velocity (PSV) is generally considered a major parameter. Nevertheless the penile dynamic color Doppler is invasive and linked to several complications. The intima-media thicknesses (IMT) of cavernosal artery would add to the predictive value of vasculogenic ED risk and outcomes. We also hypothesized the existence of a correlation between IMT cavernosal artery and IMT carotid arteries. This study seeks to evaluate these hypotheses with our experience, investigating the predictive accuracy of carotid and cavernosal Doppler ultrasound findings for discriminating patients with vasculogenic ED. Material and methods: A total of 59 subjects (32 vasculogenic ED patients - group A - and 27 no vasculogenic ED patients - group B) were evaluated in our andrological center from September 2012 to June 2013 and enrolled in the study. All subjects underwent medical history, erectile function domain of the International Index of Erectile Function, physical examination, routine and sex hormone blood tests, and high resolution dynamic color Doppler ultrasound evaluation of carotid and penile districts and valutation of IMT in both districts. Results: The values of cavernosal artery IMT in group A were higher than in group B (0,28 ± 0,06 mm vs 0,17 ± 0,07 mm). Even the values of carotid artery IMT in vasculogenic ED group were higher than in no vasculogenic ED group (0,74 ± 0,14 mm vs 0,59 ± 0,11 mm). The cavernosal IMT showed a moderate (r = 0.61) positive linear correlation (p &lt; 0.001) with the carotid artery IMT. Conclusions: An increased cavernous IMT might predict ED of vascular origin with more accuracy than PSV and could be a sensitive predictor also for systemic atherosclerosis at an earlier phase.

scholarly journals Analysis of Peripapillary and Macular Choroidal Thickness in Eyes with Pseudoexfoliative Glaucoma and Fellow Eyes

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Fan Li ◽  
Qingli Shang ◽  
Guangxian Tang ◽  
Hengli Zhang ◽  
Xiaowei Yan ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Enhanced Depth Imaging ◽  
Average Volume ◽  
Depth Imaging ◽  
Pseudoexfoliative Glaucoma ◽  
Group A ◽  
Imaging Optical Coherence Tomography ◽  
Group B ◽  
Control Study ◽  
Fellow Eyes

Purpose. To compare differences in peripapillary and macular choroidal thickness in pseudoexfoliative glaucoma (PXG) eyes, nonexfoliative fellow eyes, and normal eyes. Methods. This case-control study included 37 PXG patients (group A: 37 PXG eyes; group B: 37 nonexfoliative fellow eyes) and 37 sex-, age-, and axial length-matched healthy volunteer eyes (group C). Peripapillary and macular choroidal thickness and volume were measured in all subjects via enhanced-depth imaging-optical coherence tomography. Results. The average peripapillary (AP) choroidal thickness was (130.10 ± 46.14) μm, (131.43 ± 46.00) μm, and (147.89 ± 53.32) μm; average macular (AM) choroidal thickness was (191.72 ± 68.07) μm, (204.62 ± 69.54) μm, and (215.10 ± 45.40) μm; and average volume was (0.59 ± 0.21) μm3, (0.63 ± 0.21) μm3, and (0.65 ± 0.14) μm3 in groups A, B, and C, respectively. NIP choroidal thickness was significantly lower in groups A and B than in group C (P<0.05). TIM and TOM choroidal thickness and volume were significantly lower in group A than in group C (P<0.05). NIM, SIM, NOM, IOM, AM choroidal thickness and volume, and CSM choroidal thickness were significantly lower in group A than in group B (P<0.05). CSM, TIM, and TOM in group A and TIM, TOM choroidal thickness, and volume in group B were significantly lower than in group C (P<0.05). Conclusions. NIP choroidal thickness in PXG eyes and nonexfoliative fellow eyes and temporal macular choroidal thickness in PXG eyes were significantly lower than in normal eyes. Macular choroidal thickness (except in temporal regions) was significantly lower in PXG eyes than in nonexfoliative fellow eyes. Changes in peripapillary and macula choroidal thickness further elucidate the choroid’s role in PXG development and progression.

scholarly journals Low Iron Level is related to Telogen Effluvium in Women

2013 ◽  
Vol 21 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Md Manjurul Karim ◽  
Md Abdul Wahab ◽  
Lubna Khondoker ◽  
Md Shirajul Islam Khan
Keyword(s):  
Hair Loss ◽  
Control Group ◽  
Case Group ◽  
Iron Level ◽  
History Of ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Medical University ◽  
Control Study

