scholarly journals A RANDOMIZED CONTROLLED CLINICAL STUDY OF CHANDRASHOORPAYAS (GARDEN CRESS SEED PORRIDGE) AS DIETARY SUPPLEMENT FOR LACTATING MOTHERS

2020 ◽  
pp. 61-69
Author(s):  
Medha S.Kulkarni ◽  
Shital Pise
Keyword(s):  
Dietary Supplement ◽  
Control Group ◽  
Garden Cress ◽  
Lactating Mothers ◽  
Nursing Mothers ◽  
Safety Parameters ◽  
Cress Seed ◽  
Infant Weight Gain

In India many dietary supplements are given to lactating mothers for sustained and ample milk to nourish their baby. Chandrashoora Payas (Garden cress seeds porridge) is one such recipe given to nursing mothers to increase lactation. Objective: This study is planned to assess the role of Chandrashoor Payas as a dietary supplement in lactation deficiency (Stanyakshaya), taking control group of Shatavari Powder and milk to ascertain which is better. Shatavari powder is taken as a control group since it is a clinically proven galactagogue medicine in Ayurveda. Material and Methods: Total 64 lactating mothers diagnosed with lactation deficiency were screened for clinical trial, out of which 60 patients fulfilled the inclusion criteria and included in the trial. Selected patients were divided randomly in two groups by a simple random method. Study group was administered Chandrashoora Payas 100ml in morning; and the control group was with 5gm Shatavari powder with 100ml milk for 45 days. Follow up visit was on every 15th day. Estimation of milk production and infant weight gain were assessed by comparing difference in grades. Observations and Results: Study revealed that both Chandrashoorapayas and Shatavari and milk produced significant improvement p< 0.001 in most of the variables and were comparable in reliving all the symptoms of lactation deficiency. On comparison both the drugs show similar effect. Conclusion: No adverse effects were observed in the trial group, as safety parameters were within normal limit during the study and overall compliance to the treatment was good. Both the interventions were comprehensively effective in management of lack of lactation. Chandrashoorapayas is a dietary supplement which gives similar results as Shatvari which is a medicine.

A Group-Based Walking Study to Enhance Physical Activity Among Older Adults: The Role of Social Engagement

2020 ◽  
pp. 016402752096361
Author(s):  
Yujun Liu ◽  
Margie E. Lachman
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Social Engagement ◽  
Treatment Condition ◽  
Social Comparisons ◽  
Text Messages ◽  
Control Group ◽  
Group Members

Objectives. The aim of this study was to explore social engagement and social comparisons as mechanisms to increase physical activity among older adults. Methods. Participants (N = 60, mean age = 65.7) were randomly assigned to one of two conditions. Participants in the treatment condition used the application to track their daily walking steps and interact via text messages with their group members for 4 weeks. Participants in the control group used the application only to track their own walking steps. Outcome variables included mean weekly steps, exercise self-efficacy, and social engagement. Results. The results revealed that participants in the experimental condition significantly increased their mean weekly steps and social engagement from the pretest to the posttest whereas the control group did not. These effects were maintained at the 1-month follow up. Discussion. The study expands our understanding of the motivational role of social engagement and social comparison in increasing PA among older adults.

Short term chronic toxicity of tributyltin on the testes of adult albino rats and the possible protective role of omega-3

2020 ◽  
pp. 096032712094745
Author(s):  
Marwa G Ahmed ◽  
Mona El-Demerdash Ibrahim ◽  
Hoda R El Sayed ◽  
Samah M Ahmed
Keyword(s):  
Treated Group ◽  
Toxic Effects ◽  
Cellular Damage ◽  
Antioxidant Defenses ◽  
Control Group ◽  
Albino Rats ◽  
Omega 3 ◽  
Group I

