scholarly journals Age-related vulnerability of employees to factors of the occupation environment

2021 ◽  
Vol 100 (8) ◽  
pp. 807-811
Author(s):  
Gennady A. Sorokin ◽  
Nikolay D. Chistyakov ◽  
Viktor V. Shilov
Keyword(s):  
Relative Risk ◽  
Age Groups ◽  
Older Age ◽  
Working Environment ◽  
Educational Organizations ◽  
Production Environment ◽  
Industrial Enterprises ◽  
Age Related ◽  
Public Catering ◽  
Environment Noise

Introduction. When predicting individual health risks associated with a person’s profession, first of all, the state of their health, age and experience of harmful work are studied. A practical approach to studying the age-related vulnerability of a person to the factors of the working environment is the use of fatigue indicators. Objective: to establish age-related patterns of the influence of factors of the occupation environment on employee fatigue Materials and methods. Three thousand eight hundred fifty-one employees of industrial enterprises, public catering enterprises, healthcare and educational organizations were examined. The employees evaluated the degree of influence of factors of the production environment on fatigue - noise, microclimate, working area air, dust in the working area air, vibration. The frequency of influence (FI) of each factor of the production environment on employee fatigue was considered an indicator of age-related vulnerability (vulnerability risk). The relative risk of exceeding the FI in older age groups of employees was calculated. Results. In older medical workers, the relative risk (RR) of vulnerability to noise was =1.19 (0.88-1.60); to the microclimate OR=1.26 (0.96-1.64); RR due to the air of the working area =1.19 (0.92-1.54). School teachers have a significantly higher frequency of complaints about noise than doctors and nurses, and their age-related increase in vulnerability to noise was OR=1.23 (0.98-1.55). Employees of public catering enterprises showed an increase in age-related vulnerability to all environmental factors. Employees of older age groups of industrial enterprises are more vulnerable to all factors of the production environment. The values of FI in the groups of 30-49 years and 50-69 years, respectively, were: for noise, OR=1.20 (1.01-1.43) and OR=1.15(0.88-1.50); for microclimate, OR=1.21(1.04-1.39); for working area air, OR=1.02 (0.87-1.19) and OR = 1.31 (1.06-1.62). Conclusion. Compared with the age group of 20-30 years, the probability of the influence of factors of the working environment - “noise”, “microclimate”, “air of the working area”, on the fatigue of workers increases by 10-15% at the age of 30-49 years and by 15-25% at the age of 50-60 years.

scholarly journals TSH enhancement of FT4 to FT3 conversion is age dependent

2016 ◽  
Vol 175 (1) ◽  
pp. 49-54 ◽  
Author(s):  
David Strich ◽  
Gilad Karavani ◽  
Shalom Edri ◽  
David Gillis
Keyword(s):  
Age Groups ◽  
Thyroid Stimulating Hormone ◽  
Older Age ◽  
Age Group ◽  
Free T4 ◽  
Free T3 ◽  
Age Related ◽  
Differential Increase ◽  
Retrospective Examination ◽  
Tsh Levels

ObjectiveWe previously reported increasing free T3 (FT3) to free T4 (FT4) ratios as thyroid-stimulating hormone (TSH) increases within the normal range in children. It is not known if this phenomenon is age-related among humans, as previously reported in rats. This study examines the relationships between TSH and FT3/FT4 ratios in different ages.DesignRetrospective examination of thyroid tests from patients without thyroid disease from community clinics.MethodsFree T3, free T4, and TSH levels from 527 564 sera collected from patients aged 1 year or greater were studied. Exclusion criteria were the following: missing data, TSH greater than 7.5mIU/L, and medications that may interfere with thyroid hormone activity. A total of 27 940 samples remaining after exclusion were stratified by age. Samples with available anthropometric data were additionally stratified for body mass index (BMI). Correlations of TSH to FT4, FT3, and FT3/FT4 ratios by age group were examined.ResultsUp to age 40, for each increasing TSH quartile, FT3 and the FT3/FT4 ratio increased and FT4 decreased significantly (for both FT3, FT4 and FT3/FT4 ratio,P<0.05 for every TSH quartile when compared with the 1st quartile, except FT3 in the 30–40 age group). In older age groups, increasing TSH was not associated with increased FT3/FT4 ratio.ConclusionAs TSH levels increase, FT3/FT4 ratios increase until age 40, but this differential increase does not occur in older age groups. This may reflect a decrease in thyroxine (T4) to triiodothyronine (T3) conversion with age, which may be part of the aging process.

