scholarly journals ROLE OF KARPASABEEJA CHURNA IN THE TREATMENT OF STANYAKSHAYA - A PILOT STUDY

2020 ◽  
Vol 8 (9) ◽  
pp. 4310-4316
Author(s):  
Rajni Kanojiya ◽  
Shreyes. S ◽  
Yogitha Bali M.R
Keyword(s):  
Pilot Study ◽  
Breast Feeding ◽  
Eligibility Criteria ◽  
Health And Wellbeing ◽  
Lactating Mothers ◽  
The Common ◽  
Lukewarm Water ◽  
Normal Neonate

Background: Stanyakshaya is the common problem noticed in about 40% patients in our clinical practice. Due to adaptation of Western culture, women get exposed to stress and strain. Lactation is the process as-sociated with psychosomatic condition and lifestyle. Breast milk is the perfect food for a normal neonate. It is the best gift a mother can give her baby. Breast feeding is the ideal form of infant feeding and is cru-cial for lifelong health and wellbeing. Design: This was a single pilot study. 10 patients(lactating mothers, both primi and multi gravida) who ful-filled the eligibility criteria were selected for the study and the assessments were made before the treatment on the 1st day and after the treatment on the 30th day and follow up was done on 20th day after the comple-tion of treatment. Intervention: Karpasabeejachurna (6gms) was administered with lukewarm water as the Anupana after food twice a day for one month and follow up carried out on 20th day after the completion of treatment. Results: Karpasabeejachurna showed statistically significant results in the Stanamlanata, Stana/milk ejec-tion, breast feeding, weight of the baby and breast engorgement with p<0.001. Conclusion: Karpasabeejachoorna showed to be effective in increasing the Stanya and it is a Stan-yajanakadravya.

Short-Term Ultramicronized Palmitoylethanolamide Therapy in Patients with Myasthenia Gravis: a Pilot Study to Possible Future Implications of Treatment

2019 ◽  
Vol 18 (3) ◽  
pp. 232-238 ◽  
Author(s):  
Emanuela Onesti ◽  
Vittorio Frasca ◽  
Marco Ceccanti ◽  
Giorgio Tartaglia ◽  
Maria Cristina Gori ◽  
...  
Keyword(s):  
Pilot Study ◽  
Myasthenia Gravis ◽  
Repetitive Nerve Stimulation ◽  
Beneficial Effects ◽  
Antibody Titers ◽  
The Stability ◽  
Ultramicronized Palmitoylethanolamide ◽  
Open Pilot

Background: The cannabinoid system may be involved in the humoral mechanisms at the neuromuscular junction. Ultramicronized-palmitoylethanolamide (μm-PEA) has recently been shown to reduce the desensitization of Acetylcholine (ACh)-evoked currents in denervated patients modifying the stability of ACh receptor (AChR) function. <p> Objective: To analyze the possible beneficial effects of μm-PEA in patients with myasthenia gravis (MG) on muscular fatigue and neurophysiological changes. <p> Method: The duration of this open pilot study, which included an intra-individual control, was three weeks. Each patient was assigned to a 1-week treatment period with μm-PEA 600 mg twice a day. A neurophysiological examination based on repetitive nerve stimulation (RNS) of the masseteric and the axillary nerves was performed, and the quantitative MG (QMG) score was calculated in 22 MG patients every week in a three-week follow-up period. AChR antibody titer was investigated to analyze a possible immunomodulatory effect of PEA in MG patients. <p> Results: PEA had a significant effect on the QMG score (p=0.03418) and on RNS of the masseteric nerve (p=0.01763), thus indicating that PEA reduces the level of disability and decremental muscle response. Antibody titers did not change significantly after treatment. <p> Conclusion: According to our observations, μm-PEA as an add-on therapy could improve muscular response to fatigue in MG. The possible modulation of AChR currents as a means of eliciting a direct effect from PEA on the conformation of ACh receptors should be investigated. The co-role of cytokines also warrants an analysis. Given the rapidity and reversibility of the response, we suppose that PEA acts directly on AChR, though further studies are needed to confirm this hypothesis.