The declining rate of male fertility is a growing concern. Tributyltin (TBT) is a well-known endocrine disruptor (ED), that induces imposex in female gastropods and is widely used in various industrial applications. The aim of this study was to evaluate the toxic effects of TBT on the testes of adult albino rats and the possible role of omega-3. Forty two adult male albino rats were divided into five groups; control group (Group I) and four experimental groups: omega-3 treated group, TBT treated group, TBT & omega-3 treated group and follow up group. At the end of the study, the rats were subjected to biochemical, histological, immunohistochemical staining for Ki-67 and seminal examinations. Our results clarfied that TBT induced a significant decrease in testosterone, FSH, LH and serum glutathione peroxidase levels and a significant increase in the serum Malondialdehyde as compared to the control group. Tributyltin induced disorganization and shrinkage of seminiferous tubules, apoptosis, cellular damage and marked reduction in the germinal epithelium. A significant decrease in the cell proliferation and arrested spermatogenesis were also detected. Seminal analysis of TBT group showed a significant affection of all parameters as compared to other groups. Omega-3 ameliorated all of these hazardous effects. Follow up group still showed toxic effects. In conclusion, TBT has a toxic effect on the testis. Increased testicular oxidative stress, cellular damage and arrest of spermatogenesis with attenuation in antioxidant defenses are all contributing factors. Omega-3 can protect against TBT induced reproductive toxicity.

The Role of Allopurinol in Digital Replantation

1999 ◽  
Vol 24 (3) ◽  
pp. 325-327 ◽  
Author(s):  
S. WAIKAKUL ◽  
A. UNNANANTANA ◽  
V. VANADURONGWAN
Keyword(s):  
Proximal Phalanx ◽  
Control Group ◽  
Clinical Effects ◽  
Trial Group ◽  
Standard Management ◽  
Lower Infection ◽  
Group Recovery ◽  
Lower Infection Rate

The clinical effects of allopurinol on the attenuation of reperfusion injury in thumb replantations after prolonged ischaemic time were studied in a randomized control trial with a 2-year follow-up. There were 60 patients, in the trial group, and 38 patients in the control group. All were young, healthy labourers who had sharp or locally crushed amputations of the thumb at the proximal phalanx with a total ischaemic time of more than 10 hours. The standard management for thumb replantation was used in these patients, except that 300 mg allopurinol was given orally in the trial group on admission and a further 300 mg for another 5 days. After operation, the trial group had a lower infection rate, and less postoperative pain and chronic swelling than the control group. Recovery of sensation was also better in the trial group.

scholarly journals The role of left atrial strain in patients with functional tricuspid regurgitation before and after annuloplasty: a long-term follow-up study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Qing-long Meng ◽  
Hong Meng ◽  
Jia Tao ◽  
Shu Yang ◽  
Hao Wang
Keyword(s):  
Tricuspid Regurgitation ◽  
Mitral Stenosis ◽  
Left Atrial ◽  
Pearson Correlation ◽  
Characteristic Curve ◽  
Control Group ◽  
Rheumatic Mitral Stenosis ◽  
Functional Tricuspid Regurgitation

Abstract Background Functional tricuspid regurgitation (TR) is common among patients with left heart disease and may recur during the follow-up period after selective tricuspid valve annuloplasty (TVA). This study aims to analyse the relationship between left atrial (LA) strain and the degree of preoperative functional TR and to explore the role of LA strain in predicting TR recurrence. Methods This study included 63 patients with rheumatic mitral stenosis who underwent mitral valve replacement and concomitant TVA. Additionally, 20 healthy controls were enrolled. Preoperative conventional LA echocardiographic parameters and LA strain were measured. The association between LA strain and preoperative functional TR severity was analysed by Pearson correlation. Predictors of recurrent TR were determined by multivariate logistic regression analyses. Results Compared with the control group, the mitral stenosis group developed a significant impairment in terms of LA strain. The degree of preoperative functional TR exhibited moderate correlations with LA reservoir strain (r = − 0.57) and LA conduit strain (r = 0.48). During a median follow-up period of 66.4 ± 36.4 months, TR recurred in 18 patients. Preoperative LA reservoir strain and the mean transmitral gradient were predictors of postoperative TR recurrence. When the two indexes were combined to establish a prediction, the sensitivity and specificity of prediction increased. The area under the receiver operating characteristic curve of the combined indicator was higher than those of the single indicators (0.90 vs. 0.70 and 0.72). Conclusions LA strain correlates with preoperative functional TR severity in patients with rheumatic mitral stenosis. The LA reservoir strain and preoperative mean transmitral gradient are independent predictive factors for recurrent TR after TVA.