scholarly journals Compositional changes in human gut microbiota reveal a putative role of intestinal mycobiota in metabolic and biological decline during aging

2021 ◽  
pp. 1-15
Author(s):  
Mohammad Tahseen Al Bataineh ◽  
Ayman Alzaatreh ◽  
Rima Hajjo ◽  
Bayan Hassan Banimfreg ◽  
Nihar Ranjan Dash
Keyword(s):  
Gut Microbiota ◽  
Age Groups ◽  
Older Age ◽  
Older Individuals ◽  
Human Gut ◽  
Shotgun Metagenomics ◽  
Age Related ◽  
Health And Disease ◽  
Compositional Changes ◽  
Profiling Analysis

BACKGROUND: Age-related alterations in the composition and function of gut microbiota may influence human health and disease mechanisms. However, connections between compositional changes in gut bacterial and fungal communities, and their role in the aging process, remain poorly understood. OBJECTIVE: Compare the gut microbiota and mycobiota composition in different age groups and evaluate the functionality. METHODS: In this study, we performed 16S rRNA and ITS2 gene-based microbial profiling analysis and shotgun metagenomics using the NextSeq platform. RESULTS: We observed a shift in compositional changes of human gut microbiota with age. Older individuals revealed a significantly different gut microbiota profile compared to younger individuals. For example, gut microbiota composition of the older individuals showed increase in genera Bacteroides, Blautia, Ruminococcaceae, and Escherichia coli. Additionally, older individuals had significant reduction in fungi belonging to saccharomyces cerevisiae and candida albicans in comparison to their younger counterparts. Moreover, metagenomics functional profiling analysis using shotgun metagenomics sequencing data showed substantial differences in the enrichment of 48 pathways between the young and older age groups. Metabolic pathways such as amino acid biosynthesis, carbohydrate metabolism, cell structure biosynthesis and vitamin biosynthesis were declined in the older age group, in comparison with the younger individuals. CONCLUSIONS: The identified differences provide a new insight to enrich our understanding of age-related changes in gut microbiota, their metabolic capabilities, and potential impact on health and disease conditions.

AGE-RELATED AND POST-EXTRACTION ATROPHY OF THE JAWS AND MODERN POSSIBILITIES FOR RESTORING THE MASTICATORY APPARATUS IN THE ELDERLY PEOPLE

2021 ◽  
pp. 134-143
Author(s):  
М.И. Музыкин ◽  
Е.В. Коковихина ◽  
Е.А. Герасимова ◽  
В.Ф. Мищук ◽  
А.К. Иорданишвили ◽  
...  
Keyword(s):  
Age Groups ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Older Age ◽  
Leningrad Region ◽  
Stage Of Development ◽  
Age Related ◽  
Number Of Patients ◽  
Dental Rehabilitation ◽  
Masticatory Apparatus

