scholarly journals COVID–19: Guidance Outlines on Infection Prevention and Control for Health Care Workers

2020 ◽  
Vol 32 (1) ◽  
pp. 8-14
Author(s):  
Suresh Kumar Sharma ◽  
Shiv Mudgal ◽  
Prasan Panda ◽  
Pratima Gupta ◽  
Pradeep Aggarwal
Keyword(s):  
Severe Disease ◽  
Respiratory Illness ◽  
World Health ◽  
Infection Prevention And Control ◽  
The People ◽  
Moderate Disease ◽  
Care Workers ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control

Coronavirus are a common family of viruses and there are seven different types of coronaviruses including this new member of coronavirus i.e. 2019 novel coronavirus, which can make the people infected and sick. Some strains of this family of virus cause mild to moderate disease symptoms like common cold while other strains cause very severe disease like Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS).(1,2) In late December, in Wuhan Hubei Province, China a number of people suffered with severe respiratory illness including a cluster of pneumonia cases. On 31 December 2019, China notified the World Health Organization (WHO) about cluster of patient with symptoms of respiratory illness of unknown cause, which were connected to an open seafood and animal market of Wuhan city, China.(3)

Experience and Insight Author in Preventing and Curbing the Novel Coronavirus (Covid19) Outbreak

2020 ◽  
Vol 12 (1si) ◽  
pp. 79
Author(s):  
Rahmidha Dwijayanti
Keyword(s):  
Health Workers ◽  
Physical Contact ◽  
World Health ◽  
Infection Prevention And Control ◽  
Wholesale Market ◽  
Exotic Animals ◽  
Corona Virus ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control

Introduction: In December 31, 2019, China gave bad news the World Health Organization (WHO) throughtout an outbreak of a mysterious pneumonia characteristic in Wuhan, which is located in Hubei Province with 11 million people. On 1 January 2020, the source of the Coronavirus outbreak is a seafood market that has been closed. The Huanan Seafood Wholesale Market in Wuhan City, where the virus was first detected, fit that description to a tee, with vendors illegally trading in wild and exotic animals alongside the daily ocean catch. Discussion: This literature review retrieved the articles from databases such as Springer, PubMed, and Google Scholar. The articles on preventing were 17 articles and curbing were 15 articles. The literatur review is a critical and in-depth evaluation of previous research to obtain important information about the dangers of the corona virus and the important of preventing and curbing the corona virus. Guidance regarding personal protective equipment in infection prevention and control is provided by WHO. Goggles and face shield must always be used to protect against potential hazards, and health workers don’t touch mucous membranes (eyes, nose or mouth). Conclusion: Recommendations for preventing health and preventing Covid19 are: limiting physical contact or being in a room with people without symptoms, covering the mouth with a tissue when sneezing or coughing and then throwing the tissue into the trash. If there are no tissues, use your sleeves to avoid liquids or droplets on other people or sticking to nearby objects, do not travel to the red zone against the spread of Covid19, rub hands properly for 20 seconds with soap and water, If it is quite difficult to find water, it is advisable to always have a Hand Sanitizer with an alcohol content of at least 60% which is believed to be able to kill germs. Recommendation for curbing the spread the Covid19 include: lockdown, stay at home, and physical inactivity.

scholarly journals COVID-19: A Conundrum to Decipher

2020 ◽  
Author(s):  
Vishwajit Deshmukh ◽  
Satyendra C. Tripathi ◽  
Arvind Pandey ◽  
Vaishnavi Deshmukh ◽  
Ashlesh Patil ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Medical Condition ◽  
Management Strategies ◽  
Respiratory Illness ◽  
World Health ◽  
Chronic Medical Condition ◽  
Life Threatening ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control

OBJECTIVE: Recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), another member of coronavirus family is an ongoing worldwide life-threatening crisis. The early diagnosis and management of the disease remains a major challenge. In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2. MATERIALS AND METHODS: A broad search of the literature was performed in “PubMed” “Medline” “Web of knowledge”, and “Google Scholar” World Health Organization-WHO” using the key words “severe acute respiratory syndrome coronavirus”, “SARS”, “SARS-CoV-2” “Epidemiology” “Transmission” “Pathogenesis” “Clinical Characteristics”. We reviewed and documented the information attained from literature on epidemiology, pathogenesis and clinical appearances of SARS-CoV-2 infection. RESULTS: The global cases of COVID-19 till 30th March 2020 have rose more than 700,000 and morbidity has gone more than 37,000. The infection rate for COVID-19 has been predicted to be higher than the previous outbreaks of same family members, that includes the SARS-CoV and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The main clinical presentation ranges from asymptomatic stages to severe lower respiratory infection in the form of pneumonia. Most of the patients also presented with fever, cough, sore throat, headache, fatigue, myalgia and breathlessness. High risk includes elderly people and patients with weak immune system or suffering from chronic medical condition like hypertension, diabetes, cancer, respiratory illness and cardiovascular diseases. CONCLUSIONS: SARS-Cov-2 has emerged as a worldwide threat, affecting almost each and every country on globe. As there is still growing understanding of SARS-CoV-2 in relation to its virology, epidemiology and clinical management strategies, we need to learn our lessons to conceive comprehensive measures to prevent such outbreaks in future.