A case-control study conducted in the Department of Dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University, Dhaka from July 2008- December 2010. A total 60 female patients of telogen effluvium attending in outpatient department (OPD) were enrolled in the study with 30 having hair loss considered as case (Group-A) and another 30 females had no history of hair loss were considered as control (Group-B). The study included 60 patients and the mean age were 25.4±7 years ranging from 18 to 42 years in group A and 24.8±5.6 years ranging from 17 to 36 years in group B. Maximum number was found in the age group of 21- 30 years in both groups and nearly three fourth (73.4%) patients were unmarried in group A and 18(60.0%) in group B. Most of the patients were student in both groups, which were 21(70.0%) and 17(56.7%) in group A and group B respectively and majority of the the patients were HSC level in both groups, 15(50.0%) and 14(46.7%) in Group A and Group B respectively. Most of the patients came from middle class, which were 20(66.7%) and 16(53.3%) in group A and group B respectively. The mean serum ferritin were 18.8±8.1 g/L ranging from 4.5 to 36.54 g/L and 36.6±9.9 mg/L ranging from 18.46 to 56.3 mg/ L in group A and group B respectively. The mean Hb level was 11.5±1.4 gm/dl ranging from 8.5 to 14.0 gm/dl in group A and 12.8±1.1 gm/dl ranging from 10.5 to 14.5 gm/dl in group B. The mean difference of Hb level was statistically significant (p<0.05) between two groups in unpaired t-test. It can be concluded that low iron level is associated with telogen effluvium in women. DOI: http://dx.doi.org/10.3329/bjmed.v21i2.13617 Bangladesh J Medicine 2010; 21: 84-89

Combination Therapy Of Tadalafil And Pentoxifylline In Severe Erectile Dysfunction; A Prospective Randomized Trial

2015 ◽  
Vol 87 (8) ◽  
Author(s):  
Santosh Kumar ◽  
Rajesh Roat ◽  
Swati Agrawal ◽  
Kumar Jayant ◽  
Ravimohan S. Mavuduru ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Combination Therapy ◽  
Erectile Function ◽  
T Test ◽  
P Value ◽  
Chi Square ◽  
Significant Difference ◽  
Chi Square Test ◽  
Group A ◽  
Group B

Abstractwas to assess efficacy of Tadalafil alone versus Tadalafil plus Pentoxifylline in the treatment of erectile dysfunction by using self administered IIEF-5 questionnaire.Two hundred and thirty seven patients presenting with ED at andrology OPD were evaluated for ED by a self administered IIEF (International Index of Erectile Function) questionnaire. Patients were systematically randomized by computer generated random table into two groups groups namely, group A: Tadalafil only group, group B: combination of Tadalafil + Pentoxifyl-line. All the patients were re-assessed by IIEF-5 questionnaire after 8 weeks of medical therapy. Statistical analysis was performed using student’s unpaired t-test, paired t-test, chi square test. p-value < 0.05 was considered statistically significant.Two hundred and thirty seven patients were included in the present study, in group A: 92 patients (78.6%) showed improvement in their IIEF score after 8 weeks of tadalafil treatment. While in group B, overall 104 patients(86.6%) showed improvement after combination of Tadalafil and Pentoxifylline. There was a statistically significant difference of percentage change in IIEF score was seen in group B (group A 90.7±15.2%, group B 95.6±13.4%; p value – 0.014). We found this difference even more statistically significant in patients with severe ED (group A 72.7±47.2%, group B 132.3±54.3%; p value – 0.000). There was no significant difference in between the two groups with regards to occur-rence of side effects.Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.

scholarly journals Isoflavone in Postmenopausal Women - Are They Really Effective? A Prospective Case Control Study.

2013 ◽  
Vol 7 (1) ◽  
pp. 11-14 ◽  
Author(s):  
TS Bag ◽  
Amit Kyal ◽  
DP Saha ◽  
R Dutta ◽  
S Mondal
Keyword(s):  
Blood Pressure ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Menopausal Symptoms ◽  
Kupperman Index ◽  
Group A ◽  
Group B ◽  
Control Study ◽  
Prospective Case Control Study