Представлены данные клинического обследования 3 329 человек (1 760 мужчин и 1 569 женщин), проживающих в различных регионах РФ (Санкт-Петербург и Ленинградская обл., Москва и Московская обл., Краснодарский край). Цель работы заключалась в изучении частоты утраты зубов и клинических проявлений атрофии альвеолярных отростков (частей) челюстей у пациентов старших возрастных групп для оценки возможности стоматологической реабилитации с использованием ортопедических конструкций на дентальных имплантатах. Изучение распространенности и степени атрофии показало, что в старшей возрастной группе у пациентов в большей мере преобладала 4-я и 5-я степень атрофии, частота встречаемости составила около 20-30 %. Встречаемость 6-й степени атрофии также была выше, чем в других возрастных группах, - она была обнаружена у 17,22 % мужчин и 17,81 % женщин на верхней челюсти и у 22,18 и 15,79 % - на нижней челюсти соответственно. Несмотря на то, что количество пожилых пациентов с полной или частичной утратой зубов не имеет тенденции к снижению, на современном этапе развития стоматологии и дентальной имплантологии восстановление целостности жевательного аппарата с применением искусственных опор возможно фактически во всех клинических случаях. Наличие коморбидной или мультиморбидной патологии не является абсолютным противопоказанием, а является лишь временны΄м фактором, откладывающим стоматологическую реабилитацию до стабилизации общесоматического статуса пациента. The data of clinical examination of 3 329 people (1 760 men and 1 569 women) living in various regions of the Russian Federation (St. Petersburg and Leningrad region, Moscow and Moscow region, Krasnodar Territory) are presented. The aim of the investigation was to study the frequency of tooth loss and clinical manifestations of atrophy of the alveolar processes (parts) of the jaws in patients of older age groups to assess the possibility of dental rehabilitation using orthopedic structures on dental implants. The study of the prevalence and degree of atrophy showed that in the older age group, patients of senile age were more dominated by 4 and 5 degrees of atrophy, the frequency of their occurrence was about 20-30 %. The incidence of grade 6 atrophy was also higher than in other age groups, it was found in 17,22 % of men and 17,81 % of women in the upper jaw and 22,18 % and 15,79 % in the lower jaw, respectively. Despite the fact that the number of patients in older age groups with complete or partial loss of teeth does not tend to decrease, at the present stage of development of dentistry and dental implantology, the possibility of restoring the integrity of the masticatory apparatus with the use of artificial supports is possible in virtually all clinical cases. The presence of comorbid or multimorbid pathology is not an absolute contraindication, but is only a temporary factor that postpones dental rehabilitation until the general somatic status of the patient is stabilized.

Geriatric aspects of modern plastic surgery

2022 ◽  
pp. 948-952
Author(s):  
Б.Г. Алиханов ◽  
А.К. Иорданишвили ◽  
С.Г. Павлова ◽  
И.Д. Юшкова
Keyword(s):  
Plastic Surgery ◽  
Subcutaneous Fat ◽  
Age Groups ◽  
The Elderly ◽  
Older Age ◽  
Fat Deposits ◽  
Age Related ◽  
The Face ◽  
Main Factor ◽  
Elderly And Old People

Старение организма человека - закономерный физиологический процесс. В прошлом веке основными причинами обращения людей к пластическим хирургам служили врожденные и приобретенные деформации, а также возрастные изменения кожи лица. В наши дни внешний вид человека стал основным фактором его успешности в обществе. В работе определена мотивация людей пожилого и старческого возраста к выполнению пластических операций, а также проанализирована работа клиник по выполнению пластических операций людям старших возрастных групп. Установлено, что 96,4 % мужчин и 86,9 % женщин старших возрастных групп имеют достаточно полные представления о пластической хирургии. 27,7 % мужчин и 17,2 % женщин пожилого и старческого возраста хотели бы сделать себе пластическую операцию, однако женщины в 10,9 раза чаще обращаются к пластическим хирургам. Анализ работы клиник пластической хирургии показал устойчивую тенденцию увеличения обращаемости людей пожилого и старческого возраста, независимо от пола, к пластическим хирургам для выполнения операций, направленных, главным образом, на улучшение эстетики лица, шеи и коррекцию фигуры путем устранения гравитационного птоза и удаления избыточных подкожных жировых отложений на туловище. Основной причиной отказа от выполнения желаемой пациентом и рекомендуемой пластическим хирургом операции является недостаток денежных средств. Aging of the human body is a natural physiological process. In the last century, the main reasons for people turning to plastic surgeons were congenital and acquired deformities, as well as age-related changes in the skin of the face. Nowadays, a person’s appearance has become the main factor in his success in society. The work determines the motivation of elderly and senile people to perform plastic surgeries, and also analyzes the work of clinics in performing plastic surgeries for people of older age groups. It was found that 96,4 % of men and 86,9 % of women in older age groups have a fairly complete understanding of plastic surgery. Among the elderly and old people, 27,7 % of men and 17,2 % of women have a desire to perform plastic surgery for themselves, however, women are 10,9 times more likely to go to plastic surgeons. Analysis of the plastic surgery clinics showed a steady trend of increasing the number of elderly and senile people, regardless of gender, to plastic surgeons to perform operations aimed mainly at improving the aesthetics of the face, neck and body shaping by eliminating gravitational ptosis and removing excess subcutaneous fat. deposits on the trunk. The main reason for refusal to perform the operation desired by the patient and recommended by the plastic surgeon is the lack of funds.