scholarly journals A review of the management and safe handling of bodies in cases involving COVID-19

2020 ◽  
Vol 60 (4) ◽  
pp. 287-293 ◽  
Author(s):  
Smitha Rani
Keyword(s):  
Control Measures ◽  
World Health ◽  
Disease Spread ◽  
Infection Prevention And Control ◽  
Causative Organism ◽  
The World ◽  
Prevention And Control Measures ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control

Wuhan Municipal Health Commission, China, reported a cluster of cases of ‘pneumonia of unknown aetiology’ in Wuhan, Hubei province in late 2019. The causative organism was eventually identified as a novel coronavirus. Subsequently, the disease spread to more provinces in China, then the rest of the world, and the World Health Organization declared it a pandemic. The virus was named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the disease was termed COVID-19 (Coronavirus disease). Since then, an increasing number of people have succumbed to this infectious disease. High contagiousness and rapid spread of the disease has been a matter of concern, as it may overburden healthcare systems. Hence, it is vital to implement strict infection prevention and control measures to curb the spread of the disease. This article reviews the guidelines available for the handling of bodies of deceased persons with suspected or confirmed COVID-19, and for their safe disposal. It also provides a summary of recommendations for conducting autopsies in cases where COVID-19 is suspected.

scholarly journals An evidence-based systematic review on emerging therapeutic and preventive strategies to treat novel coronavirus (SARS-CoV-2) during an outbreak scenario

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Anupama M. Gudadappanavar ◽  
Jyoti Benni
Keyword(s):  
Antiviral Drug ◽  
Drug Repurposing ◽  
Respiratory Illness ◽  
World Health ◽  
Recombinant Vaccines ◽  
Subunit Vaccines ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Full Length Genome

AbstractA novel coronavirus infection coronavirus disease 2019 (COVID-19) emerged from Wuhan, Hubei Province of China, in December 2019 caused by SARS-CoV-2 is believed to be originated from bats in the local wet markets. Later, animal to human and human-to-human transmission of the virus began and resulting in widespread respiratory illness worldwide to around more than 180 countries. The World Health Organization declared this disease as a pandemic in March 2020. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. Nevertheless, few broad-spectrum antiviral drugs have been studied against COVID-19 in clinical trials with clinical recovery. In the current review, we summarize the morphology and pathogenesis of COVID-19 infection. A strong rational groundwork was made keeping the focus on current development of therapeutic agents and vaccines for SARS-CoV-2. Among the proposed therapeutic regimen, hydroxychloroquine, chloroquine, remdisevir, azithromycin, toclizumab and cromostat mesylate have shown promising results, and limited benefit was seen with lopinavir–ritonavir treatment in hospitalized adult patients with severe COVID-19. Early development of SARS-CoV-2 vaccine started based on the full-length genome analysis of severe acute respiratory syndrome coronavirus. Several subunit vaccines, peptides, nucleic acids, plant-derived, recombinant vaccines are under pipeline. This article concludes and highlights ongoing advances in drug repurposing, therapeutics and vaccines to counter COVID-19, which collectively could enable efforts to halt the pandemic virus infection.

scholarly journals Aerosol and surface contamination of SARS-CoV-2 observed in quarantine and isolation care

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Joshua L. Santarpia ◽  
Danielle N. Rivera ◽  
Vicki L. Herrera ◽  
M. Jane Morwitzer ◽  
Hannah M. Creager ◽  
...  
Keyword(s):  
Medical Center ◽  
World Health ◽  
Infection Prevention And Control ◽  
The Novel ◽  
Viral Shedding ◽  
Surface Samples ◽  
Significant Public Health ◽  
Health Organization ◽  
The University ◽  
And Control

Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan, China in late 2019, and its resulting coronavirus disease, COVID-19, was declared a pandemic by the World Health Organization on March 11, 2020. The rapid global spread of COVID-19 represents perhaps the most significant public health emergency in a century. As the pandemic progressed, a continued paucity of evidence on routes of SARS-CoV-2 transmission has resulted in shifting infection prevention and control guidelines between classically-defined airborne and droplet precautions. During the initial isolation of 13 individuals with COVID-19 at the University of Nebraska Medical Center, we collected air and surface samples to examine viral shedding from isolated individuals. We detected viral contamination among all samples, supporting the use of airborne isolation precautions when caring for COVID-19 patients.

scholarly journals The Online Education Mode and Reopening Plans for Chinese Schools During the COVID-19 Pandemic: A Mini Review

2020 ◽  
Vol 8 ◽  
Author(s):  
Xuanzhen Cen ◽  
Dong Sun ◽  
Ming Rong ◽  
Gusztáv Fekete ◽  
Julien S. Baker ◽  
...  
Keyword(s):  
Online Education ◽  
Prevention And Control ◽  
World Health ◽  
Classroom Teaching ◽  
Full Time ◽  
The Novel ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control

Recently, an unprecedented coronavirus pandemic has emerged and has spread around the world. The novel coronavirus termed COVID-19 by the World Health Organization has posed a huge threat to human safety and social development. This mini review aimed to summarize the online education mode and plans for schools to resume full-time campus study in China during COVID-19. Chinese schools have made significant contributions to the prevention and control of the transmission of COVID-19 by adopting online learning from home. However, normal opening and classroom teaching have been affected. For education systems at all levels, online education may be an effective way to make up for the lack of classroom teaching during the epidemic. To protect staff and students from COVID-19, the timing of students returning to full-time campus study needs to be considered carefully. Reviewing and summarizing of the Chinese education system's response to the virus would be of great value not only in developing educational policy but also in guiding other countries to formulate educational countermeasures.

scholarly journals Analysis of SARS-CoV-2 genomes from across Africa reveals potentially clinically relevant mutations

2020 ◽  
Author(s):  
Modeline N. Longjohn ◽  
Olivia S. Egbule ◽  
Samuel O. Danso ◽  
Eugene E. Akujuru ◽  
Victor T. Ibubeleye ◽  
...  
Keyword(s):  
Vaccine Coverage ◽  
Phylogenetic Analyses ◽  
Severe Disease ◽  
Case Fatality ◽  
Climatic Conditions ◽  
Etiologic Agent ◽  
World Health ◽  
Sequence Alignments ◽  
Novel Coronavirus ◽  
Health Organization

AbstractSARS-CoV-2 is a betacoronavirus, the etiologic agent of the novel Coronavirus disease 2019 (COVID-19). The World Health Organization officially declared COVID-19 as a pandemic in March 2020 after the outbreak in Wuhan, China, in late 2019. Across the continents and specifically in Africa, all index cases were travel-related. Understanding how the virus’s transportation across continents and different climatic conditions affect the genetic composition and the consequent effects on transmissibility, infectivity, and virulence of the virus is critical. Thus, it is crucial to compare COVID-19 genome sequences from the African continent with sequences from selected COVID-19 hotspots/countries in Asia, Europe, North and South America and Oceania.To identify possible distinguishing mutations in the African SARS-CoV-2 genomes compared to those from these selected countries, we conducted in silico analyses and comparisons. Complete African SARS-CoV-2 genomes deposited in GISAID and NCBI databases as of June 2020 were downloaded and aligned with genomes from Wuhan, China and other SARS-CoV-2 hotspots. Using phylogenetic analysis and amino acid sequence alignments of the spike and replicase (NSP12) proteins, we searched for possible vaccine coverage targets or potential therapeutic agents. Identity plots for the alignments were created with BioEdit software and the phylogenetic analyses with the MEGA X software.Our results showed mutations in the spike and replicate proteins of the SARS-Cov-2 virus. Phylogenetic tree analyses demonstrated variability across the various regions/countries in Africa as there were different clades in the viral proteins. However, a substantial proportion of these mutations (90%) were similar to those described in all the other settings, including the Wuhan strain. There were, however, novel mutations in the genomes of the circulating strains of the virus in African. To the best of our knowledge, this is the first study reporting these findings from Africa. However, these findings’ implications on symptomatic or asymptomatic manifestations, progression to severe disease and case fatality for those affected, and the cross efficacy of vaccines developed from other settings when applied in Africa are unknown.