scholarly journals Learning French Liaison with Gradient Symbolic Representations: Errors, Predictions, Consequences

2021 ◽  
Vol 9 ◽  
Author(s):  
Anne-Michelle Tessier ◽  
Karen Jesney
Keyword(s):  
Pilot Study ◽  
Symbolic Representations ◽  
French Words

Smolensky & Goldrick (2016) first made the case for Gradient Symbolic Representations (GSRs) as the inputs to phonological grammar using the phenomena of French liaison. Under this view, many common French words are stored underlyingly with partially-activated word-final consonants, and others with gradient blends of partially-activated word-initial consonants. In this paper, we follow up some of that view's predictions and consequences, focusing on the acquisition of French liaison using GSRs. We compare our simulations of error-driven GSR learning with observed errors made by French-learning children, and find the results to be encouragingly similar. We also compare predictions about the end state of GSR learning with a pilot study reporting adult French speakers' use of liaison in nonce words, where we find a rather less good explanatory fit. The paper emphasizes the role of word and collocation frequency in the development of phonological patterns by a GSR learner, and outlines many future avenues for research. 

scholarly journals A phase I pilot study of preoperative radiotherapy for prostate cancer: Long-term toxicity and oncologic outcomes.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 60-60
Author(s):  
Noelia Sanmamed ◽  
Rachel Glicksman ◽  
John Thoms ◽  
Alexandre Zlotta ◽  
Antonio Finelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
High Risk ◽  
Phase I ◽  
Oncologic Outcomes ◽  
Gu Toxicity ◽  
Long Term Follow Up

60 Background: Pre-operative radiotherapy (PreORT) improves local control in various cancer types, and has become an established oncologic treatment strategy. During 2001-2004, we conducted a phase I pilot study assessing the role of short-course PreORT for men with unfavourable intermediate- and high-risk localized prostate cancer (PCa). We present long-term follow-up toxicity and oncologic outcomes. Methods: Eligible patients had histologically proven PCa, cT1-T2N0M0, PSA > 15-35 ng/ml with any Gleason score, or PSA 10-15 ng/ml with Gleason score ≥7. Patients received 25 Gy in five consecutive daily fractions to the prostate, followed by radical prostatectomy (RadP) within 14 days after RT completion. Primary outcomes were intra-operative morbidity, and late genitourinary (GU) and gastrointestinal (GI) toxicities. Acute toxicity was assessed during radiotherapy treatment on daily basis using RTOG grade scoring scale. Patients were assessed post-RadP clinically and with PSA at 1 and 6 months, and every 6 months. Intra- and Post-RadP toxicity was documented prospectively and scored as per Common Terminology Criteria for Adverse Events v4.0. Biochemical failure (BF) was determined based on two consecutive post-RadP PSA > 0.2 ng/ml. Results: Fifteen patients were enrolled; 14 patients completed PreORT followed by RadP, which also included bilateral lymph node dissections in 13 cases. Median follow-up was 12.2 years (range 6.7-16.3 years). Late GU toxicity was common, with 2 patients (14.3%) experiencing G2 toxicity, and 6 patients (42.8%) G3 toxicity. There were no G4-5 late GU toxicity. Late GI toxicity was infrequent, with only 1 patient (7.1%) experiencing transient G2 proctitis. At last follow-up, 8 (57.1%) and 6 (42.8%) patients experienced BF and metastatic disease recurrence, respectively. Conclusions: The use of PreORT in men with high-risk PCa is associated with unexpected high-rates of late GU toxicity. Future studies examining the role of RT pre-RadP must cautiously select RT technique and dose schedule. Importantly, long-term follow-up data is essential to fully determine the therapeutic index of PreORT in the management of localized PCa. Clinical trial information: NCT00252447.

scholarly journals Early and late pulmonary manifestations of COVID-19 on computed tomography scan