scholarly journals The role of ablation index-guided pulmonary vein isolation in high-sensitivity TrThe role of ablation index-guided pulmonary vein isolation in high-sensitivoponin I and atrial fibrillation recurrence

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
D De Campos ◽  
L Puga ◽  
P Sousa ◽  
N Antonio ◽  
L Elvas
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Contact Force ◽  
High Sensitivity ◽  
Left Ventricular Ejection ◽  
Control Group ◽  
Ablation Index

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Ablation Index (AI) software has been associated with better freedom from atrial arrhythmias after pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF). There is conflicting data regarding the relationship between high sensitivity cardiac Troponin I (Hs-cTnI) and arrhythmia recurrence. The objective was to evaluate the impact of AI on Hs-cTnI level and on ablation effectiveness quotient (AEQ) and to assess if these markers are predictors of arrhythmia recurrence.  Methods Prospective observational study of consecutive patients referred for PVI for paroxysmal AF ablation from October 2017 to June 2018 according to a pre-specified AI protocol. Procedural endpoints and 2-year follow-up outcomes were assessed and compared to a retrospective cohort of conventional PVI contact-force-guided group .  Results A total of 56 patients were included: 29 patients the AI group and 27 patients in the control group. The mean age was 60.5 ± 10.3 years, 48% males. Left ventricular ejection fraction (60 ± 6 % AI vs 61 ± 5 % control, P = 0.07) and left atrium diameter (43 ± 7 mm AI vs 44 ± 6 mm control, P = 0.58) were comparable between groups. First-pass isolation was shown to be higher in the AI group (79% AI vs 44%, p= 0.01). Mean number of radiofrequency applications was lower in the AI group (93 ± 24 vs 111 ± 30, P = 0.02). Average contact-force was similar between groups (17.6 ± 4.1 g vs 22.6 ± 10.7 g, P =0.166). Patients that performed PVI guided by the AI had lower Hs-cTnI (1815 ± 1146 ng/L vs 3274 ± 1696 ng/L, p &lt; 0.001) and lower AEQ (1.01 ± 0.7 ng/L/s vs 1.51 ± 0.7 ng/L/s, P = 0.011) compared to patients in the control group. During a mean follow-up of 26 ± 11 months, AF recurrence was documented in 10.3% of patients in the AI group and 22.2% in the control group (P = 0.223). Neither Hs-cTnI nor AEQ levels were predictors of arrhythmia recurrence.  Conclusions These data suggest that AI-guided catheter ablation is associated with reduced levels of of Hs-cTnI and AEQ. Neither Hs-cTnI and AEQ should be used to predict arrhythmia recurrence. Abstract Figure.

scholarly journals The role of the trainer in adapted physical activity for osteoporosis to improve quality of life

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Marini ◽  
A Masini ◽  
P Maietta Latessa ◽  
T Sanna ◽  
A Raggi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Control Group ◽  
Improve Quality ◽  
Adapted Physical Activity ◽  
Structured Interviews ◽  
Substantial Impact

Abstract Background Osteoporosis is a major health burden worldwide and require a multi-modal approach including exercise. Fractures have a substantial impact on quality of life (QoL) so exercise programs may to be conducted by trainers able to deal with this condition, because exercise alone, even if in the right dosage, seems to be not enough to improve QoL. A quasi-experimental pilot study performed to determine the feasibility and safety of an Adapted Physical Activity (APA) protocol specifically designed for osteoporotic women with vertebral fractures and its effect on QoL, with a specific focus on trainer's role. Methods The Experimental Group (EG) performed APA protocol 1hour twice a week for 6 months, while the Control Group (CG) received standard care. QoL was assessed at baseline and follow-up with ECOS-16 questionnaire and semi structured interviews to understand women perceptions regarding trainer's role. Using mixed-methods quantitative and qualitative data were analyzed using SPSS 5 and NVivo 12, respectively. Results 40 post-menopausal women (mean age: 67.6±4.6) divided in 2 groups EG = 22 and CG = 18, completed the study. At follow-up, EG improved significantly QoL (EG: -0.5±0.5 vs CG: 0.0±0.3 p = 0.02). The APA intervention had a significant effect on all the components of QoL, as measured by the disease-specific ECOS-16 questionnaire: Physical Component Summary (PCS) (EG: -0.4±0.5 vs CG: 0.0±0.4 p = 0.06) and Mental Component Summary (MCS) (EG: -0.5±0.6 vs CG: 0.1±0.5 p = 0.02). The interviews confirmed this result, emphasizing the key role of the trainer in improving their QoL. The adherence calculated as number of sessions performed compared to the sessions proposed was 75.8%. No injuries were observed. Conclusions The feasibility, the safety, and the positive effect of the proposed exercise protocol on QoL confirmed also by the interviews, show that principles of exercise education applied by trainers should be extended also to patients with other chronic condition. Key messages Trainers specifically educated, could be a means of achieving the goal improving people’s QoL, as they occupy the role of exercise experts and also an educational, relational and support role. The management of osteoporosis is multi-modal and includes exercise, often recommended as a beneficial non-pharmacological treatment to slow the rate of bone loss and improve quality of life.