A prospective case control study was conducted at Medical College, Kolkata with the aim of evaluating the role of isoflavone( a class of phytoestrogen –plant compounds having the beneficial effects of estrogen but lesser risks and side effects) in postmenopausal women. 100 postmenopausal women (those who underwent total abdominal hysterectomy and bilateral salpingooopherectomy for different benign indications, aged between 40-50 years and who were menstruating before operation) were alternately distributed into two groups-Group A (n=50, received 60mg of isoflavone and 500mg of calcium per day for 6 months) and Group B (n=50, received 500mg of calcium per day only for 6 months). To evaluate the menopausal symptoms, the menopausal Kupperman index questionnaire was applied. Other outcomes measured were body mass index, blood pressure and lipid profile. Menopausal symptoms in Group A(those using isoflavones) were lower compared to Group B. The present study showed that Kupperman index decreased significantly in Group A (from 28.48 ± 2.03 to 16.32 ± 1.06 i.e. 45% decline) compared to Group B (from 24.56 ± 1.52 to 18.44 ± 1.11 i.e. 25% decline). No differences in blood pressure or body mass index were found during treatment between the two groups. . In our study total cholesterol, triglycerides and low-density lipoproteins (LDL) decreased significantly in Group A compared to Group B. Therefore our clinical study indicates that isoflavone can be an invaluable resource for postmenopausal women for combating menopausal symptoms. Nepal Journal of Obstetrics and Gynaecology / Vol 7 / No. 1 / Issue 13 / Jan- June, 2012 / 11-14 DOI: http://dx.doi.org/10.3126/njog.v7i1.8826

scholarly journals Shortened versus standard post-partum maintenance therapy of magnesium sulphate in severe pre-eclampsia: a randomised control trial

2020 ◽  
Vol 9 (4) ◽  
pp. 1646
Author(s):  
Idowu B. Orisabinone ◽  
Uche Onwudiegwu ◽  
Adebanjo B. Adeyemi ◽  
Chibuzor P. Oriji ◽  
Olakunle I. Makinde
Keyword(s):  
Magnesium Sulphate ◽  
Maintenance Dose ◽  
Post Partum ◽  
University Teaching ◽  
Randomised Control Trial ◽  
Loading Dose ◽  
Cell Dysfunction ◽  
Group A ◽  
Group B ◽  
Control Study

Background: Pre-eclampsia is a pregnancy-associated multi-organ disorder caused by altered trophoblastic invasion and endothelial cell dysfunction. It is associated with significant maternal and perinatal morbidity and mortality, especially in developing countries. Magnesium sulphate (MgSO4) is effective in the management of severe pre-eclampsia/eclampsia. Objective of this study was to compare the effectiveness of a shortened course of MgSO4 to the Pritchard regimen in patients with severe pre-eclampsiaMethods: This study was carried out at the obstetrics and gynecology department of the Obafemi Awolowo University Teaching Hospital, Ile-Ife. It was a randomised control study of 116 patients, 58 in each group. Group A received the standard Pritchard regimen: a loading dose of MgSO4 4g slow IV bolus plus 10 g IM (5 g in each buttock), followed by maintenance dose of 5g MgSO4 IM 4-hourly into alternate buttocks until 24 hours after delivery. Group B received same loading dose, but the maintenance dose was limited to three doses of 5g MgSO4 IM four hours apart after delivery. In both regimens, 2g MgSO4 was given IV for breakthrough fit. Data were analyzed using SPSS version 20.Results: This study revealed that twelve-hour postpartum MgSO4 was as effective as the Pritchard regime with no statistically difference in occurrence of seizures (X2 = 0.341, df = 1, p = 0.514). The average total dose of magnesium sulphate used was lower in the study Group B.Conclusions: Twelve-hour postpartum MgSO4 is as effective as the standard 24-hour Pritchard regime.

Clinical Factors in Trunk Capillary Malformations in the Neonate: When to Suspect Other Associated Malformations? A Case–Control Study

2019 ◽  
Vol 30 (01) ◽  
pp. 122-126
Author(s):  
Carlos Delgado-Miguel ◽  
Miriam Vicente ◽  
Antonio Jesus Serrano-Muñoz ◽  
Miriam Miguel-Ferrero ◽  
Mercedes Diaz ◽  
...  
Keyword(s):  
Case Control Study ◽  
Vascular Malformations ◽  
Venous Malformation ◽  
Clinical History ◽  
Case Control ◽  
Gender And Age ◽  
Group A ◽  
Associated Malformations ◽  
Group B ◽  
Control Study

Abstract Introduction Capillary malformations (CMs) can be sporadic or syndromic, in association with other underlying venous malformation (VM) or lymphatic malformation (LM). The objective of this study is to describe the clinical patterns in the neonate that allow us to differentiate sporadic CMs from those associated with other vascular malformations. Materials and Methods A case–control study was performed in neonates with CM located in the trunk, followed at our institution between 2008 and 2018. The patients were divided into two groups: group A (cases: CM associated with VM or LM) and group B (controls: sporadic CM without associated malformations). Demographic and clinical variables collected in the clinical history were evaluated (color, location, multifocality, bilaterality, position regarding the vascular axis, and involvement of the midline). Results Thirty-eight patients were included (18 cases and 20 controls) without differences in gender and age. In group A, the totality of patients presented CM with uniform color and lateral location (p < 0.001). In this group, bilateral and multifocal involvements were lower than in group B, without significant differences between both groups. The distribution of CMs in group A was always parallel to the vascular axis and the midline was always respected, without observing these characteristics in the group B (p < 0.001). Conclusion The presence of a CM in the trunk of a neonate with uniform color, lateral location, parallel position to the vascular axis, and absence of involvement of the midline should make us suspect other underlying vascular malformations, which should be studied with complementary tests.