Influence of luminal nutrient composition on hemodynamics and oxygenation in developing intestine

1992 ◽  
Vol 263 (2) ◽  
pp. G254-G260 ◽  
Author(s):  
K. D. Crissinger ◽  
D. L. Burney
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Oxygen Uptake ◽  
Vascular Resistance ◽  
Corn Oil ◽  
Age Groups ◽  
Older Age ◽  
Intestinal Blood Flow ◽  
Oxygen Extraction ◽  
Age Related

Age-related differences in the intestinal hemodynamic and oxygenation responses to carbohydrate, protein, and lipid were studied in 1-day-, 3-day-, 2-wk-, and 1-mo-old piglets. A branch of the mesenteric vein draining an isolated loop of jejunoileum was used to measure intestinal blood flow, arteriovenous oxygen content difference, and venous and capillary pressure and to calculate oxygen uptake and vascular resistance. Fractionated intestinal flow was measured with radiolabeled microspheres. Measurements were made before and after luminal placement of either 5% glucose, 2.3% casec, or 5% corn oil. In 1-day-old animals, unlike all older age groups, total intestinal blood flow and vascular resistance were unchanged by any nutrient. Fractionated flow to the mucosa/submucosa levels did, however, increase in the intestine of 1-day-old piglets to a similar extent as that in older age groups. Placement of lipid or protein into the lumen led to increased oxygen uptake in all age groups, whereas carbohydrate absorption resulted in no increase in intestinal oxygen consumption in 1- and 3-day-old animals. In 1-day-olds, the increased oxygen consumption was achieved by enhanced oxygen extraction with no change in total blood flow, whereas all other groups demonstrated increases in blood flow and/or oxygen extraction. Compared with a mixed meal, oxygen consumption was not significantly greater for an individual nutrient component.

scholarly journals Age-Related Differences in the Informational Experiences and Needs of Patients with Lymphoma: Results from the 2020 Lymphoma Coalition Global Patient Survey

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 1929-1929
Author(s):  
Olufunmilayo A Bamigbola ◽  
Lorna E Warwick
Keyword(s):  
Information Needs ◽  
Medical Information ◽  
Age Groups ◽  
Older Age ◽  
Age Group ◽  
Younger Patients ◽  
Amount Of Information ◽  
Age Related ◽  
Younger Age ◽  
Significant Difference