scholarly journals Fractional Exhaled Nitric Oxide Measurement in Pulmonary Hypertension: A Follow-Up Study

2017 ◽  
Vol 24 (3) ◽  
pp. 483-488 ◽  
Author(s):  
Nilay Orak Akbay ◽  
Zuleyha Bingol ◽  
Esen Kiyan ◽  
Ekrem Bilal Karaayvaz ◽  
Ahmet Kaya Bilge ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Pulmonary Function Tests ◽  
Exhaled Nitric Oxide ◽  
World Health ◽  
Control Group ◽  
Healthy Controls ◽  
Fractional Exhaled Nitric Oxide

Pulmonary hypertension (PH) is a fatal disease although significant improvements in treatment are achieved. Easily implemented and noninvasive prognostic techniques are needed while following-up these patients. The aim was to investigate the role of fractional exhaled nitric oxide (FeNO) in follow-up for patients with PH. In this longitudinal study, patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH) who were seen in PH Outpatient Clinic, Istanbul Faculty of Medicine, Istanbul University, were enrolled in the study. Echocardiography, 6-minute walking test, brain natriuretic peptide, and FeNO measurements were performed, and World Health Organization functional class was evaluated to all patients at baseline, and third, and sixth months. Right-heart catheterization and pulmonary function tests at the time of diagnosis were recorded. The study comprised 31 patients (23 women, 8 men; mean age: 53.4 ± 17.1 years) with PAH (n = 19) and CTEPH (n = 12) and 80 healthy controls. Patients with PH had lower FeNO values than the control group (16.5 ppb vs 19.8 ppb; P < .05). Fractional exhaled nitric oxide values did not change during follow-up and did not correlate with other follow-up measures except tricuspid annular plane systolic excursion values. Fractional exhaled nitric oxide was higher in the idiopathic PAH subgroup at baseline and at third month than patients with PAH associated with other diseases. Fractional exhaled nitric oxide did not change in patients who had clinical deterioration. As a conclusion; Patients with PH had lower FeNO values than healthy controls, but FeNO did not change significantly during follow-up. Large-scale studies with prolonged follow-up periods are needed to understand the role of FeNO in the follow-up of the patients with PH.

Role of Ultrahigh Frequency Ultrasound in Evaluating Experimental Flaps

2020 ◽  
Author(s):  
Stefan Morarasu ◽  
Nicolae Ghetu ◽  
Corneliu George Coman ◽  
Bianca Codrina Morarasu ◽  
Daniel Boicu ◽  
...  
Keyword(s):  
Histological Analysis ◽  
Ultrasound Contrast Agents ◽  
Ultrahigh Frequency ◽  
Control Group ◽  
Groin Flap ◽  
Flap Viability ◽  
Group B ◽  
Frequency Ultrasound