scholarly journals Nonsurgical Periodontal Therapy decreases the Severity of Rheumatoid Arthritis: A Case–control Study

2016 ◽  
Vol 17 (6) ◽  
pp. 484-488 ◽  
Author(s):  
Neha Khare ◽  
Bhavuk Vanza ◽  
Deepak Sagar ◽  
Kumar Saurav ◽  
Rohit Chauhan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oral Hygiene ◽  
Case Control Study ◽  
Case Control ◽  
Periodontal Therapy ◽  
Clinical Observations ◽  
Nonsurgical Periodontal Therapy ◽  
Group A ◽  
Group B ◽  
Control Study

ABSTRACT Introduction Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory conditions. Several studies suggested a relationship between RA and periodontitis. Recent studies have shown a beneficial effect of periodontal treatment on the severity of active RA. So the aim of this study was to examine the effect of nonsurgical periodontal therapy on the clinical parameters of RA. Materials and methods A total of 60 subjects with moderateto- severe chronic generalized periodontitis and active RA in the age range 18 to 65 were selected for the study. They were divided into two groups. Group A (control group) consisted of 30 subjects with chronic generalized periodontitis and RA, and group B of 30 subjects with chronic generalized periodontitis and RA and they received nonsurgical periodontal therapy (scaling, root planning, and oral hygiene instructions). Evaluation of clinical observations of Simplified Oral Hygiene Index (OHI-S), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), number of swollen joints (SJ), number of tender joints (TJ), values of erythrocyte sedimentation rate (ESR), visual analogue scale (VAS) for patient's global assessment, 3 months disease activity score (DAS) index, and C-reactive protein (CRP) was done at baseline and 3 months. Statistical evaluation of clinical observations was carried out. Results Group B subjects who received nonsurgical periodontal therapy showed statistically significant improvement in all periodontal and RA parameters at 3 months, compared with group A who did not receive periodontal therapy. Conclusion It can be concluded from the result that nonsurgical periodontal therapy may contribute to reduction in severity and symptoms of RA. Clinical significance Rheumatoid arthritis patients should be evaluated for periodontitis and treated for the same in order to reduce its severity level. How to cite this article Khare N, Vanza B, Sagar D, Saurav K, Chauhan R, Mishra S. Nonsurgical Periodontal Therapy decreases the Severity of Rheumatoid Arthritis: A Case–control Study. J Contemp Dent Pract 2016;17(6):484-488.

scholarly journals Effect of Low-Energy Shockwave Therapy Versus Platelets Rich Plasma Therapy in Patients with Erectile Dysfunction

2021 ◽  
pp. 168-172
Author(s):  
Kumail Sajjad ◽  
Muhammad Sohail ◽  
Hafiz Abdul Momin ◽  
Raja Asim Shafique ◽  
Muhammad Nazir ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Platelet Rich Plasma ◽  
Self Esteem ◽  
Low Energy ◽  
Plasma Therapy ◽  
Shockwave Therapy ◽  
Group A ◽  
Group B ◽  
Near Future ◽  
Phosphodiesterase 5

Phosphodiesterase 5 inhibitors (PDE5Is) and low-energy shock wave therapy (LESWT) have created a revolution in the treatment of erectile dysfunction (ED).  However, they are not able to restore the actual changes in the penis. An emerging new therapy called platelet-rich plasma (PRP) is believed to be more beneficial in treating ED.  The objective of this study is to evaluate and compare the efficacy of LESWT and PRP in treating ED. A total of sixty participants of pathological ED was included in the study and divided into two groups. Group A received the LESWT, whereas Group B received the PRP. The benefits were measured by the International Index of Erectile Function (IIEF), an erection hardness score (EHS) and Self-Esteem And Relationship (SEAR) questionnaires. The results of this analysis demonstrated a larger effect in treatment group B in percentage terms, but there were no statistical differences in the two groups. In the near future, PCP may be a new modality for treating ED, especially PDE5I non-respondents with organic ED. However, more extensive preclinical and applied research needs to be conducted.

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