Abstract Background Lymphomas can occur in all age groups but most commonly occur in older adults. Despite the shift towards patient- centered care, very little has been done to explore the information needs of patients with lymphoma by age. It is important for information to accessible to patients of all ages, as informed patients are consistently associated with better outcomes and healthcare experiences. In this study, Lymphoma Coalition (LC) describes the age-related differences in the information needs of patients with lymphoma using the 2020 LC Global Patient Survey (GPS). The objectives of this study were to identify: 1) how patients felt about the amount of information they received at diagnosis 2) the content of the information received at diagnosis and the level of understanding, and 3) their informational needs. Methods Globally, 11,878 respondents including 9,179 patients and 2,699 caregivers took part in the 2020 LC GPS. There were 9,078 patients included in this analysis who self-identified their age. These patients were grouped into five age groups for analysis: 18-29 (n=638), 30-39 (n=1,196), 40-59 (n=3,261), 60-69 (n=2,216), and 70+ (n=1,767). Demographics of the five age groups were examined, and descriptive analyses for all questions relating to information needs were performed in IBM SPSS v27. Results The five age groups differed significantly (p&lt; 0.001) in all the demographic categories examined. These categories included lymphoma subtype, sex, area of residence, education level, employment status, and household status. Patients were asked how they felt about the amount of information given to them at diagnosis. The oldest age group (70+) reported the highest prevalence (70%) of having received the right amount of information (Table 1). The younger age groups (18-29; 30-39; and 40-59) reported the highest prevalence of not receiving enough information (38%, 42%, and 41% respectively). Although not many patients reported being given too much information, of those who did, the younger age groups (18-29; 30-39; and 40-59) were the most prevalent (10%; 7%; and 5% respectively) (Table 1). Patients were asked about the type of information given to them at diagnosis, and how well they understood it. Compared to the younger age groups, the older age groups (60-69 and 70+) more frequently reported that they received and understood information given to them on different medical treatment options, the process and stages of their care, and how to manage side effects of treatment (Table 1). Patients were also asked what they needed more information about (Table 1). The top three areas that all patients needed more information about (regardless of age group) were treatment options, side effects from treatment, and their diagnosis and what it means. There was significant difference in the prevalence of how these information needs were reported between the age groups (Table 1). There was also significant difference in the prevalence of reporting a need for more information on support for self care, psychological support/counselling, and fertility across the age categories (Table 1). The lowest prevalence for needing more information in any of these areas was observed in the older age groups (60-69 and 70+), while the highest prevalence was observed in the youngest age groups (18-29 and 30-39) (Table 1). Although few patients reported not needing more information in any of these areas, its reporting was most prevalent in the older age groups (60-69 and 70+) (12% and 19%, respectively) (Table 1). Summary/Conclusions This analysis revealed that patients with lymphoma/CLL experience medical information differently across age groups. Compared to the mid and oldest patient groups, younger patients with lymphoma or CLL reported experiencing medical information differently than older patients do and reported less understanding of the medical information given to them. The younger patients also reported higher informational needs about their disease and treatment that may also be related to their age (e.g. information on fertility and family support). Clinicians should note these differences in age-group experiences and information needs, with the understanding that younger patients with lymphoma or CLL may require additional information, attention, and support. In the future, LC would like to explore how demographic differences may have confounded results. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Mother’s age as a risk factor of birth defects

2020 ◽  
Vol 65 (2) ◽  
pp. 34-39
Author(s):  
N. S. Demikova ◽  
M. А. Podolnaya ◽  
A. S. Lapina
Keyword(s):  
Risk Factor ◽  
Relative Risk ◽  
Birth Defects ◽  
Age Structure ◽  
Chromosomal Abnormalities ◽  
Age Groups ◽  
Age Group ◽  
Relative Risks ◽  
Age Related ◽  
Mother’S Age

Objective. To analyze the age structure of the mothers of children with birth defects and to assess the age-related risks of chromosomal and non-chromosomal congenital anomalies.Material and methods. The authors analyzed the data from 23 regional registers of birth defects from 2011 to 2018. There were total 5 047 468 births during this period. The authors calculated the incidence and relative risks of chromosomal and non-chromosomal birth defects in different age groups of mothers: under 20, from 20 to 34, from 35 to 39, 40–44, and above 45 years old.Results. The incidence of chromosomal abnormalities significantly increases with the mother’s age. The relative risk (RR) of chromosomal abnormalities in different age groups: 4,67 (95% CI 4,44–4,92) in Group 35-39, 15,00 (95% CI 14,10–15,96) in Group 40–44, and 26,49 (95% CI 21,89–32,07) in Group ≥45 as compared with the main age group of 20–34 years old. The authors also revealed the dependence of the non-chromosomal birth defects on the age of the mother: RR 1,15 (95% CI 1,08–1,23) in Group <20 years, RR 1,18 (95% CI 1,13–1,23) in Group 35–39, RR 1,35 (95% CI 1,24–1,47) in Group 40–44, and RR 2,03 (95% CI 1,47–2,79) in Group ≥ 45 years old.Conclusion. The study demonstrates the dependence of chromosomal and non-chromosomal birth defects on the mother’s age.

scholarly journals Relationship between age and intensive care unit-acquired bloodstream infections in infectious disease patients in Croatia