2021 ◽  
Author(s):  
Samarra Mongi Kaabi ◽  
Ahmad Nasser Madkhali ◽  
Naif Hussain Alqahtani ◽  
Ammar Adel Bakhsh ◽  
Yousef Hussain Alharthi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Literature Review ◽  
Ct Imaging ◽  
Diagnosis And Prognosis ◽  
Halo Sign ◽  
Pulmonary Manifestations ◽  
The Common ◽  
Tomography Scan

Computed tomography (CT) of the chest has been previously reported as an efficacious approach for the early diagnosis and suspicion of COVID-19 infection, as diagnosis with other modalities is usually time-consuming and cannot detect the disease within the early stages. Many pulmonary manifestations have been previously observed under CT imaging of the chest. All of them have been linked with the different stages of the disease, indicating their abilities to diagnose and follow-up these patients.This present literature review aims to discuss the role of CT imaging of the chest in COVID-19 infections and it also aims to elaborate the common pulmonary manifestations that can be frequently observed to help with the diagnosis and prognosis of the disease. Moreover, ground-glass opacities (GGOs) have been reported among studies in the literature to be the most common findings as they remain the earliest among other diseases. The literature review also aims to invistagate whether GGOs can fade away or progress to consolidate in order to decide the prognosis of the disease and to identify the severity of cases. Consolidations have also been previously stated among studies in the literature as frequent pulmonary manifestations affecting patients with COVID-19 infections and are estimated to be present in 2-63% of patients with COVID-19 infections. Other pulmonary manifestations might also include bronchiectasis, lymphadenopathy, nodules, pleural effusion or thickening, and halo sign.

scholarly journals Effect of Murivenna Ointment in the Management of Parikarthika (Acute Fissure in Ano) – A Pilot Study

2021 ◽  
pp. 156-161
Author(s):  
M. V. Sreerag ◽  
Mukhund Dhule
Keyword(s):  
Pilot Study ◽  
Fissure In Ano ◽  
Painful Condition ◽  
Burning Pain ◽  
Life Styles ◽  
Bleeding Per Rectum ◽  
Lukewarm Water ◽  
Cardinal Symptoms ◽  
Present Pilot Study

Parikarthika (Fissure in ano) is one of the most painful condition which is occurring in the ano rectal region. Due to irregular food habits and modern life styles of peoples in the present era has also added to the increase in the rate of incidence of fissure in ano. The aim of the present pilot study was to assess the effectiveness of Murivenna ointment in the management of Parikarthika. This study was conducted in 22 patients diagnosed as acute fissure in ano. Patients Murivenna ointment was applied locally with digitally in fissure bed (Parikartika) of all 22 patients. All patients were advised to follow this twice daily after sitz bath for 4 weeks or till healing of fissure bed whichever is earlier. Adjuvant drug Triphalachurnam 5 gm orally at bedtime with lukewarm water was prescribed daily to all patients with constipation. There was significant relief in symptoms like pain in ano and bleeding per rectum in all patients after 30 days of treatment. The anal sphincter tonicity became normal in 21 patients (95.45%) after 30 days of treatment. Ulcer in ano was completely healed in 19 patients (86.36%) after 30 days of treatment. There was no reoccurrence in all patients after 30 days of follow up. The irritable symptoms like pain and bleeding per rectum were effectively relieved within 14 days of treatment in all patients. It is one of the effective treatments in the management of fissure in ano as it relieved the cardinal symptoms of fissure in ano such as cutting pain and burning pain.

scholarly journals The G20’s Role in Fulfilling the UN 2030 Agenda

2016 ◽  
Vol 02 (03) ◽  
pp. 311-326
Author(s):  
Zhang Chun
Keyword(s):  
Sustainable Development ◽  
Ad Hoc ◽  
Public Awareness ◽  
2030 Agenda ◽  
Behavioral Rules ◽  
The Common ◽  
Common But Differentiated Responsibility