scholarly journals Immunomodulators for Curtailing COVID-19: a Positive Approach

2020 ◽  
Vol 10 (3-s) ◽  
pp. 286-294 ◽  
Author(s):  
Shabir Ahmad Bhat ◽  
Shameem Ahmad Rather ◽  
Arsheed Iqbal ◽  
Haider Ali Qureshi ◽  
Naquibul Islam
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Viral Infections ◽  
Herbal Medicines ◽  
Specific Treatment ◽  
The Body ◽  
World Health ◽  
The People ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Past Experiences

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly infectious, spreading swiftly from man to man which has not been previously recognized in humans. World Health Organization (WHO) on February 11, 2020 named the infection as COVID-19 as an acronym for ‘coronavirus disease-2019’ and on March 11, 2020 declared the outbreak as pandemic. It affects all the people without discrimination, however, older, immune compromised are more susceptible. The virus chiefly spread through droplet infection from infected person to healthy one by coughing, sneezing or with infected hands when touched to eyes, nose or mouth. Symptoms of the infection range from mild to severe ones. In severe cases (approx. 14% of cases) fever typically of high grade (104oF), breathlessness, pneumonia and severe acute respiratory syndrome may appear. So far no specific treatment or vaccine for novel coronavirus-2019 is there. From the past and recent past experiences we have learnt that herbal medicines have proven beneficial against various dreadful viral infections. Assessment of immune enhancing herbs in this paper may definitely be helpful for the body to fight COVID-19 infection. Keywords:   Severe acute respiratory syndrome coronavirus-2, COVID-19, Pneumonia, Immune, Herbs

scholarly journals An 11-Year-Old Boy Infected with COVID-19 with Presentation of Acute Liver Failure

2020 ◽  
Vol 20 (6) ◽  
Author(s):  
Amir Saeed ◽  
Eslam Shorafa ◽  
Iraj Shahramian ◽  
Mahdi Afshari ◽  
Mehrdad Salahifard ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Liver Enzymes ◽  
Multiorgan Failure ◽  
Severe Disease ◽  
Pediatric Intensive Care ◽  
Respiratory Illness ◽  
World Health ◽  
Elevated Liver Enzymes ◽  
The World ◽  
Health Organization

: Coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China, in December 2019. Then, it spread to the whole world so that THE World Health Organization (WHO) declared a worldwide pandemic on March 11, 2020. Coronavirus disease 2019 is a novel and mysterious infectious disease that causes respiratory illness, multiorgan failure (MOF), and death. Although pediatric COVID-19 accounts for a small percentage of patients and is often milder than in adults, it can progress to severe disease in some cases. Liver involvement in COVID-19 and its severity have not been clearly investigated. In this paper, we present an 11-year-old boy admitted to a Pediatric Intensive Care Unit (PICU) with COVID-19 diagnosis in combination with elevated liver enzymes and bilirubin.

scholarly journals Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort by the Global Community

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-35 ◽  
Author(s):  
Zichao Luo ◽  
Melgious Jin Yan Ang ◽  
Siew Yin Chan ◽  
Zhigao Yi ◽  
Yi Yiing Goh ◽  
...  
Keyword(s):  
Respiratory Illness ◽  
Viral Disease ◽  
Disease Diagnosis ◽  
World Health ◽  
Rt Pcr ◽  
Sudden Loss ◽  
Difficulty Breathing ◽  
Polymerase Chain ◽  
Novel Coronavirus ◽  
Health Organization

The World Health Organization (WHO) has declared the outbreak of 2019 novel coronavirus, known as 2019-nCoV, a pandemic, as the coronavirus has now infected over 2.6 million people globally and caused more than 185,000 fatalities as of April 23, 2020. Coronavirus disease 2019 (COVID-19) causes a respiratory illness with symptoms such as dry cough, fever, sudden loss of smell, and, in more severe cases, difficulty breathing. To date, there is no specific vaccine or treatment proven effective against this viral disease. Early and accurate diagnosis of COVID-19 is thus critical to curbing its spread and improving health outcomes. Reverse transcription-polymerase chain reaction (RT-PCR) is commonly used to detect the presence of COVID-19. Other techniques, such as recombinase polymerase amplification (RPA), loop-mediated isothermal amplification (LAMP), clustered regularly interspaced short palindromic repeats (CRISPR), and microfluidics, have allowed better disease diagnosis. Here, as part of the effort to expand screening capacity, we review advances and challenges in the rapid detection of COVID-19 by targeting nucleic acids, antigens, or antibodies. We also summarize potential treatments and vaccines against COVID-19 and discuss ongoing clinical trials of interventions to reduce viral progression.

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