2018 ◽  
Vol 12 (05) ◽  
pp. 352-358
Author(s):  
Mirjana Balen Topic ◽  
Marija Santini ◽  
Bruno Barsic
Keyword(s):  
Infectious Disease ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Age Groups ◽  
Bloodstream Infections ◽  
Venous Catheter ◽  
Older Age ◽  
Mechanically Ventilated ◽  
Age Related ◽  
Significant Difference

Introduction: Intensive care unit-acquired bloodstream infections (ICU-BSI) belong to the most important nosocomial infections. Since there is scarce data available on their relationship with older age, we performed this study to estimate the age-related incidence of ICU-BSI and the odds of acquiring ICU-BSI in elderly critically ill infectious disease patients. Methodology: A retrospective observational analysis of prospectively collected demographic and clinical data of adult mechanically ventilated infectious disease patients, treated in a teaching hospital in Croatia between 1994 and 2008, using univariate, bivariate, and multivariate logistic regression analyses. Results: Of the 1,093 included patients, 509 (46.6%) were ≥ 65 years old, among 256 (23.4%) of whom a total of 353 ICU-BSI episodes were recorded. No significant difference among ICU-BSI causative microorganisms between the observed age groups was found (P = 0.4940). The rate of patients with ICU-BSI was higher among elderly ones (26.1 vs. 21.1%, P = 0.048), and elderly patients used the ICU facilities (ICU stay, duration of mechanical ventilation and central venous catheter [CVC] use) significantly longer (P < 0.05). However, older age was not positively related with the development of ICU-BSI (OR 0.99, 95% CI: 0.71-1.38); as opposed to the duration of CVC use (OR 1.09, 95% CI: 1.07-1.10). Conclusion: It seems that among adult mechanically ventilated infectious disease patients, borderline significantly higher rate of ICU-BSI among those aged ≥ 65 years was related to longer use of ICU facilities, rather than to their older age itself. The duration of CVC use was identified as the only factor positively related to the development of ICU-BSI.

scholarly journals Risks of perioperative complications in patients of older age groups: causes, mechanisms and prognostic possibilities

2021 ◽  
Vol 5 (3) ◽  
pp. 150-155
Author(s):  
D.V. Trotsyuk ◽  
◽  
D.S. Medvedev ◽  
Z.A. Zaripova ◽  
A.E. Chikov ◽  
...  
Keyword(s):  
Exercise Testing ◽  
Perioperative Complications ◽  
Objective Assessment ◽  
Cardiopulmonary Exercise Testing ◽  
Age Groups ◽  
The Body ◽  
Older Age ◽  
Operational Stress ◽  
Cardiopulmonary Exercise ◽  
Age Related

Age-related changes in the body and concomitant somatic pathology can have a significant impact on the body adaptation processes to operational stress, which is associated with the development of adverse events in the intraoperative period, postoperative complications and long-term prognosis. Both the initial state of the body and the severity of changes in metabolism in response to operational stress, as well as the involvement degree of the body functional reserves, are important. Traditionally used methods for risk stratification, based on a patient’s survey or assessment of his daily activity, do not always provide a comprehensive, objective assessment of the body functional capabilities, especially in patients of older age groups. The prognostic value of cardiopulmonary exercise testing for determining the indications and the risk of complications in various types of surgical interventions has been proved. Based on the results of preoperative cardiopulmonary exercise testing, it is possible to make a more complete, comprehensive assessment of the patient’s body functional status, which is especially important for polymorbid patients. However, at present, there are no clearly defined normative limits for the indicators of cardiopulmonary exercise testing for patients of older age groups, which determines the future prospects for studying the use of this method for patients over 60 years of age with various pathological conditions. KEYWORDS: aging, operational stress, adaptation, functional reserve, prognosis, age-related features, cardiopulmonary exercise testing. FOR CITATION: Trotsyuk D.V., Medvedev D.S., Zaripova Z.A., Chikov A.E. Risks of perioperative complications in patients of older age groups: causes, mechanisms and prognostic possibilities. Russian Medical Inquiry. 2021;5(3):150–155. DOI: 10.32364/2587-6821-2021-5-3-150-155.

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