Thanks to their huge potential and effective toolkit, the Group of Twenty (G20) countries have exhibited strong resolve to implement the United Nations 2030 Agenda for Sustainable Development (UN 2030 Agenda). Their joint endeavor will, in turn, facilitate the transition of the G20 from an ad hoc mechanism to a long-term institution for sustainable development. With regard to the remaining gap of political willingness among countries and the absence of behavioral rules in implementing the Agenda, the coordinating authority of the G20 should be strengthened and the existing institutions reformed. Specific measures must be taken, which include: (a) strengthening the coordinating capability of the Development Working Group under the G20 (G20-DWG); (b) making the G20 an example for the rest of the world in realizing the Agenda; (c) calling for an upgraded version of the common but differentiated responsibility (CBDR) principle; (d) strengthening coordination with related organizations for the follow-up and review mechanisms of the Agenda; (e) enhancing public awareness of those post-MDG targets and lost-targets to strengthen the central role of the G20 in implementing the Agenda; and (f) making the G20 a long-term leader in supporting development rights of the developing world.

scholarly journals Common problems Encountered during Lactation and their Management in a Lactation Management Center

2020 ◽  
Vol 33 (1) ◽  
pp. 36-39
Author(s):  
Sabiha Shimul ◽  
Sameena Chowdhury ◽  
Mahe Jabeen ◽  
Ummay Salma ◽  
Mahbuba Akter ◽  
...  
Keyword(s):  
Breast Feeding ◽  
Cross Sectional Study ◽  
Inverted Nipple ◽  
Cross Sectional ◽  
Lactating Mothers ◽  
Breast Feed ◽  
Feeding Technique ◽  
The Common ◽  
Common Problems ◽  
Breast Fed

Background: Breastfeeding is widely known to be beneficial for infants and the mothersand also economically advantageous for the community. Objective: The principal purpose of this study was to explore the common problemsencountered during lactation and their management in a lactation management center. Method: A cross sectional study was conducted at lactation management center of Instituteof Child and Maternal Health (ICMH), Dhaka. A total of 100 lactating mothers were recruitedconsecutively during the period of August 2008 to October 2008. Data was collected byhistory taking and required examination. Result: In this study, 46.0% mothers complained of poor milk secretion, 13.0% had breastengorgement, 9.0% had cracked nipple, 3.0% had inverted nipple, 2.0% had nipple infection,2.0% had flat nipple, 1.0% had sore nipple, 1.0% had breast abscess and in 23% casesthere was no reasonable cause. During interview twenty seven percent of the mothers wereadvised to start nursing as soon as possible; 45.0% mothers breast fed on demand, 75.0%mothers demonstrated proper breast feeding technique, 36.0% mothers avoided use ofartificial milk, 10.0% mothers applied last part of milk on nipple, then dry by exposing to air,12.0% mothers manually express milk from the areola before breast feed if it is engorgedand 1.0% advised to slip the index or little finger into the infant’s mouth between his/hergums before the infant is taken off of the breast, to break suction. Conclusion: Almost half of the mothers complained of less milk production. Apart from this13.0% mothers had breast engorgement, 9.0% mothers had cracked nipple and no reasonablecause for lactation problem was found in 23.0% cases. More than half of the mothers hadincorrect knowledge and skill of breast feeding. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(1) : 36-39

scholarly journals A RANDOMIZED CONTROLLED CLINICAL STUDY OF CHANDRASHOORPAYAS (GARDEN CRESS SEED PORRIDGE) AS DIETARY SUPPLEMENT FOR LACTATING MOTHERS

2020 ◽  
pp. 61-69
Author(s):  
Medha S.Kulkarni ◽  
Shital Pise
Keyword(s):  
Dietary Supplement ◽  
Control Group ◽  
Garden Cress ◽  
Lactating Mothers ◽  
Nursing Mothers ◽  
Safety Parameters ◽  
Cress Seed ◽  
Infant Weight Gain