Abstract Background Experimental flap follow-up needs faster, safer, and less invasive techniques that can be easily correlated to clinical procedures. For this reason, we aimed to test the role of ultrahigh frequency ultrasound in follow-up of flap viability. Further on, we aimed to analyze if the chimeric groin flap can be mobilized in a sandwiched position without affecting its vascular supply by twisting its pedicle. Methods A total of 12 male Wistar rats, split into three groups, were used. Group A (n = 4) had the chimeric groin flap repositioned in a sandwich position on the anterior abdominal wall and underwent ultrahigh frequency ultrasound follow-up at days 10 and 14. Group B (n = 4) also had the flaps sandwiched, however, at day 14 the vascularity of flaps was proven by infusion of nontargeted ultrasound contrast agents, after which flaps were sent for histological analysis. Group C (C1 n = 2, C2 n = 2) was the control group. In C1 the chimeric groin flap was harvested and sent for histology on day 0, acting as a histological benchmark of flap viability, and in C2 the chimeric groin flap was re-sutured in its anatomical position and after 14 days, flaps were harvested and sent for histological analysis, acting as a direct control for Group B. Results Ultrasound showed constant vascular flow in both adipose and skin flaps in the sandwiched position. Microbubble study showed diffuse perfusion within flaps. Ultrasound measurements of flow velocity, flap volume, and percentage of vascularity showed a decrease in flap volume and increase in vascularity over 14 days. Histology showed similar viability in both groups. Conclusion Ultrahigh frequency ultrasound may be a valuable tool for postoperative flap assessment, while the chimeric flap can be moved freely in a sandwich position making it suitable for adding tissue substitutes within its components.

scholarly journals To Study the Role of Zinc Supplementation on Growth of Low Birth Weight Infants

2014 ◽  
Vol 1 (1) ◽  
pp. 25
Author(s):  
Ravindra Sonawane ◽  
Suhas Patil ◽  
Lalit Gulati ◽  
Sagar Sonawane
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Head Circumference ◽  
Zinc Supplementation ◽  
Controlled Trial ◽  
Control Group ◽  
Low Birth Weight Infants ◽  
Length Gain

This was a randomized controlled trial undertaken to study the role of zinc supplementation on growth of low birth weight infants (b.wt≤2500 gm). Out of 120 LBW infants, 23 were excluded due to loss of follow up. The remaining 97 LBW eligible neonates were randomized in to 2 group (zinc &amp; control group), zinc group were given zinc supplementation at a dose of 2 mg/kg/day for 8 weeks from enrollment. They were then followed up every 4 weeks up to 8 weeks. At each visit, detail anthropometry including e weight, length, and head circumference were recorded at each visit. The infants in the zinc group had significantly higher weight gain (p&lt;0.000), length gain (p&lt;0.000), linear growth velocity and head circumference at 8 weeks. We concluded that zinc supplementation at 2 mg/kg/day for 8 weeks in LBW infants improves their growth during infancy.

scholarly journals ROLE OF KARPASABEEJA CHURNA IN THE TREATMENT OF STANYAKSHAYA - A PILOT STUDY

2020 ◽  
Vol 8 (9) ◽  
pp. 4310-4316
Author(s):  
Rajni Kanojiya ◽  
Shreyes. S ◽  
Yogitha Bali M.R
Keyword(s):  
Pilot Study ◽  
Breast Feeding ◽  
Eligibility Criteria ◽  
Health And Wellbeing ◽  
Lactating Mothers ◽  
The Common ◽  
Lukewarm Water ◽  
Normal Neonate

Background: Stanyakshaya is the common problem noticed in about 40% patients in our clinical practice. Due to adaptation of Western culture, women get exposed to stress and strain. Lactation is the process as-sociated with psychosomatic condition and lifestyle. Breast milk is the perfect food for a normal neonate. It is the best gift a mother can give her baby. Breast feeding is the ideal form of infant feeding and is cru-cial for lifelong health and wellbeing. Design: This was a single pilot study. 10 patients(lactating mothers, both primi and multi gravida) who ful-filled the eligibility criteria were selected for the study and the assessments were made before the treatment on the 1st day and after the treatment on the 30th day and follow up was done on 20th day after the comple-tion of treatment. Intervention: Karpasabeejachurna (6gms) was administered with lukewarm water as the Anupana after food twice a day for one month and follow up carried out on 20th day after the completion of treatment. Results: Karpasabeejachurna showed statistically significant results in the Stanamlanata, Stana/milk ejec-tion, breast feeding, weight of the baby and breast engorgement with p<0.001. Conclusion: Karpasabeejachoorna showed to be effective in increasing the Stanya and it is a Stan-yajanakadravya.

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