In India many dietary supplements are given to lactating mothers for sustained and ample milk to nourish their baby. Chandrashoora Payas (Garden cress seeds porridge) is one such recipe given to nursing mothers to increase lactation. Objective: This study is planned to assess the role of Chandrashoor Payas as a dietary supplement in lactation deficiency (Stanyakshaya), taking control group of Shatavari Powder and milk to ascertain which is better. Shatavari powder is taken as a control group since it is a clinically proven galactagogue medicine in Ayurveda. Material and Methods: Total 64 lactating mothers diagnosed with lactation deficiency were screened for clinical trial, out of which 60 patients fulfilled the inclusion criteria and included in the trial. Selected patients were divided randomly in two groups by a simple random method. Study group was administered Chandrashoora Payas 100ml in morning; and the control group was with 5gm Shatavari powder with 100ml milk for 45 days. Follow up visit was on every 15th day. Estimation of milk production and infant weight gain were assessed by comparing difference in grades. Observations and Results: Study revealed that both Chandrashoorapayas and Shatavari and milk produced significant improvement p< 0.001 in most of the variables and were comparable in reliving all the symptoms of lactation deficiency. On comparison both the drugs show similar effect. Conclusion: No adverse effects were observed in the trial group, as safety parameters were within normal limit during the study and overall compliance to the treatment was good. Both the interventions were comprehensively effective in management of lack of lactation. Chandrashoorapayas is a dietary supplement which gives similar results as Shatvari which is a medicine.

scholarly journals Breastfeeding technique and associated factors among lactating mothers visiting Gondar town health facilities, Northwest Ethiopia: observational method

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Boko Loka Safayi ◽  
Nega Tezera Assimamaw ◽  
Destaye Guadie Kassie
Keyword(s):  
Breast Feeding ◽  
Associated Factors ◽  
Northwest Ethiopia ◽  
Health Facilities ◽  
Age Group ◽  
Cross Sectional ◽  
Lactating Mothers ◽  
Feeding Technique ◽  
Gondar Town

Abstract Background The breastfeeding technique is explained positioning, attachment, and suckling during breastfeeding. Ineffective breast feeding technique is one of the factors leading to premature discontinuation of breastfeeding and malnutrition. There is a limited study on the assessments of BFT and associated factors among lactating mothers in the study area. Therefore, the study aimed to assess breastfeeding technique and the associated factors among lactating mothers visiting Gondar town health facilities, Northwest Ethiopia. Methods An institution-based cross-sectional study was conducted from February 20 to March 20, 2020. An observational checklist and structured interviewer-administered questionnaire were applied to collect the data. The data were entered into Epi-Data 4.6 version and transferred to analyzed using SPSS version 20. Bi-variable and multivariable logistic regressions were performed to identify the association. The strength of association was identified using odds ratio with a 95% confidence interval (), and a p-value of 0.05 was declare as statistically significant. Results The proportion of effective BFT was 48% (95%, CI: 43.0–53.0%). The likelihood of applying proper BFT among age group of 18–20 years was 70% lower than (AOR = 0.3; 95% CI: 0.11–0.83) age group > 30 years. The odds of effective BFT in primipara mothers were 49% (AOR = 0.51; 95% CI: 0.32–0.82) lower compared to multiparous mothers. Likewise, the provability of effective BFT was 55% (AOR = 0.45; 95% CI: 0.29–0.70) times lower in women who had no counseling immediately after delivery compared to their counterparts. Moreover, effective breast feeding technique mothers who have breast problem was 78% lower than (AOR = 0.22; 95% CI: 0.07–0.68) mothers who have no breast problem. And mothers who had counselling of BFT during ANC follow up was 55% (AOR = 0.45; 95% CI: 0.29, 0.70) lower than mothers who had no counseling. Conclusion Just under half of the women in the study area applied proper breast feeding technique Younger and primipara mothers poorly performed to effective BFT. But women having counseling during antenatal care follow-up and immediately after delivery and not having breast problems applied BFT effectively. Hence, special emphasis have to give for younger and primipara mothers. Besides, educate the mother for preventing breast problems and working on enhancing counseling at postnatal clinic.

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